CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJX4_LEIBR

TriTrypDb:

LbrM.31.3730 , LBRM2903_310024600

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.683
CLV_MEL_PAP_1	209	215	PF00089	0.524
CLV_NRD_NRD_1	288	290	PF00675	0.725
CLV_NRD_NRD_1	424	426	PF00675	0.573
CLV_NRD_NRD_1	494	496	PF00675	0.500
CLV_NRD_NRD_1	497	499	PF00675	0.495
CLV_NRD_NRD_1	516	518	PF00675	0.517
CLV_PCSK_FUR_1	306	310	PF00082	0.419
CLV_PCSK_FUR_1	495	499	PF00082	0.494
CLV_PCSK_KEX2_1	308	310	PF00082	0.427
CLV_PCSK_KEX2_1	494	496	PF00082	0.539
CLV_PCSK_KEX2_1	497	499	PF00082	0.533
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.427
CLV_PCSK_SKI1_1	277	281	PF00082	0.694
CLV_PCSK_SKI1_1	353	357	PF00082	0.563
DEG_APCC_KENBOX_2	68	72	PF00400	0.535
DEG_Nend_Nbox_1	1	3	PF02207	0.500
DOC_PP1_RVXF_1	441	447	PF00149	0.406
DOC_PP2B_LxvP_1	245	248	PF13499	0.709
DOC_PP2B_LxvP_1	472	475	PF13499	0.633
DOC_USP7_MATH_1	145	149	PF00917	0.546
DOC_USP7_MATH_1	189	193	PF00917	0.559
DOC_USP7_MATH_1	204	208	PF00917	0.540
DOC_USP7_MATH_1	236	240	PF00917	0.566
DOC_USP7_MATH_1	259	263	PF00917	0.518
DOC_USP7_MATH_1	30	34	PF00917	0.588
DOC_USP7_MATH_1	327	331	PF00917	0.366
DOC_USP7_MATH_1	44	48	PF00917	0.535
DOC_WW_Pin1_4	122	127	PF00397	0.540
DOC_WW_Pin1_4	149	154	PF00397	0.517
DOC_WW_Pin1_4	224	229	PF00397	0.542
DOC_WW_Pin1_4	238	243	PF00397	0.569
DOC_WW_Pin1_4	26	31	PF00397	0.557
DOC_WW_Pin1_4	282	287	PF00397	0.754
DOC_WW_Pin1_4	49	54	PF00397	0.634
DOC_WW_Pin1_4	5	10	PF00397	0.669
DOC_WW_Pin1_4	510	515	PF00397	0.486
DOC_WW_Pin1_4	540	545	PF00397	0.496
DOC_WW_Pin1_4	64	69	PF00397	0.542
LIG_14-3-3_CanoR_1	219	228	PF00244	0.531
LIG_14-3-3_CanoR_1	405	411	PF00244	0.503
LIG_14-3-3_CanoR_1	425	435	PF00244	0.434
LIG_14-3-3_CanoR_1	536	544	PF00244	0.669
LIG_14-3-3_CterR_2	542	547	PF00244	0.491
LIG_Actin_WH2_2	445	460	PF00022	0.412
LIG_BRCT_BRCA1_1	197	201	PF00533	0.664
LIG_BRCT_BRCA1_1	261	265	PF00533	0.519
LIG_CtBP_PxDLS_1	242	246	PF00389	0.525
LIG_FHA_1	203	209	PF00498	0.509
LIG_FHA_1	227	233	PF00498	0.607
LIG_FHA_1	283	289	PF00498	0.677
LIG_FHA_1	320	326	PF00498	0.385
LIG_FHA_1	480	486	PF00498	0.479
LIG_FHA_1	53	59	PF00498	0.572
LIG_FHA_2	188	194	PF00498	0.663
LIG_FHA_2	355	361	PF00498	0.584
LIG_FHA_2	365	371	PF00498	0.662
LIG_FHA_2	491	497	PF00498	0.490
LIG_FHA_2	74	80	PF00498	0.535
LIG_LIR_Gen_1	161	171	PF02991	0.576
LIG_LIR_Gen_1	79	86	PF02991	0.527
LIG_LIR_Nem_3	161	166	PF02991	0.579
LIG_LIR_Nem_3	197	202	PF02991	0.548
LIG_LIR_Nem_3	412	417	PF02991	0.403
LIG_LIR_Nem_3	79	83	PF02991	0.531
LIG_SH2_CRK	251	255	PF00017	0.685
LIG_SH2_CRK	316	320	PF00017	0.393
LIG_SH2_CRK	417	421	PF00017	0.427
LIG_SH2_SRC	142	145	PF00017	0.523
LIG_SH2_STAP1	251	255	PF00017	0.685
LIG_SH2_STAT3	119	122	PF00017	0.671
LIG_SH2_STAT5	119	122	PF00017	0.591
LIG_SH2_STAT5	142	145	PF00017	0.588
LIG_SH2_STAT5	22	25	PF00017	0.497
LIG_SH2_STAT5	397	400	PF00017	0.501
LIG_SH2_STAT5	403	406	PF00017	0.409
LIG_SH3_3	110	116	PF00018	0.661
LIG_SH3_3	15	21	PF00018	0.526
LIG_SH3_3	521	527	PF00018	0.495
LIG_SH3_3	6	12	PF00018	0.470
LIG_SH3_3	92	98	PF00018	0.525
LIG_SUMO_SIM_anti_2	372	377	PF11976	0.491
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.525
LIG_SUMO_SIM_par_1	372	377	PF11976	0.571
LIG_SUMO_SIM_par_1	482	489	PF11976	0.483
LIG_SxIP_EBH_1	508	522	PF03271	0.488
LIG_TRAF2_1	76	79	PF00917	0.537
LIG_TYR_ITIM	415	420	PF00017	0.414
LIG_UBA3_1	468	477	PF00899	0.435
LIG_WRC_WIRS_1	183	188	PF05994	0.526
LIG_WW_1	248	251	PF00397	0.684
MOD_CDK_SPK_2	540	545	PF00069	0.496
MOD_CDK_SPK_2	64	69	PF00069	0.536
MOD_CDK_SPxxK_3	282	289	PF00069	0.680
MOD_CDK_SPxxK_3	510	517	PF00069	0.485
MOD_CK1_1	102	108	PF00069	0.564
MOD_CK1_1	125	131	PF00069	0.599
MOD_CK1_1	148	154	PF00069	0.577
MOD_CK1_1	177	183	PF00069	0.714
MOD_CK1_1	185	191	PF00069	0.613
MOD_CK1_1	192	198	PF00069	0.510
MOD_CK1_1	203	209	PF00069	0.532
MOD_CK1_1	215	221	PF00069	0.536
MOD_CK1_1	282	288	PF00069	0.732
MOD_CK1_1	354	360	PF00069	0.603
MOD_CK1_1	49	55	PF00069	0.619
MOD_CK1_1	5	11	PF00069	0.530
MOD_CK1_1	500	506	PF00069	0.576
MOD_CK2_1	187	193	PF00069	0.643
MOD_CK2_1	266	272	PF00069	0.528
MOD_CK2_1	338	344	PF00069	0.621
MOD_CK2_1	64	70	PF00069	0.536
MOD_CK2_1	73	79	PF00069	0.505
MOD_GlcNHglycan	110	113	PF01048	0.524
MOD_GlcNHglycan	135	138	PF01048	0.667
MOD_GlcNHglycan	145	148	PF01048	0.552
MOD_GlcNHglycan	160	163	PF01048	0.608
MOD_GlcNHglycan	179	182	PF01048	0.500
MOD_GlcNHglycan	187	190	PF01048	0.556
MOD_GlcNHglycan	202	205	PF01048	0.489
MOD_GlcNHglycan	214	217	PF01048	0.745
MOD_GlcNHglycan	229	232	PF01048	0.579
MOD_GlcNHglycan	236	239	PF01048	0.633
MOD_GlcNHglycan	257	260	PF01048	0.533
MOD_GlcNHglycan	272	276	PF01048	0.509
MOD_GlcNHglycan	319	322	PF01048	0.382
MOD_GlcNHglycan	32	35	PF01048	0.638
MOD_GlcNHglycan	376	379	PF01048	0.658
MOD_GlcNHglycan	390	393	PF01048	0.441
MOD_GlcNHglycan	48	51	PF01048	0.579
MOD_GlcNHglycan	488	491	PF01048	0.586
MOD_GlcNHglycan	531	534	PF01048	0.542
MOD_GSK3_1	102	109	PF00069	0.658
MOD_GSK3_1	143	150	PF00069	0.617
MOD_GSK3_1	154	161	PF00069	0.494
MOD_GSK3_1	185	192	PF00069	0.598
MOD_GSK3_1	200	207	PF00069	0.593
MOD_GSK3_1	211	218	PF00069	0.532
MOD_GSK3_1	220	227	PF00069	0.600
MOD_GSK3_1	234	241	PF00069	0.535
MOD_GSK3_1	250	257	PF00069	0.566
MOD_GSK3_1	26	33	PF00069	0.620
MOD_GSK3_1	340	347	PF00069	0.550
MOD_GSK3_1	351	358	PF00069	0.600
MOD_GSK3_1	477	484	PF00069	0.477
MOD_GSK3_1	486	493	PF00069	0.501
MOD_GSK3_1	52	59	PF00069	0.676
MOD_GSK3_1	69	76	PF00069	0.709
MOD_N-GLC_1	243	248	PF02516	0.524
MOD_N-GLC_1	255	260	PF02516	0.478
MOD_N-GLC_1	30	35	PF02516	0.535
MOD_NEK2_1	108	113	PF00069	0.538
MOD_NEK2_1	133	138	PF00069	0.636
MOD_NEK2_1	158	163	PF00069	0.582
MOD_NEK2_1	202	207	PF00069	0.641
MOD_NEK2_1	468	473	PF00069	0.472
MOD_NEK2_1	486	491	PF00069	0.473
MOD_NEK2_1	537	542	PF00069	0.505
MOD_NEK2_1	56	61	PF00069	0.792
MOD_NEK2_1	73	78	PF00069	0.531
MOD_NEK2_2	327	332	PF00069	0.374
MOD_NEK2_2	520	525	PF00069	0.499
MOD_PIKK_1	32	38	PF00454	0.547
MOD_PK_1	497	503	PF00069	0.499
MOD_PKA_1	425	431	PF00069	0.501
MOD_PKA_1	497	503	PF00069	0.499
MOD_PKA_2	211	217	PF00069	0.535
MOD_PKA_2	218	224	PF00069	0.511
MOD_PKA_2	497	503	PF00069	0.499
MOD_PKB_1	495	503	PF00069	0.497
MOD_Plk_1	192	198	PF00069	0.661
MOD_Plk_1	369	375	PF00069	0.592
MOD_Plk_1	69	75	PF00069	0.537
MOD_Plk_4	14	20	PF00069	0.489
MOD_Plk_4	204	210	PF00069	0.514
MOD_Plk_4	250	256	PF00069	0.686
MOD_Plk_4	259	265	PF00069	0.570
MOD_Plk_4	369	375	PF00069	0.560
MOD_Plk_4	481	487	PF00069	0.482
MOD_Plk_4	69	75	PF00069	0.608
MOD_Plk_4	91	97	PF00069	0.647
MOD_ProDKin_1	122	128	PF00069	0.540
MOD_ProDKin_1	149	155	PF00069	0.516
MOD_ProDKin_1	224	230	PF00069	0.543
MOD_ProDKin_1	238	244	PF00069	0.571
MOD_ProDKin_1	26	32	PF00069	0.562
MOD_ProDKin_1	282	288	PF00069	0.749
MOD_ProDKin_1	49	55	PF00069	0.634
MOD_ProDKin_1	5	11	PF00069	0.668
MOD_ProDKin_1	510	516	PF00069	0.483
MOD_ProDKin_1	540	546	PF00069	0.493
MOD_ProDKin_1	64	70	PF00069	0.542
MOD_SUMO_for_1	446	449	PF00179	0.409
MOD_SUMO_rev_2	347	355	PF00179	0.587
MOD_SUMO_rev_2	455	465	PF00179	0.509
TRG_DiLeu_BaEn_2	334	340	PF01217	0.479
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.491
TRG_ENDOCYTIC_2	251	254	PF00928	0.687
TRG_ENDOCYTIC_2	316	319	PF00928	0.397
TRG_ENDOCYTIC_2	417	420	PF00928	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J5	Leptomonas seymouri	36%	94%
A0A3Q8ICJ1	Leishmania donovani	56%	100%
A4HJB8	Leishmania braziliensis	96%	100%
A4I6R1	Leishmania infantum	56%	100%
E9B1T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q4Q6C8	Leishmania major	55%	100%