Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJU4_LEIBR

TriTrypDb:

LbrM.31.3430 , LBRM2903_310044600

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HJU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.593
CLV_C14_Caspase3-7	78	82	PF00656	0.382
CLV_NRD_NRD_1	128	130	PF00675	0.372
CLV_NRD_NRD_1	132	134	PF00675	0.390
CLV_NRD_NRD_1	6	8	PF00675	0.682
CLV_PCSK_KEX2_1	128	130	PF00082	0.370
CLV_PCSK_KEX2_1	132	134	PF00082	0.392
CLV_PCSK_KEX2_1	215	217	PF00082	0.526
CLV_PCSK_KEX2_1	6	8	PF00082	0.721
CLV_PCSK_KEX2_1	85	87	PF00082	0.653
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.587
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.714
CLV_PCSK_PC7_1	128	134	PF00082	0.423
CLV_PCSK_SKI1_1	154	158	PF00082	0.415
DEG_MDM2_SWIB_1	117	124	PF02201	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DOC_CKS1_1	51	56	PF01111	0.525
DOC_MAPK_gen_1	6	14	PF00069	0.399
DOC_USP7_MATH_1	191	195	PF00917	0.633
DOC_USP7_MATH_1	219	223	PF00917	0.771
DOC_USP7_MATH_1	234	238	PF00917	0.738
DOC_WW_Pin1_4	5	10	PF00397	0.400
DOC_WW_Pin1_4	50	55	PF00397	0.490
LIG_14-3-3_CanoR_1	7	13	PF00244	0.480
LIG_BIR_III_4	35	39	PF00653	0.436
LIG_FHA_1	180	186	PF00498	0.576
LIG_FHA_1	187	193	PF00498	0.579
LIG_FHA_1	208	214	PF00498	0.770
LIG_FHA_1	46	52	PF00498	0.437
LIG_FHA_1	94	100	PF00498	0.462
LIG_LIR_Apic_2	105	110	PF02991	0.420
LIG_LIR_Apic_2	69	75	PF02991	0.419
LIG_LIR_Gen_1	87	95	PF02991	0.397
LIG_LIR_Nem_3	87	91	PF02991	0.321
LIG_Pex14_1	103	107	PF04695	0.438
LIG_Pex14_2	117	121	PF04695	0.404
LIG_SH2_CRK	107	111	PF00017	0.335
LIG_SH2_CRK	72	76	PF00017	0.408
LIG_SH2_NCK_1	107	111	PF00017	0.331
LIG_SH2_STAT5	72	75	PF00017	0.343
LIG_SH3_3	206	212	PF00018	0.595
LIG_SH3_3	48	54	PF00018	0.544
LIG_SUMO_SIM_anti_2	146	154	PF11976	0.584
MOD_CK1_1	179	185	PF00069	0.620
MOD_CK1_1	222	228	PF00069	0.630
MOD_CK1_1	47	53	PF00069	0.539
MOD_CK1_1	58	64	PF00069	0.464
MOD_CK1_1	66	72	PF00069	0.457
MOD_CK2_1	217	223	PF00069	0.615
MOD_CMANNOS	123	126	PF00535	0.396
MOD_GlcNHglycan	202	205	PF01048	0.479
MOD_GlcNHglycan	23	26	PF01048	0.751
MOD_GlcNHglycan	57	60	PF01048	0.725
MOD_GlcNHglycan	65	68	PF01048	0.720
MOD_GlcNHglycan	87	91	PF01048	0.556
MOD_GSK3_1	187	194	PF00069	0.625
MOD_GSK3_1	40	47	PF00069	0.534
MOD_GSK3_1	55	62	PF00069	0.539
MOD_GSK3_1	86	93	PF00069	0.355
MOD_N-GLC_1	154	159	PF02516	0.443
MOD_N-GLC_1	45	50	PF02516	0.672
MOD_NEK2_1	98	103	PF00069	0.446
MOD_PIKK_1	60	66	PF00454	0.415
MOD_PIKK_1	98	104	PF00454	0.509
MOD_PK_1	193	199	PF00069	0.660
MOD_PKA_2	127	133	PF00069	0.588
MOD_PKA_2	186	192	PF00069	0.577
MOD_PKA_2	197	203	PF00069	0.645
MOD_Plk_1	86	92	PF00069	0.451
MOD_ProDKin_1	5	11	PF00069	0.399
MOD_ProDKin_1	50	56	PF00069	0.490
TRG_ER_diArg_1	131	133	PF00400	0.592
TRG_ER_diArg_1	5	7	PF00400	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR85	Leptomonas seymouri	65%	100%
A0A3S7X4Y5	Leishmania donovani	79%	100%
A4I7A9	Leishmania infantum	79%	100%
C9ZWJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E8NHP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q5V3	Leishmania major	79%	100%