Iron/zinc transporter protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

iron/zinc transporter protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJV0_LEIBR

TriTrypDb:

LbrM.31.3490 , LBRM2903_310044900

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	28
GO:0110165	cellular anatomical entity	1	28
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	3

Expansion

Sequence features

A4HJV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJV0

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	3
GO:0006810	transport	3	3
GO:0006811	monoatomic ion transport	4	3
GO:0006812	monoatomic cation transport	5	3
GO:0006829	zinc ion transport	8	3
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0009987	cellular process	1	3
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	3
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	3
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071577	zinc ion transmembrane transport	6	3
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098655	monoatomic cation transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098662	inorganic cation transmembrane transport	5	3
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	28
GO:0008324	monoatomic cation transmembrane transporter activity	4	28
GO:0015075	monoatomic ion transmembrane transporter activity	3	28
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	28
GO:0022857	transmembrane transporter activity	2	28
GO:0022890	inorganic cation transmembrane transporter activity	4	28
GO:0046873	metal ion transmembrane transporter activity	5	28
GO:0005385	zinc ion transmembrane transporter activity	7	3
GO:0046915	transition metal ion transmembrane transporter activity	6	3
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.438
CLV_MEL_PAP_1	18	24	PF00089	0.527
CLV_PCSK_KEX2_1	78	80	PF00082	0.276
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.276
CLV_PCSK_SKI1_1	13	17	PF00082	0.457
CLV_PCSK_SKI1_1	157	161	PF00082	0.353
CLV_PCSK_SKI1_1	321	325	PF00082	0.170
CLV_PCSK_SKI1_1	401	405	PF00082	0.321
DEG_APCC_DBOX_1	320	328	PF00400	0.417
DEG_Nend_UBRbox_3	1	3	PF02207	0.466
DOC_MAPK_gen_1	319	328	PF00069	0.473
DOC_MAPK_gen_1	399	408	PF00069	0.448
DOC_MAPK_gen_1	78	86	PF00069	0.533
DOC_MAPK_HePTP_8	402	414	PF00069	0.370
DOC_MAPK_MEF2A_6	294	302	PF00069	0.254
DOC_MAPK_MEF2A_6	319	328	PF00069	0.515
DOC_MAPK_MEF2A_6	401	410	PF00069	0.479
DOC_MAPK_RevD_3	64	79	PF00069	0.159
DOC_USP7_MATH_1	195	199	PF00917	0.413
DOC_USP7_MATH_1	207	211	PF00917	0.352
DOC_USP7_MATH_1	310	314	PF00917	0.308
DOC_USP7_MATH_1	352	356	PF00917	0.337
DOC_USP7_UBL2_3	160	164	PF12436	0.545
DOC_WW_Pin1_4	229	234	PF00397	0.540
DOC_WW_Pin1_4	347	352	PF00397	0.256
LIG_14-3-3_CanoR_1	13	22	PF00244	0.474
LIG_14-3-3_CanoR_1	181	191	PF00244	0.489
LIG_14-3-3_CanoR_1	263	272	PF00244	0.458
LIG_CtBP_PxDLS_1	255	259	PF00389	0.482
LIG_eIF4E_1	133	139	PF01652	0.299
LIG_eIF4E_1	376	382	PF01652	0.312
LIG_FHA_1	1	7	PF00498	0.401
LIG_FHA_1	10	16	PF00498	0.307
LIG_FHA_1	104	110	PF00498	0.324
LIG_FHA_1	216	222	PF00498	0.570
LIG_FHA_1	260	266	PF00498	0.450
LIG_FHA_1	282	288	PF00498	0.249
LIG_FHA_1	378	384	PF00498	0.349
LIG_FHA_1	405	411	PF00498	0.181
LIG_FHA_1	96	102	PF00498	0.316
LIG_FHA_2	168	174	PF00498	0.440
LIG_FHA_2	287	293	PF00498	0.264
LIG_FHA_2	320	326	PF00498	0.386
LIG_FHA_2	5	11	PF00498	0.295
LIG_LIR_Gen_1	357	366	PF02991	0.295
LIG_LIR_Gen_1	407	416	PF02991	0.181
LIG_LIR_Nem_3	128	132	PF02991	0.249
LIG_LIR_Nem_3	278	283	PF02991	0.336
LIG_LIR_Nem_3	317	323	PF02991	0.436
LIG_LIR_Nem_3	357	362	PF02991	0.332
LIG_LIR_Nem_3	407	412	PF02991	0.293
LIG_PDZ_Wminus1_1	424	426	PF00595	0.472
LIG_Pex14_1	82	86	PF04695	0.362
LIG_Pex14_2	302	306	PF04695	0.347
LIG_Pex14_2	409	413	PF04695	0.262
LIG_Pex14_2	61	65	PF04695	0.338
LIG_Pex14_2	86	90	PF04695	0.362
LIG_SH2_CRK	129	133	PF00017	0.275
LIG_SH2_SRC	27	30	PF00017	0.323
