Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJT2_LEIBR

TriTrypDb:

LbrM.31.3300 , LBRM2903_310042900

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.478
CLV_PCSK_KEX2_1	125	127	PF00082	0.467
CLV_PCSK_SKI1_1	65	69	PF00082	0.544
DEG_Nend_UBRbox_3	1	3	PF02207	0.457
DOC_CDC14_PxL_1	195	203	PF14671	0.521
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.409
DOC_MAPK_gen_1	7	15	PF00069	0.403
DOC_MAPK_MEF2A_6	7	15	PF00069	0.403
DOC_PP1_RVXF_1	233	240	PF00149	0.451
DOC_PP2B_LxvP_1	42	45	PF13499	0.425
DOC_USP7_MATH_1	120	124	PF00917	0.528
DOC_USP7_MATH_1	154	158	PF00917	0.606
DOC_USP7_MATH_1	168	172	PF00917	0.458
DOC_WW_Pin1_4	166	171	PF00397	0.543
DOC_WW_Pin1_4	19	24	PF00397	0.539
DOC_WW_Pin1_4	97	102	PF00397	0.353
LIG_14-3-3_CanoR_1	65	70	PF00244	0.445
LIG_14-3-3_CanoR_1	7	12	PF00244	0.409
LIG_FHA_1	85	91	PF00498	0.398
LIG_FHA_2	122	128	PF00498	0.524
LIG_FHA_2	214	220	PF00498	0.428
LIG_FHA_2	83	89	PF00498	0.450
LIG_FHA_2	93	99	PF00498	0.363
LIG_Integrin_RGD_1	159	161	PF01839	0.423
LIG_LIR_Gen_1	131	142	PF02991	0.460
LIG_LIR_Gen_1	171	180	PF02991	0.545
LIG_LIR_Nem_3	131	137	PF02991	0.485
LIG_LIR_Nem_3	171	176	PF02991	0.532
LIG_LIR_Nem_3	196	201	PF02991	0.573
LIG_LIR_Nem_3	87	92	PF02991	0.297
LIG_LYPXL_yS_3	198	201	PF13949	0.554
LIG_NRBOX	229	235	PF00104	0.424
LIG_PDZ_Class_2	244	249	PF00595	0.512
LIG_Rb_LxCxE_1	53	70	PF01857	0.296
LIG_SH2_CRK	134	138	PF00017	0.478
LIG_SH2_CRK	64	68	PF00017	0.457
LIG_SH2_NCK_1	134	138	PF00017	0.408
LIG_SH2_STAP1	134	138	PF00017	0.392
LIG_SH2_STAP1	173	177	PF00017	0.547
LIG_SH2_STAT5	134	137	PF00017	0.444
LIG_SH3_3	185	191	PF00018	0.475
LIG_SH3_3	33	39	PF00018	0.336
LIG_SUMO_SIM_anti_2	10	17	PF11976	0.404
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.370
LIG_SUMO_SIM_par_1	10	17	PF11976	0.404
LIG_SUMO_SIM_par_1	135	141	PF11976	0.374
LIG_SUMO_SIM_par_1	65	70	PF11976	0.456
LIG_SUMO_SIM_par_1	91	98	PF11976	0.405
LIG_TRAF2_1	143	146	PF00917	0.352
LIG_TYR_ITIM	62	67	PF00017	0.443
LIG_UBA3_1	233	240	PF00899	0.412
MOD_CK1_1	110	116	PF00069	0.314
MOD_CK1_1	171	177	PF00069	0.537
MOD_CK1_1	179	185	PF00069	0.548
MOD_CK1_1	81	87	PF00069	0.430
MOD_CK2_1	121	127	PF00069	0.644
MOD_CK2_1	213	219	PF00069	0.487
MOD_GlcNHglycan	156	159	PF01048	0.635
MOD_GlcNHglycan	178	181	PF01048	0.596
MOD_GlcNHglycan	230	233	PF01048	0.413
MOD_GlcNHglycan	69	72	PF01048	0.480
MOD_GlcNHglycan	80	83	PF01048	0.473
MOD_GSK3_1	121	128	PF00069	0.557
MOD_GSK3_1	150	157	PF00069	0.542
MOD_GSK3_1	67	74	PF00069	0.492
MOD_GSK3_1	78	85	PF00069	0.493
MOD_GSK3_1	88	95	PF00069	0.401
MOD_N-GLC_1	154	159	PF02516	0.464
MOD_N-GLC_2	226	228	PF02516	0.467
MOD_NEK2_1	14	19	PF00069	0.446
MOD_NEK2_1	176	181	PF00069	0.561
MOD_PK_1	7	13	PF00069	0.406
MOD_PKA_1	125	131	PF00069	0.459
MOD_PKA_2	125	131	PF00069	0.501
MOD_Plk_4	107	113	PF00069	0.420
MOD_Plk_4	132	138	PF00069	0.406
MOD_Plk_4	168	174	PF00069	0.550
MOD_Plk_4	92	98	PF00069	0.453
MOD_ProDKin_1	166	172	PF00069	0.537
MOD_ProDKin_1	19	25	PF00069	0.536
MOD_ProDKin_1	97	103	PF00069	0.366
TRG_ENDOCYTIC_2	134	137	PF00928	0.482
TRG_ENDOCYTIC_2	173	176	PF00928	0.598
TRG_ENDOCYTIC_2	198	201	PF00928	0.517
TRG_ENDOCYTIC_2	64	67	PF00928	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJH1	Leptomonas seymouri	46%	97%
A0A3Q8IF52	Leishmania donovani	72%	100%
A0A3R7LVK8	Trypanosoma rangeli	27%	100%
A4I798	Leishmania infantum	72%	100%
E9B293	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q5W5	Leishmania major	72%	100%