LeishMANIAdb
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Acetyl-CoA carboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Acetyl-CoA carboxylase
Gene product:
acetyl-CoA carboxylase
Species:
Leishmania braziliensis
UniProt:
A4HJT6_LEIBR
TriTrypDb:
LbrM.31.3340 , LBRM2903_310043300 *
Length:
2168

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005777 peroxisome 6 1
GO:0009343 obsolete biotin carboxylase complex 3 1
GO:0020015 glycosome 7 1
GO:0032991 protein-containing complex 1 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
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Expansion

Sequence features

A4HJT6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
TermNameLevelCount
GO:0006082 organic acid metabolic process 3 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006163 purine nucleotide metabolic process 5 12
GO:0006164 purine nucleotide biosynthetic process 6 12
GO:0006629 lipid metabolic process 3 12
GO:0006631 fatty acid metabolic process 4 12
GO:0006633 fatty acid biosynthetic process 5 12
GO:0006637 acyl-CoA metabolic process 4 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006753 nucleoside phosphate metabolic process 4 12
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0003989 acetyl-CoA carboxylase activity 5 12
GO:0004075 biotin carboxylase activity 4 1
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016421 CoA carboxylase activity 4 12
GO:0016740 transferase activity 2 1
GO:0016874 ligase activity 2 12
GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1023 1027 PF00656 0.426
CLV_C14_Caspase3-7 2058 2062 PF00656 0.427
CLV_C14_Caspase3-7 606 610 PF00656 0.265
CLV_C14_Caspase3-7 757 761 PF00656 0.516
CLV_C14_Caspase3-7 867 871 PF00656 0.530
CLV_NRD_NRD_1 1155 1157 PF00675 0.306
CLV_NRD_NRD_1 1425 1427 PF00675 0.515
CLV_NRD_NRD_1 1444 1446 PF00675 0.269
CLV_NRD_NRD_1 1451 1453 PF00675 0.447
CLV_NRD_NRD_1 1515 1517 PF00675 0.330
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IIR0 Leptomonas seymouri 80% 100%
A0A0S4J8F9 Bodo saltans 51% 96%
A0A1X0NIK5 Trypanosomatidae 61% 99%
A0A3Q8IIV7 Leishmania donovani 85% 100%
A0A3R7NC46 Trypanosoma rangeli 58% 98%
A4I7A2 Leishmania infantum 85% 100%
C9ZWK0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 99%
E9B297 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q5W1 Leishmania major 85% 100%
V5BGP0 Trypanosoma cruzi 60% 99%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS