LeishMANIAdb
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Sodium stibogluconate resistance protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Sodium stibogluconate resistance protein, putative
Gene product:
sodium stibogluconate resistance protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HJW7_LEIBR
TriTrypDb:
LbrM.31.3660 , LBRM2903_310019000
Length:
451

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJW7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJW7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 134 136 PF00675 0.672
CLV_NRD_NRD_1 139 141 PF00675 0.635
CLV_NRD_NRD_1 282 284 PF00675 0.444
CLV_NRD_NRD_1 370 372 PF00675 0.744
CLV_NRD_NRD_1 407 409 PF00675 0.541
CLV_NRD_NRD_1 445 447 PF00675 0.568
CLV_NRD_NRD_1 63 65 PF00675 0.507
CLV_NRD_NRD_1 85 87 PF00675 0.545
CLV_PCSK_KEX2_1 139 141 PF00082 0.433
CLV_PCSK_KEX2_1 354 356 PF00082 0.697
CLV_PCSK_KEX2_1 369 371 PF00082 0.509
CLV_PCSK_KEX2_1 62 64 PF00082 0.510
CLV_PCSK_KEX2_1 85 87 PF00082 0.545
CLV_PCSK_PC1ET2_1 354 356 PF00082 0.730
CLV_PCSK_PC1ET2_1 369 371 PF00082 0.509
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.510
CLV_PCSK_PC7_1 135 141 PF00082 0.396
CLV_PCSK_SKI1_1 199 203 PF00082 0.525
CLV_PCSK_SKI1_1 64 68 PF00082 0.717
DEG_SCF_FBW7_1 218 224 PF00400 0.502
DOC_CKS1_1 218 223 PF01111 0.503
DOC_CKS1_1 35 40 PF01111 0.380
DOC_CYCLIN_RxL_1 22 36 PF00134 0.394
DOC_CYCLIN_RxL_1 61 71 PF00134 0.554
DOC_CYCLIN_yCln2_LP_2 396 402 PF00134 0.306
DOC_MAPK_gen_1 22 32 PF00069 0.407
DOC_MAPK_gen_1 62 68 PF00069 0.511
DOC_MAPK_MEF2A_6 383 390 PF00069 0.648
DOC_MAPK_RevD_3 395 409 PF00069 0.341
DOC_PP1_RVXF_1 26 33 PF00149 0.392
DOC_PP2B_LxvP_1 396 399 PF13499 0.383
DOC_PP4_FxxP_1 308 311 PF00568 0.508
DOC_USP7_MATH_1 221 225 PF00917 0.771
DOC_USP7_MATH_1 291 295 PF00917 0.568
DOC_USP7_MATH_1 336 340 PF00917 0.615
DOC_USP7_MATH_1 346 350 PF00917 0.651
DOC_USP7_MATH_1 433 437 PF00917 0.555
DOC_USP7_MATH_1 80 84 PF00917 0.628
DOC_USP7_MATH_2 164 170 PF00917 0.712
DOC_USP7_UBL2_3 361 365 PF12436 0.491
DOC_WW_Pin1_4 1 6 PF00397 0.502
DOC_WW_Pin1_4 217 222 PF00397 0.750
DOC_WW_Pin1_4 250 255 PF00397 0.743
DOC_WW_Pin1_4 34 39 PF00397 0.384
LIG_14-3-3_CanoR_1 111 115 PF00244 0.387
LIG_14-3-3_CanoR_1 135 142 PF00244 0.474
LIG_14-3-3_CanoR_1 199 205 PF00244 0.506
LIG_14-3-3_CanoR_1 236 240 PF00244 0.697
LIG_14-3-3_CanoR_1 257 261 PF00244 0.573
LIG_14-3-3_CanoR_1 283 287 PF00244 0.466
LIG_14-3-3_CanoR_1 371 379 PF00244 0.667
LIG_14-3-3_CanoR_1 95 100 PF00244 0.701
LIG_Actin_WH2_2 267 285 PF00022 0.700
LIG_BRCT_BRCA1_1 97 101 PF00533 0.663
LIG_CSL_BTD_1 218 221 PF09270 0.753
LIG_FHA_1 16 22 PF00498 0.599
LIG_FHA_1 267 273 PF00498 0.544
LIG_FHA_1 94 100 PF00498 0.690
LIG_FHA_2 299 305 PF00498 0.729
LIG_LIR_Apic_2 306 311 PF02991 0.506
LIG_LIR_Gen_1 113 121 PF02991 0.409
LIG_LIR_Gen_1 37 44 PF02991 0.395
LIG_LIR_Gen_1 418 426 PF02991 0.415
LIG_LIR_Gen_1 435 445 PF02991 0.568
LIG_LIR_Gen_1 70 80 PF02991 0.552
LIG_LIR_Nem_3 113 117 PF02991 0.439
LIG_LIR_Nem_3 37 43 PF02991 0.397
LIG_LIR_Nem_3 418 423 PF02991 0.441
LIG_LIR_Nem_3 435 441 PF02991 0.498
LIG_LIR_Nem_3 70 76 PF02991 0.553
LIG_LIR_Nem_3 98 103 PF02991 0.428
LIG_MLH1_MIPbox_1 97 101 PF16413 0.416
LIG_PCNA_yPIPBox_3 14 28 PF02747 0.433
LIG_SH2_CRK 121 125 PF00017 0.508
LIG_SH2_PTP2 420 423 PF00017 0.397
LIG_SH2_STAT5 114 117 PF00017 0.593
LIG_SH2_STAT5 121 124 PF00017 0.495
LIG_SH2_STAT5 158 161 PF00017 0.531
LIG_SH2_STAT5 167 170 PF00017 0.670
LIG_SH2_STAT5 20 23 PF00017 0.580
LIG_SH2_STAT5 262 265 PF00017 0.707
LIG_SH2_STAT5 420 423 PF00017 0.417
LIG_SH2_STAT5 73 76 PF00017 0.553
LIG_SH3_3 173 179 PF00018 0.484
LIG_SH3_3 215 221 PF00018 0.756
LIG_SH3_3 269 275 PF00018 0.700
LIG_SH3_3 323 329 PF00018 0.824
LIG_SUMO_SIM_anti_2 268 275 PF11976 0.719
LIG_SUMO_SIM_anti_2 8 16 PF11976 0.471
LIG_SUMO_SIM_par_1 200 207 PF11976 0.502
LIG_SUMO_SIM_par_1 228 234 PF11976 0.487
LIG_TRAF2_1 238 241 PF00917 0.613
LIG_TRAF2_1 303 306 PF00917 0.498
LIG_TYR_ITIM 119 124 PF00017 0.439
LIG_UBA3_1 125 133 PF00899 0.365
LIG_UBA3_1 401 409 PF00899 0.442
LIG_UBA3_1 440 447 PF00899 0.553
MOD_CDK_SPK_2 34 39 PF00069 0.384
MOD_CDK_SPxxK_3 250 257 PF00069 0.740
MOD_CK1_1 15 21 PF00069 0.428
MOD_CK1_1 203 209 PF00069 0.557
MOD_CK1_1 419 425 PF00069 0.441
MOD_CK2_1 235 241 PF00069 0.628
MOD_CK2_1 298 304 PF00069 0.706
MOD_GlcNHglycan 180 183 PF01048 0.532
MOD_GlcNHglycan 214 217 PF01048 0.764
MOD_GlcNHglycan 223 226 PF01048 0.613
MOD_GlcNHglycan 321 325 PF01048 0.787
MOD_GlcNHglycan 347 351 PF01048 0.761
MOD_GlcNHglycan 410 413 PF01048 0.578
MOD_GSK3_1 186 193 PF00069 0.815
MOD_GSK3_1 217 224 PF00069 0.776
MOD_GSK3_1 231 238 PF00069 0.544
MOD_GSK3_1 239 246 PF00069 0.580
MOD_GSK3_1 256 263 PF00069 0.684
MOD_GSK3_1 336 343 PF00069 0.600
MOD_GSK3_1 377 384 PF00069 0.708
MOD_GSK3_1 67 74 PF00069 0.554
MOD_GSK3_1 75 82 PF00069 0.556
MOD_GSK3_1 8 15 PF00069 0.488
MOD_GSK3_1 89 96 PF00069 0.744
MOD_N-GLC_1 377 382 PF02516 0.464
MOD_N-GLC_2 120 122 PF02516 0.534
MOD_NEK2_1 125 130 PF00069 0.604
MOD_NEK2_1 13 18 PF00069 0.468
MOD_NEK2_1 186 191 PF00069 0.712
MOD_NEK2_1 212 217 PF00069 0.764
MOD_NEK2_1 231 236 PF00069 0.468
MOD_NEK2_1 282 287 PF00069 0.690
MOD_NEK2_1 33 38 PF00069 0.682
MOD_NEK2_1 401 406 PF00069 0.529
MOD_NEK2_1 93 98 PF00069 0.625
MOD_NEK2_1 99 104 PF00069 0.640
MOD_PIKK_1 219 225 PF00454 0.656
MOD_PKA_1 408 414 PF00069 0.573
MOD_PKA_2 110 116 PF00069 0.351
MOD_PKA_2 134 140 PF00069 0.478
MOD_PKA_2 235 241 PF00069 0.692
MOD_PKA_2 256 262 PF00069 0.573
MOD_PKA_2 282 288 PF00069 0.462
MOD_PKA_2 336 342 PF00069 0.609
MOD_PKB_1 318 326 PF00069 0.541
MOD_Plk_1 381 387 PF00069 0.670
MOD_Plk_4 110 116 PF00069 0.396
MOD_Plk_4 154 160 PF00069 0.377
MOD_Plk_4 401 407 PF00069 0.501
MOD_Plk_4 416 422 PF00069 0.411
MOD_Plk_4 8 14 PF00069 0.559
MOD_Plk_4 95 101 PF00069 0.696
MOD_ProDKin_1 1 7 PF00069 0.500
MOD_ProDKin_1 217 223 PF00069 0.750
MOD_ProDKin_1 250 256 PF00069 0.741
MOD_ProDKin_1 34 40 PF00069 0.380
MOD_SUMO_for_1 353 356 PF00179 0.480
TRG_DiLeu_BaEn_1 392 397 PF01217 0.349
TRG_DiLeu_BaLyEn_6 225 230 PF01217 0.730
TRG_ENDOCYTIC_2 114 117 PF00928 0.580
TRG_ENDOCYTIC_2 121 124 PF00928 0.482
TRG_ENDOCYTIC_2 420 423 PF00928 0.397
TRG_ENDOCYTIC_2 73 76 PF00928 0.553
TRG_ER_diArg_1 139 141 PF00400 0.431
TRG_NLS_Bipartite_1 354 373 PF00514 0.714
TRG_Pf-PMV_PEXEL_1 178 183 PF00026 0.508
TRG_Pf-PMV_PEXEL_1 447 451 PF00026 0.508

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFG5 Leishmania donovani 59% 73%
A0A3Q8ISI8 Leishmania donovani 60% 73%
A0A3S7X4A3 Leishmania donovani 59% 73%
A4HJ70 Leishmania braziliensis 92% 100%
A4HJ71 Leishmania braziliensis 87% 100%
A4I6I2 Leishmania infantum 59% 68%
A4I6L8 Leishmania infantum 60% 73%
E8NHD1 Leishmania infantum 60% 76%
E8NHD2 Leishmania infantum 60% 98%
E8NHE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 73%
E8NHE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 73%
E9B1P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 73%
Q4Q6G7 Leishmania major 60% 100%
Q4Q6G8 Leishmania major 61% 100%
Q4Q6H0 Leishmania major 60% 100%
Q9BHE5 Leishmania major 61% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS