Phosphoglycan beta 1,3 galactosyltransferase 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallopeptidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HJU8_LEIBR

TriTrypDb:

LbrM.31.3470 , LBRM2903_310045500

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJU8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0019538	protein metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0003824	catalytic activity	1	10
GO:0004175	endopeptidase activity	4	10
GO:0004222	metalloendopeptidase activity	5	10
GO:0008233	peptidase activity	3	10
GO:0008237	metallopeptidase activity	4	10
GO:0016740	transferase activity	2	5
GO:0016757	glycosyltransferase activity	3	5
GO:0016787	hydrolase activity	2	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.492
CLV_C14_Caspase3-7	629	633	PF00656	0.375
CLV_C14_Caspase3-7	677	681	PF00656	0.416
CLV_C14_Caspase3-7	737	741	PF00656	0.633
CLV_NRD_NRD_1	270	272	PF00675	0.370
CLV_NRD_NRD_1	355	357	PF00675	0.525
CLV_NRD_NRD_1	380	382	PF00675	0.326
CLV_NRD_NRD_1	705	707	PF00675	0.523
CLV_PCSK_KEX2_1	270	272	PF00082	0.460
CLV_PCSK_KEX2_1	380	382	PF00082	0.438
CLV_PCSK_KEX2_1	617	619	PF00082	0.531
CLV_PCSK_KEX2_1	705	707	PF00082	0.523
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.510
CLV_PCSK_SKI1_1	111	115	PF00082	0.554
CLV_PCSK_SKI1_1	27	31	PF00082	0.543
CLV_PCSK_SKI1_1	277	281	PF00082	0.406
CLV_PCSK_SKI1_1	356	360	PF00082	0.293
CLV_PCSK_SKI1_1	380	384	PF00082	0.406
CLV_PCSK_SKI1_1	392	396	PF00082	0.480
CLV_PCSK_SKI1_1	453	457	PF00082	0.552
CLV_PCSK_SKI1_1	553	557	PF00082	0.474
CLV_PCSK_SKI1_1	61	65	PF00082	0.587
CLV_PCSK_SKI1_1	651	655	PF00082	0.485
CLV_PCSK_SKI1_1	671	675	PF00082	0.384
CLV_PCSK_SKI1_1	706	710	PF00082	0.514
DEG_APCC_DBOX_1	26	34	PF00400	0.531
DEG_APCC_DBOX_1	552	560	PF00400	0.451
DEG_APCC_DBOX_1	705	713	PF00400	0.575
DOC_CKS1_1	112	117	PF01111	0.473
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.579
DOC_MAPK_gen_1	356	363	PF00069	0.519
DOC_MAPK_MEF2A_6	356	363	PF00069	0.304
DOC_PP1_RVXF_1	59	65	PF00149	0.525
DOC_PP1_RVXF_1	590	597	PF00149	0.380
DOC_PP2B_LxvP_1	187	190	PF13499	0.595
DOC_PP2B_LxvP_1	233	236	PF13499	0.368
DOC_PP2B_LxvP_1	733	736	PF13499	0.501
DOC_USP7_MATH_1	234	238	PF00917	0.514
DOC_WW_Pin1_4	111	116	PF00397	0.474
DOC_WW_Pin1_4	247	252	PF00397	0.488
DOC_WW_Pin1_4	259	264	PF00397	0.422
DOC_WW_Pin1_4	286	291	PF00397	0.368
DOC_WW_Pin1_4	292	297	PF00397	0.368
DOC_WW_Pin1_4	482	487	PF00397	0.449
DOC_WW_Pin1_4	525	530	PF00397	0.446
LIG_14-3-3_CanoR_1	220	225	PF00244	0.437
LIG_14-3-3_CanoR_1	403	409	PF00244	0.511
LIG_14-3-3_CanoR_1	447	455	PF00244	0.500
LIG_14-3-3_CanoR_1	692	701	PF00244	0.493
LIG_14-3-3_CanoR_1	758	763	PF00244	0.549
LIG_Actin_WH2_2	16	33	PF00022	0.532
LIG_Actin_WH2_2	460	476	PF00022	0.600
LIG_BRCT_BRCA1_1	542	546	PF00533	0.412
LIG_CtBP_PxDLS_1	230	234	PF00389	0.479
LIG_EH_1	238	242	PF12763	0.368
LIG_EH1_1	500	508	PF00400	0.280
LIG_eIF4E_1	431	437	PF01652	0.517
LIG_FHA_1	18	24	PF00498	0.619
LIG_FHA_1	208	214	PF00498	0.449
LIG_FHA_1	403	409	PF00498	0.514
LIG_FHA_1	447	453	PF00498	0.559
LIG_FHA_1	526	532	PF00498	0.432
LIG_FHA_1	694	700	PF00498	0.543
LIG_FHA_1	728	734	PF00498	0.638
LIG_FHA_2	162	168	PF00498	0.787
LIG_FHA_2	365	371	PF00498	0.462
LIG_FHA_2	607	613	PF00498	0.358
LIG_FHA_2	658	664	PF00498	0.561
LIG_FHA_2	735	741	PF00498	0.573
LIG_GBD_Chelix_1	32	40	PF00786	0.332
LIG_LIR_Gen_1	183	193	PF02991	0.474
LIG_LIR_Gen_1	349	359	PF02991	0.387
LIG_LIR_Gen_1	422	432	PF02991	0.506
LIG_LIR_Gen_1	499	508	PF02991	0.534
LIG_LIR_Gen_1	51	58	PF02991	0.385
LIG_LIR_Gen_1	544	555	PF02991	0.426
LIG_LIR_Gen_1	639	648	PF02991	0.548
LIG_LIR_Nem_3	183	189	PF02991	0.480
LIG_LIR_Nem_3	24	29	PF02991	0.406
LIG_LIR_Nem_3	244	249	PF02991	0.363
LIG_LIR_Nem_3	34	40	PF02991	0.404
LIG_LIR_Nem_3	349	355	PF02991	0.375
LIG_LIR_Nem_3	369	374	PF02991	0.182
LIG_LIR_Nem_3	388	394	PF02991	0.474
LIG_LIR_Nem_3	420	424	PF02991	0.423
LIG_LIR_Nem_3	499	504	PF02991	0.462
LIG_LIR_Nem_3	544	550	PF02991	0.412
LIG_LIR_Nem_3	639	645	PF02991	0.539
LIG_LIR_Nem_3	668	673	PF02991	0.415
LIG_MLH1_MIPbox_1	543	547	PF16413	0.423
LIG_Pex14_2	670	674	PF04695	0.476
LIG_PTB_Apo_2	223	230	PF02174	0.287
LIG_PTB_Phospho_1	223	229	PF10480	0.287
LIG_REV1ctd_RIR_1	672	682	PF16727	0.495
LIG_RPA_C_Fungi	673	685	PF08784	0.573
LIG_RPA_C_Fungi	687	699	PF08784	0.358
LIG_SH2_CRK	208	212	PF00017	0.514
LIG_SH2_CRK	293	297	PF00017	0.331
LIG_SH2_CRK	301	305	PF00017	0.372
LIG_SH2_CRK	319	323	PF00017	0.368
LIG_SH2_CRK	37	41	PF00017	0.406
LIG_SH2_CRK	391	395	PF00017	0.479
LIG_SH2_NCK_1	249	253	PF00017	0.269
LIG_SH2_NCK_1	750	754	PF00017	0.355
LIG_SH2_SRC	374	377	PF00017	0.406
LIG_SH2_SRC	431	434	PF00017	0.528
LIG_SH2_STAP1	301	305	PF00017	0.411
LIG_SH2_STAP1	319	323	PF00017	0.288
LIG_SH2_STAP1	348	352	PF00017	0.477
LIG_SH2_STAP1	371	375	PF00017	0.394
LIG_SH2_STAP1	750	754	PF00017	0.583
LIG_SH2_STAT3	109	112	PF00017	0.499
LIG_SH2_STAT5	109	112	PF00017	0.553
LIG_SH2_STAT5	268	271	PF00017	0.453
LIG_SH2_STAT5	301	304	PF00017	0.431
LIG_SH2_STAT5	374	377	PF00017	0.445
LIG_SH2_STAT5	407	410	PF00017	0.368
LIG_SH2_STAT5	424	427	PF00017	0.396
LIG_SH2_STAT5	431	434	PF00017	0.380
LIG_SH2_STAT5	558	561	PF00017	0.422
LIG_SH2_STAT5	588	591	PF00017	0.289
LIG_SH2_STAT5	642	645	PF00017	0.491
LIG_SH3_3	208	214	PF00018	0.466
LIG_SH3_3	225	231	PF00018	0.254
LIG_SH3_3	284	290	PF00018	0.479
LIG_SH3_3	337	343	PF00018	0.374
LIG_SH3_3	466	472	PF00018	0.490
LIG_SH3_3	505	511	PF00018	0.531
LIG_SH3_3	66	72	PF00018	0.428
LIG_Sin3_3	351	358	PF02671	0.406
LIG_SUMO_SIM_anti_2	360	365	PF11976	0.406
LIG_SUMO_SIM_anti_2	9	16	PF11976	0.335
LIG_SUMO_SIM_par_1	18	24	PF11976	0.563
LIG_SUMO_SIM_par_1	696	702	PF11976	0.340
LIG_SUMO_SIM_par_1	727	737	PF11976	0.675
LIG_TRAF2_1	138	141	PF00917	0.654
LIG_TRAF2_1	181	184	PF00917	0.649
LIG_TRAF2_1	367	370	PF00917	0.514
LIG_TRAF2_1	609	612	PF00917	0.578
LIG_TRAF2_1	714	717	PF00917	0.702
LIG_TYR_ITIM	35	40	PF00017	0.437
LIG_UBA3_1	394	400	PF00899	0.287
LIG_UBA3_1	620	626	PF00899	0.580
LIG_WRC_WIRS_1	424	429	PF05994	0.553
LIG_WRC_WIRS_1	498	503	PF05994	0.573
LIG_WRC_WIRS_1	735	740	PF05994	0.609
MOD_CDK_SPK_2	482	487	PF00069	0.388
MOD_CDK_SPK_2	525	530	PF00069	0.574
MOD_CDK_SPxxK_3	292	299	PF00069	0.411
MOD_CK1_1	198	204	PF00069	0.505
MOD_CK1_1	496	502	PF00069	0.485
MOD_CK1_1	659	665	PF00069	0.557
MOD_CK1_1	690	696	PF00069	0.460
MOD_CK1_1	724	730	PF00069	0.701
MOD_CK1_1	749	755	PF00069	0.577
MOD_CK2_1	142	148	PF00069	0.715
MOD_CK2_1	161	167	PF00069	0.710
MOD_CK2_1	178	184	PF00069	0.438
MOD_CK2_1	364	370	PF00069	0.479
MOD_CK2_1	595	601	PF00069	0.548
MOD_CK2_1	606	612	PF00069	0.396
MOD_CK2_1	643	649	PF00069	0.569
MOD_CK2_1	657	663	PF00069	0.525
MOD_CK2_1	711	717	PF00069	0.707
MOD_CK2_1	740	746	PF00069	0.508
MOD_CK2_1	749	755	PF00069	0.410
MOD_GlcNHglycan	165	170	PF01048	0.775
MOD_GlcNHglycan	176	181	PF01048	0.603
MOD_GlcNHglycan	331	334	PF01048	0.399
MOD_GlcNHglycan	433	436	PF01048	0.346
MOD_GlcNHglycan	578	581	PF01048	0.427
MOD_GlcNHglycan	597	600	PF01048	0.389
MOD_GlcNHglycan	689	692	PF01048	0.433
MOD_GlcNHglycan	701	704	PF01048	0.459
MOD_GlcNHglycan	751	754	PF01048	0.589
MOD_GSK3_1	15	22	PF00069	0.544
MOD_GSK3_1	161	168	PF00069	0.767
MOD_GSK3_1	307	314	PF00069	0.481
MOD_GSK3_1	493	500	PF00069	0.611
MOD_GSK3_1	502	509	PF00069	0.582
MOD_GSK3_1	643	650	PF00069	0.594
MOD_GSK3_1	674	681	PF00069	0.491
MOD_GSK3_1	724	731	PF00069	0.728
MOD_GSK3_1	736	743	PF00069	0.521
MOD_GSK3_1	745	752	PF00069	0.393
MOD_N-GLC_1	493	498	PF02516	0.651
MOD_N-GLC_1	83	88	PF02516	0.514
MOD_NEK2_1	103	108	PF00069	0.526
MOD_NEK2_1	133	138	PF00069	0.566
MOD_NEK2_1	15	20	PF00069	0.553
MOD_NEK2_1	185	190	PF00069	0.509
