LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HJX2_LEIBR
TriTrypDb:
LbrM.31.3710 , LBRM2903_310032600 *
Length:
541

Annotations

LeishMANIAdb annotations

A bacterial-type Mg2+ transporter found in kinetoplastids.. Expanded extensively on multiple lineages, especially T cruzi

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4HJX2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJX2

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006811 monoatomic ion transport 4 1
GO:0006812 monoatomic cation transport 5 1
GO:0015693 magnesium ion transport 7 1
GO:0030001 metal ion transport 6 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0008324 monoatomic cation transmembrane transporter activity 4 1
GO:0015075 monoatomic ion transmembrane transporter activity 3 1
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1
GO:0022890 inorganic cation transmembrane transporter activity 4 1
GO:0046873 metal ion transmembrane transporter activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 256 260 PF00656 0.501
CLV_C14_Caspase3-7 272 276 PF00656 0.499
CLV_C14_Caspase3-7 384 388 PF00656 0.663
CLV_NRD_NRD_1 163 165 PF00675 0.654
CLV_NRD_NRD_1 185 187 PF00675 0.546
CLV_NRD_NRD_1 278 280 PF00675 0.320
CLV_NRD_NRD_1 285 287 PF00675 0.327
CLV_NRD_NRD_1 291 293 PF00675 0.345
CLV_NRD_NRD_1 535 537 PF00675 0.367
CLV_PCSK_KEX2_1 163 165 PF00082 0.655
CLV_PCSK_KEX2_1 185 187 PF00082 0.546
CLV_PCSK_KEX2_1 25 27 PF00082 0.502
CLV_PCSK_KEX2_1 278 280 PF00082 0.320
CLV_PCSK_KEX2_1 284 286 PF00082 0.334
CLV_PCSK_KEX2_1 291 293 PF00082 0.345
CLV_PCSK_KEX2_1 535 537 PF00082 0.293
CLV_PCSK_PC1ET2_1 25 27 PF00082 0.502
CLV_PCSK_SKI1_1 278 282 PF00082 0.351
CLV_PCSK_SKI1_1 286 290 PF00082 0.344
CLV_PCSK_SKI1_1 291 295 PF00082 0.356
CLV_PCSK_SKI1_1 317 321 PF00082 0.420
CLV_PCSK_SKI1_1 431 435 PF00082 0.398
CLV_PCSK_SKI1_1 444 448 PF00082 0.266
CLV_PCSK_SKI1_1 91 95 PF00082 0.361
DOC_CDC14_PxL_1 420 428 PF14671 0.571
DOC_CKS1_1 46 51 PF01111 0.531
DOC_CYCLIN_yCln2_LP_2 304 310 PF00134 0.533
DOC_CYCLIN_yCln2_LP_2 319 325 PF00134 0.574
DOC_CYCLIN_yCln2_LP_2 46 52 PF00134 0.537
DOC_CYCLIN_yCln2_LP_2 525 531 PF00134 0.199
DOC_CYCLIN_yCln2_LP_2 94 100 PF00134 0.578
DOC_MAPK_gen_1 317 325 PF00069 0.541
DOC_PP1_RVXF_1 289 296 PF00149 0.547
DOC_PP1_RVXF_1 406 412 PF00149 0.602
DOC_PP1_RVXF_1 455 461 PF00149 0.546
DOC_PP2B_LxvP_1 213 216 PF13499 0.466
DOC_PP2B_LxvP_1 94 97 PF13499 0.569
DOC_USP7_MATH_1 216 220 PF00917 0.395
DOC_USP7_MATH_1 257 261 PF00917 0.498
DOC_USP7_MATH_1 364 368 PF00917 0.603
DOC_USP7_MATH_1 388 392 PF00917 0.719
DOC_USP7_MATH_1 397 401 PF00917 0.663
DOC_USP7_MATH_1 412 416 PF00917 0.723
DOC_USP7_MATH_1 422 426 PF00917 0.598
DOC_USP7_MATH_1 68 72 PF00917 0.686
DOC_WW_Pin1_4 198 203 PF00397 0.446
DOC_WW_Pin1_4 24 29 PF00397 0.794
DOC_WW_Pin1_4 318 323 PF00397 0.647
DOC_WW_Pin1_4 327 332 PF00397 0.621
DOC_WW_Pin1_4 368 373 PF00397 0.612
DOC_WW_Pin1_4 393 398 PF00397 0.624
DOC_WW_Pin1_4 45 50 PF00397 0.525
DOC_WW_Pin1_4 505 510 PF00397 0.345
DOC_WW_Pin1_4 64 69 PF00397 0.585
LIG_14-3-3_CanoR_1 123 129 PF00244 0.637
LIG_14-3-3_CanoR_1 378 386 PF00244 0.615
LIG_14-3-3_CanoR_1 408 412 PF00244 0.631
LIG_14-3-3_CanoR_1 464 472 PF00244 0.636
LIG_14-3-3_CanoR_1 91 97 PF00244 0.561
LIG_CSL_BTD_1 323 326 PF09270 0.568
LIG_FHA_1 136 142 PF00498 0.299
LIG_FHA_1 153 159 PF00498 0.510
LIG_FHA_1 179 185 PF00498 0.300
LIG_FHA_1 221 227 PF00498 0.393
LIG_FHA_1 371 377 PF00498 0.638
LIG_FHA_1 432 438 PF00498 0.519
LIG_FHA_1 448 454 PF00498 0.467
LIG_FHA_1 521 527 PF00498 0.235
LIG_FHA_1 532 538 PF00498 0.609
LIG_FHA_2 157 163 PF00498 0.452
LIG_FHA_2 25 31 PF00498 0.632
LIG_FHA_2 54 60 PF00498 0.613
LIG_GBD_Chelix_1 39 47 PF00786 0.395
LIG_Integrin_isoDGR_2 392 394 PF01839 0.430
LIG_LIR_Apic_2 410 414 PF02991 0.597
LIG_LIR_Gen_1 175 184 PF02991 0.372
LIG_LIR_Gen_1 229 240 PF02991 0.286
LIG_LIR_Gen_1 35 46 PF02991 0.621
LIG_LIR_Gen_1 470 480 PF02991 0.533
LIG_LIR_Nem_3 175 179 PF02991 0.380
LIG_LIR_Nem_3 229 235 PF02991 0.286
LIG_LIR_Nem_3 239 245 PF02991 0.242
LIG_LIR_Nem_3 35 41 PF02991 0.615
LIG_LIR_Nem_3 468 474 PF02991 0.615
LIG_LIR_Nem_3 507 513 PF02991 0.385
LIG_NRBOX 42 48 PF00104 0.609
LIG_PAM2_1 484 496 PF00658 0.265
LIG_PCNA_yPIPBox_3 77 91 PF02747 0.559
LIG_PDZ_Class_2 536 541 PF00595 0.606
LIG_RPA_C_Fungi 280 292 PF08784 0.408
LIG_SH2_CRK 242 246 PF00017 0.440
LIG_SH2_PTP2 38 41 PF00017 0.508
LIG_SH2_PTP2 478 481 PF00017 0.323
LIG_SH2_SRC 538 541 PF00017 0.501
LIG_SH2_STAP1 454 458 PF00017 0.355
LIG_SH2_STAT5 139 142 PF00017 0.323
LIG_SH2_STAT5 244 247 PF00017 0.427
LIG_SH2_STAT5 38 41 PF00017 0.626
LIG_SH2_STAT5 454 457 PF00017 0.353
LIG_SH2_STAT5 471 474 PF00017 0.262
LIG_SH2_STAT5 478 481 PF00017 0.316
LIG_SH2_STAT5 538 541 PF00017 0.469
LIG_SH3_3 103 109 PF00018 0.478
LIG_SH3_3 138 144 PF00018 0.308
LIG_SH3_3 479 485 PF00018 0.434
LIG_TRAF2_1 71 74 PF00917 0.507
MOD_CDC14_SPxK_1 396 399 PF00782 0.520
MOD_CDK_SPK_2 24 29 PF00069 0.522
MOD_CDK_SPxK_1 327 333 PF00069 0.501
MOD_CDK_SPxK_1 393 399 PF00069 0.524
MOD_CDK_SPxxK_3 198 205 PF00069 0.570
MOD_CK1_1 122 128 PF00069 0.550
MOD_CK1_1 214 220 PF00069 0.687
MOD_CK1_1 318 324 PF00069 0.661
MOD_CK1_1 379 385 PF00069 0.574
MOD_CK1_1 463 469 PF00069 0.447
MOD_CK1_1 53 59 PF00069 0.487
MOD_CK1_1 92 98 PF00069 0.434
MOD_CK2_1 53 59 PF00069 0.495
MOD_CK2_1 68 74 PF00069 0.749
MOD_GlcNHglycan 159 162 PF01048 0.556
MOD_GlcNHglycan 212 216 PF01048 0.606
MOD_GlcNHglycan 238 241 PF01048 0.316
MOD_GlcNHglycan 327 330 PF01048 0.586
MOD_GlcNHglycan 339 342 PF01048 0.554
MOD_GlcNHglycan 34 37 PF01048 0.439
MOD_GlcNHglycan 344 347 PF01048 0.525
MOD_GlcNHglycan 366 369 PF01048 0.621
MOD_GlcNHglycan 52 55 PF01048 0.564
MOD_GlcNHglycan 70 73 PF01048 0.647
MOD_GSK3_1 152 159 PF00069 0.545
MOD_GSK3_1 20 27 PF00069 0.630
MOD_GSK3_1 216 223 PF00069 0.573
MOD_GSK3_1 227 234 PF00069 0.202
MOD_GSK3_1 364 371 PF00069 0.689
MOD_GSK3_1 376 383 PF00069 0.603
MOD_GSK3_1 393 400 PF00069 0.665
MOD_GSK3_1 448 455 PF00069 0.543
MOD_GSK3_1 458 465 PF00069 0.485
MOD_GSK3_1 64 71 PF00069 0.530
MOD_GSK3_1 85 92 PF00069 0.499
MOD_N-GLC_1 356 361 PF02516 0.500
MOD_N-GLC_1 388 393 PF02516 0.569
MOD_N-GLC_1 448 453 PF02516 0.442
MOD_N-GLC_1 458 463 PF02516 0.454
MOD_NEK2_1 134 139 PF00069 0.308
MOD_NEK2_1 156 161 PF00069 0.571
MOD_NEK2_1 227 232 PF00069 0.246
MOD_NEK2_1 235 240 PF00069 0.229
MOD_NEK2_1 315 320 PF00069 0.602
MOD_NEK2_1 356 361 PF00069 0.500
MOD_NEK2_1 447 452 PF00069 0.310
MOD_NEK2_1 460 465 PF00069 0.568
MOD_NEK2_1 89 94 PF00069 0.571
MOD_NMyristoyl 1 7 PF02799 0.469
MOD_PIKK_1 116 122 PF00454 0.627
MOD_PKA_2 122 128 PF00069 0.548
MOD_PKA_2 379 385 PF00069 0.546
MOD_PKA_2 407 413 PF00069 0.498
MOD_PKA_2 463 469 PF00069 0.428
MOD_PKB_1 378 386 PF00069 0.514
MOD_Plk_1 448 454 PF00069 0.437
MOD_Plk_4 135 141 PF00069 0.319
MOD_Plk_4 227 233 PF00069 0.263
MOD_Plk_4 257 263 PF00069 0.338
MOD_Plk_4 42 48 PF00069 0.506
MOD_Plk_4 432 438 PF00069 0.381
MOD_Plk_4 448 454 PF00069 0.385
MOD_ProDKin_1 198 204 PF00069 0.561
MOD_ProDKin_1 24 30 PF00069 0.762
MOD_ProDKin_1 318 324 PF00069 0.568
MOD_ProDKin_1 327 333 PF00069 0.525
MOD_ProDKin_1 368 374 PF00069 0.512
MOD_ProDKin_1 393 399 PF00069 0.528
MOD_ProDKin_1 45 51 PF00069 0.396
MOD_ProDKin_1 505 511 PF00069 0.415
MOD_ProDKin_1 64 70 PF00069 0.475
TRG_DiLeu_BaEn_1 12 17 PF01217 0.496
TRG_DiLeu_BaEn_1 42 47 PF01217 0.500
TRG_DiLeu_BaLyEn_6 130 135 PF01217 0.583
TRG_DiLeu_BaLyEn_6 260 265 PF01217 0.407
TRG_DiLeu_BaLyEn_6 289 294 PF01217 0.412
TRG_ENDOCYTIC_2 242 245 PF00928 0.395
TRG_ENDOCYTIC_2 38 41 PF00928 0.526
TRG_ENDOCYTIC_2 471 474 PF00928 0.360
TRG_ENDOCYTIC_2 478 481 PF00928 0.287
TRG_ER_diArg_1 184 186 PF00400 0.455
TRG_ER_diArg_1 277 279 PF00400 0.417
TRG_ER_diArg_1 283 286 PF00400 0.436
TRG_ER_diArg_1 291 293 PF00400 0.419
TRG_ER_diArg_1 535 537 PF00400 0.371
TRG_Pf-PMV_PEXEL_1 250 254 PF00026 0.295
TRG_Pf-PMV_PEXEL_1 291 296 PF00026 0.422

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZK3 Leptomonas seymouri 43% 100%
A0A3S7X4P2 Leishmania donovani 60% 70%
A4I6Y6 Leishmania infantum 60% 70%
C9ZWQ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 96%
E9B207 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 67%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS