Putative nucleoporin (NUP54/57)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoporin (NUP54/57), putative

Species:

Leishmania braziliensis

UniProt:

A4HJS8_LEIBR

TriTrypDb:

LbrM.31.3260 , LBRM2903_310042500

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:0044613	nuclear pore central transport channel	3	1

Expansion

Sequence features

A4HJS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJS8

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	1
GO:0006607	NLS-bearing protein import into nucleus	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0006996	organelle organization	4	1
GO:0006997	nucleus organization	5	1
GO:0006999	nuclear pore organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0036228	protein localization to nuclear inner membrane	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090435	protein localization to nuclear envelope	7	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1
GO:0017056	structural constituent of nuclear pore	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	269	271	PF00675	0.391
CLV_NRD_NRD_1	282	284	PF00675	0.245
CLV_NRD_NRD_1	304	306	PF00675	0.414
CLV_NRD_NRD_1	331	333	PF00675	0.402
CLV_PCSK_KEX2_1	268	270	PF00082	0.380
CLV_PCSK_KEX2_1	304	306	PF00082	0.414
CLV_PCSK_KEX2_1	331	333	PF00082	0.402
CLV_PCSK_SKI1_1	351	355	PF00082	0.326
CLV_PCSK_SKI1_1	368	372	PF00082	0.331
CLV_Separin_Metazoa	328	332	PF03568	0.388
DEG_Nend_Nbox_1	1	3	PF02207	0.720
DOC_MAPK_DCC_7	255	263	PF00069	0.302
DOC_MAPK_gen_1	268	280	PF00069	0.380
DOC_PP2B_LxvP_1	354	357	PF13499	0.312
DOC_PP4_FxxP_1	125	128	PF00568	0.662
DOC_PP4_FxxP_1	59	62	PF00568	0.673
DOC_USP7_MATH_1	186	190	PF00917	0.605
DOC_USP7_MATH_1	382	386	PF00917	0.433
DOC_USP7_MATH_1	454	458	PF00917	0.594
DOC_USP7_MATH_1	62	66	PF00917	0.663
DOC_USP7_UBL2_3	446	450	PF12436	0.495
DOC_WW_Pin1_4	247	252	PF00397	0.327
DOC_WW_Pin1_4	256	261	PF00397	0.303
DOC_WW_Pin1_4	49	54	PF00397	0.673
DOC_WW_Pin1_4	70	75	PF00397	0.625
LIG_14-3-3_CanoR_1	183	191	PF00244	0.527
LIG_14-3-3_CanoR_1	319	324	PF00244	0.316
LIG_14-3-3_CanoR_1	332	338	PF00244	0.325
LIG_14-3-3_CanoR_1	359	367	PF00244	0.377
LIG_14-3-3_CanoR_1	368	378	PF00244	0.429
LIG_Clathr_ClatBox_1	191	195	PF01394	0.433
LIG_deltaCOP1_diTrp_1	426	430	PF00928	0.434
LIG_eIF4E_1	337	343	PF01652	0.231
LIG_FHA_1	128	134	PF00498	0.515
LIG_FHA_1	166	172	PF00498	0.580
LIG_FHA_1	173	179	PF00498	0.582
LIG_FHA_1	228	234	PF00498	0.541
LIG_FHA_1	25	31	PF00498	0.687
LIG_FHA_2	175	181	PF00498	0.590
LIG_LIR_Apic_2	122	128	PF02991	0.663
LIG_LIR_Apic_2	57	62	PF02991	0.614
LIG_LIR_Gen_1	195	203	PF02991	0.423
LIG_LIR_Gen_1	426	434	PF02991	0.429
LIG_LIR_Nem_3	195	201	PF02991	0.424
LIG_LIR_Nem_3	227	232	PF02991	0.454
LIG_LIR_Nem_3	426	430	PF02991	0.434
LIG_NRBOX	349	355	PF00104	0.388
LIG_NRBOX	440	446	PF00104	0.429
LIG_PCNA_PIPBox_1	184	193	PF02747	0.439
LIG_PCNA_yPIPBox_3	183	191	PF02747	0.527
LIG_Pex14_2	55	59	PF04695	0.684
LIG_SH2_CRK	198	202	PF00017	0.426
LIG_SH2_CRK	321	325	PF00017	0.312
LIG_SH2_CRK	360	364	PF00017	0.231
LIG_SH2_GRB2like	232	235	PF00017	0.533
LIG_SH2_SRC	232	235	PF00017	0.485
LIG_SH2_STAP1	229	233	PF00017	0.560
LIG_SH2_STAP1	360	364	PF00017	0.231
LIG_SH2_STAT5	190	193	PF00017	0.433
LIG_SH2_STAT5	229	232	PF00017	0.547
LIG_SH3_3	156	162	PF00018	0.704
LIG_SUMO_SIM_anti_2	313	318	PF11976	0.334
LIG_SUMO_SIM_par_1	174	180	PF11976	0.600
MOD_CK1_1	87	93	PF00069	0.700
MOD_CK2_1	333	339	PF00069	0.388
MOD_CK2_1	342	348	PF00069	0.296
MOD_CK2_1	454	460	PF00069	0.392
MOD_GlcNHglycan	112	115	PF01048	0.727
MOD_GlcNHglycan	122	125	PF01048	0.595
MOD_GlcNHglycan	136	139	PF01048	0.529
MOD_GlcNHglycan	184	187	PF01048	0.585
MOD_GlcNHglycan	384	387	PF01048	0.583
MOD_GlcNHglycan	407	410	PF01048	0.528
MOD_GlcNHglycan	64	67	PF01048	0.626
MOD_GlcNHglycan	70	73	PF01048	0.608
MOD_GlcNHglycan	82	85	PF01048	0.552
MOD_GlcNHglycan	86	89	PF01048	0.609
MOD_GSK3_1	116	123	PF00069	0.664
MOD_GSK3_1	182	189	PF00069	0.560
MOD_GSK3_1	2	9	PF00069	0.527
MOD_GSK3_1	21	28	PF00069	0.592
MOD_GSK3_1	32	39	PF00069	0.656
MOD_GSK3_1	338	345	PF00069	0.234
MOD_GSK3_1	369	376	PF00069	0.432
MOD_GSK3_1	382	389	PF00069	0.460
MOD_GSK3_1	42	49	PF00069	0.620
MOD_GSK3_1	80	87	PF00069	0.612
MOD_N-GLC_1	33	38	PF02516	0.694
MOD_N-GLC_1	386	391	PF02516	0.609
MOD_N-GLC_2	213	215	PF02516	0.406
MOD_NEK2_1	194	199	PF00069	0.495
MOD_NEK2_1	2	7	PF00069	0.593
MOD_NEK2_1	25	30	PF00069	0.686
MOD_NEK2_1	342	347	PF00069	0.388
MOD_PIKK_1	261	267	PF00454	0.418
MOD_PIKK_1	358	364	PF00454	0.378
MOD_PKA_1	268	274	PF00069	0.270
MOD_PKA_2	182	188	PF00069	0.537
MOD_PKA_2	227	233	PF00069	0.517
MOD_PKA_2	268	274	PF00069	0.388
MOD_PKA_2	358	364	PF00069	0.364
MOD_Plk_1	194	200	PF00069	0.496
MOD_Plk_1	338	344	PF00069	0.231
MOD_Plk_1	373	379	PF00069	0.571
MOD_Plk_4	186	192	PF00069	0.507
MOD_Plk_4	319	325	PF00069	0.312
MOD_Plk_4	338	344	PF00069	0.312
MOD_Plk_4	6	12	PF00069	0.502
MOD_ProDKin_1	247	253	PF00069	0.327
MOD_ProDKin_1	256	262	PF00069	0.303
MOD_ProDKin_1	49	55	PF00069	0.677
MOD_ProDKin_1	70	76	PF00069	0.625
MOD_SUMO_rev_2	442	452	PF00179	0.494
TRG_DiLeu_BaEn_2	365	371	PF01217	0.435
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.587
TRG_ENDOCYTIC_2	198	201	PF00928	0.432
TRG_ENDOCYTIC_2	321	324	PF00928	0.312
TRG_ENDOCYTIC_2	360	363	PF00928	0.231
TRG_ER_diArg_1	267	270	PF00400	0.471
TRG_ER_diArg_1	303	305	PF00400	0.428
TRG_ER_diArg_1	330	332	PF00400	0.391
TRG_ER_diArg_1	455	458	PF00400	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICT1	Leishmania donovani	79%	100%
A0A3R7KYW1	Trypanosoma rangeli	40%	100%
A4I794	Leishmania infantum	79%	100%
E9B289	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q5W9	Leishmania major	74%	99%