MOD_NEK2_1	207	212	PF00069	0.428
MOD_NEK2_1	331	336	PF00069	0.374
MOD_NEK2_1	40	45	PF00069	0.352
MOD_NEK2_1	532	537	PF00069	0.428
MOD_NEK2_1	541	546	PF00069	0.385
MOD_NEK2_1	561	566	PF00069	0.231
MOD_NEK2_1	643	648	PF00069	0.490
MOD_NEK2_1	674	679	PF00069	0.430
MOD_NEK2_1	699	704	PF00069	0.393
MOD_NEK2_2	275	280	PF00069	0.287
MOD_PIKK_1	341	347	PF00454	0.479
MOD_PK_1	357	363	PF00069	0.304
MOD_PK_1	758	764	PF00069	0.385
MOD_PKA_2	195	201	PF00069	0.479
MOD_PKA_2	402	408	PF00069	0.506
MOD_PKA_2	446	452	PF00069	0.578
MOD_PKA_2	480	486	PF00069	0.503
MOD_Plk_1	103	109	PF00069	0.526
MOD_Plk_1	15	21	PF00069	0.474
MOD_Plk_1	244	250	PF00069	0.368
MOD_Plk_1	493	499	PF00069	0.659
MOD_Plk_1	727	733	PF00069	0.587
MOD_Plk_1	745	751	PF00069	0.502
MOD_Plk_2-3	126	132	PF00069	0.456
MOD_Plk_2-3	161	167	PF00069	0.738
MOD_Plk_2-3	370	376	PF00069	0.497
MOD_Plk_4	220	226	PF00069	0.497
MOD_Plk_4	370	376	PF00069	0.457
MOD_Plk_4	423	429	PF00069	0.514
MOD_Plk_4	493	499	PF00069	0.631
MOD_Plk_4	502	508	PF00069	0.532
MOD_Plk_4	542	548	PF00069	0.423
MOD_Plk_4	728	734	PF00069	0.602
MOD_Plk_4	758	764	PF00069	0.420
MOD_ProDKin_1	111	117	PF00069	0.479
MOD_ProDKin_1	247	253	PF00069	0.488
MOD_ProDKin_1	259	265	PF00069	0.422
MOD_ProDKin_1	286	292	PF00069	0.368
MOD_ProDKin_1	482	488	PF00069	0.460
MOD_ProDKin_1	525	531	PF00069	0.446
MOD_SUMO_for_1	56	59	PF00179	0.488
MOD_SUMO_rev_2	485	493	PF00179	0.532
MOD_SUMO_rev_2	659	668	PF00179	0.497
TRG_DiLeu_BaEn_1	433	438	PF01217	0.520
TRG_ENDOCYTIC_2	208	211	PF00928	0.479
TRG_ENDOCYTIC_2	301	304	PF00928	0.367
TRG_ENDOCYTIC_2	319	322	PF00928	0.246
TRG_ENDOCYTIC_2	348	351	PF00928	0.477
TRG_ENDOCYTIC_2	37	40	PF00928	0.410
TRG_ENDOCYTIC_2	391	394	PF00928	0.441
TRG_ENDOCYTIC_2	424	427	PF00928	0.329
TRG_ENDOCYTIC_2	53	56	PF00928	0.472
TRG_ENDOCYTIC_2	558	561	PF00928	0.441
TRG_ENDOCYTIC_2	642	645	PF00928	0.535
TRG_ER_diArg_1	269	271	PF00400	0.460
TRG_ER_diArg_1	379	381	PF00400	0.287
TRG_ER_diArg_1	478	481	PF00400	0.622
TRG_ER_diArg_1	550	553	PF00400	0.452
TRG_ER_diArg_1	705	707	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P423	Leptomonas seymouri	62%	71%
A0A1X0NIF3	Trypanosomatidae	39%	71%
A0A3R7LVD3	Trypanosoma rangeli	41%	72%
A0A3S7X521	Leishmania donovani	80%	68%
A4HJV3	Leishmania braziliensis	99%	71%
A4I7B5	Leishmania infantum	80%	68%
C9ZWJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	72%
E9B2A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	71%
O22941	Arabidopsis thaliana	23%	79%
Q4Q5U8	Leishmania major	78%	100%
V5BDV9	Trypanosoma cruzi	41%	84%