Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJU0_LEIBR

TriTrypDb:

LbrM.31.3380 , LBRM2903_310043900

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJU0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.687
CLV_NRD_NRD_1	163	165	PF00675	0.468
CLV_NRD_NRD_1	196	198	PF00675	0.534
CLV_NRD_NRD_1	413	415	PF00675	0.702
CLV_NRD_NRD_1	43	45	PF00675	0.552
CLV_NRD_NRD_1	434	436	PF00675	0.641
CLV_NRD_NRD_1	453	455	PF00675	0.475
CLV_PCSK_FUR_1	103	107	PF00082	0.469
CLV_PCSK_KEX2_1	105	107	PF00082	0.481
CLV_PCSK_KEX2_1	15	17	PF00082	0.711
CLV_PCSK_KEX2_1	162	164	PF00082	0.538
CLV_PCSK_KEX2_1	198	200	PF00082	0.532
CLV_PCSK_KEX2_1	210	212	PF00082	0.608
CLV_PCSK_KEX2_1	43	45	PF00082	0.552
CLV_PCSK_KEX2_1	434	436	PF00082	0.641
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.473
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.538
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.532
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.553
CLV_PCSK_PC7_1	158	164	PF00082	0.506
CLV_PCSK_SKI1_1	116	120	PF00082	0.361
CLV_PCSK_SKI1_1	21	25	PF00082	0.583
CLV_PCSK_SKI1_1	242	246	PF00082	0.593
CLV_PCSK_SKI1_1	387	391	PF00082	0.529
CLV_PCSK_SKI1_1	406	410	PF00082	0.517
CLV_Separin_Metazoa	155	159	PF03568	0.508
DOC_CKS1_1	243	248	PF01111	0.496
DOC_CKS1_1	450	455	PF01111	0.657
DOC_CYCLIN_RxL_1	403	412	PF00134	0.518
DOC_MAPK_gen_1	20	26	PF00069	0.488
DOC_MAPK_gen_1	287	295	PF00069	0.524
DOC_MAPK_MEF2A_6	287	295	PF00069	0.524
DOC_PP4_FxxP_1	243	246	PF00568	0.499
DOC_USP7_MATH_1	186	190	PF00917	0.522
DOC_USP7_MATH_1	19	23	PF00917	0.611
DOC_USP7_MATH_1	219	223	PF00917	0.738
DOC_USP7_MATH_1	365	369	PF00917	0.656
DOC_USP7_MATH_1	375	379	PF00917	0.562
DOC_USP7_MATH_1	391	395	PF00917	0.705
DOC_USP7_MATH_1	71	75	PF00917	0.548
DOC_USP7_MATH_1	77	81	PF00917	0.404
DOC_USP7_MATH_2	375	381	PF00917	0.553
DOC_WW_Pin1_4	242	247	PF00397	0.502
DOC_WW_Pin1_4	361	366	PF00397	0.660
DOC_WW_Pin1_4	389	394	PF00397	0.597
DOC_WW_Pin1_4	398	403	PF00397	0.621
DOC_WW_Pin1_4	419	424	PF00397	0.641
DOC_WW_Pin1_4	428	433	PF00397	0.549
DOC_WW_Pin1_4	449	454	PF00397	0.778
DOC_WW_Pin1_4	5	10	PF00397	0.731
LIG_14-3-3_CanoR_1	116	126	PF00244	0.382
LIG_14-3-3_CanoR_1	15	24	PF00244	0.688
LIG_14-3-3_CanoR_1	237	242	PF00244	0.605
LIG_14-3-3_CanoR_1	387	395	PF00244	0.610
LIG_14-3-3_CanoR_1	414	419	PF00244	0.728
LIG_14-3-3_CanoR_1	97	102	PF00244	0.462
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BRCT_BRCA1_1	239	243	PF00533	0.506
LIG_deltaCOP1_diTrp_1	214	224	PF00928	0.440
LIG_FHA_1	174	180	PF00498	0.523
LIG_FHA_1	390	396	PF00498	0.530
LIG_FHA_1	402	408	PF00498	0.496
LIG_FHA_1	83	89	PF00498	0.401
LIG_FHA_2	102	108	PF00498	0.390
LIG_FHA_2	168	174	PF00498	0.367
LIG_FHA_2	34	40	PF00498	0.565
LIG_FHA_2	350	356	PF00498	0.489
LIG_FXI_DFP_1	224	228	PF00024	0.506
LIG_LIR_Apic_2	240	246	PF02991	0.502
LIG_LIR_Apic_2	394	400	PF02991	0.524
LIG_LIR_Gen_1	152	161	PF02991	0.372
LIG_LIR_Gen_1	328	338	PF02991	0.520
LIG_LIR_Gen_1	444	453	PF02991	0.653
LIG_LIR_Nem_3	152	157	PF02991	0.411
LIG_LIR_Nem_3	222	227	PF02991	0.655
LIG_LIR_Nem_3	328	333	PF02991	0.523
LIG_LIR_Nem_3	34	40	PF02991	0.556
LIG_LIR_Nem_3	444	450	PF02991	0.650
LIG_Pex14_2	447	451	PF04695	0.653
LIG_SH2_NCK_1	165	169	PF00017	0.523
LIG_SH2_SRC	90	93	PF00017	0.379
LIG_SH2_STAT5	90	93	PF00017	0.512
LIG_SH3_3	247	253	PF00018	0.473
LIG_SH3_3	335	341	PF00018	0.510
LIG_SH3_3	369	375	PF00018	0.670
LIG_SH3_3	447	453	PF00018	0.498
LIG_TRAF2_1	147	150	PF00917	0.452
LIG_TRAF2_1	193	196	PF00917	0.517
LIG_TRAF2_1	231	234	PF00917	0.511
MOD_CDC14_SPxK_1	431	434	PF00782	0.538
MOD_CDK_SPK_2	449	454	PF00069	0.657
MOD_CDK_SPxK_1	428	434	PF00069	0.548
MOD_CDK_SPxK_1	449	455	PF00069	0.777
MOD_CDK_SPxxK_3	428	435	PF00069	0.547
MOD_CK1_1	269	275	PF00069	0.399
MOD_CK1_1	3	9	PF00069	0.590
MOD_CK1_1	364	370	PF00069	0.689
MOD_CK1_1	398	404	PF00069	0.643
MOD_CK2_1	101	107	PF00069	0.392
MOD_CK2_1	167	173	PF00069	0.366
MOD_CK2_1	190	196	PF00069	0.574
MOD_CK2_1	312	318	PF00069	0.588
MOD_CK2_1	33	39	PF00069	0.666
MOD_CK2_1	340	346	PF00069	0.514
MOD_CK2_1	349	355	PF00069	0.458
MOD_CK2_1	414	420	PF00069	0.566
MOD_DYRK1A_RPxSP_1	428	432	PF00069	0.550
MOD_GlcNHglycan	17	20	PF01048	0.667
MOD_GlcNHglycan	21	24	PF01048	0.605
MOD_GlcNHglycan	268	271	PF01048	0.444
MOD_GlcNHglycan	303	306	PF01048	0.500
MOD_GlcNHglycan	309	312	PF01048	0.511
MOD_GlcNHglycan	314	317	PF01048	0.488
MOD_GlcNHglycan	333	336	PF01048	0.487
MOD_GlcNHglycan	342	345	PF01048	0.539
MOD_GlcNHglycan	361	364	PF01048	0.688
MOD_GlcNHglycan	367	370	PF01048	0.709
MOD_GlcNHglycan	397	400	PF01048	0.734
MOD_GlcNHglycan	409	412	PF01048	0.543
MOD_GlcNHglycan	425	428	PF01048	0.609
MOD_GlcNHglycan	73	76	PF01048	0.659
MOD_GSK3_1	15	22	PF00069	0.678
MOD_GSK3_1	186	193	PF00069	0.522
MOD_GSK3_1	289	296	PF00069	0.560
MOD_GSK3_1	3	10	PF00069	0.649
MOD_GSK3_1	329	336	PF00069	0.589
MOD_GSK3_1	355	362	PF00069	0.529
MOD_GSK3_1	387	394	PF00069	0.597
MOD_GSK3_1	409	416	PF00069	0.740
MOD_GSK3_1	419	426	PF00069	0.649
MOD_GSK3_1	97	104	PF00069	0.437
MOD_N-GLC_1	173	178	PF02516	0.368
MOD_N-GLC_1	3	8	PF02516	0.568
MOD_NEK2_1	101	106	PF00069	0.387
MOD_NEK2_1	167	172	PF00069	0.365
MOD_NEK2_1	190	195	PF00069	0.496
MOD_NEK2_1	266	271	PF00069	0.550
MOD_NEK2_1	306	311	PF00069	0.632
MOD_NEK2_1	31	36	PF00069	0.567
MOD_NEK2_1	409	414	PF00069	0.517
MOD_NEK2_1	418	423	PF00069	0.521
MOD_NEK2_2	446	451	PF00069	0.651
MOD_PIKK_1	401	407	PF00454	0.494
MOD_PK_1	237	243	PF00069	0.564
MOD_PKA_1	15	21	PF00069	0.621
MOD_PKA_1	414	420	PF00069	0.586
MOD_PKA_2	15	21	PF00069	0.711
MOD_PKA_2	236	242	PF00069	0.676
MOD_PKA_2	289	295	PF00069	0.635
MOD_PKA_2	326	332	PF00069	0.618
MOD_PKA_2	413	419	PF00069	0.609
MOD_Plk_1	213	219	PF00069	0.465
MOD_Plk_4	349	355	PF00069	0.467
MOD_Plk_4	414	420	PF00069	0.532
MOD_Plk_4	446	452	PF00069	0.660
MOD_ProDKin_1	242	248	PF00069	0.498
MOD_ProDKin_1	361	367	PF00069	0.665
MOD_ProDKin_1	389	395	PF00069	0.596
MOD_ProDKin_1	398	404	PF00069	0.621
MOD_ProDKin_1	419	425	PF00069	0.645
MOD_ProDKin_1	428	434	PF00069	0.543
MOD_ProDKin_1	449	455	PF00069	0.777
MOD_ProDKin_1	5	11	PF00069	0.730
MOD_SUMO_for_1	177	180	PF00179	0.613
TRG_DiLeu_BaEn_4	128	134	PF01217	0.385
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.691
TRG_ENDOCYTIC_2	154	157	PF00928	0.580
TRG_ER_diArg_1	163	165	PF00400	0.468
TRG_ER_diArg_1	197	200	PF00400	0.534
TRG_ER_diArg_1	434	436	PF00400	0.682
TRG_ER_diArg_1	96	99	PF00400	0.354
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X505	Leishmania donovani	62%	88%
A4I7A6	Leishmania infantum	60%	100%
E9B2A0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	82%
Q4Q5V7	Leishmania major	63%	100%