LeishMANIAdb
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PX domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PX domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HJS9_LEIBR
TriTrypDb:
LbrM.31.3270 , LBRM2903_310042600
Length:
83

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HJS9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJS9

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_APCC_KENBOX_2 15 19 PF00400 0.465
DOC_WW_Pin1_4 46 51 PF00397 0.474
LIG_14-3-3_CterR_2 78 83 PF00244 0.510
LIG_Actin_WH2_2 48 65 PF00022 0.327
LIG_BIR_II_1 1 5 PF00653 0.647
LIG_FHA_1 37 43 PF00498 0.564
LIG_FHA_1 47 53 PF00498 0.472
LIG_PCNA_yPIPBox_3 53 66 PF02747 0.332
LIG_PDZ_Class_1 78 83 PF00595 0.543
LIG_SH2_STAP1 38 42 PF00017 0.472
LIG_SH2_STAT5 38 41 PF00017 0.449
LIG_SH3_3 4 10 PF00018 0.584
LIG_SH3_3 58 64 PF00018 0.411
LIG_WW_2 7 10 PF00397 0.482
MOD_N-GLC_1 36 41 PF02516 0.364
MOD_NEK2_1 36 41 PF00069 0.492
MOD_NEK2_1 77 82 PF00069 0.460
MOD_PKA_2 77 83 PF00069 0.550
MOD_Plk_1 36 42 PF00069 0.550
MOD_ProDKin_1 46 52 PF00069 0.475
MOD_SUMO_for_1 14 17 PF00179 0.621
TRG_DiLeu_LyEn_5 47 52 PF01217 0.459

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4U1 Leptomonas seymouri 60% 100%
A0A3Q8IGL5 Leishmania donovani 69% 100%
A4I795 Leishmania infantum 69% 100%
C9ZMH2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 99%
E9B290 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
Q4Q5W8 Leishmania major 73% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS