RSN1_TM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJX0_LEIBR

TriTrypDb:

LbrM.31.3690 , LBRM2903_330028800

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	11
GO:0016020	membrane	2	10
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HJX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJX0

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0045047	protein targeting to ER	6	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0070972	protein localization to endoplasmic reticulum	6	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	189	191	PF00082	0.735
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.714
CLV_PCSK_SKI1_1	168	172	PF00082	0.562
CLV_PCSK_SKI1_1	84	88	PF00082	0.212
DEG_Nend_UBRbox_1	1	4	PF02207	0.320
DOC_CKS1_1	19	24	PF01111	0.286
DOC_PP1_RVXF_1	26	32	PF00149	0.312
DOC_USP7_UBL2_3	164	168	PF12436	0.461
DOC_USP7_UBL2_3	185	189	PF12436	0.525
DOC_WW_Pin1_4	176	181	PF00397	0.603
DOC_WW_Pin1_4	18	23	PF00397	0.294
LIG_14-3-3_CanoR_1	2	6	PF00244	0.314
LIG_14-3-3_CanoR_1	28	34	PF00244	0.277
LIG_BRCT_BRCA1_1	124	128	PF00533	0.339
LIG_CSL_BTD_1	19	22	PF09270	0.299
LIG_deltaCOP1_diTrp_1	153	159	PF00928	0.256
LIG_FHA_1	102	108	PF00498	0.293
LIG_FHA_1	2	8	PF00498	0.481
LIG_FHA_1	30	36	PF00498	0.463
LIG_FHA_2	65	71	PF00498	0.533
LIG_LIR_Gen_1	32	41	PF02991	0.374
LIG_LIR_Gen_1	43	51	PF02991	0.384
LIG_LIR_Gen_1	9	19	PF02991	0.312
LIG_LIR_Nem_3	103	108	PF02991	0.331
LIG_LIR_Nem_3	32	36	PF02991	0.322
LIG_LIR_Nem_3	43	49	PF02991	0.346
LIG_LIR_Nem_3	9	14	PF02991	0.311
LIG_NRP_CendR_1	189	191	PF00754	0.702
LIG_Pex14_2	48	52	PF04695	0.294
LIG_SH2_STAT5	30	33	PF00017	0.283
LIG_SH2_STAT5	46	49	PF00017	0.354
LIG_SH2_STAT5	66	69	PF00017	0.446
LIG_SH3_3	174	180	PF00018	0.406
LIG_SH3_3	59	65	PF00018	0.547
LIG_SUMO_SIM_par_1	109	115	PF11976	0.338
LIG_SUMO_SIM_par_1	3	9	PF11976	0.437
LIG_UBA3_1	112	120	PF00899	0.336
LIG_UBA3_1	127	133	PF00899	0.186
LIG_WRC_WIRS_1	10	15	PF05994	0.369
LIG_WRC_WIRS_1	30	35	PF05994	0.229
MOD_CK1_1	162	168	PF00069	0.318
MOD_CK1_1	184	190	PF00069	0.476
MOD_CK1_1	9	15	PF00069	0.444
MOD_CK2_1	64	70	PF00069	0.556
MOD_GlcNHglycan	172	175	PF01048	0.679
MOD_GlcNHglycan	97	100	PF01048	0.442
MOD_GSK3_1	159	166	PF00069	0.449
MOD_GSK3_1	64	71	PF00069	0.552
MOD_N-GLC_1	159	164	PF02516	0.619
MOD_NEK2_1	1	6	PF00069	0.508
MOD_NEK2_1	100	105	PF00069	0.288
MOD_NEK2_1	112	117	PF00069	0.302
MOD_NEK2_1	170	175	PF00069	0.529
MOD_NEK2_1	86	91	PF00069	0.477
MOD_PKA_2	1	7	PF00069	0.338
MOD_Plk_1	55	61	PF00069	0.501
MOD_Plk_1	84	90	PF00069	0.410
MOD_Plk_2-3	64	70	PF00069	0.518
MOD_Plk_4	1	7	PF00069	0.417
MOD_Plk_4	55	61	PF00069	0.545
MOD_ProDKin_1	176	182	PF00069	0.606
MOD_ProDKin_1	18	24	PF00069	0.289
MOD_SUMO_for_1	132	135	PF00179	0.313
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.274
TRG_ENDOCYTIC_2	105	108	PF00928	0.358
TRG_ENDOCYTIC_2	30	33	PF00928	0.334
TRG_ENDOCYTIC_2	46	49	PF00928	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP6	Leptomonas seymouri	60%	100%
A0A0S4IMC9	Bodo saltans	31%	96%
A0A3S7X6X6	Leishmania donovani	67%	100%
A0A422N623	Trypanosoma rangeli	37%	100%
A4HLQ4	Leishmania braziliensis	98%	100%
A4I954	Leishmania infantum	67%	100%
D0A6C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B429	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q3Z5	Leishmania major	69%	100%