TATE DNA Transposon

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

TATE DNA Transposon

Gene product:

TATE DNA Transposon

Species:

Leishmania braziliensis

UniProt:

A4HJX9_LEIBR

TriTrypDb:

LbrM.32.0040 , LBRM2903_110018000 , LBRM2903_180005100 , LBRM2903_350005500

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJX9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015074	DNA integration	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.359
CLV_C14_Caspase3-7	97	101	PF00656	0.482
CLV_NRD_NRD_1	262	264	PF00675	0.366
CLV_NRD_NRD_1	290	292	PF00675	0.350
CLV_NRD_NRD_1	51	53	PF00675	0.444
CLV_NRD_NRD_1	612	614	PF00675	0.662
CLV_NRD_NRD_1	760	762	PF00675	0.553
CLV_PCSK_KEX2_1	165	167	PF00082	0.505
CLV_PCSK_KEX2_1	181	183	PF00082	0.329
CLV_PCSK_KEX2_1	186	188	PF00082	0.421
CLV_PCSK_KEX2_1	261	263	PF00082	0.372
CLV_PCSK_KEX2_1	290	292	PF00082	0.350
CLV_PCSK_KEX2_1	611	613	PF00082	0.670
CLV_PCSK_KEX2_1	759	761	PF00082	0.534
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.505
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.329
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.409
CLV_PCSK_PC7_1	182	188	PF00082	0.469
CLV_PCSK_SKI1_1	104	108	PF00082	0.474
CLV_PCSK_SKI1_1	153	157	PF00082	0.511
CLV_PCSK_SKI1_1	186	190	PF00082	0.465
CLV_PCSK_SKI1_1	208	212	PF00082	0.478
CLV_PCSK_SKI1_1	263	267	PF00082	0.406
CLV_PCSK_SKI1_1	298	302	PF00082	0.361
CLV_PCSK_SKI1_1	321	325	PF00082	0.369
CLV_PCSK_SKI1_1	452	456	PF00082	0.474
CLV_PCSK_SKI1_1	485	489	PF00082	0.441
CLV_PCSK_SKI1_1	53	57	PF00082	0.376
CLV_PCSK_SKI1_1	661	665	PF00082	0.428
CLV_PCSK_SKI1_1	77	81	PF00082	0.407
DEG_APCC_DBOX_1	405	413	PF00400	0.472
DEG_Nend_Nbox_1	1	3	PF02207	0.422
DOC_CKS1_1	359	364	PF01111	0.433
DOC_CYCLIN_RxL_1	99	111	PF00134	0.471
DOC_MAPK_gen_1	295	305	PF00069	0.332
DOC_MAPK_gen_1	491	501	PF00069	0.490
DOC_MAPK_MEF2A_6	298	305	PF00069	0.328
DOC_MAPK_MEF2A_6	446	455	PF00069	0.359
DOC_PP1_RVXF_1	496	502	PF00149	0.463
DOC_PP2B_LxvP_1	176	179	PF13499	0.492
DOC_PP4_FxxP_1	195	198	PF00568	0.432
DOC_PP4_FxxP_1	253	256	PF00568	0.477
DOC_PP4_FxxP_1	620	623	PF00568	0.644
DOC_PP4_FxxP_1	743	746	PF00568	0.432
DOC_USP7_MATH_1	112	116	PF00917	0.522
DOC_USP7_MATH_1	731	735	PF00917	0.480
DOC_USP7_UBL2_3	446	450	PF12436	0.400
DOC_WW_Pin1_4	165	170	PF00397	0.484
DOC_WW_Pin1_4	22	27	PF00397	0.418
DOC_WW_Pin1_4	358	363	PF00397	0.429
DOC_WW_Pin1_4	400	405	PF00397	0.376
LIG_14-3-3_CanoR_1	182	189	PF00244	0.496
LIG_14-3-3_CanoR_1	262	268	PF00244	0.364
LIG_14-3-3_CanoR_1	334	339	PF00244	0.346
LIG_14-3-3_CanoR_1	343	347	PF00244	0.347
LIG_14-3-3_CanoR_1	442	446	PF00244	0.430
LIG_14-3-3_CanoR_1	463	469	PF00244	0.363
LIG_14-3-3_CanoR_1	498	502	PF00244	0.473
LIG_14-3-3_CanoR_1	540	549	PF00244	0.489
LIG_14-3-3_CanoR_1	633	640	PF00244	0.434
LIG_Actin_WH2_2	189	207	PF00022	0.467
LIG_Actin_WH2_2	438	454	PF00022	0.350
LIG_APCC_ABBA_1	24	29	PF00400	0.409
LIG_BIR_III_2	310	314	PF00653	0.410
LIG_BIR_III_2	508	512	PF00653	0.472
LIG_BIR_III_4	730	734	PF00653	0.503
LIG_BRCT_BRCA1_1	469	473	PF00533	0.412
LIG_BRCT_BRCA1_1	723	727	PF00533	0.394
LIG_deltaCOP1_diTrp_1	575	583	PF00928	0.453
LIG_eIF4E_1	688	694	PF01652	0.347
LIG_FHA_1	1	7	PF00498	0.435
LIG_FHA_1	215	221	PF00498	0.314
LIG_FHA_1	264	270	PF00498	0.551
LIG_FHA_1	351	357	PF00498	0.355
LIG_FHA_1	364	370	PF00498	0.386
LIG_FHA_1	423	429	PF00498	0.522
LIG_FHA_1	582	588	PF00498	0.585
LIG_FHA_1	695	701	PF00498	0.329
LIG_FHA_1	730	736	PF00498	0.426
LIG_FHA_2	166	172	PF00498	0.586
LIG_FHA_2	214	220	PF00498	0.462
LIG_FHA_2	252	258	PF00498	0.423
LIG_FHA_2	353	359	PF00498	0.324
LIG_FHA_2	365	371	PF00498	0.353
LIG_FHA_2	541	547	PF00498	0.460
LIG_FHA_2	7	13	PF00498	0.389
LIG_FHA_2	95	101	PF00498	0.482
LIG_GBD_Chelix_1	6	14	PF00786	0.390
LIG_Integrin_isoDGR_2	435	437	PF01839	0.481
LIG_LIR_Apic_2	741	746	PF02991	0.445
LIG_LIR_Gen_1	144	154	PF02991	0.477
LIG_LIR_Gen_1	306	316	PF02991	0.393
LIG_LIR_Gen_1	353	362	PF02991	0.375
LIG_LIR_Gen_1	546	557	PF02991	0.368
LIG_LIR_Nem_3	144	149	PF02991	0.469
LIG_LIR_Nem_3	199	204	PF02991	0.458
LIG_LIR_Nem_3	304	308	PF02991	0.422
LIG_LIR_Nem_3	329	335	PF02991	0.442
LIG_LIR_Nem_3	353	357	PF02991	0.357
LIG_LIR_Nem_3	470	476	PF02991	0.457
LIG_LIR_Nem_3	500	504	PF02991	0.520
LIG_LIR_Nem_3	546	552	PF02991	0.392
LIG_LIR_Nem_3	560	565	PF02991	0.348
LIG_LIR_Nem_3	707	713	PF02991	0.380
LIG_PCNA_PIPBox_1	78	87	PF02747	0.417
LIG_PCNA_yPIPBox_3	641	651	PF02747	0.441
LIG_PCNA_yPIPBox_3	77	85	PF02747	0.409
LIG_Pex14_2	743	747	PF04695	0.432
LIG_RPA_C_Fungi	94	106	PF08784	0.479
LIG_SH2_CRK	201	205	PF00017	0.424
LIG_SH2_CRK	309	313	PF00017	0.371
LIG_SH2_CRK	493	497	PF00017	0.372
LIG_SH2_CRK	549	553	PF00017	0.367
LIG_SH2_NCK_1	309	313	PF00017	0.337
LIG_SH2_NCK_1	549	553	PF00017	0.444
LIG_SH2_SRC	512	515	PF00017	0.408
LIG_SH2_SRC	712	715	PF00017	0.413
LIG_SH2_STAP1	284	288	PF00017	0.498
LIG_SH2_STAP1	296	300	PF00017	0.273
LIG_SH2_STAP1	549	553	PF00017	0.444
LIG_SH2_STAP1	634	638	PF00017	0.549
LIG_SH2_STAP1	696	700	PF00017	0.325
LIG_SH2_STAP1	723	727	PF00017	0.456
LIG_SH2_STAT3	299	302	PF00017	0.322
LIG_SH2_STAT3	87	90	PF00017	0.500
LIG_SH2_STAT5	432	435	PF00017	0.527
LIG_SH2_STAT5	512	515	PF00017	0.408
LIG_SH2_STAT5	696	699	PF00017	0.327
LIG_SH2_STAT5	712	715	PF00017	0.351
LIG_SH2_STAT5	84	87	PF00017	0.428
LIG_SH3_3	238	244	PF00018	0.558
LIG_SH3_3	526	532	PF00018	0.381
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.339
LIG_SUMO_SIM_par_1	355	361	PF11976	0.337
LIG_SUMO_SIM_par_1	383	390	PF11976	0.418
LIG_TRAF2_1	132	135	PF00917	0.470
LIG_TRAF2_1	19	22	PF00917	0.444
LIG_TRAF2_1	413	416	PF00917	0.467
LIG_TRAF2_1	520	523	PF00917	0.455
LIG_TRAF2_1	9	12	PF00917	0.393
LIG_TRFH_1	229	233	PF08558	0.292
LIG_UBA3_1	69	77	PF00899	0.400
MOD_CDC14_SPxK_1	403	406	PF00782	0.393
MOD_CDK_SPxK_1	400	406	PF00069	0.375
MOD_CK1_1	121	127	PF00069	0.559
MOD_CK1_1	422	428	PF00069	0.444
MOD_CK1_1	444	450	PF00069	0.355
MOD_CK1_1	464	470	PF00069	0.390
MOD_CK2_1	213	219	PF00069	0.466
MOD_CK2_1	251	257	PF00069	0.419
MOD_CK2_1	410	416	PF00069	0.435
MOD_CK2_1	517	523	PF00069	0.499
MOD_CK2_1	540	546	PF00069	0.456
MOD_CK2_1	6	12	PF00069	0.391
MOD_Cter_Amidation	259	262	PF01082	0.384
MOD_Cter_Amidation	288	291	PF01082	0.436
MOD_GlcNHglycan	143	146	PF01048	0.411
MOD_GlcNHglycan	421	424	PF01048	0.443
MOD_GlcNHglycan	615	618	PF01048	0.768
MOD_GlcNHglycan	634	637	PF01048	0.346
MOD_GlcNHglycan	72	75	PF01048	0.405
MOD_GSK3_1	118	125	PF00069	0.567
MOD_GSK3_1	177	184	PF00069	0.489
MOD_GSK3_1	513	520	PF00069	0.494
MOD_GSK3_1	541	548	PF00069	0.535
MOD_GSK3_1	571	578	PF00069	0.451
MOD_LATS_1	75	81	PF00433	0.405
MOD_NEK2_1	204	209	PF00069	0.396
MOD_NEK2_1	455	460	PF00069	0.475
MOD_NEK2_1	476	481	PF00069	0.346
MOD_NEK2_1	6	11	PF00069	0.391
MOD_NEK2_1	70	75	PF00069	0.395
MOD_NEK2_2	112	117	PF00069	0.523
MOD_NEK2_2	497	502	PF00069	0.472
MOD_PIKK_1	118	124	PF00454	0.566
MOD_PIKK_1	476	482	PF00454	0.423
MOD_PKA_1	17	23	PF00069	0.456
MOD_PKA_1	181	187	PF00069	0.479
MOD_PKA_2	181	187	PF00069	0.479
MOD_PKA_2	204	210	PF00069	0.427
MOD_PKA_2	342	348	PF00069	0.341
MOD_PKA_2	441	447	PF00069	0.348
MOD_PKA_2	497	503	PF00069	0.475
MOD_PKA_2	581	587	PF00069	0.623
MOD_PKA_2	632	638	PF00069	0.465
MOD_PKB_1	261	269	PF00069	0.398
MOD_PKB_1	611	619	PF00069	0.644
MOD_Plk_1	430	436	PF00069	0.355
MOD_Plk_1	513	519	PF00069	0.471
MOD_Plk_1	545	551	PF00069	0.530
MOD_Plk_1	555	561	PF00069	0.509
MOD_Plk_1	694	700	PF00069	0.386
MOD_Plk_2-3	410	416	PF00069	0.412
MOD_Plk_2-3	545	551	PF00069	0.480
MOD_Plk_4	112	118	PF00069	0.528
MOD_Plk_4	171	177	PF00069	0.486
MOD_Plk_4	196	202	PF00069	0.447
MOD_Plk_4	364	370	PF00069	0.360
MOD_Plk_4	422	428	PF00069	0.427
MOD_Plk_4	464	470	PF00069	0.389
MOD_Plk_4	77	83	PF00069	0.476
MOD_ProDKin_1	165	171	PF00069	0.483
MOD_ProDKin_1	22	28	PF00069	0.408
MOD_ProDKin_1	358	364	PF00069	0.428
MOD_ProDKin_1	400	406	PF00069	0.375
MOD_SUMO_rev_2	12	20	PF00179	0.403
TRG_DiLeu_BaEn_1	152	157	PF01217	0.480
TRG_DiLeu_BaEn_1	30	35	PF01217	0.432
TRG_DiLeu_BaEn_4	415	421	PF01217	0.476
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.403
TRG_DiLeu_BaLyEn_6	436	441	PF01217	0.439
TRG_ENDOCYTIC_2	201	204	PF00928	0.417
TRG_ENDOCYTIC_2	309	312	PF00928	0.363
TRG_ENDOCYTIC_2	332	335	PF00928	0.422
TRG_ENDOCYTIC_2	493	496	PF00928	0.367
TRG_ENDOCYTIC_2	549	552	PF00928	0.505
TRG_ER_diArg_1	261	263	PF00400	0.406
TRG_ER_diArg_1	290	293	PF00400	0.435
TRG_ER_diArg_1	324	327	PF00400	0.358
TRG_ER_diArg_1	333	336	PF00400	0.354
TRG_ER_diArg_1	579	582	PF00400	0.461
TRG_ER_diArg_1	610	613	PF00400	0.639
TRG_ER_diArg_1	759	761	PF00400	0.534
TRG_NES_CRM1_1	245	257	PF08389	0.456
TRG_NES_CRM1_1	5	16	PF08389	0.393
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	519	523	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	589	594	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	648	652	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NZ81	Trypanosomatidae	47%	100%
A0A1X0NZU3	Trypanosomatidae	47%	100%
A0A1X0P2J1	Trypanosomatidae	48%	100%
A4H9A6	Leishmania braziliensis	99%	100%
A4HEK4	Leishmania braziliensis	99%	100%
A4HEK5	Leishmania braziliensis	96%	100%
A4HIQ7	Leishmania braziliensis	93%	100%
A4HIW1	Leishmania braziliensis	99%	100%
A4HM37	Leishmania braziliensis	93%	84%