LIG_SH2_STAP1	27	31	PF00017	0.324
LIG_SH2_STAT5	133	136	PF00017	0.439
LIG_SH2_STAT5	14	17	PF00017	0.476
LIG_SH2_STAT5	376	379	PF00017	0.290
LIG_SH2_STAT5	393	396	PF00017	0.464
LIG_SH3_3	19	25	PF00018	0.372
LIG_SH3_3	227	233	PF00018	0.461
LIG_SH3_3	249	255	PF00018	0.553
LIG_SH3_3	81	87	PF00018	0.413
LIG_SUMO_SIM_anti_2	322	328	PF11976	0.533
LIG_SUMO_SIM_anti_2	361	368	PF11976	0.256
LIG_SUMO_SIM_par_1	100	106	PF11976	0.312
LIG_SUMO_SIM_par_1	217	223	PF11976	0.381
LIG_SUMO_SIM_par_1	361	368	PF11976	0.361
LIG_SUMO_SIM_par_1	379	385	PF11976	0.178
LIG_SxIP_EBH_1	66	79	PF03271	0.351
LIG_TRAF2_1	7	10	PF00917	0.275
MOD_CDK_SPK_2	229	234	PF00069	0.372
MOD_CK1_1	103	109	PF00069	0.313
MOD_CK1_1	125	131	PF00069	0.286
MOD_CK1_1	39	45	PF00069	0.417
MOD_CK1_1	95	101	PF00069	0.413
MOD_CK2_1	182	188	PF00069	0.500
MOD_CK2_1	286	292	PF00069	0.262
MOD_CK2_1	39	45	PF00069	0.449
MOD_CK2_1	4	10	PF00069	0.482
MOD_Cter_Amidation	76	79	PF01082	0.276
MOD_GlcNHglycan	184	187	PF01048	0.372
MOD_GlcNHglycan	192	195	PF01048	0.337
MOD_GlcNHglycan	209	212	PF01048	0.179
MOD_GlcNHglycan	22	25	PF01048	0.681
MOD_GlcNHglycan	265	268	PF01048	0.310
MOD_GlcNHglycan	334	337	PF01048	0.379
MOD_GlcNHglycan	354	357	PF01048	0.343
MOD_GlcNHglycan	94	97	PF01048	0.431
MOD_GSK3_1	259	266	PF00069	0.392
MOD_GSK3_1	281	288	PF00069	0.204
MOD_GSK3_1	354	361	PF00069	0.253
MOD_GSK3_1	4	11	PF00069	0.480
MOD_GSK3_1	45	52	PF00069	0.364
MOD_GSK3_1	64	71	PF00069	0.295
MOD_GSK3_1	88	95	PF00069	0.513
MOD_NEK2_1	102	107	PF00069	0.300
MOD_NEK2_1	220	225	PF00069	0.485
MOD_NEK2_1	272	277	PF00069	0.337
MOD_NEK2_1	332	337	PF00069	0.327
MOD_NEK2_1	354	359	PF00069	0.304
MOD_NEK2_1	377	382	PF00069	0.356
MOD_NEK2_1	47	52	PF00069	0.343
MOD_NEK2_1	64	69	PF00069	0.308
MOD_NEK2_1	88	93	PF00069	0.471
MOD_PKA_1	404	410	PF00069	0.382
MOD_PKA_2	20	26	PF00069	0.352
MOD_Plk_1	39	45	PF00069	0.463
MOD_Plk_1	9	15	PF00069	0.259
MOD_Plk_2-3	115	121	PF00069	0.237
MOD_Plk_4	215	221	PF00069	0.368
MOD_Plk_4	275	281	PF00069	0.312
MOD_Plk_4	358	364	PF00069	0.315
MOD_Plk_4	64	70	PF00069	0.316
MOD_ProDKin_1	229	235	PF00069	0.540
MOD_ProDKin_1	347	353	PF00069	0.256
MOD_SUMO_for_1	163	166	PF00179	0.443
MOD_SUMO_rev_2	173	179	PF00179	0.362
MOD_SUMO_rev_2	290	296	PF00179	0.289
MOD_SUMO_rev_2	313	320	PF00179	0.301
TRG_DiLeu_LyEn_5	292	297	PF01217	0.256
TRG_ENDOCYTIC_2	129	132	PF00928	0.231
TRG_ENDOCYTIC_2	133	136	PF00928	0.254
TRG_ENDOCYTIC_2	27	30	PF00928	0.323
TRG_ENDOCYTIC_2	376	379	PF00928	0.300
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.166
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU5	Leptomonas seymouri	58%	99%
A0A1X0NR51	Trypanosomatidae	42%	100%
A0A1X0NSB9	Trypanosomatidae	36%	100%
A0A1X0NSI7	Trypanosomatidae	37%	100%
A0A3S7X1N7	Leishmania donovani	41%	92%
A0A3S7X501	Leishmania donovani	75%	99%
A0A3S7X7B0	Leishmania donovani	33%	100%
A0A422MUI2	Trypanosoma rangeli	35%	100%
A4HGP7	Leishmania braziliensis	44%	92%
A4HJU9	Leishmania braziliensis	96%	100%
A4HJV1	Leishmania braziliensis	63%	100%
A4HM27	Leishmania braziliensis	31%	100%
A4I3R9	Leishmania infantum	41%	92%
A4I7B1	Leishmania infantum	75%	99%
A4I9G1	Leishmania infantum	34%	100%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	95%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
O04089	Arabidopsis thaliana	27%	100%
O81123	Arabidopsis thaliana	25%	100%
O81850	Arabidopsis thaliana	23%	100%
O82643	Arabidopsis thaliana	25%	100%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q12436	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q4Q5V0	Leishmania major	72%	100%
Q4Q5V1	Leishmania major	72%	100%
Q4Q873	Leishmania major	42%	100%
Q6L8G0	Oryza sativa subsp. japonica	27%	100%
Q6L8G1	Oryza sativa subsp. japonica	23%	100%
Q8LE59	Arabidopsis thaliana	27%	100%
Q9FIS2	Arabidopsis thaliana	27%	100%
V5AWN3	Trypanosoma cruzi	35%	100%
V5BC34	Trypanosoma cruzi	36%	100%
V5DCU2	Trypanosoma cruzi	43%	100%