SMK-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJT7_LEIBR

TriTrypDb:

LbrM.31.3350 , LBRM2903_310043400

Length:

988

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0030289	protein phosphatase 4 complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

A4HJT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJT7

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0008047	enzyme activator activity	3	1
GO:0019208	phosphatase regulator activity	3	1
GO:0019211	phosphatase activator activity	4	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0072542	protein phosphatase activator activity	5	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.617
CLV_C14_Caspase3-7	599	603	PF00656	0.431
CLV_C14_Caspase3-7	867	871	PF00656	0.682
CLV_NRD_NRD_1	146	148	PF00675	0.511
CLV_NRD_NRD_1	255	257	PF00675	0.295
CLV_NRD_NRD_1	268	270	PF00675	0.238
CLV_NRD_NRD_1	518	520	PF00675	0.410
CLV_NRD_NRD_1	631	633	PF00675	0.582
CLV_NRD_NRD_1	650	652	PF00675	0.259
CLV_NRD_NRD_1	954	956	PF00675	0.744
CLV_NRD_NRD_1	979	981	PF00675	0.497
CLV_PCSK_FUR_1	144	148	PF00082	0.506
CLV_PCSK_KEX2_1	146	148	PF00082	0.510
CLV_PCSK_KEX2_1	179	181	PF00082	0.533
CLV_PCSK_KEX2_1	255	257	PF00082	0.295
CLV_PCSK_KEX2_1	268	270	PF00082	0.238
CLV_PCSK_KEX2_1	518	520	PF00082	0.367
CLV_PCSK_KEX2_1	60	62	PF00082	0.730
CLV_PCSK_KEX2_1	631	633	PF00082	0.582
CLV_PCSK_KEX2_1	650	652	PF00082	0.252
CLV_PCSK_KEX2_1	954	956	PF00082	0.744
CLV_PCSK_KEX2_1	959	961	PF00082	0.732
CLV_PCSK_KEX2_1	979	981	PF00082	0.721
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.533
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.730
CLV_PCSK_PC1ET2_1	959	961	PF00082	0.732
CLV_PCSK_PC7_1	56	62	PF00082	0.505
CLV_PCSK_PC7_1	955	961	PF00082	0.735
CLV_PCSK_SKI1_1	134	138	PF00082	0.537
CLV_PCSK_SKI1_1	268	272	PF00082	0.274
CLV_PCSK_SKI1_1	379	383	PF00082	0.400
CLV_PCSK_SKI1_1	469	473	PF00082	0.426
CLV_PCSK_SKI1_1	477	481	PF00082	0.461
CLV_PCSK_SKI1_1	654	658	PF00082	0.455
CLV_Separin_Metazoa	521	525	PF03568	0.486
DEG_APCC_DBOX_1	468	476	PF00400	0.461
DEG_APCC_DBOX_1	533	541	PF00400	0.330
DEG_Nend_UBRbox_2	1	3	PF02207	0.563
DEG_SPOP_SBC_1	791	795	PF00917	0.504
DOC_CKS1_1	824	829	PF01111	0.672
DOC_CYCLIN_yClb5_NLxxxL_5	162	171	PF00134	0.397
DOC_MAPK_gen_1	179	185	PF00069	0.516
DOC_MAPK_gen_1	255	265	PF00069	0.350
DOC_MAPK_gen_1	379	388	PF00069	0.393
DOC_MAPK_gen_1	518	525	PF00069	0.392
DOC_MAPK_gen_1	650	658	PF00069	0.419
DOC_MAPK_MEF2A_6	296	303	PF00069	0.274
DOC_MAPK_MEF2A_6	469	476	PF00069	0.385
DOC_MAPK_NFAT4_5	296	304	PF00069	0.308
DOC_MAPK_NFAT4_5	469	477	PF00069	0.390
DOC_MAPK_RevD_3	504	519	PF00069	0.532
DOC_PP2B_PxIxI_1	283	289	PF00149	0.350
DOC_PP4_FxxP_1	222	225	PF00568	0.350
DOC_PP4_FxxP_1	272	275	PF00568	0.279
DOC_SPAK_OSR1_1	159	163	PF12202	0.302
DOC_SPAK_OSR1_1	524	528	PF12202	0.395
DOC_USP7_MATH_1	173	177	PF00917	0.376
DOC_USP7_MATH_1	37	41	PF00917	0.687
DOC_USP7_MATH_1	51	55	PF00917	0.683
DOC_USP7_MATH_1	601	605	PF00917	0.271
DOC_USP7_MATH_1	751	755	PF00917	0.440
DOC_USP7_MATH_1	791	795	PF00917	0.514
DOC_USP7_MATH_1	858	862	PF00917	0.572
DOC_USP7_MATH_1	882	886	PF00917	0.724
DOC_USP7_MATH_1	900	904	PF00917	0.725
DOC_WW_Pin1_4	221	226	PF00397	0.334
DOC_WW_Pin1_4	329	334	PF00397	0.326
DOC_WW_Pin1_4	348	353	PF00397	0.614
DOC_WW_Pin1_4	625	630	PF00397	0.478
DOC_WW_Pin1_4	661	666	PF00397	0.530
DOC_WW_Pin1_4	717	722	PF00397	0.561
DOC_WW_Pin1_4	779	784	PF00397	0.446
DOC_WW_Pin1_4	819	824	PF00397	0.588
DOC_WW_Pin1_4	892	897	PF00397	0.666
LIG_14-3-3_CanoR_1	134	140	PF00244	0.564
LIG_14-3-3_CanoR_1	268	273	PF00244	0.274
LIG_14-3-3_CanoR_1	320	326	PF00244	0.425
LIG_14-3-3_CanoR_1	477	482	PF00244	0.479
LIG_14-3-3_CanoR_1	483	491	PF00244	0.442
LIG_14-3-3_CanoR_1	569	579	PF00244	0.597
LIG_14-3-3_CanoR_1	605	610	PF00244	0.394
LIG_14-3-3_CanoR_1	654	659	PF00244	0.454
LIG_14-3-3_CanoR_1	941	945	PF00244	0.723
LIG_14-3-3_CanoR_1	954	959	PF00244	0.545
LIG_14-3-3_CanoR_1	960	968	PF00244	0.486
LIG_APCC_ABBA_1	506	511	PF00400	0.557
LIG_CORNRBOX	213	221	PF00104	0.303
LIG_DLG_GKlike_1	605	612	PF00625	0.261
LIG_FHA_1	104	110	PF00498	0.436
LIG_FHA_1	314	320	PF00498	0.417
LIG_FHA_1	325	331	PF00498	0.417
LIG_FHA_1	36	42	PF00498	0.662
LIG_FHA_1	406	412	PF00498	0.402
LIG_FHA_1	476	482	PF00498	0.232
LIG_FHA_1	563	569	PF00498	0.615
LIG_FHA_1	622	628	PF00498	0.572
LIG_FHA_1	639	645	PF00498	0.272
LIG_FHA_1	658	664	PF00498	0.433
LIG_FHA_1	668	674	PF00498	0.332
LIG_FHA_1	795	801	PF00498	0.547
LIG_FHA_1	824	830	PF00498	0.636
LIG_FHA_1	910	916	PF00498	0.672
LIG_FHA_2	207	213	PF00498	0.193
LIG_FHA_2	269	275	PF00498	0.417
LIG_FHA_2	388	394	PF00498	0.386
LIG_FHA_2	407	413	PF00498	0.176
LIG_FHA_2	511	517	PF00498	0.356
LIG_FHA_2	63	69	PF00498	0.638
LIG_FHA_2	844	850	PF00498	0.750
LIG_FHA_2	928	934	PF00498	0.500
LIG_FHA_2	99	105	PF00498	0.333
LIG_FXI_DFP_1	808	812	PF00024	0.561
LIG_GBD_Chelix_1	540	548	PF00786	0.405
LIG_Integrin_RGD_1	727	729	PF01839	0.538
LIG_LIR_Apic_2	271	275	PF02991	0.274
LIG_LIR_Gen_1	259	270	PF02991	0.277
LIG_LIR_Gen_1	310	319	PF02991	0.417
LIG_LIR_Gen_1	392	403	PF02991	0.330
LIG_LIR_Gen_1	720	726	PF02991	0.565
LIG_LIR_Gen_1	806	816	PF02991	0.441
LIG_LIR_Nem_3	130	136	PF02991	0.391
LIG_LIR_Nem_3	20	24	PF02991	0.557
LIG_LIR_Nem_3	259	265	PF02991	0.277
LIG_LIR_Nem_3	310	314	PF02991	0.349
LIG_LIR_Nem_3	392	398	PF02991	0.325
LIG_LIR_Nem_3	720	725	PF02991	0.554
LIG_LIR_Nem_3	806	811	PF02991	0.484
LIG_NBox_RRM_1	538	548	PF00076	0.235
LIG_NRBOX	470	476	PF00104	0.299
LIG_NRBOX	543	549	PF00104	0.242
LIG_NRBOX	608	614	PF00104	0.262
LIG_PCNA_PIPBox_1	637	646	PF02747	0.400
LIG_PCNA_yPIPBox_3	631	644	PF02747	0.357
LIG_PDZ_Class_1	983	988	PF00595	0.720
LIG_Pex14_2	317	321	PF04695	0.417
LIG_SH2_CRK	133	137	PF00017	0.509
LIG_SH2_CRK	311	315	PF00017	0.417
LIG_SH2_NCK_1	446	450	PF00017	0.433
LIG_SH2_SRC	111	114	PF00017	0.558
LIG_SH2_SRC	887	890	PF00017	0.512
LIG_SH2_STAP1	111	115	PF00017	0.538
LIG_SH2_STAP1	446	450	PF00017	0.217
LIG_SH2_STAT3	100	103	PF00017	0.347
LIG_SH2_STAT5	100	103	PF00017	0.354
LIG_SH2_STAT5	184	187	PF00017	0.412
LIG_SH2_STAT5	191	194	PF00017	0.309
LIG_SH2_STAT5	294	297	PF00017	0.288
LIG_SH2_STAT5	539	542	PF00017	0.429
LIG_SH2_STAT5	675	678	PF00017	0.475
LIG_SH2_STAT5	887	890	PF00017	0.512
LIG_SH3_3	29	35	PF00018	0.447
LIG_SH3_3	327	333	PF00018	0.430
LIG_SH3_3	429	435	PF00018	0.477
LIG_SH3_3	497	503	PF00018	0.478
LIG_SH3_3	529	535	PF00018	0.503
LIG_SH3_3	565	571	PF00018	0.483
LIG_SH3_3	742	748	PF00018	0.546
LIG_SH3_3	875	881	PF00018	0.654
LIG_SUMO_SIM_anti_2	243	250	PF11976	0.368
LIG_SUMO_SIM_anti_2	478	485	PF11976	0.242
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.197
LIG_SUMO_SIM_anti_2	608	614	PF11976	0.527
LIG_SUMO_SIM_par_1	299	304	PF11976	0.205
LIG_SUMO_SIM_par_1	608	614	PF11976	0.461
LIG_SUMO_SIM_par_1	654	660	PF11976	0.521
LIG_TRAF2_1	264	267	PF00917	0.308
LIG_TRAF2_1	65	68	PF00917	0.637
LIG_TRAF2_1	778	781	PF00917	0.421
LIG_TYR_ITIM	131	136	PF00017	0.275
LIG_TYR_ITIM	537	542	PF00017	0.232
LIG_TYR_ITIM	770	775	PF00017	0.559
LIG_UBA3_1	198	205	PF00899	0.193
LIG_UBA3_1	609	617	PF00899	0.547
LIG_WRC_WIRS_1	262	267	PF05994	0.334
LIG_WRC_WIRS_1	314	319	PF05994	0.417
LIG_WRC_WIRS_1	640	645	PF05994	0.381
LIG_WRC_WIRS_1	924	929	PF05994	0.495
LIG_WW_3	433	437	PF00397	0.418
MOD_CDC14_SPxK_1	628	631	PF00782	0.521
MOD_CDK_SPxK_1	625	631	PF00069	0.489
MOD_CDK_SPxxK_3	625	632	PF00069	0.495
MOD_CK1_1	312	318	PF00069	0.327
MOD_CK1_1	638	644	PF00069	0.396
MOD_CK1_1	710	716	PF00069	0.643
MOD_CK1_1	794	800	PF00069	0.526
MOD_CK1_1	803	809	PF00069	0.480
MOD_CK1_1	845	851	PF00069	0.588
MOD_CK1_1	861	867	PF00069	0.737
MOD_CK1_1	909	915	PF00069	0.765
MOD_CK1_1	92	98	PF00069	0.549
MOD_CK1_1	923	929	PF00069	0.785
MOD_CK2_1	206	212	PF00069	0.193
MOD_CK2_1	261	267	PF00069	0.308
MOD_CK2_1	387	393	PF00069	0.304
MOD_CK2_1	406	412	PF00069	0.173
MOD_CK2_1	481	487	PF00069	0.475
MOD_CK2_1	510	516	PF00069	0.411
MOD_CK2_1	605	611	PF00069	0.468
MOD_CK2_1	62	68	PF00069	0.644
MOD_CK2_1	730	736	PF00069	0.639
MOD_CK2_1	795	801	PF00069	0.629
MOD_CK2_1	844	850	PF00069	0.698
MOD_CK2_1	866	872	PF00069	0.694
MOD_CK2_1	900	906	PF00069	0.655
MOD_CK2_1	940	946	PF00069	0.748
MOD_Cter_Amidation	253	256	PF01082	0.308
MOD_Cter_Amidation	58	61	PF01082	0.732
MOD_GlcNHglycan	2	5	PF01048	0.619
MOD_GlcNHglycan	259	262	PF01048	0.334
MOD_GlcNHglycan	484	487	PF01048	0.420
MOD_GlcNHglycan	712	715	PF01048	0.646
MOD_GlcNHglycan	753	756	PF01048	0.423
MOD_GlcNHglycan	801	805	PF01048	0.621
MOD_GlcNHglycan	884	887	PF01048	0.733
MOD_GlcNHglycan	889	892	PF01048	0.565
MOD_GlcNHglycan	902	905	PF01048	0.715
MOD_GlcNHglycan	908	911	PF01048	0.571
MOD_GlcNHglycan	917	920	PF01048	0.482
MOD_GlcNHglycan	938	941	PF01048	0.691
MOD_GlcNHglycan	984	988	PF01048	0.722
MOD_GSK3_1	135	142	PF00069	0.453
MOD_GSK3_1	221	228	PF00069	0.319
MOD_GSK3_1	257	264	PF00069	0.308
MOD_GSK3_1	309	316	PF00069	0.324
MOD_GSK3_1	37	44	PF00069	0.678
MOD_GSK3_1	389	396	PF00069	0.265
MOD_GSK3_1	477	484	PF00069	0.394
MOD_GSK3_1	596	603	PF00069	0.479
MOD_GSK3_1	621	628	PF00069	0.320
MOD_GSK3_1	635	642	PF00069	0.309
MOD_GSK3_1	657	664	PF00069	0.456
MOD_GSK3_1	713	720	PF00069	0.600
MOD_GSK3_1	728	735	PF00069	0.574
MOD_GSK3_1	751	758	PF00069	0.508
MOD_GSK3_1	79	86	PF00069	0.352
MOD_GSK3_1	790	797	PF00069	0.525
MOD_GSK3_1	819	826	PF00069	0.641
MOD_GSK3_1	840	847	PF00069	0.639
MOD_GSK3_1	88	95	PF00069	0.356
MOD_GSK3_1	892	899	PF00069	0.666
MOD_GSK3_1	906	913	PF00069	0.766
MOD_GSK3_1	915	922	PF00069	0.680
MOD_GSK3_1	923	930	PF00069	0.771
MOD_GSK3_1	936	943	PF00069	0.606
MOD_NEK2_1	313	318	PF00069	0.308
MOD_NEK2_1	319	324	PF00069	0.308
MOD_NEK2_1	406	411	PF00069	0.229
MOD_NEK2_1	475	480	PF00069	0.227
MOD_NEK2_1	577	582	PF00069	0.530
MOD_NEK2_1	613	618	PF00069	0.386
MOD_NEK2_1	622	627	PF00069	0.398
MOD_NEK2_1	636	641	PF00069	0.276
MOD_NEK2_1	643	648	PF00069	0.345
MOD_NEK2_1	667	672	PF00069	0.405
MOD_NEK2_1	684	689	PF00069	0.277
MOD_NEK2_1	705	710	PF00069	0.579
MOD_NEK2_1	840	845	PF00069	0.724
MOD_NEK2_1	88	93	PF00069	0.377
MOD_NEK2_1	927	932	PF00069	0.587
MOD_NEK2_2	51	56	PF00069	0.479
MOD_OFUCOSY	442	448	PF10250	0.359
MOD_PIKK_1	173	179	PF00454	0.495
MOD_PIKK_1	510	516	PF00454	0.313
MOD_PIKK_1	755	761	PF00454	0.465
MOD_PK_1	874	880	PF00069	0.528
MOD_PKA_1	268	274	PF00069	0.274
MOD_PKA_1	954	960	PF00069	0.738
MOD_PKA_2	268	274	PF00069	0.282
MOD_PKA_2	319	325	PF00069	0.431
MOD_PKA_2	482	488	PF00069	0.278
MOD_PKA_2	940	946	PF00069	0.748
MOD_PKA_2	954	960	PF00069	0.738
MOD_Plk_1	103	109	PF00069	0.381
MOD_Plk_1	111	117	PF00069	0.423
MOD_Plk_1	206	212	PF00069	0.475
MOD_Plk_1	51	57	PF00069	0.652
MOD_Plk_1	510	516	PF00069	0.420
MOD_Plk_1	728	734	PF00069	0.606
MOD_Plk_1	735	741	PF00069	0.625
MOD_Plk_1	791	797	PF00069	0.536
MOD_Plk_1	874	880	PF00069	0.528
MOD_Plk_1	910	916	PF00069	0.515
MOD_Plk_1	947	953	PF00069	0.512
MOD_Plk_2-3	207	213	PF00069	0.350
MOD_Plk_2-3	487	493	PF00069	0.452
MOD_Plk_2-3	866	872	PF00069	0.680
MOD_Plk_2-3	98	104	PF00069	0.285
MOD_Plk_4	103	109	PF00069	0.348
MOD_Plk_4	27	33	PF00069	0.393
MOD_Plk_4	278	284	PF00069	0.291
MOD_Plk_4	309	315	PF00069	0.274
MOD_Plk_4	321	327	PF00069	0.274
MOD_Plk_4	331	337	PF00069	0.446
MOD_Plk_4	394	400	PF00069	0.346
MOD_Plk_4	406	412	PF00069	0.329
MOD_Plk_4	441	447	PF00069	0.366
MOD_Plk_4	487	493	PF00069	0.452
MOD_Plk_4	577	583	PF00069	0.512
MOD_Plk_4	605	611	PF00069	0.403
MOD_Plk_4	622	628	PF00069	0.327
MOD_Plk_4	639	645	PF00069	0.223
MOD_Plk_4	663	669	PF00069	0.474
MOD_Plk_4	721	727	PF00069	0.621
MOD_Plk_4	940	946	PF00069	0.748
MOD_ProDKin_1	221	227	PF00069	0.334
MOD_ProDKin_1	329	335	PF00069	0.326
MOD_ProDKin_1	348	354	PF00069	0.615
MOD_ProDKin_1	625	631	PF00069	0.489
MOD_ProDKin_1	661	667	PF00069	0.515
MOD_ProDKin_1	717	723	PF00069	0.559
MOD_ProDKin_1	779	785	PF00069	0.450
MOD_ProDKin_1	819	825	PF00069	0.597
MOD_ProDKin_1	892	898	PF00069	0.668
MOD_SUMO_rev_2	224	233	PF00179	0.312
MOD_SUMO_rev_2	866	876	PF00179	0.530
TRG_AP2beta_CARGO_1	259	269	PF09066	0.326
TRG_DiLeu_BaEn_1	127	132	PF01217	0.257
TRG_DiLeu_BaEn_2	368	374	PF01217	0.335
TRG_ENDOCYTIC_2	133	136	PF00928	0.400
TRG_ENDOCYTIC_2	311	314	PF00928	0.417
TRG_ENDOCYTIC_2	539	542	PF00928	0.236
TRG_ENDOCYTIC_2	772	775	PF00928	0.559
TRG_ER_diArg_1	144	147	PF00400	0.501
TRG_ER_diArg_1	631	633	PF00400	0.585
TRG_ER_diArg_1	953	955	PF00400	0.768
TRG_ER_diArg_1	979	981	PF00400	0.497
TRG_NES_CRM1_1	20	34	PF08389	0.292
TRG_NLS_MonoExtC_3	958	964	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	777	781	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P1	Leptomonas seymouri	65%	100%
A0A1X0NIG3	Trypanosomatidae	37%	100%
A0A3Q8IFV0	Leishmania donovani	82%	100%
A0A3S5IR35	Trypanosoma rangeli	36%	100%
A4I7A3	Leishmania infantum	82%	100%
C9ZMI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZWJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B298	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5W0	Leishmania major	82%	100%
V5B7M8	Trypanosoma cruzi	37%	100%