LeishMANIAdb
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BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
BTB domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HJS5_LEIBR
TriTrypDb:
LbrM.31.3230 , LBRM2903_310042200
Length:
149

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJS5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJS5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 49 51 PF00082 0.528
CLV_PCSK_KEX2_1 5 7 PF00082 0.621
CLV_PCSK_PC1ET2_1 49 51 PF00082 0.541
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.621
CLV_PCSK_SKI1_1 110 114 PF00082 0.389
DOC_CYCLIN_yCln2_LP_2 127 133 PF00134 0.390
DOC_PP2B_PxIxI_1 81 87 PF00149 0.551
DOC_WW_Pin1_4 60 65 PF00397 0.290
LIG_14-3-3_CanoR_1 50 60 PF00244 0.441
LIG_Actin_WH2_2 16 32 PF00022 0.344
LIG_CtBP_PxDLS_1 130 134 PF00389 0.279
LIG_FHA_2 10 16 PF00498 0.431
LIG_FHA_2 53 59 PF00498 0.546
LIG_LIR_Gen_1 89 98 PF02991 0.477
LIG_LIR_Nem_3 89 95 PF02991 0.510
LIG_NRP_CendR_1 148 149 PF00754 0.474
LIG_SH2_NCK_1 104 108 PF00017 0.389
LIG_SH3_3 76 82 PF00018 0.561
LIG_UBA3_1 26 30 PF00899 0.284
MOD_CK1_1 119 125 PF00069 0.517
MOD_CK2_1 5 11 PF00069 0.642
MOD_Cter_Amidation 1 4 PF01082 0.671
MOD_GSK3_1 5 12 PF00069 0.600
MOD_GSK3_1 93 100 PF00069 0.339
MOD_NEK2_1 93 98 PF00069 0.446
MOD_PKA_1 5 11 PF00069 0.609
MOD_PKA_2 5 11 PF00069 0.578
MOD_PKA_2 52 58 PF00069 0.538
MOD_PKA_2 86 92 PF00069 0.467
MOD_Plk_1 14 20 PF00069 0.526
MOD_Plk_4 14 20 PF00069 0.503
MOD_ProDKin_1 60 66 PF00069 0.284
MOD_SUMO_rev_2 41 51 PF00179 0.531
TRG_ENDOCYTIC_2 104 107 PF00928 0.382
TRG_ER_diArg_1 147 149 PF00400 0.309
TRG_NLS_MonoCore_2 2 7 PF00514 0.751
TRG_NLS_MonoExtC_3 3 9 PF00514 0.726
TRG_NLS_MonoExtN_4 3 8 PF00514 0.734

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HX47 Leptomonas seymouri 68% 100%
A0A1X0NIB2 Trypanosomatidae 52% 99%
A0A3R7KD53 Trypanosoma rangeli 51% 99%
A0A3S7X4Y0 Leishmania donovani 83% 100%
A4I791 Leishmania infantum 83% 100%
C9ZMH0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
C9ZWL5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9B286 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS