Iron/zinc transporter protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

iron/zinc transporter protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJU6_LEIBR

TriTrypDb:

LbrM.31.3450 , LBRM2903_310045200

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

A4HJU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	19
GO:0008324	monoatomic cation transmembrane transporter activity	4	19
GO:0015075	monoatomic ion transmembrane transporter activity	3	19
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	19
GO:0022857	transmembrane transporter activity	2	19
GO:0022890	inorganic cation transmembrane transporter activity	4	19
GO:0046873	metal ion transmembrane transporter activity	5	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.620
CLV_PCSK_SKI1_1	156	160	PF00082	0.213
CLV_PCSK_SKI1_1	236	240	PF00082	0.222
CLV_PCSK_SKI1_1	48	52	PF00082	0.300
DEG_APCC_DBOX_1	155	163	PF00400	0.373
DOC_MAPK_gen_1	154	163	PF00069	0.329
DOC_MAPK_gen_1	234	243	PF00069	0.364
DOC_MAPK_HePTP_8	237	249	PF00069	0.329
DOC_MAPK_MEF2A_6	129	137	PF00069	0.177
DOC_MAPK_MEF2A_6	154	163	PF00069	0.441
DOC_MAPK_MEF2A_6	236	245	PF00069	0.369
DOC_USP7_MATH_1	145	149	PF00917	0.303
DOC_USP7_MATH_1	187	191	PF00917	0.208
DOC_USP7_MATH_1	63	67	PF00917	0.585
DOC_WW_Pin1_4	182	187	PF00397	0.259
DOC_WW_Pin1_4	21	26	PF00397	0.510
DOC_WW_Pin1_4	3	8	PF00397	0.568
LIG_14-3-3_CanoR_1	98	107	PF00244	0.341
LIG_BIR_III_4	43	47	PF00653	0.487
LIG_CtBP_PxDLS_1	90	94	PF00389	0.344
LIG_eIF4E_1	211	217	PF01652	0.237
LIG_FHA_1	117	123	PF00498	0.209
LIG_FHA_1	213	219	PF00498	0.318
LIG_FHA_1	240	246	PF00498	0.138
LIG_FHA_1	95	101	PF00498	0.350
LIG_FHA_2	122	128	PF00498	0.240
LIG_FHA_2	155	161	PF00498	0.329
LIG_LIR_Gen_1	192	201	PF02991	0.181
LIG_LIR_Gen_1	242	251	PF02991	0.138
LIG_LIR_Nem_3	113	118	PF02991	0.263
LIG_LIR_Nem_3	152	158	PF02991	0.386
LIG_LIR_Nem_3	192	197	PF02991	0.194
LIG_LIR_Nem_3	242	247	PF02991	0.266
LIG_PDZ_Wminus1_1	259	261	PF00595	0.317
LIG_Pex14_2	137	141	PF04695	0.292
LIG_Pex14_2	244	248	PF04695	0.157
LIG_SH2_CRK	47	51	PF00017	0.501
LIG_SH2_STAT5	211	214	PF00017	0.248
LIG_SH2_STAT5	228	231	PF00017	0.404
LIG_SH3_3	84	90	PF00018	0.465
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.436
LIG_SUMO_SIM_anti_2	196	203	PF11976	0.138
LIG_SUMO_SIM_par_1	196	203	PF11976	0.138
LIG_SUMO_SIM_par_1	214	220	PF11976	0.198
LIG_TYR_ITIM	45	50	PF00017	0.495
LIG_UBA3_1	28	33	PF00899	0.502
MOD_CDK_SPxK_1	21	27	PF00069	0.524
MOD_CK1_1	36	42	PF00069	0.473
MOD_CK2_1	121	127	PF00069	0.237
MOD_GlcNHglycan	100	103	PF01048	0.179
MOD_GlcNHglycan	169	172	PF01048	0.267
MOD_GlcNHglycan	189	192	PF01048	0.420
MOD_GSK3_1	116	123	PF00069	0.200
MOD_GSK3_1	15	22	PF00069	0.730
MOD_GSK3_1	189	196	PF00069	0.142
MOD_GSK3_1	32	39	PF00069	0.529
MOD_GSK3_1	63	70	PF00069	0.690
MOD_GSK3_1	94	101	PF00069	0.546
MOD_N-GLC_1	3	8	PF02516	0.348
MOD_NEK2_1	107	112	PF00069	0.243
MOD_NEK2_1	167	172	PF00069	0.254
MOD_NEK2_1	189	194	PF00069	0.214
MOD_NEK2_1	212	217	PF00069	0.218
MOD_NEK2_1	32	37	PF00069	0.484
MOD_NEK2_1	51	56	PF00069	0.510
MOD_NEK2_1	61	66	PF00069	0.701
MOD_PIKK_1	53	59	PF00454	0.507
MOD_PK_1	15	21	PF00069	0.547
MOD_PKA_1	239	245	PF00069	0.138
MOD_Plk_1	15	21	PF00069	0.629
MOD_Plk_1	33	39	PF00069	0.617
MOD_Plk_4	110	116	PF00069	0.235
MOD_Plk_4	193	199	PF00069	0.227
MOD_Plk_4	56	62	PF00069	0.699
MOD_ProDKin_1	182	188	PF00069	0.259
MOD_ProDKin_1	21	27	PF00069	0.509
MOD_ProDKin_1	3	9	PF00069	0.570
MOD_SUMO_rev_2	125	131	PF00179	0.152
MOD_SUMO_rev_2	148	155	PF00179	0.138
TRG_DiLeu_LyEn_5	127	132	PF01217	0.129
TRG_ENDOCYTIC_2	211	214	PF00928	0.282
TRG_ENDOCYTIC_2	47	50	PF00928	0.503
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.121

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E9	Leptomonas seymouri	55%	94%
A0A0N0P5K7	Leptomonas seymouri	37%	94%
A0A1X0NR51	Trypanosomatidae	53%	70%
A0A1X0NSI7	Trypanosomatidae	46%	69%
A0A3R7LZX6	Trypanosoma rangeli	45%	74%
A0A3S7X7B0	Leishmania donovani	44%	78%
A4HGP7	Leishmania braziliensis	55%	74%
A4I9G1	Leishmania infantum	44%	78%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	66%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	66%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	66%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	68%
E8NHP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	78%
O23039	Arabidopsis thaliana	33%	72%
O81123	Arabidopsis thaliana	27%	74%
O81850	Arabidopsis thaliana	30%	75%
Q6L8G0	Oryza sativa subsp. japonica	31%	74%
Q6L8G1	Oryza sativa subsp. japonica	28%	71%
Q75HB1	Oryza sativa subsp. japonica	29%	70%
Q7XLD4	Oryza sativa subsp. japonica	32%	72%
Q8W245	Arabidopsis thaliana	30%	72%
Q9FIS2	Arabidopsis thaliana	33%	74%
V5AWN3	Trypanosoma cruzi	46%	70%
V5BC34	Trypanosoma cruzi	36%	71%
V5DCU2	Trypanosoma cruzi	53%	71%