Mutt/nudix family protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mutt/nudix family protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJT4_LEIBR

TriTrypDb:

LbrM.31.3320 , LBRM2903_310043100

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJT4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006734	NADH metabolic process	2	1
GO:0006739	NADP metabolic process	7	1
GO:0006742	NADP catabolic process	7	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019364	pyridine nucleotide catabolic process	6	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019677	NAD catabolic process	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:0072526	pyridine-containing compound catabolic process	5	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000210	NAD+ diphosphatase activity	7	7
GO:0003824	catalytic activity	1	7
GO:0004551	dinucleotide phosphatase activity	6	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0035529	NADH pyrophosphatase activity	7	7
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.442
CLV_NRD_NRD_1	15	17	PF00675	0.456
CLV_NRD_NRD_1	195	197	PF00675	0.287
CLV_NRD_NRD_1	220	222	PF00675	0.287
CLV_PCSK_KEX2_1	15	17	PF00082	0.456
CLV_PCSK_KEX2_1	195	197	PF00082	0.287
CLV_PCSK_KEX2_1	220	222	PF00082	0.287
CLV_PCSK_SKI1_1	281	285	PF00082	0.361
CLV_PCSK_SKI1_1	317	321	PF00082	0.364
CLV_PCSK_SKI1_1	74	78	PF00082	0.446
DEG_APCC_KENBOX_2	43	47	PF00400	0.337
DOC_MAPK_gen_1	195	204	PF00069	0.287
DOC_MAPK_gen_1	74	82	PF00069	0.427
DOC_PP1_RVXF_1	1	8	PF00149	0.418
DOC_PP1_RVXF_1	268	275	PF00149	0.288
DOC_USP7_MATH_1	229	233	PF00917	0.319
DOC_WW_Pin1_4	256	261	PF00397	0.369
DOC_WW_Pin1_4	296	301	PF00397	0.377
LIG_14-3-3_CanoR_1	104	112	PF00244	0.474
LIG_14-3-3_CanoR_1	195	205	PF00244	0.206
LIG_14-3-3_CanoR_1	287	293	PF00244	0.331
LIG_APCC_ABBA_1	208	213	PF00400	0.363
LIG_BIR_II_1	1	5	PF00653	0.425
LIG_BIR_III_2	257	261	PF00653	0.363
LIG_BRCT_BRCA1_1	140	144	PF00533	0.348
LIG_FHA_1	153	159	PF00498	0.451
LIG_FHA_1	259	265	PF00498	0.206
LIG_FHA_2	148	154	PF00498	0.533
LIG_FHA_2	70	76	PF00498	0.292
LIG_LIR_Apic_2	239	245	PF02991	0.316
LIG_LIR_Gen_1	157	165	PF02991	0.403
LIG_LIR_Gen_1	298	308	PF02991	0.353
LIG_LIR_Gen_1	90	101	PF02991	0.433
LIG_LIR_Nem_3	157	163	PF02991	0.400
LIG_LIR_Nem_3	298	304	PF02991	0.355
LIG_LIR_Nem_3	313	318	PF02991	0.295
LIG_NRBOX	200	206	PF00104	0.206
LIG_PDZ_Class_1	320	325	PF00595	0.534
LIG_Pex14_1	242	246	PF04695	0.363
LIG_SH2_CRK	301	305	PF00017	0.362
LIG_SH2_CRK	315	319	PF00017	0.317
LIG_SH2_NCK_1	253	257	PF00017	0.287
LIG_SH2_STAT5	236	239	PF00017	0.287
LIG_SH2_STAT5	246	249	PF00017	0.287
LIG_SH2_STAT5	49	52	PF00017	0.492
LIG_SH2_STAT5	81	84	PF00017	0.335
LIG_SH3_3	315	321	PF00018	0.420
LIG_SUMO_SIM_par_1	179	185	PF11976	0.484
LIG_SUMO_SIM_par_1	199	206	PF11976	0.158
LIG_SUMO_SIM_par_1	259	265	PF11976	0.206
LIG_SUMO_SIM_par_1	38	43	PF11976	0.378
LIG_SUMO_SIM_par_1	68	75	PF11976	0.283
LIG_TRAF2_1	214	217	PF00917	0.287
MOD_CK1_1	273	279	PF00069	0.206
MOD_CK2_1	211	217	PF00069	0.287
MOD_GlcNHglycan	205	208	PF01048	0.287
MOD_GlcNHglycan	213	216	PF01048	0.307
MOD_GlcNHglycan	9	12	PF01048	0.376
MOD_GSK3_1	147	154	PF00069	0.391
MOD_GSK3_1	196	203	PF00069	0.320
MOD_GSK3_1	211	218	PF00069	0.311
MOD_NEK2_1	119	124	PF00069	0.411
MOD_NEK2_1	131	136	PF00069	0.395
MOD_NEK2_1	5	10	PF00069	0.435
MOD_NEK2_2	215	220	PF00069	0.287
MOD_NEK2_2	69	74	PF00069	0.299
MOD_PIKK_1	103	109	PF00454	0.476
MOD_PIKK_1	190	196	PF00454	0.287
MOD_PIKK_1	236	242	PF00454	0.287
MOD_PIKK_1	50	56	PF00454	0.421
MOD_PKA_1	196	202	PF00069	0.287
MOD_PKA_2	103	109	PF00069	0.479
MOD_PKA_2	286	292	PF00069	0.400
MOD_Plk_1	215	221	PF00069	0.287
MOD_Plk_1	5	11	PF00069	0.379
MOD_Plk_4	200	206	PF00069	0.287
MOD_Plk_4	270	276	PF00069	0.269
MOD_ProDKin_1	256	262	PF00069	0.369
MOD_ProDKin_1	296	302	PF00069	0.376
MOD_SUMO_rev_2	265	272	PF00179	0.206
MOD_SUMO_rev_2	285	293	PF00179	0.323
TRG_ENDOCYTIC_2	246	249	PF00928	0.333
TRG_ENDOCYTIC_2	252	255	PF00928	0.335
TRG_ENDOCYTIC_2	301	304	PF00928	0.356
TRG_ENDOCYTIC_2	315	318	PF00928	0.312
TRG_ER_diArg_1	14	16	PF00400	0.459
TRG_ER_diArg_1	219	221	PF00400	0.287
TRG_NES_CRM1_1	200	213	PF08389	0.206
TRG_NLS_MonoExtN_4	195	200	PF00514	0.201
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.446
TRG_PTS1	322	325	PF00515	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP7	Leptomonas seymouri	65%	100%
A0A3Q8IKF6	Leishmania donovani	82%	100%
A4I7A0	Leishmania infantum	82%	100%
E9B295	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
P53164	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	85%
Q4Q5W3	Leishmania major	81%	100%
Q4R7L8	Macaca fascicularis	29%	70%
Q5RD76	Pongo abelii	28%	70%
Q7N961	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	28%	100%
Q9BQG2	Homo sapiens	29%	70%
Q9Y7J0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	86%