EF-hand domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJY0_LEIBR

TriTrypDb:

LbrM.32.0050 , LBRM2903_320005400

Length:

134

Annotations

LeishMANIAdb annotations

A protein with unclear topology, conserved but entirely restricted to Kinetoplastida.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HJY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJY0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.628
CLV_NRD_NRD_1	106	108	PF00675	0.648
CLV_NRD_NRD_1	36	38	PF00675	0.453
CLV_PCSK_KEX2_1	103	105	PF00082	0.708
CLV_PCSK_KEX2_1	36	38	PF00082	0.462
CLV_PCSK_KEX2_1	44	46	PF00082	0.460
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.523
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DOC_MAPK_gen_1	44	50	PF00069	0.403
DOC_USP7_MATH_1	116	120	PF00917	0.436
DOC_USP7_MATH_1	126	130	PF00917	0.375
DOC_USP7_MATH_1	19	23	PF00917	0.722
DOC_WW_Pin1_4	9	14	PF00397	0.694
LIG_14-3-3_CanoR_1	3	7	PF00244	0.647
LIG_14-3-3_CanoR_1	71	76	PF00244	0.416
LIG_BRCT_BRCA1_1	128	132	PF00533	0.370
LIG_LIR_Gen_1	52	61	PF02991	0.355
LIG_LIR_Gen_1	93	101	PF02991	0.413
LIG_LIR_Nem_3	52	56	PF02991	0.358
LIG_LIR_Nem_3	60	64	PF02991	0.292
LIG_PALB2_WD40_1	26	34	PF16756	0.561
LIG_SH2_STAT5	67	70	PF00017	0.363
LIG_SH3_3	80	86	PF00018	0.486
LIG_WRC_WIRS_1	58	63	PF05994	0.355
MOD_CK1_1	74	80	PF00069	0.427
MOD_CK2_1	32	38	PF00069	0.624
MOD_GSK3_1	32	39	PF00069	0.642
MOD_N-GLC_1	71	76	PF02516	0.659
MOD_NEK2_1	2	7	PF00069	0.628
MOD_NEK2_1	59	64	PF00069	0.357
MOD_NEK2_2	116	121	PF00069	0.339
MOD_PK_1	36	42	PF00069	0.627
MOD_PKA_1	36	42	PF00069	0.672
MOD_PKA_2	2	8	PF00069	0.671
MOD_PKA_2	36	42	PF00069	0.669
MOD_Plk_1	71	77	PF00069	0.403
MOD_Plk_4	126	132	PF00069	0.369
MOD_Plk_4	2	8	PF00069	0.655
MOD_ProDKin_1	9	15	PF00069	0.695
TRG_DiLeu_BaEn_2	42	48	PF01217	0.550
TRG_ER_diArg_1	103	105	PF00400	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P8	Leptomonas seymouri	74%	100%
A0A0S4J967	Bodo saltans	45%	100%
A0A1X0PA05	Trypanosomatidae	57%	99%
A0A3S7X509	Leishmania donovani	79%	100%
A4I7G4	Leishmania infantum	78%	100%
D0A202	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	99%
E9B2C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q5T5	Leishmania major	78%	100%