TPH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 14

Species:

Leishmania braziliensis

UniProt:

A4HJV6_LEIBR

TriTrypDb:

LbrM.31.3550 , LBRM2903_310045800

Length:

828

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.590
CLV_C14_Caspase3-7	657	661	PF00656	0.740
CLV_NRD_NRD_1	140	142	PF00675	0.515
CLV_NRD_NRD_1	149	151	PF00675	0.529
CLV_NRD_NRD_1	169	171	PF00675	0.502
CLV_NRD_NRD_1	190	192	PF00675	0.546
CLV_NRD_NRD_1	29	31	PF00675	0.608
CLV_NRD_NRD_1	302	304	PF00675	0.521
CLV_NRD_NRD_1	383	385	PF00675	0.614
CLV_NRD_NRD_1	394	396	PF00675	0.573
CLV_NRD_NRD_1	44	46	PF00675	0.652
CLV_NRD_NRD_1	455	457	PF00675	0.584
CLV_NRD_NRD_1	469	471	PF00675	0.548
CLV_NRD_NRD_1	527	529	PF00675	0.524
CLV_NRD_NRD_1	59	61	PF00675	0.391
CLV_NRD_NRD_1	601	603	PF00675	0.711
CLV_NRD_NRD_1	699	701	PF00675	0.511
CLV_NRD_NRD_1	710	712	PF00675	0.607
CLV_PCSK_KEX2_1	139	141	PF00082	0.492
CLV_PCSK_KEX2_1	148	150	PF00082	0.474
CLV_PCSK_KEX2_1	169	171	PF00082	0.495
CLV_PCSK_KEX2_1	190	192	PF00082	0.592
CLV_PCSK_KEX2_1	229	231	PF00082	0.587
CLV_PCSK_KEX2_1	278	280	PF00082	0.410
CLV_PCSK_KEX2_1	29	31	PF00082	0.608
CLV_PCSK_KEX2_1	302	304	PF00082	0.565
CLV_PCSK_KEX2_1	394	396	PF00082	0.448
CLV_PCSK_KEX2_1	44	46	PF00082	0.652
CLV_PCSK_KEX2_1	484	486	PF00082	0.575
CLV_PCSK_KEX2_1	491	493	PF00082	0.489
CLV_PCSK_KEX2_1	527	529	PF00082	0.593
CLV_PCSK_KEX2_1	601	603	PF00082	0.749
CLV_PCSK_KEX2_1	699	701	PF00082	0.390
CLV_PCSK_KEX2_1	710	712	PF00082	0.532
CLV_PCSK_KEX2_1	790	792	PF00082	0.704
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.579
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.434
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.590
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.486
CLV_PCSK_PC1ET2_1	790	792	PF00082	0.585
CLV_PCSK_PC7_1	225	231	PF00082	0.380
CLV_PCSK_SKI1_1	208	212	PF00082	0.457
CLV_PCSK_SKI1_1	241	245	PF00082	0.458
CLV_PCSK_SKI1_1	258	262	PF00082	0.504
CLV_PCSK_SKI1_1	384	388	PF00082	0.657
CLV_PCSK_SKI1_1	418	422	PF00082	0.627
CLV_PCSK_SKI1_1	480	484	PF00082	0.596
CLV_PCSK_SKI1_1	528	532	PF00082	0.515
CLV_PCSK_SKI1_1	585	589	PF00082	0.747
CLV_PCSK_SKI1_1	647	651	PF00082	0.548
DEG_APCC_DBOX_1	569	577	PF00400	0.418
DOC_CKS1_1	586	591	PF01111	0.539
DOC_CKS1_1	740	745	PF01111	0.528
DOC_CYCLIN_yClb5_NLxxxL_5	770	778	PF00134	0.425
DOC_MAPK_gen_1	190	196	PF00069	0.383
DOC_MAPK_gen_1	564	573	PF00069	0.378
DOC_MAPK_gen_1	699	707	PF00069	0.565
DOC_MAPK_MEF2A_6	567	575	PF00069	0.396
DOC_USP7_MATH_1	21	25	PF00917	0.591
DOC_USP7_MATH_1	345	349	PF00917	0.763
DOC_USP7_MATH_1	654	658	PF00917	0.650
DOC_USP7_MATH_1	75	79	PF00917	0.519
DOC_USP7_MATH_1	806	810	PF00917	0.639
DOC_USP7_UBL2_3	312	316	PF12436	0.542
DOC_USP7_UBL2_3	464	468	PF12436	0.446
DOC_USP7_UBL2_3	471	475	PF12436	0.495
DOC_USP7_UBL2_3	480	484	PF12436	0.544
DOC_USP7_UBL2_3	643	647	PF12436	0.420
DOC_WW_Pin1_4	12	17	PF00397	0.707
DOC_WW_Pin1_4	324	329	PF00397	0.574
DOC_WW_Pin1_4	580	585	PF00397	0.675
DOC_WW_Pin1_4	587	592	PF00397	0.689
DOC_WW_Pin1_4	662	667	PF00397	0.767
DOC_WW_Pin1_4	739	744	PF00397	0.553
DOC_WW_Pin1_4	817	822	PF00397	0.511
LIG_14-3-3_CanoR_1	139	145	PF00244	0.408
LIG_14-3-3_CanoR_1	190	195	PF00244	0.385
LIG_14-3-3_CanoR_1	347	355	PF00244	0.482
LIG_14-3-3_CanoR_1	44	49	PF00244	0.588
LIG_14-3-3_CanoR_1	618	625	PF00244	0.425
LIG_BRCT_BRCA1_1	34	38	PF00533	0.640
LIG_BRCT_BRCA1_1	594	598	PF00533	0.552
LIG_deltaCOP1_diTrp_1	86	91	PF00928	0.432
LIG_DLG_GKlike_1	140	147	PF00625	0.385
LIG_FHA_1	163	169	PF00498	0.364
LIG_FHA_1	209	215	PF00498	0.460
LIG_FHA_1	740	746	PF00498	0.757
LIG_FHA_1	748	754	PF00498	0.656
LIG_FHA_1	762	768	PF00498	0.559
LIG_FHA_2	240	246	PF00498	0.607
LIG_FHA_2	269	275	PF00498	0.571
LIG_FHA_2	348	354	PF00498	0.501
LIG_FHA_2	673	679	PF00498	0.468
LIG_FHA_2	749	755	PF00498	0.605
LIG_IRF3_LxIS_1	526	533	PF10401	0.583
LIG_LIR_Gen_1	86	95	PF02991	0.428
LIG_LIR_LC3C_4	703	707	PF02991	0.569
LIG_LIR_Nem_3	86	91	PF02991	0.430
LIG_Pex14_2	87	91	PF04695	0.539
LIG_SH2_STAP1	702	706	PF00017	0.525
LIG_SH3_3	737	743	PF00018	0.519
LIG_SUMO_SIM_par_1	353	359	PF11976	0.468
LIG_TRAF2_1	104	107	PF00917	0.520
LIG_TRAF2_1	272	275	PF00917	0.399
LIG_TRAF2_1	328	331	PF00917	0.682
LIG_TRAF2_1	376	379	PF00917	0.484
LIG_TRAF2_1	431	434	PF00917	0.450
LIG_TRAF2_1	675	678	PF00917	0.503
LIG_TRAF2_2	376	381	PF00917	0.677
MOD_CDK_SPK_2	580	585	PF00069	0.675
MOD_CDK_SPK_2	817	822	PF00069	0.511
MOD_CDK_SPxxK_3	587	594	PF00069	0.693
MOD_CDK_SPxxK_3	817	824	PF00069	0.510
MOD_CK1_1	32	38	PF00069	0.611
MOD_CK1_1	40	46	PF00069	0.585
MOD_CK1_1	442	448	PF00069	0.554
MOD_CK1_1	658	664	PF00069	0.653
MOD_CK1_1	671	677	PF00069	0.516
MOD_CK1_1	820	826	PF00069	0.502
MOD_CK2_1	101	107	PF00069	0.516
MOD_CK2_1	239	245	PF00069	0.613
MOD_CK2_1	268	274	PF00069	0.597
MOD_CK2_1	316	322	PF00069	0.647
MOD_CK2_1	333	339	PF00069	0.601
MOD_CK2_1	345	351	PF00069	0.760
MOD_CK2_1	471	477	PF00069	0.437
MOD_CK2_1	51	57	PF00069	0.564
MOD_CK2_1	516	522	PF00069	0.499
MOD_CK2_1	672	678	PF00069	0.564
MOD_CK2_1	748	754	PF00069	0.796
MOD_CK2_1	763	769	PF00069	0.434
MOD_GlcNHglycan	495	500	PF01048	0.583
MOD_GlcNHglycan	512	515	PF01048	0.450
MOD_GlcNHglycan	6	10	PF01048	0.576
MOD_GlcNHglycan	609	612	PF01048	0.492
MOD_GlcNHglycan	652	655	PF01048	0.619
MOD_GlcNHglycan	670	673	PF01048	0.574
MOD_GlcNHglycan	810	813	PF01048	0.741
MOD_GlcNHglycan	824	827	PF01048	0.562
MOD_GSK3_1	158	165	PF00069	0.370
MOD_GSK3_1	21	28	PF00069	0.633
MOD_GSK3_1	29	36	PF00069	0.531
MOD_GSK3_1	40	47	PF00069	0.551
MOD_GSK3_1	506	513	PF00069	0.616
MOD_GSK3_1	590	597	PF00069	0.730
MOD_GSK3_1	650	657	PF00069	0.608
MOD_GSK3_1	658	665	PF00069	0.774
MOD_GSK3_1	668	675	PF00069	0.635
MOD_GSK3_1	735	742	PF00069	0.545
MOD_GSK3_1	781	788	PF00069	0.501
MOD_GSK3_1	806	813	PF00069	0.594
MOD_LATS_1	188	194	PF00433	0.387
MOD_LATS_1	592	598	PF00433	0.554
MOD_N-GLC_1	25	30	PF02516	0.640
MOD_N-GLC_1	762	767	PF02516	0.476
MOD_NEK2_1	25	30	PF00069	0.621
MOD_NEK2_1	33	38	PF00069	0.460
MOD_NEK2_1	333	338	PF00069	0.498
MOD_NEK2_1	810	815	PF00069	0.577
MOD_PIKK_1	219	225	PF00454	0.424
MOD_PIKK_1	311	317	PF00454	0.635
MOD_PIKK_1	516	522	PF00454	0.553
MOD_PIKK_1	530	536	PF00454	0.533
MOD_PIKK_1	658	664	PF00454	0.549
MOD_PIKK_1	735	741	PF00454	0.493
MOD_PK_1	190	196	PF00069	0.383
MOD_PK_1	44	50	PF00069	0.730
MOD_PKA_1	140	146	PF00069	0.378
MOD_PKA_1	190	196	PF00069	0.383
MOD_PKA_1	29	35	PF00069	0.607
MOD_PKA_1	44	50	PF00069	0.693
MOD_PKA_2	120	126	PF00069	0.554
MOD_PKA_2	140	146	PF00069	0.357
MOD_PKA_2	190	196	PF00069	0.413
MOD_PKA_2	29	35	PF00069	0.563
MOD_PKA_2	36	42	PF00069	0.593
MOD_PKA_2	43	49	PF00069	0.611
MOD_PKA_2	709	715	PF00069	0.568
MOD_PKA_2	769	775	PF00069	0.495
MOD_PKA_2	781	787	PF00069	0.459
MOD_PKB_1	237	245	PF00069	0.487
MOD_Plk_1	21	27	PF00069	0.517
MOD_Plk_1	239	245	PF00069	0.416
MOD_Plk_1	296	302	PF00069	0.590
MOD_Plk_1	748	754	PF00069	0.787
MOD_Plk_1	762	768	PF00069	0.422
MOD_Plk_2-3	162	168	PF00069	0.370
MOD_Plk_2-3	51	57	PF00069	0.564
MOD_Plk_4	541	547	PF00069	0.378
MOD_ProDKin_1	12	18	PF00069	0.710
MOD_ProDKin_1	324	330	PF00069	0.575
MOD_ProDKin_1	580	586	PF00069	0.679
MOD_ProDKin_1	587	593	PF00069	0.690
MOD_ProDKin_1	662	668	PF00069	0.768
MOD_ProDKin_1	739	745	PF00069	0.555
MOD_ProDKin_1	817	823	PF00069	0.511
MOD_SUMO_for_1	159	162	PF00179	0.494
MOD_SUMO_for_1	340	343	PF00179	0.501
MOD_SUMO_for_1	376	379	PF00179	0.484
MOD_SUMO_rev_2	213	220	PF00179	0.400
MOD_SUMO_rev_2	273	280	PF00179	0.605
MOD_SUMO_rev_2	359	369	PF00179	0.619
MOD_SUMO_rev_2	411	420	PF00179	0.437
MOD_SUMO_rev_2	450	459	PF00179	0.629
MOD_SUMO_rev_2	461	466	PF00179	0.506
MOD_SUMO_rev_2	524	533	PF00179	0.453
MOD_SUMO_rev_2	642	650	PF00179	0.568
TRG_DiLeu_BaEn_1	107	112	PF01217	0.511
TRG_DiLeu_BaEn_1	76	81	PF01217	0.565
TRG_DiLeu_BaEn_4	151	157	PF01217	0.490
TRG_ENDOCYTIC_2	702	705	PF00928	0.534
TRG_ER_diArg_1	138	141	PF00400	0.489
TRG_ER_diArg_1	147	150	PF00400	0.466
TRG_ER_diArg_1	168	170	PF00400	0.375
TRG_ER_diArg_1	190	192	PF00400	0.557
TRG_ER_diArg_1	301	303	PF00400	0.571
TRG_ER_diArg_1	526	528	PF00400	0.477
TRG_ER_diArg_1	600	602	PF00400	0.792
TRG_ER_diArg_1	709	711	PF00400	0.626
TRG_NLS_Bipartite_1	44	64	PF00514	0.621
TRG_NLS_Bipartite_1	456	474	PF00514	0.411
TRG_NLS_MonoExtN_4	468	474	PF00514	0.411
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I335	Leptomonas seymouri	48%	95%
A0A3R7NBX7	Trypanosoma rangeli	31%	100%
A0A3S7X4Z8	Leishmania donovani	66%	98%
A4I7B8	Leishmania infantum	67%	98%
E9B2B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	98%
Q4Q5U5	Leishmania major	66%	100%