Putative inositol polyphosphate 1-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol polyphosphate 1-phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HJT1_LEIBR

TriTrypDb:

LbrM.31.3290 , LBRM2903_310042800

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJT1

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006066	alcohol metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0016311	dephosphorylation	5	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019751	polyol metabolic process	4	12
GO:0043647	inositol phosphate metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044262	obsolete cellular carbohydrate metabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046164	alcohol catabolic process	4	12
GO:0046174	polyol catabolic process	5	12
GO:0046434	organophosphate catabolic process	4	12
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	12
GO:0046855	obsolete inositol phosphate dephosphorylation	5	12
GO:0071545	inositol phosphate catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901575	organic substance catabolic process	3	12
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1901616	organic hydroxy compound catabolic process	4	12
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006661	phosphatidylinositol biosynthetic process	6	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046488	phosphatidylinositol metabolic process	6	1
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	8	6
GO:0016312	inositol bisphosphate phosphatase activity	7	6
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0052745	inositol phosphate phosphatase activity	6	6
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.367
CLV_NRD_NRD_1	287	289	PF00675	0.446
CLV_NRD_NRD_1	423	425	PF00675	0.367
CLV_PCSK_KEX2_1	184	186	PF00082	0.368
CLV_PCSK_KEX2_1	423	425	PF00082	0.367
CLV_PCSK_SKI1_1	301	305	PF00082	0.350
CLV_PCSK_SKI1_1	307	311	PF00082	0.468
CLV_PCSK_SKI1_1	332	336	PF00082	0.340
CLV_PCSK_SKI1_1	64	68	PF00082	0.211
DEG_SCF_FBW7_1	241	248	PF00400	0.193
DEG_SPOP_SBC_1	396	400	PF00917	0.439
DOC_CKS1_1	257	262	PF01111	0.476
DOC_CKS1_1	344	349	PF01111	0.217
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.193
DOC_CYCLIN_yCln2_LP_2	257	263	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	274	280	PF00134	0.365
DOC_MAPK_DCC_7	247	255	PF00069	0.326
DOC_MAPK_FxFP_2	229	232	PF00069	0.417
DOC_MAPK_gen_1	184	191	PF00069	0.278
DOC_MAPK_gen_1	288	294	PF00069	0.193
DOC_MAPK_MEF2A_6	184	191	PF00069	0.275
DOC_MAPK_MEF2A_6	247	255	PF00069	0.326
DOC_PP1_RVXF_1	421	428	PF00149	0.410
DOC_PP2B_LxvP_1	147	150	PF13499	0.193
DOC_PP4_FxxP_1	190	193	PF00568	0.247
DOC_PP4_FxxP_1	229	232	PF00568	0.417
DOC_PP4_FxxP_1	351	354	PF00568	0.274
DOC_USP7_MATH_1	245	249	PF00917	0.318
DOC_USP7_MATH_1	395	399	PF00917	0.525
DOC_USP7_MATH_1	46	50	PF00917	0.521
DOC_USP7_UBL2_3	332	336	PF12436	0.193
DOC_WW_Pin1_4	241	246	PF00397	0.209
DOC_WW_Pin1_4	256	261	PF00397	0.395
DOC_WW_Pin1_4	313	318	PF00397	0.303
DOC_WW_Pin1_4	343	348	PF00397	0.328
DOC_WW_Pin1_4	411	416	PF00397	0.452
DOC_WW_Pin1_4	42	47	PF00397	0.653
DOC_WW_Pin1_4	425	430	PF00397	0.549
LIG_14-3-3_CanoR_1	108	117	PF00244	0.314
LIG_14-3-3_CanoR_1	15	19	PF00244	0.317
LIG_14-3-3_CanoR_1	234	241	PF00244	0.223
LIG_14-3-3_CanoR_1	288	293	PF00244	0.372
LIG_14-3-3_CanoR_1	307	314	PF00244	0.348
LIG_Actin_WH2_2	218	236	PF00022	0.318
LIG_APCC_ABBA_1	173	178	PF00400	0.369
LIG_APCC_ABBA_1	187	192	PF00400	0.209
LIG_APCC_ABBAyCdc20_2	186	192	PF00400	0.247
LIG_BIR_III_4	391	395	PF00653	0.326
LIG_BRCT_BRCA1_1	110	114	PF00533	0.472
LIG_EH1_1	22	30	PF00400	0.292
LIG_eIF4E_1	23	29	PF01652	0.232
LIG_eIF4E_1	325	331	PF01652	0.417
LIG_FHA_1	257	263	PF00498	0.290
LIG_FHA_1	289	295	PF00498	0.308
LIG_FHA_1	298	304	PF00498	0.392
LIG_FHA_1	405	411	PF00498	0.472
LIG_FHA_1	426	432	PF00498	0.501
LIG_FHA_1	95	101	PF00498	0.191
LIG_FHA_2	297	303	PF00498	0.368
LIG_FHA_2	308	314	PF00498	0.368
LIG_FHA_2	344	350	PF00498	0.368
LIG_FHA_2	53	59	PF00498	0.399
LIG_FHA_2	94	100	PF00498	0.187
LIG_LIR_Apic_2	202	208	PF02991	0.279
LIG_LIR_Apic_2	349	354	PF02991	0.274
LIG_LIR_Gen_1	154	164	PF02991	0.451
LIG_LIR_Gen_1	264	274	PF02991	0.403
LIG_LIR_Nem_3	111	117	PF02991	0.278
LIG_LIR_Nem_3	142	147	PF02991	0.215
LIG_LIR_Nem_3	154	159	PF02991	0.451
LIG_LIR_Nem_3	264	269	PF02991	0.403
LIG_LYPXL_yS_3	387	390	PF13949	0.350
LIG_NRBOX	304	310	PF00104	0.326
LIG_Pex14_2	369	373	PF04695	0.193
LIG_PTB_Apo_2	223	230	PF02174	0.274
LIG_SH2_CRK	144	148	PF00017	0.417
LIG_SH2_CRK	156	160	PF00017	0.193
LIG_SH2_CRK	328	332	PF00017	0.417
LIG_SH2_PTP2	23	26	PF00017	0.235
LIG_SH2_STAP1	151	155	PF00017	0.350
LIG_SH2_STAT5	23	26	PF00017	0.225
LIG_SH2_STAT5	371	374	PF00017	0.318
LIG_SH3_3	112	118	PF00018	0.192
LIG_SH3_3	311	317	PF00018	0.247
LIG_SH3_3	341	347	PF00018	0.429
LIG_SH3_3	349	355	PF00018	0.408
LIG_SUMO_SIM_par_1	409	414	PF11976	0.453
LIG_SUMO_SIM_par_1	55	61	PF11976	0.339
LIG_TYR_ITIM	385	390	PF00017	0.334
LIG_UBA3_1	25	30	PF00899	0.248
LIG_UBA3_1	330	336	PF00899	0.193
LIG_WRC_WIRS_1	370	375	PF05994	0.193
MOD_CDK_SPxK_1	241	247	PF00069	0.193
MOD_CDK_SPxxK_3	411	418	PF00069	0.344
MOD_CK1_1	297	303	PF00069	0.281
MOD_CK1_1	398	404	PF00069	0.472
MOD_CK1_1	45	51	PF00069	0.531
MOD_CK2_1	296	302	PF00069	0.417
MOD_CK2_1	307	313	PF00069	0.417
MOD_CK2_1	396	402	PF00069	0.519
MOD_GlcNHglycan	129	132	PF01048	0.260
MOD_GlcNHglycan	48	51	PF01048	0.547
MOD_GSK3_1	241	248	PF00069	0.281
MOD_GSK3_1	284	291	PF00069	0.272
MOD_GSK3_1	36	43	PF00069	0.473
MOD_GSK3_1	396	403	PF00069	0.552
MOD_N-GLC_1	36	41	PF02516	0.642
MOD_NEK2_1	110	115	PF00069	0.405
MOD_NEK2_1	155	160	PF00069	0.466
MOD_NEK2_1	369	374	PF00069	0.303
MOD_NEK2_1	67	72	PF00069	0.249
MOD_PIKK_1	307	313	PF00454	0.395
MOD_PKA_1	288	294	PF00069	0.402
MOD_PKA_2	14	20	PF00069	0.316
MOD_PKA_2	233	239	PF00069	0.264
MOD_PKA_2	287	293	PF00069	0.369
MOD_Plk_1	36	42	PF00069	0.402
MOD_Plk_1	401	407	PF00069	0.313
MOD_Plk_4	207	213	PF00069	0.274
MOD_Plk_4	24	30	PF00069	0.242
MOD_Plk_4	251	257	PF00069	0.259
MOD_Plk_4	401	407	PF00069	0.547
MOD_Plk_4	427	433	PF00069	0.388
MOD_Plk_4	52	58	PF00069	0.343
MOD_ProDKin_1	241	247	PF00069	0.209
MOD_ProDKin_1	256	262	PF00069	0.395
MOD_ProDKin_1	313	319	PF00069	0.303
MOD_ProDKin_1	343	349	PF00069	0.328
MOD_ProDKin_1	411	417	PF00069	0.451
MOD_ProDKin_1	42	48	PF00069	0.653
MOD_ProDKin_1	425	431	PF00069	0.555
MOD_SUMO_for_1	417	420	PF00179	0.250
MOD_SUMO_rev_2	76	81	PF00179	0.193
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.350
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.193
TRG_ENDOCYTIC_2	144	147	PF00928	0.368
TRG_ENDOCYTIC_2	156	159	PF00928	0.437
TRG_ENDOCYTIC_2	23	26	PF00928	0.235
TRG_ENDOCYTIC_2	328	331	PF00928	0.374
TRG_ENDOCYTIC_2	387	390	PF00928	0.334
TRG_ER_diArg_1	183	186	PF00400	0.308
TRG_ER_diArg_1	423	425	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U3	Leptomonas seymouri	56%	100%
A0A0S4ISE9	Bodo saltans	31%	88%
A0A1X0NIY3	Trypanosomatidae	39%	100%
A0A3R7KA15	Trypanosoma rangeli	37%	100%
A0A3S5H7Q8	Leishmania donovani	76%	100%
A4I797	Leishmania infantum	76%	100%
C9ZWL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B292	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q5W6	Leishmania major	72%	100%
V5AS37	Trypanosoma cruzi	38%	100%