Nuclear segregation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear segregation protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJX8_LEIBR

TriTrypDb:

LbrM.32.0030 , LBRM2903_320005500

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	1
GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HJX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJX8

Function

Biological processes
Term	Name	Level	Count
GO:0006403	RNA localization	3	1
GO:0008298	intracellular mRNA localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.375
CLV_C14_Caspase3-7	80	84	PF00656	0.532
CLV_MEL_PAP_1	237	243	PF00089	0.589
CLV_NRD_NRD_1	103	105	PF00675	0.413
CLV_NRD_NRD_1	106	108	PF00675	0.439
CLV_NRD_NRD_1	138	140	PF00675	0.515
CLV_NRD_NRD_1	152	154	PF00675	0.523
CLV_NRD_NRD_1	269	271	PF00675	0.517
CLV_NRD_NRD_1	284	286	PF00675	0.413
CLV_NRD_NRD_1	291	293	PF00675	0.548
CLV_NRD_NRD_1	341	343	PF00675	0.576
CLV_NRD_NRD_1	436	438	PF00675	0.451
CLV_NRD_NRD_1	45	47	PF00675	0.530
CLV_NRD_NRD_1	85	87	PF00675	0.463
CLV_NRD_NRD_1	92	94	PF00675	0.461
CLV_PCSK_FUR_1	104	108	PF00082	0.493
CLV_PCSK_FUR_1	339	343	PF00082	0.613
CLV_PCSK_FUR_1	90	94	PF00082	0.567
CLV_PCSK_KEX2_1	105	107	PF00082	0.428
CLV_PCSK_KEX2_1	152	154	PF00082	0.523
CLV_PCSK_KEX2_1	213	215	PF00082	0.601
CLV_PCSK_KEX2_1	284	286	PF00082	0.512
CLV_PCSK_KEX2_1	291	293	PF00082	0.511
CLV_PCSK_KEX2_1	300	302	PF00082	0.496
CLV_PCSK_KEX2_1	341	343	PF00082	0.596
CLV_PCSK_KEX2_1	45	47	PF00082	0.480
CLV_PCSK_KEX2_1	92	94	PF00082	0.522
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.416
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.601
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.473
CLV_PCSK_SKI1_1	179	183	PF00082	0.547
CLV_PCSK_SKI1_1	72	76	PF00082	0.605
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DOC_MAPK_gen_1	407	416	PF00069	0.551
DOC_USP7_MATH_1	18	22	PF00917	0.625
DOC_USP7_MATH_1	247	251	PF00917	0.372
DOC_USP7_MATH_1	302	306	PF00917	0.457
DOC_USP7_MATH_1	391	395	PF00917	0.764
DOC_USP7_UBL2_3	209	213	PF12436	0.597
DOC_USP7_UBL2_3	267	271	PF12436	0.478
DOC_USP7_UBL2_3	296	300	PF12436	0.539
DOC_USP7_UBL2_3	374	378	PF12436	0.721
DOC_USP7_UBL2_3	381	385	PF12436	0.690
LIG_14-3-3_CanoR_1	238	248	PF00244	0.596
LIG_14-3-3_CanoR_1	301	311	PF00244	0.451
LIG_Clathr_ClatBox_1	413	417	PF01394	0.397
LIG_deltaCOP1_diTrp_1	261	265	PF00928	0.473
LIG_EH1_1	429	437	PF00400	0.387
LIG_FHA_1	173	179	PF00498	0.478
LIG_FHA_1	318	324	PF00498	0.513
LIG_FHA_1	443	449	PF00498	0.593
LIG_FHA_2	124	130	PF00498	0.407
LIG_FHA_2	180	186	PF00498	0.530
LIG_FHA_2	25	31	PF00498	0.427
LIG_FHA_2	311	317	PF00498	0.386
LIG_FHA_2	422	428	PF00498	0.582
LIG_FHA_2	475	481	PF00498	0.708
LIG_IBAR_NPY_1	309	311	PF08397	0.528
LIG_LIR_Gen_1	191	199	PF02991	0.454
LIG_LIR_Nem_3	191	195	PF02991	0.434
LIG_LIR_Nem_3	30	34	PF02991	0.545
LIG_PTB_Apo_2	200	207	PF02174	0.555
LIG_PTB_Phospho_1	200	206	PF10480	0.553
LIG_RPA_C_Fungi	328	340	PF08784	0.432
LIG_SH2_CRK	192	196	PF00017	0.561
LIG_SH2_STAP1	206	210	PF00017	0.528
LIG_SH2_STAP1	311	315	PF00017	0.476
LIG_SH2_STAP1	439	443	PF00017	0.494
LIG_SH2_STAT3	273	276	PF00017	0.523
LIG_SH2_STAT3	324	327	PF00017	0.561
LIG_SH2_STAT5	273	276	PF00017	0.513
LIG_SH2_STAT5	324	327	PF00017	0.462
LIG_SH3_2	23	28	PF14604	0.625
LIG_SH3_2	383	388	PF14604	0.587
LIG_SH3_3	20	26	PF00018	0.478
LIG_SH3_3	349	355	PF00018	0.479
LIG_SH3_3	380	386	PF00018	0.590
LIG_SH3_3	6	12	PF00018	0.663
LIG_TRAF2_1	182	185	PF00917	0.541
LIG_TRAF2_1	3	6	PF00917	0.756
LIG_TRAF2_1	477	480	PF00917	0.793
LIG_TRAF2_1	58	61	PF00917	0.419
LIG_UBA3_1	321	328	PF00899	0.496
LIG_UBA3_1	48	53	PF00899	0.527
MOD_CK1_1	464	470	PF00069	0.670
MOD_CK2_1	123	129	PF00069	0.381
MOD_CK2_1	179	185	PF00069	0.563
MOD_CK2_1	474	480	PF00069	0.713
MOD_CK2_1	55	61	PF00069	0.507
MOD_CMANNOS	262	265	PF00535	0.458
MOD_GlcNHglycan	142	146	PF01048	0.528
MOD_GlcNHglycan	451	454	PF01048	0.748
MOD_GlcNHglycan	77	82	PF01048	0.548
MOD_GSK3_1	370	377	PF00069	0.745
MOD_GSK3_1	461	468	PF00069	0.663
MOD_GSK3_1	51	58	PF00069	0.515
MOD_NEK2_1	141	146	PF00069	0.517
MOD_NEK2_1	448	453	PF00069	0.707
MOD_NEK2_1	55	60	PF00069	0.511
MOD_NEK2_2	123	128	PF00069	0.424
MOD_NEK2_2	247	252	PF00069	0.480
MOD_PIKK_1	302	308	PF00454	0.624
MOD_PIKK_1	62	68	PF00454	0.655
MOD_PKA_2	239	245	PF00069	0.603
MOD_PKA_2	302	308	PF00069	0.589
MOD_Plk_1	418	424	PF00069	0.543
MOD_Plk_4	317	323	PF00069	0.439
MOD_Plk_4	348	354	PF00069	0.538
MOD_SUMO_for_1	386	389	PF00179	0.813
MOD_SUMO_rev_2	162	166	PF00179	0.542
MOD_SUMO_rev_2	205	210	PF00179	0.576
TRG_DiLeu_BaEn_2	70	76	PF01217	0.635
TRG_ENDOCYTIC_2	192	195	PF00928	0.533
TRG_ER_diArg_1	103	106	PF00400	0.534
TRG_ER_diArg_1	237	240	PF00400	0.589
TRG_ER_diArg_1	339	342	PF00400	0.640
TRG_NLS_Bipartite_1	284	304	PF00514	0.628
TRG_NLS_Bipartite_1	86	108	PF00514	0.564
TRG_NLS_MonoCore_2	103	108	PF00514	0.525
TRG_NLS_MonoExtC_3	103	109	PF00514	0.572
TRG_NLS_MonoExtN_4	102	108	PF00514	0.575
TRG_NLS_MonoExtN_4	267	274	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD36	Leptomonas seymouri	54%	96%
A0A0S4J925	Bodo saltans	36%	100%
A0A1X0P6U5	Trypanosomatidae	41%	100%
A0A3R7KQ83	Trypanosoma rangeli	42%	96%
A0A3S7X525	Leishmania donovani	76%	98%
A4HJY1	Leishmania braziliensis	100%	100%
A4I7G5	Leishmania infantum	75%	98%
C9ZZZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B2C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%
Q4Q5T4	Leishmania major	76%	100%
V5BS50	Trypanosoma cruzi	44%	96%