RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Region in Clathrin and VPS, putative

Species:

Leishmania braziliensis

UniProt:

A4HJS7_LEIBR

TriTrypDb:

LbrM.31.3250 , LBRM2903_310042400

Length:

1238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005768	endosome	7	1
GO:0030897	HOPS complex	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Expansion

Sequence features

A4HJS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJS7

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0006904	vesicle docking involved in exocytosis	3	1
GO:0006996	organelle organization	4	1
GO:0007032	endosome organization	6	1
GO:0007033	vacuole organization	5	1
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016043	cellular component organization	3	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0060090	molecular adaptor activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	1070	1072	PF00675	0.470
CLV_NRD_NRD_1	1128	1130	PF00675	0.448
CLV_NRD_NRD_1	1224	1226	PF00675	0.604
CLV_NRD_NRD_1	544	546	PF00675	0.429
CLV_NRD_NRD_1	620	622	PF00675	0.384
CLV_NRD_NRD_1	730	732	PF00675	0.535
CLV_NRD_NRD_1	895	897	PF00675	0.397
CLV_PCSK_FUR_1	1222	1226	PF00082	0.515
CLV_PCSK_KEX2_1	1128	1130	PF00082	0.505
CLV_PCSK_KEX2_1	1159	1161	PF00082	0.425

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I535	Leptomonas seymouri	61%	96%
A0A0S4JQ10	Bodo saltans	36%	100%
A0A1X0NIS4	Trypanosomatidae	37%	100%
A0A3Q8ISW8	Leishmania donovani	77%	100%
A0A422NF71	Trypanosoma rangeli	38%	100%
A4I793	Leishmania infantum	76%	100%
C9ZWL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B288	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q5X0	Leishmania major	77%	99%

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