Autophagy_act_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein 10 (ATG10)

Species:

Leishmania braziliensis

UniProt:

A4HJV5_LEIBR

TriTrypDb:

LbrM.31.3540 , LBRM2903_310045700

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJV5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.384
CLV_C14_Caspase3-7	52	56	PF00656	0.427
CLV_NRD_NRD_1	148	150	PF00675	0.542
CLV_PCSK_FUR_1	146	150	PF00082	0.481
CLV_PCSK_FUR_1	31	35	PF00082	0.597
CLV_PCSK_KEX2_1	148	150	PF00082	0.542
CLV_PCSK_KEX2_1	33	35	PF00082	0.523
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.577
CLV_PCSK_SKI1_1	34	38	PF00082	0.477
DEG_Nend_UBRbox_1	1	4	PF02207	0.579
DOC_CDC14_PxL_1	169	177	PF14671	0.503
DOC_MAPK_DCC_7	92	100	PF00069	0.498
DOC_MAPK_MEF2A_6	92	100	PF00069	0.498
DOC_MAPK_RevD_3	133	149	PF00069	0.560
DOC_PP2B_LxvP_1	174	177	PF13499	0.561
DOC_USP7_MATH_1	119	123	PF00917	0.458
DOC_USP7_MATH_2	27	33	PF00917	0.583
DOC_WW_Pin1_4	23	28	PF00397	0.597
LIG_14-3-3_CanoR_1	163	171	PF00244	0.436
LIG_14-3-3_CanoR_1	59	69	PF00244	0.320
LIG_BH_BH3_1	154	170	PF00452	0.532
LIG_BIR_III_4	111	115	PF00653	0.467
LIG_BIR_III_4	35	39	PF00653	0.446
LIG_BRCT_BRCA1_1	165	169	PF00533	0.441
LIG_FHA_1	139	145	PF00498	0.434
LIG_FHA_1	45	51	PF00498	0.470
LIG_FHA_1	56	62	PF00498	0.403
LIG_LIR_Apic_2	72	76	PF02991	0.414
LIG_LIR_Nem_3	13	18	PF02991	0.547
LIG_LIR_Nem_3	166	171	PF02991	0.539
LIG_MLH1_MIPbox_1	165	169	PF16413	0.441
LIG_MYND_1	173	177	PF01753	0.518
LIG_PTB_Apo_2	67	74	PF02174	0.542
LIG_PTB_Phospho_1	67	73	PF10480	0.290
LIG_SH2_CRK	73	77	PF00017	0.304
LIG_SH2_NCK_1	73	77	PF00017	0.362
LIG_SH2_STAT3	18	21	PF00017	0.315
LIG_SH2_STAT5	168	171	PF00017	0.480
LIG_SH3_3	167	173	PF00018	0.501
LIG_SH3_3	90	96	PF00018	0.449
LIG_SH3_3	98	104	PF00018	0.549
LIG_Sin3_3	172	179	PF02671	0.589
LIG_WRC_WIRS_1	120	125	PF05994	0.564
MOD_CK1_1	49	55	PF00069	0.390
MOD_CK1_1	83	89	PF00069	0.533
MOD_CK2_1	23	29	PF00069	0.597
MOD_GSK3_1	46	53	PF00069	0.559
MOD_GSK3_1	57	64	PF00069	0.343
MOD_GSK3_1	80	87	PF00069	0.501
MOD_N-GLC_1	81	86	PF02516	0.570
MOD_N-GLC_1	96	101	PF02516	0.580
MOD_NEK2_1	113	118	PF00069	0.505
MOD_NEK2_1	44	49	PF00069	0.437
MOD_NEK2_1	54	59	PF00069	0.478
MOD_NEK2_1	80	85	PF00069	0.481
MOD_PIKK_1	13	19	PF00454	0.303
MOD_PKA_2	11	17	PF00069	0.567
MOD_Plk_1	44	50	PF00069	0.466
MOD_Plk_1	81	87	PF00069	0.598
MOD_Plk_1	96	102	PF00069	0.595
MOD_Plk_4	156	162	PF00069	0.497
MOD_Plk_4	96	102	PF00069	0.520
MOD_ProDKin_1	23	29	PF00069	0.597
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.565
TRG_ENDOCYTIC_2	132	135	PF00928	0.483
TRG_ENDOCYTIC_2	168	171	PF00928	0.480
TRG_ER_diArg_1	145	148	PF00400	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N4	Leptomonas seymouri	46%	100%
A0A1X0NI81	Trypanosomatidae	28%	100%
A0A3S5H7Q9	Leishmania donovani	77%	74%
A4I7B7	Leishmania infantum	77%	85%
C9ZWJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B2B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q5U6	Leishmania major	75%	100%