BTB/POZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJV2_LEIBR

TriTrypDb:

LbrM.31.3510 , LBRM2903_310045400

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.443
CLV_NRD_NRD_1	55	57	PF00675	0.385
CLV_PCSK_FUR_1	52	56	PF00082	0.363
CLV_PCSK_KEX2_1	121	123	PF00082	0.681
CLV_PCSK_KEX2_1	54	56	PF00082	0.387
CLV_PCSK_KEX2_1	78	80	PF00082	0.337
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.681
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.382
CLV_PCSK_SKI1_1	290	294	PF00082	0.435
CLV_PCSK_SKI1_1	84	88	PF00082	0.354
DEG_Nend_UBRbox_2	1	3	PF02207	0.653
DEG_SPOP_SBC_1	12	16	PF00917	0.522
DOC_CYCLIN_RxL_1	78	90	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.551
DOC_MAPK_gen_1	121	131	PF00069	0.449
DOC_MAPK_gen_1	141	150	PF00069	0.536
DOC_MAPK_MEF2A_6	144	152	PF00069	0.365
DOC_MAPK_RevD_3	65	79	PF00069	0.285
DOC_PP1_RVXF_1	264	270	PF00149	0.384
DOC_PP1_RVXF_1	288	294	PF00149	0.439
DOC_PP1_RVXF_1	296	303	PF00149	0.459
DOC_PP2B_LxvP_1	248	251	PF13499	0.463
DOC_SPAK_OSR1_1	184	188	PF12202	0.551
DOC_SPAK_OSR1_1	79	83	PF12202	0.373
DOC_USP7_MATH_1	12	16	PF00917	0.560
DOC_USP7_MATH_1	322	326	PF00917	0.351
DOC_USP7_MATH_1	328	332	PF00917	0.386
LIG_14-3-3_CanoR_1	184	194	PF00244	0.532
LIG_14-3-3_CanoR_1	195	199	PF00244	0.436
LIG_14-3-3_CanoR_1	21	31	PF00244	0.679
LIG_BRCT_BRCA1_1	212	216	PF00533	0.403
LIG_BRCT_BRCA1_1	92	96	PF00533	0.336
LIG_FHA_1	15	21	PF00498	0.676
LIG_LIR_Nem_3	171	177	PF02991	0.338
LIG_MLH1_MIPbox_1	212	216	PF16413	0.403
LIG_NRBOX	148	154	PF00104	0.330
LIG_PCNA_yPIPBox_3	141	149	PF02747	0.356
LIG_Pex14_1	181	185	PF04695	0.372
LIG_PTB_Apo_2	302	309	PF02174	0.479
LIG_PTB_Phospho_1	302	308	PF10480	0.476
LIG_SH2_GRB2like	261	264	PF00017	0.360
LIG_SH2_STAT5	103	106	PF00017	0.497
LIG_SH2_STAT5	193	196	PF00017	0.556
LIG_SH2_STAT5	270	273	PF00017	0.529
LIG_SH2_STAT5	308	311	PF00017	0.509
LIG_SH2_STAT5	74	77	PF00017	0.430
LIG_SH3_3	62	68	PF00018	0.406
LIG_SUMO_SIM_anti_2	331	338	PF11976	0.510
LIG_TRAF2_1	244	247	PF00917	0.490
LIG_TRAF2_1	251	254	PF00917	0.447
LIG_TRAF2_1	3	6	PF00917	0.566
MOD_CK1_1	105	111	PF00069	0.513
MOD_CK1_1	15	21	PF00069	0.542
MOD_CK1_1	180	186	PF00069	0.321
MOD_CK1_1	331	337	PF00069	0.527
MOD_CK1_1	97	103	PF00069	0.355
MOD_CK2_1	164	170	PF00069	0.421
MOD_CK2_1	42	48	PF00069	0.591
MOD_CK2_1	82	88	PF00069	0.272
MOD_Cter_Amidation	76	79	PF01082	0.401
MOD_GlcNHglycan	104	107	PF01048	0.474
MOD_GlcNHglycan	177	180	PF01048	0.439
MOD_GlcNHglycan	34	37	PF01048	0.690
MOD_GSK3_1	11	18	PF00069	0.667
MOD_GSK3_1	194	201	PF00069	0.547
MOD_GSK3_1	210	217	PF00069	0.300
MOD_GSK3_1	331	338	PF00069	0.555
MOD_GSK3_1	90	97	PF00069	0.523
MOD_N-GLC_1	12	17	PF02516	0.503
MOD_NEK2_1	177	182	PF00069	0.417
MOD_NEK2_1	185	190	PF00069	0.533
MOD_NEK2_1	194	199	PF00069	0.551
MOD_NEK2_1	215	220	PF00069	0.371
MOD_NEK2_1	225	230	PF00069	0.460
MOD_NEK2_1	23	28	PF00069	0.740
MOD_NEK2_1	237	242	PF00069	0.478
MOD_NEK2_1	271	276	PF00069	0.500
MOD_NEK2_1	32	37	PF00069	0.567
MOD_NEK2_1	80	85	PF00069	0.513
MOD_NEK2_1	94	99	PF00069	0.388
MOD_NEK2_2	164	169	PF00069	0.417
MOD_NEK2_2	265	270	PF00069	0.456
MOD_PIKK_1	225	231	PF00454	0.396
MOD_PIKK_1	328	334	PF00454	0.491
MOD_PIKK_1	97	103	PF00454	0.285
MOD_PKA_2	194	200	PF00069	0.377
MOD_PKA_2	328	334	PF00069	0.408
MOD_PKA_2	40	46	PF00069	0.571
MOD_Plk_1	223	229	PF00069	0.455
MOD_Plk_2-3	42	48	PF00069	0.466
MOD_Plk_4	15	21	PF00069	0.681
MOD_Plk_4	23	29	PF00069	0.664
MOD_Plk_4	265	271	PF00069	0.464
MOD_Plk_4	331	337	PF00069	0.525
MOD_Plk_4	90	96	PF00069	0.338
TRG_ENDOCYTIC_2	174	177	PF00928	0.365
TRG_ENDOCYTIC_2	57	60	PF00928	0.555
TRG_ER_diArg_1	52	55	PF00400	0.393
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N2	Leptomonas seymouri	59%	97%
A0A1X0NIJ4	Trypanosomatidae	38%	100%
A0A3R7K9T3	Trypanosoma rangeli	36%	100%
A0A3S7X510	Leishmania donovani	81%	94%
A4HJU7	Leishmania braziliensis	100%	100%
A4I7B4	Leishmania infantum	80%	94%
C9ZWJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B2A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q5U9	Leishmania major	80%	100%
V5B9A8	Trypanosoma cruzi	37%	100%