Methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJV8_LEIBR

TriTrypDb:

LbrM.31.3570 , LBRM2903_310046000

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	2

Expansion

Sequence features

A4HJV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJV8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004485	methylcrotonoyl-CoA carboxylase activity	5	7
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016421	CoA carboxylase activity	4	7
GO:0016874	ligase activity	2	12
GO:0016885	ligase activity, forming carbon-carbon bonds	3	7
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004075	biotin carboxylase activity	4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.476
CLV_MEL_PAP_1	533	539	PF00089	0.241
CLV_NRD_NRD_1	10	12	PF00675	0.430
CLV_NRD_NRD_1	244	246	PF00675	0.208
CLV_NRD_NRD_1	633	635	PF00675	0.166
CLV_PCSK_KEX2_1	131	133	PF00082	0.211
CLV_PCSK_KEX2_1	196	198	PF00082	0.211
CLV_PCSK_KEX2_1	215	217	PF00082	0.312
CLV_PCSK_KEX2_1	244	246	PF00082	0.226
CLV_PCSK_KEX2_1	445	447	PF00082	0.242
CLV_PCSK_KEX2_1	633	635	PF00082	0.156
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.211
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.211
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.302
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.242
CLV_PCSK_SKI1_1	177	181	PF00082	0.222
CLV_PCSK_SKI1_1	197	201	PF00082	0.108
CLV_PCSK_SKI1_1	207	211	PF00082	0.200
CLV_PCSK_SKI1_1	212	216	PF00082	0.209
CLV_PCSK_SKI1_1	231	235	PF00082	0.334
CLV_PCSK_SKI1_1	336	340	PF00082	0.302
CLV_PCSK_SKI1_1	363	367	PF00082	0.270
CLV_PCSK_SKI1_1	468	472	PF00082	0.465
CLV_PCSK_SKI1_1	497	501	PF00082	0.566
CLV_PCSK_SKI1_1	532	536	PF00082	0.483
DEG_Nend_Nbox_1	1	3	PF02207	0.538
DOC_CYCLIN_RxL_1	331	344	PF00134	0.502
DOC_CYCLIN_RxL_1	465	472	PF00134	0.387
DOC_CYCLIN_RxL_1	595	604	PF00134	0.515
DOC_MAPK_gen_1	11	18	PF00069	0.331
DOC_MAPK_gen_1	263	271	PF00069	0.424
DOC_MAPK_gen_1	27	37	PF00069	0.386
DOC_MAPK_gen_1	317	325	PF00069	0.502
DOC_PP1_RVXF_1	159	165	PF00149	0.412
DOC_PP1_RVXF_1	229	236	PF00149	0.502
DOC_PP1_RVXF_1	334	341	PF00149	0.502
DOC_PP1_RVXF_1	408	415	PF00149	0.411
DOC_PP1_RVXF_1	530	536	PF00149	0.549
DOC_PP2B_LxvP_1	471	474	PF13499	0.518
DOC_PP4_FxxP_1	113	116	PF00568	0.400
DOC_USP7_MATH_1	123	127	PF00917	0.325
DOC_USP7_MATH_1	550	554	PF00917	0.599
DOC_USP7_MATH_1	613	617	PF00917	0.562
DOC_USP7_MATH_1	67	71	PF00917	0.444
DOC_USP7_UBL2_3	127	131	PF12436	0.400
DOC_USP7_UBL2_3	327	331	PF12436	0.502
DOC_WW_Pin1_4	357	362	PF00397	0.410
DOC_WW_Pin1_4	474	479	PF00397	0.494
DOC_WW_Pin1_4	618	623	PF00397	0.237
LIG_14-3-3_CanoR_1	27	37	PF00244	0.400
LIG_14-3-3_CanoR_1	3	9	PF00244	0.494
LIG_14-3-3_CanoR_1	455	463	PF00244	0.461
LIG_14-3-3_CanoR_1	522	530	PF00244	0.479
LIG_14-3-3_CanoR_1	574	578	PF00244	0.480
LIG_APCC_ABBA_1	40	45	PF00400	0.467
LIG_APCC_ABBA_1	400	405	PF00400	0.400
LIG_APCC_ABBA_1	521	526	PF00400	0.469
LIG_Clathr_ClatBox_1	644	648	PF01394	0.380
LIG_CtBP_PxDLS_1	322	326	PF00389	0.400
LIG_deltaCOP1_diTrp_1	494	500	PF00928	0.582
LIG_FHA_1	310	316	PF00498	0.400
LIG_FHA_1	37	43	PF00498	0.412
LIG_FHA_1	458	464	PF00498	0.428
LIG_FHA_1	475	481	PF00498	0.364
LIG_FHA_1	484	490	PF00498	0.416
LIG_FHA_2	29	35	PF00498	0.421
LIG_FHA_2	386	392	PF00498	0.479
LIG_FHA_2	437	443	PF00498	0.420
LIG_FHA_2	580	586	PF00498	0.381
LIG_Integrin_RGD_1	634	636	PF01839	0.156
LIG_Integrin_RGD_1	73	75	PF01839	0.267
LIG_LIR_Apic_2	112	116	PF02991	0.411
LIG_LIR_Gen_1	186	195	PF02991	0.387
LIG_LIR_Gen_1	295	305	PF02991	0.411
LIG_LIR_Gen_1	564	573	PF02991	0.408
LIG_LIR_Nem_3	377	382	PF02991	0.472
LIG_LIR_Nem_3	564	568	PF02991	0.353
LIG_MAD2	248	256	PF02301	0.467
LIG_PCNA_yPIPBox_3	3	17	PF02747	0.446
LIG_Pex14_1	496	500	PF04695	0.578
LIG_Pex14_2	565	569	PF04695	0.445
LIG_REV1ctd_RIR_1	200	208	PF16727	0.400
LIG_REV1ctd_RIR_1	232	242	PF16727	0.390
LIG_REV1ctd_RIR_1	532	540	PF16727	0.245
LIG_SH2_CRK	246	250	PF00017	0.442
LIG_SH2_CRK	530	534	PF00017	0.499
LIG_SH2_CRK	93	97	PF00017	0.400
LIG_SH2_SRC	357	360	PF00017	0.411
LIG_SH2_SRC	513	516	PF00017	0.294
LIG_SH2_STAT5	213	216	PF00017	0.400
LIG_SH2_STAT5	279	282	PF00017	0.400
LIG_SH2_STAT5	297	300	PF00017	0.400
LIG_SH2_STAT5	513	516	PF00017	0.573
LIG_SH2_STAT5	71	74	PF00017	0.400
LIG_SH3_3	137	143	PF00018	0.400
LIG_SH3_3	159	165	PF00018	0.454
LIG_SH3_3	179	185	PF00018	0.437
LIG_SH3_3	304	310	PF00018	0.400
LIG_SUMO_SIM_anti_2	343	350	PF11976	0.445
LIG_SUMO_SIM_anti_2	576	583	PF11976	0.387
LIG_SUMO_SIM_anti_2	585	591	PF11976	0.345
LIG_SUMO_SIM_par_1	576	583	PF11976	0.388
LIG_SUMO_SIM_par_1	642	648	PF11976	0.169
LIG_UBA3_1	619	626	PF00899	0.266
LIG_UBA3_1	644	651	PF00899	0.157
LIG_WRC_WIRS_1	589	594	PF05994	0.412
MOD_CDC14_SPxK_1	360	363	PF00782	0.467
MOD_CDK_SPxK_1	357	363	PF00069	0.467
MOD_CK1_1	119	125	PF00069	0.493
MOD_CK1_1	259	265	PF00069	0.342
MOD_CK1_1	385	391	PF00069	0.421
MOD_CK1_1	545	551	PF00069	0.388
MOD_CK2_1	106	112	PF00069	0.474
MOD_CK2_1	123	129	PF00069	0.246
MOD_CK2_1	28	34	PF00069	0.421
MOD_CK2_1	347	353	PF00069	0.422
MOD_CK2_1	436	442	PF00069	0.447
MOD_CK2_1	664	670	PF00069	0.266
MOD_GlcNHglycan	108	111	PF01048	0.262
MOD_GlcNHglycan	118	121	PF01048	0.206
MOD_GlcNHglycan	171	174	PF01048	0.200
MOD_GlcNHglycan	193	196	PF01048	0.225
MOD_GlcNHglycan	368	371	PF01048	0.224
MOD_GlcNHglycan	547	550	PF01048	0.568
MOD_GlcNHglycan	615	618	PF01048	0.450
MOD_GSK3_1	119	126	PF00069	0.482
MOD_GSK3_1	366	373	PF00069	0.484
MOD_GSK3_1	385	392	PF00069	0.421
MOD_GSK3_1	545	552	PF00069	0.529
MOD_GSK3_1	584	591	PF00069	0.352
MOD_N-GLC_1	148	153	PF02516	0.243
MOD_N-GLC_1	607	612	PF02516	0.522
MOD_N-GLC_2	491	493	PF02516	0.444
MOD_NEK2_1	191	196	PF00069	0.400
MOD_NEK2_1	289	294	PF00069	0.502
MOD_NEK2_1	347	352	PF00069	0.438
MOD_NEK2_1	483	488	PF00069	0.351
MOD_NEK2_1	573	578	PF00069	0.368
MOD_NEK2_1	679	684	PF00069	0.266
MOD_OFUCOSY	26	32	PF10250	0.200
MOD_PIKK_1	338	344	PF00454	0.465
MOD_PK_1	238	244	PF00069	0.400
MOD_PKA_2	2	8	PF00069	0.503
MOD_PKA_2	382	388	PF00069	0.362
MOD_PKA_2	573	579	PF00069	0.421
MOD_PKB_1	387	395	PF00069	0.467
MOD_Plk_1	238	244	PF00069	0.400
MOD_Plk_1	563	569	PF00069	0.335
MOD_Plk_1	584	590	PF00069	0.364
MOD_Plk_1	607	613	PF00069	0.602
MOD_Plk_4	370	376	PF00069	0.467
MOD_Plk_4	557	563	PF00069	0.433
MOD_Plk_4	573	579	PF00069	0.359
MOD_Plk_4	584	590	PF00069	0.275
MOD_Plk_4	67	73	PF00069	0.406
MOD_ProDKin_1	357	363	PF00069	0.410
MOD_ProDKin_1	474	480	PF00069	0.484
MOD_ProDKin_1	618	624	PF00069	0.237
MOD_SUMO_for_1	195	198	PF00179	0.411
MOD_SUMO_for_1	650	653	PF00179	0.237
MOD_SUMO_rev_2	126	133	PF00179	0.248
MOD_SUMO_rev_2	553	561	PF00179	0.461
TRG_DiLeu_BaEn_1	343	348	PF01217	0.451
TRG_DiLeu_BaEn_2	185	191	PF01217	0.454
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.460
TRG_ENDOCYTIC_2	246	249	PF00928	0.442
TRG_ENDOCYTIC_2	404	407	PF00928	0.428
TRG_ENDOCYTIC_2	530	533	PF00928	0.510
TRG_ENDOCYTIC_2	93	96	PF00928	0.400
TRG_ER_diArg_1	244	246	PF00400	0.439
TRG_ER_diArg_1	263	266	PF00400	0.327
TRG_ER_diArg_1	387	390	PF00400	0.467
TRG_NES_CRM1_1	642	653	PF08389	0.271
TRG_NES_CRM1_1	75	87	PF08389	0.454
TRG_NLS_MonoExtN_4	212	219	PF00514	0.502
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.200
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.261
TRG_Pf-PMV_PEXEL_1	657	661	PF00026	0.156

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P730	Leptomonas seymouri	37%	100%
A0A0N1HV47	Leptomonas seymouri	82%	100%
A0A0S4IX46	Bodo saltans	57%	100%
A0A0S4JIQ8	Bodo saltans	41%	100%
A0A1X0NJV2	Trypanosomatidae	59%	100%
A0A3Q8IKH3	Leishmania donovani	91%	100%
A0A422NEZ1	Trypanosoma rangeli	57%	100%
A0A451EJ63	Leishmania donovani	37%	100%
A4H339	Leishmania braziliensis	37%	100%
A4HRC6	Leishmania infantum	37%	100%
A4I7C0	Leishmania infantum	92%	100%
B9HBA8	Populus trichocarpa	45%	100%
B9N843	Populus trichocarpa	44%	100%
C9ZWI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	93%
E9ABZ4	Leishmania major	37%	100%
E9AJ91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B2B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
I3R7G3	Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)	38%	100%
P05165	Homo sapiens	39%	94%
P0A509	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	41%	100%
P0DTA4	Sus scrofa	39%	94%
P14882	Rattus norvegicus	38%	93%
P9WPQ2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	41%	100%
P9WPQ3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	41%	100%
Q19842	Caenorhabditis elegans	38%	95%
Q2QMG2	Oryza sativa subsp. japonica	52%	93%
Q42523	Arabidopsis thaliana	42%	94%
Q42777	Glycine max	41%	94%
Q4Q5U3	Leishmania major	92%	100%
Q54KE6	Dictyostelium discoideum	44%	98%
Q5I0C3	Rattus norvegicus	44%	96%
Q5LUF3	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	47%	100%
Q612F5	Caenorhabditis briggsae	37%	93%
Q91ZA3	Mus musculus	38%	95%
Q96RQ3	Homo sapiens	44%	95%
Q99MR8	Mus musculus	43%	96%
V5BDW2	Trypanosoma cruzi	57%	98%