J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJV4_LEIBR

TriTrypDb:

LbrM.31.3530 , LBRM2903_310045600

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 15
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A4HJV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJV4

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.445
CLV_C14_Caspase3-7	157	161	PF00656	0.763
CLV_MEL_PAP_1	131	137	PF00089	0.430
CLV_NRD_NRD_1	6	8	PF00675	0.727
CLV_NRD_NRD_1	96	98	PF00675	0.595
CLV_PCSK_KEX2_1	35	37	PF00082	0.481
CLV_PCSK_KEX2_1	6	8	PF00082	0.727
CLV_PCSK_KEX2_1	95	97	PF00082	0.632
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.471
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.561
CLV_PCSK_SKI1_1	40	44	PF00082	0.486
CLV_PCSK_SKI1_1	6	10	PF00082	0.718
DEG_SPOP_SBC_1	104	108	PF00917	0.487
DOC_MAPK_gen_1	35	43	PF00069	0.293
DOC_MAPK_MEF2A_6	36	45	PF00069	0.293
DOC_MAPK_RevD_3	131	145	PF00069	0.201
DOC_PP1_RVXF_1	116	123	PF00149	0.300
DOC_PP4_FxxP_1	139	142	PF00568	0.619
DOC_USP7_MATH_1	164	168	PF00917	0.617
DOC_USP7_MATH_1	27	31	PF00917	0.365
DOC_USP7_UBL2_3	31	35	PF12436	0.298
DOC_WW_Pin1_4	23	28	PF00397	0.281
LIG_14-3-3_CanoR_1	134	138	PF00244	0.361
LIG_BRCT_BRCA1_1	135	139	PF00533	0.350
LIG_BRCT_BRCA1_1	54	58	PF00533	0.271
LIG_LIR_Apic_2	136	142	PF02991	0.430
LIG_LIR_Gen_1	116	125	PF02991	0.298
LIG_LIR_Gen_1	55	65	PF02991	0.272
LIG_LIR_Nem_3	116	122	PF02991	0.424
LIG_LIR_Nem_3	136	141	PF02991	0.365
LIG_LIR_Nem_3	18	23	PF02991	0.264
LIG_LIR_Nem_3	196	202	PF02991	0.656
LIG_LIR_Nem_3	55	61	PF02991	0.277
LIG_LIR_Nem_3	63	68	PF02991	0.291
LIG_MLH1_MIPbox_1	135	139	PF16413	0.327
LIG_Pex14_2	128	132	PF04695	0.398
LIG_SH2_CRK	20	24	PF00017	0.293
LIG_SH2_CRK	38	42	PF00017	0.293
LIG_SH2_NCK_1	101	105	PF00017	0.466
LIG_SH2_STAT5	111	114	PF00017	0.445
LIG_SH2_STAT5	119	122	PF00017	0.248
LIG_SH2_STAT5	99	102	PF00017	0.474
LIG_SH3_2	16	21	PF14604	0.293
LIG_SH3_3	13	19	PF00018	0.407
LIG_TRAF2_1	154	157	PF00917	0.595
LIG_TRAF2_1	193	196	PF00917	0.658
LIG_TRAF2_1	30	33	PF00917	0.271
LIG_UBA3_1	137	145	PF00899	0.586
LIG_WRC_WIRS_1	165	170	PF05994	0.463
MOD_CK1_1	113	119	PF00069	0.546
MOD_CK1_1	159	165	PF00069	0.553
MOD_CK2_1	27	33	PF00069	0.321
MOD_CK2_1	46	52	PF00069	0.243
MOD_GlcNHglycan	112	115	PF01048	0.622
MOD_GlcNHglycan	151	154	PF01048	0.565
MOD_GlcNHglycan	183	186	PF01048	0.630
MOD_GlcNHglycan	187	190	PF01048	0.630
MOD_GlcNHglycan	48	51	PF01048	0.430
MOD_GlcNHglycan	86	89	PF01048	0.628
MOD_GSK3_1	171	178	PF00069	0.496
MOD_GSK3_1	181	188	PF00069	0.461
MOD_GSK3_1	23	30	PF00069	0.255
MOD_N-GLC_1	203	208	PF02516	0.449
MOD_PK_1	187	193	PF00069	0.609
MOD_PKA_2	133	139	PF00069	0.361
MOD_PKA_2	2	8	PF00069	0.615
MOD_Plk_1	171	177	PF00069	0.548
MOD_Plk_4	133	139	PF00069	0.408
MOD_ProDKin_1	23	29	PF00069	0.329
MOD_SUMO_rev_2	194	202	PF00179	0.576
MOD_SUMO_rev_2	30	37	PF00179	0.356
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.652
TRG_ENDOCYTIC_2	119	122	PF00928	0.430
TRG_ENDOCYTIC_2	199	202	PF00928	0.637
TRG_ENDOCYTIC_2	20	23	PF00928	0.346
TRG_ENDOCYTIC_2	38	41	PF00928	0.353
TRG_ENDOCYTIC_2	65	68	PF00928	0.380
TRG_ER_diArg_1	6	8	PF00400	0.715
TRG_ER_diArg_1	96	98	PF00400	0.445
TRG_NLS_MonoExtN_4	94	99	PF00514	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ1	Leptomonas seymouri	62%	100%
A0A0N1PA62	Leptomonas seymouri	27%	89%
A0A0S4IP06	Bodo saltans	38%	96%
A0A0S4JTE9	Bodo saltans	28%	76%
A0A3Q8IAY4	Leishmania donovani	28%	89%
A0A3R7M6A3	Trypanosoma rangeli	29%	92%
A0A3S7X515	Leishmania donovani	76%	100%
A4H9D7	Leishmania braziliensis	28%	100%
A4HXQ8	Leishmania infantum	28%	89%
A4I7B6	Leishmania infantum	76%	100%
C9ZWJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	94%
E9ARH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	89%
E9B2A9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q5U7	Leishmania major	76%	100%
Q4QE09	Leishmania major	28%	100%