Iron/zinc transporter protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

iron/zinc transporter protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJV1_LEIBR

TriTrypDb:

LbrM.31.3500 , LBRM2903_310044900

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	3

Expansion

Sequence features

A4HJV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJV1

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	3
GO:0006810	transport	3	3
GO:0006811	monoatomic ion transport	4	3
GO:0006812	monoatomic cation transport	5	3
GO:0006829	zinc ion transport	8	3
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0009987	cellular process	1	3
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	3
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	3
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071577	zinc ion transmembrane transport	6	3
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098655	monoatomic cation transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098662	inorganic cation transmembrane transport	5	3
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	20
GO:0008324	monoatomic cation transmembrane transporter activity	4	20
GO:0015075	monoatomic ion transmembrane transporter activity	3	20
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	20
GO:0022857	transmembrane transporter activity	2	20
GO:0022890	inorganic cation transmembrane transporter activity	4	20
GO:0046873	metal ion transmembrane transporter activity	5	20
GO:0005385	zinc ion transmembrane transporter activity	7	3
GO:0046915	transition metal ion transmembrane transporter activity	6	3
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.451
CLV_C14_Caspase3-7	164	168	PF00656	0.367
CLV_PCSK_SKI1_1	115	119	PF00082	0.340
CLV_PCSK_SKI1_1	194	198	PF00082	0.159
CLV_PCSK_SKI1_1	302	306	PF00082	0.180
CLV_PCSK_SKI1_1	382	386	PF00082	0.330
CLV_PCSK_SKI1_1	81	85	PF00082	0.359
DEG_APCC_DBOX_1	193	201	PF00400	0.359
DEG_APCC_DBOX_1	301	309	PF00400	0.435
DOC_MAPK_gen_1	300	309	PF00069	0.450
DOC_MAPK_gen_1	380	389	PF00069	0.468
DOC_MAPK_HePTP_8	383	395	PF00069	0.380
DOC_MAPK_MEF2A_6	275	283	PF00069	0.273
DOC_MAPK_MEF2A_6	300	309	PF00069	0.494
DOC_MAPK_MEF2A_6	382	391	PF00069	0.499
DOC_USP7_MATH_1	153	157	PF00917	0.389
DOC_USP7_MATH_1	209	213	PF00917	0.372
DOC_USP7_MATH_1	291	295	PF00917	0.322
DOC_USP7_MATH_1	333	337	PF00917	0.280
DOC_USP7_MATH_1	60	64	PF00917	0.189
DOC_USP7_MATH_1	89	93	PF00917	0.199
DOC_WW_Pin1_4	167	172	PF00397	0.453
DOC_WW_Pin1_4	328	333	PF00397	0.275
LIG_14-3-3_CanoR_1	244	253	PF00244	0.463
LIG_Actin_WH2_2	193	210	PF00022	0.359
LIG_BIR_III_4	189	193	PF00653	0.519
LIG_BRCT_BRCA1_1	6	10	PF00533	0.307
LIG_CtBP_PxDLS_1	236	240	PF00389	0.459
LIG_EH_1	43	47	PF12763	0.370
LIG_eIF4E_1	357	363	PF01652	0.319
LIG_FHA_1	102	108	PF00498	0.209
LIG_FHA_1	15	21	PF00498	0.179
LIG_FHA_1	241	247	PF00498	0.487
LIG_FHA_1	263	269	PF00498	0.261
LIG_FHA_1	359	365	PF00498	0.347
LIG_FHA_1	386	392	PF00498	0.192
LIG_FHA_1	62	68	PF00498	0.340
LIG_FHA_2	268	274	PF00498	0.282
LIG_FHA_2	301	307	PF00498	0.397
LIG_GBD_Chelix_1	23	31	PF00786	0.201
LIG_LIR_Gen_1	106	117	PF02991	0.358
LIG_LIR_Gen_1	17	27	PF02991	0.301
LIG_LIR_Gen_1	338	347	PF02991	0.273
LIG_LIR_Gen_1	388	397	PF02991	0.192
LIG_LIR_Nem_3	106	112	PF02991	0.204
LIG_LIR_Nem_3	17	22	PF02991	0.289
LIG_LIR_Nem_3	259	264	PF02991	0.351
LIG_LIR_Nem_3	298	304	PF02991	0.439
LIG_LIR_Nem_3	338	343	PF02991	0.315
LIG_LIR_Nem_3	388	393	PF02991	0.300
LIG_LIR_Nem_3	7	13	PF02991	0.399
LIG_LIR_Nem_3	82	87	PF02991	0.264
LIG_MLH1_MIPbox_1	6	10	PF16413	0.277
LIG_NRBOX	22	28	PF00104	0.162
LIG_PDZ_Wminus1_1	405	407	PF00595	0.420
LIG_Pex14_2	283	287	PF04695	0.338
LIG_Pex14_2	390	394	PF04695	0.309
LIG_SH2_CRK	193	197	PF00017	0.359
LIG_SH2_PTP2	37	40	PF00017	0.387
LIG_SH2_STAT5	357	360	PF00017	0.304
LIG_SH2_STAT5	37	40	PF00017	0.448
LIG_SH2_STAT5	374	377	PF00017	0.471
LIG_SH2_STAT5	9	12	PF00017	0.278
LIG_SH3_3	230	236	PF00018	0.498
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.359
LIG_SUMO_SIM_anti_2	17	25	PF11976	0.162
LIG_SUMO_SIM_anti_2	303	309	PF11976	0.490
LIG_SUMO_SIM_anti_2	342	349	PF11976	0.275
LIG_SUMO_SIM_anti_2	91	98	PF11976	0.162
LIG_SUMO_SIM_par_1	129	135	PF11976	0.359
LIG_SUMO_SIM_par_1	17	25	PF11976	0.180
LIG_SUMO_SIM_par_1	342	349	PF11976	0.366
LIG_SUMO_SIM_par_1	360	366	PF11976	0.177
LIG_SUMO_SIM_par_1	98	104	PF11976	0.162
LIG_TYR_ITIM	191	196	PF00017	0.359
LIG_UBA3_1	174	179	PF00899	0.359
MOD_CDK_SPxK_1	167	173	PF00069	0.359
MOD_CK1_1	182	188	PF00069	0.538
MOD_CK1_1	4	10	PF00069	0.416
MOD_CK1_1	61	67	PF00069	0.358
MOD_CK2_1	146	152	PF00069	0.422
MOD_CK2_1	267	273	PF00069	0.240
MOD_GlcNHglycan	138	141	PF01048	0.200
MOD_GlcNHglycan	246	249	PF01048	0.324
MOD_GlcNHglycan	315	318	PF01048	0.344
MOD_GlcNHglycan	335	338	PF01048	0.350
MOD_GlcNHglycan	6	9	PF01048	0.514
MOD_GSK3_1	132	139	PF00069	0.425
MOD_GSK3_1	161	168	PF00069	0.381
MOD_GSK3_1	178	185	PF00069	0.563
MOD_GSK3_1	209	216	PF00069	0.388
MOD_GSK3_1	22	29	PF00069	0.329
MOD_GSK3_1	240	247	PF00069	0.402
MOD_GSK3_1	262	269	PF00069	0.243
MOD_GSK3_1	335	342	PF00069	0.274
MOD_GSK3_1	46	53	PF00069	0.492
MOD_NEK2_1	1	6	PF00069	0.427
MOD_NEK2_1	107	112	PF00069	0.255
MOD_NEK2_1	15	20	PF00069	0.338
MOD_NEK2_1	178	183	PF00069	0.365
MOD_NEK2_1	207	212	PF00069	0.459
MOD_NEK2_1	22	27	PF00069	0.344
MOD_NEK2_1	253	258	PF00069	0.336
MOD_NEK2_1	313	318	PF00069	0.339
MOD_NEK2_1	335	340	PF00069	0.346
MOD_NEK2_1	358	363	PF00069	0.354
MOD_NEK2_1	46	51	PF00069	0.471
MOD_NEK2_1	75	80	PF00069	0.261
MOD_PIKK_1	199	205	PF00454	0.388
MOD_PK_1	161	167	PF00069	0.394
MOD_PKA_1	385	391	PF00069	0.393
MOD_PKA_2	153	159	PF00069	0.401
MOD_Plk_1	179	185	PF00069	0.466
MOD_Plk_4	15	21	PF00069	0.362
MOD_Plk_4	202	208	PF00069	0.374
MOD_Plk_4	22	28	PF00069	0.356
MOD_Plk_4	256	262	PF00069	0.319
MOD_Plk_4	339	345	PF00069	0.286
MOD_Plk_4	89	95	PF00069	0.230
MOD_ProDKin_1	167	173	PF00069	0.453
MOD_ProDKin_1	328	334	PF00069	0.275
MOD_SUMO_rev_2	271	277	PF00179	0.290
MOD_SUMO_rev_2	294	301	PF00179	0.325
TRG_DiLeu_LyEn_5	273	278	PF01217	0.275
TRG_ENDOCYTIC_2	193	196	PF00928	0.359
TRG_ENDOCYTIC_2	357	360	PF00928	0.331
TRG_ENDOCYTIC_2	37	40	PF00928	0.496
TRG_NES_CRM1_1	57	70	PF08389	0.162
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.176

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E9	Leptomonas seymouri	41%	100%
A0A0N1PCU5	Leptomonas seymouri	55%	95%
A0A1X0NSI7	Trypanosomatidae	33%	100%
A0A3S7X1N7	Leishmania donovani	36%	88%
A0A3S7X501	Leishmania donovani	59%	94%
A4HGP7	Leishmania braziliensis	40%	89%
A4HJU9	Leishmania braziliensis	64%	100%
A4HJV0	Leishmania braziliensis	63%	100%
A4I3R9	Leishmania infantum	36%	88%
A4I7B1	Leishmania infantum	59%	94%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	90%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	94%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	94%
O82643	Arabidopsis thaliana	24%	100%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q12436	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	96%
Q4Q5V0	Leishmania major	57%	100%
Q4Q5V1	Leishmania major	57%	100%
Q4Q873	Leishmania major	36%	100%
V5DCU2	Trypanosoma cruzi	36%	100%