Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJU1_LEIBR

TriTrypDb:

LbrM.31.3390 , LBRM2903_310044000

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.530
CLV_C14_Caspase3-7	286	290	PF00656	0.500
CLV_C14_Caspase3-7	56	60	PF00656	0.566
CLV_NRD_NRD_1	100	102	PF00675	0.590
CLV_NRD_NRD_1	190	192	PF00675	0.658
CLV_NRD_NRD_1	408	410	PF00675	0.615
CLV_PCSK_FUR_1	409	413	PF00082	0.524
CLV_PCSK_KEX2_1	100	102	PF00082	0.632
CLV_PCSK_KEX2_1	411	413	PF00082	0.756
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.756
CLV_PCSK_SKI1_1	217	221	PF00082	0.484
CLV_PCSK_SKI1_1	231	235	PF00082	0.549
DOC_CYCLIN_yClb3_PxF_3	364	372	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.499
DOC_MAPK_MEF2A_6	141	149	PF00069	0.507
DOC_MAPK_MEF2A_6	183	190	PF00069	0.528
DOC_MAPK_MEF2A_6	80	89	PF00069	0.501
DOC_PP1_RVXF_1	229	236	PF00149	0.451
DOC_PP1_RVXF_1	394	401	PF00149	0.596
DOC_PP2B_LxvP_1	329	332	PF13499	0.530
DOC_PP2B_LxvP_1	83	86	PF13499	0.501
DOC_PP4_FxxP_1	320	323	PF00568	0.562
DOC_PP4_FxxP_1	377	380	PF00568	0.611
DOC_USP7_MATH_1	145	149	PF00917	0.570
DOC_USP7_MATH_1	165	169	PF00917	0.616
DOC_USP7_MATH_1	173	177	PF00917	0.639
DOC_USP7_MATH_1	184	188	PF00917	0.676
DOC_USP7_MATH_1	293	297	PF00917	0.688
DOC_USP7_MATH_1	325	329	PF00917	0.706
DOC_USP7_MATH_1	358	362	PF00917	0.557
DOC_USP7_MATH_1	90	94	PF00917	0.763
DOC_USP7_UBL2_3	248	252	PF12436	0.413
DOC_WW_Pin1_4	122	127	PF00397	0.583
DOC_WW_Pin1_4	161	166	PF00397	0.656
DOC_WW_Pin1_4	177	182	PF00397	0.488
DOC_WW_Pin1_4	258	263	PF00397	0.485
DOC_WW_Pin1_4	295	300	PF00397	0.650
DOC_WW_Pin1_4	319	324	PF00397	0.568
DOC_WW_Pin1_4	327	332	PF00397	0.605
DOC_WW_Pin1_4	344	349	PF00397	0.602
DOC_WW_Pin1_4	360	365	PF00397	0.595
DOC_WW_Pin1_4	414	419	PF00397	0.652
DOC_WW_Pin1_4	57	62	PF00397	0.569
LIG_14-3-3_CanoR_1	115	121	PF00244	0.658
LIG_14-3-3_CanoR_1	128	133	PF00244	0.573
LIG_14-3-3_CanoR_1	177	181	PF00244	0.598
LIG_14-3-3_CanoR_1	183	189	PF00244	0.520
LIG_14-3-3_CanoR_1	277	285	PF00244	0.647
LIG_14-3-3_CanoR_1	295	299	PF00244	0.492
LIG_14-3-3_CanoR_1	341	347	PF00244	0.743
LIG_14-3-3_CanoR_1	353	358	PF00244	0.525
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_BRCT_BRCA1_1	152	156	PF00533	0.511
LIG_BRCT_BRCA1_1	16	20	PF00533	0.604
LIG_BRCT_BRCA1_1	365	369	PF00533	0.514
LIG_BRCT_BRCA1_1	80	84	PF00533	0.506
LIG_CSL_BTD_1	345	348	PF09270	0.678
LIG_deltaCOP1_diTrp_1	247	253	PF00928	0.499
LIG_FHA_1	107	113	PF00498	0.663
LIG_FHA_1	183	189	PF00498	0.803
LIG_FHA_1	236	242	PF00498	0.419
LIG_FHA_1	269	275	PF00498	0.581
LIG_FHA_1	324	330	PF00498	0.535
LIG_FHA_1	383	389	PF00498	0.601
LIG_FHA_1	415	421	PF00498	0.614
LIG_FHA_2	54	60	PF00498	0.597
LIG_LIR_Gen_1	116	122	PF02991	0.542
LIG_LIR_Gen_1	153	161	PF02991	0.658
LIG_LIR_Gen_1	203	212	PF02991	0.518
LIG_LIR_Gen_1	247	258	PF02991	0.431
LIG_LIR_Gen_1	283	293	PF02991	0.573
LIG_LIR_Nem_3	153	159	PF02991	0.658
LIG_LIR_Nem_3	203	207	PF02991	0.542
LIG_LIR_Nem_3	247	253	PF02991	0.413
LIG_LIR_Nem_3	283	288	PF02991	0.568
LIG_LIR_Nem_3	81	87	PF02991	0.499
LIG_MYND_1	414	418	PF01753	0.504
LIG_Pex14_1	249	253	PF04695	0.413
LIG_SH2_CRK	230	234	PF00017	0.585
LIG_SH2_STAP1	246	250	PF00017	0.408
LIG_SH2_STAT5	132	135	PF00017	0.528
LIG_SH3_3	139	145	PF00018	0.586
LIG_SH3_3	178	184	PF00018	0.665
LIG_SH3_3	361	367	PF00018	0.709
LIG_SH3_3	377	383	PF00018	0.492
LIG_SH3_3	38	44	PF00018	0.534
LIG_SH3_3	417	423	PF00018	0.684
LIG_SUMO_SIM_anti_2	146	151	PF11976	0.566
LIG_WRC_WIRS_1	288	293	PF05994	0.577
LIG_WRC_WIRS_1	354	359	PF05994	0.664
LIG_WW_3	125	129	PF00397	0.494
LIG_WW_3	330	334	PF00397	0.529
MOD_CDC14_SPxK_1	180	183	PF00782	0.526
MOD_CDC14_SPxK_1	261	264	PF00782	0.504
MOD_CDC14_SPxK_1	330	333	PF00782	0.553
MOD_CDK_SPK_2	319	324	PF00069	0.582
MOD_CDK_SPxK_1	122	128	PF00069	0.496
MOD_CDK_SPxK_1	177	183	PF00069	0.527
MOD_CDK_SPxK_1	258	264	PF00069	0.489
MOD_CDK_SPxK_1	327	333	PF00069	0.575
MOD_CDK_SPxxK_3	414	421	PF00069	0.499
MOD_CK1_1	105	111	PF00069	0.664
MOD_CK1_1	116	122	PF00069	0.515
MOD_CK1_1	15	21	PF00069	0.589
MOD_CK1_1	176	182	PF00069	0.629
MOD_CK1_1	196	202	PF00069	0.499
MOD_CK1_1	223	229	PF00069	0.403
MOD_CK1_1	266	272	PF00069	0.680
MOD_CK1_1	280	286	PF00069	0.553
MOD_CK1_1	294	300	PF00069	0.696
MOD_CK1_1	303	309	PF00069	0.710
MOD_CK1_1	342	348	PF00069	0.584
MOD_CK1_1	363	369	PF00069	0.742
MOD_CK2_1	36	42	PF00069	0.592
MOD_DYRK1A_RPxSP_1	295	299	PF00069	0.519
MOD_DYRK1A_RPxSP_1	57	61	PF00069	0.559
MOD_GlcNHglycan	195	198	PF01048	0.496
MOD_GlcNHglycan	21	24	PF01048	0.707
MOD_GlcNHglycan	222	225	PF01048	0.505
MOD_GlcNHglycan	279	282	PF01048	0.729
MOD_GlcNHglycan	341	344	PF01048	0.548
MOD_GlcNHglycan	358	361	PF01048	0.571
MOD_GlcNHglycan	38	41	PF01048	0.604
MOD_GSK3_1	102	109	PF00069	0.693
MOD_GSK3_1	12	19	PF00069	0.564
MOD_GSK3_1	161	168	PF00069	0.583
MOD_GSK3_1	169	176	PF00069	0.730
MOD_GSK3_1	273	280	PF00069	0.670
MOD_GSK3_1	283	290	PF00069	0.580
MOD_GSK3_1	291	298	PF00069	0.634
MOD_GSK3_1	319	326	PF00069	0.704
MOD_GSK3_1	335	342	PF00069	0.596
MOD_GSK3_1	356	363	PF00069	0.545
MOD_GSK3_1	53	60	PF00069	0.843
MOD_N-GLC_1	122	127	PF02516	0.493
MOD_N-GLC_1	15	20	PF02516	0.484
MOD_N-GLC_1	4	9	PF02516	0.542
MOD_NEK2_1	14	19	PF00069	0.590
MOD_NEK2_1	193	198	PF00069	0.528
MOD_NEK2_1	218	223	PF00069	0.671
MOD_NEK2_1	235	240	PF00069	0.446
MOD_NEK2_1	265	270	PF00069	0.679
MOD_NEK2_1	275	280	PF00069	0.707
MOD_NEK2_1	291	296	PF00069	0.597
MOD_NEK2_1	78	83	PF00069	0.554
MOD_NEK2_1	89	94	PF00069	0.649
MOD_NEK2_2	90	95	PF00069	0.531
MOD_PIKK_1	235	241	PF00454	0.420
MOD_PIKK_1	266	272	PF00454	0.513
MOD_PIKK_1	78	84	PF00454	0.641
MOD_PKA_2	102	108	PF00069	0.585
MOD_PKA_2	176	182	PF00069	0.614
MOD_PKA_2	263	269	PF00069	0.552
MOD_PKA_2	294	300	PF00069	0.522
MOD_PKB_1	101	109	PF00069	0.546
MOD_Plk_1	145	151	PF00069	0.523
MOD_Plk_1	15	21	PF00069	0.559
MOD_Plk_1	4	10	PF00069	0.586
MOD_Plk_1	64	70	PF00069	0.553
MOD_Plk_4	128	134	PF00069	0.592
MOD_Plk_4	145	151	PF00069	0.568
MOD_Plk_4	65	71	PF00069	0.702
MOD_ProDKin_1	122	128	PF00069	0.586
MOD_ProDKin_1	161	167	PF00069	0.656
MOD_ProDKin_1	177	183	PF00069	0.488
MOD_ProDKin_1	258	264	PF00069	0.489
MOD_ProDKin_1	295	301	PF00069	0.651
MOD_ProDKin_1	319	325	PF00069	0.568
MOD_ProDKin_1	327	333	PF00069	0.608
MOD_ProDKin_1	344	350	PF00069	0.599
MOD_ProDKin_1	360	366	PF00069	0.595
MOD_ProDKin_1	414	420	PF00069	0.650
MOD_ProDKin_1	57	63	PF00069	0.569
MOD_SUMO_for_1	151	154	PF00179	0.512
MOD_SUMO_for_1	94	97	PF00179	0.548
TRG_DiLeu_BaEn_1	74	79	PF01217	0.514
TRG_ENDOCYTIC_2	230	233	PF00928	0.509
TRG_ER_diArg_1	100	103	PF00400	0.591
TRG_NLS_MonoCore_2	408	413	PF00514	0.545
TRG_NLS_MonoExtC_3	409	414	PF00514	0.523
TRG_NLS_MonoExtN_4	407	414	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	198	203	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T5	Leptomonas seymouri	39%	97%
A0A3Q8IGM6	Leishmania donovani	51%	91%
A4I7A7	Leishmania infantum	51%	91%
E9B2A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	94%
Q4Q5V6	Leishmania major	51%	100%