LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
tousled-like kinase II, putative
Species:
Leishmania braziliensis
UniProt:
A4HJS4_LEIBR
TriTrypDb:
LbrM.31.3220 , LBRM2903_310042100
Length:
677

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HJS4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJS4

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006260 DNA replication 5 1
GO:0006281 DNA repair 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0007059 chromosome segregation 2 1
GO:0007165 signal transduction 2 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0033554 cellular response to stress 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0035556 intracellular signal transduction 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0065007 biological regulation 1 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 148 152 PF00656 0.585
CLV_C14_Caspase3-7 21 25 PF00656 0.658
CLV_C14_Caspase3-7 288 292 PF00656 0.560
CLV_C14_Caspase3-7 602 606 PF00656 0.188
CLV_C14_Caspase3-7 68 72 PF00656 0.657
CLV_NRD_NRD_1 124 126 PF00675 0.556
CLV_NRD_NRD_1 170 172 PF00675 0.547
CLV_NRD_NRD_1 212 214 PF00675 0.419
CLV_NRD_NRD_1 336 338 PF00675 0.390
CLV_NRD_NRD_1 576 578 PF00675 0.267
CLV_NRD_NRD_1 586 588 PF00675 0.318
CLV_NRD_NRD_1 645 647 PF00675 0.555
CLV_PCSK_KEX2_1 124 126 PF00082 0.673
CLV_PCSK_KEX2_1 17 19 PF00082 0.636
CLV_PCSK_KEX2_1 170 172 PF00082 0.547
CLV_PCSK_KEX2_1 212 214 PF00082 0.419
CLV_PCSK_KEX2_1 255 257 PF00082 0.405
CLV_PCSK_KEX2_1 336 338 PF00082 0.390
CLV_PCSK_KEX2_1 453 455 PF00082 0.294
CLV_PCSK_KEX2_1 576 578 PF00082 0.294
CLV_PCSK_KEX2_1 586 588 PF00082 0.294
CLV_PCSK_KEX2_1 645 647 PF00082 0.555
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.636
CLV_PCSK_PC1ET2_1 255 257 PF00082 0.468
CLV_PCSK_PC1ET2_1 453 455 PF00082 0.294
CLV_PCSK_PC7_1 208 214 PF00082 0.416
CLV_PCSK_SKI1_1 124 128 PF00082 0.550
CLV_PCSK_SKI1_1 212 216 PF00082 0.426
CLV_PCSK_SKI1_1 243 247 PF00082 0.487
CLV_PCSK_SKI1_1 328 332 PF00082 0.417
CLV_PCSK_SKI1_1 357 361 PF00082 0.312
CLV_PCSK_SKI1_1 456 460 PF00082 0.336
CLV_PCSK_SKI1_1 464 468 PF00082 0.277
DEG_APCC_DBOX_1 356 364 PF00400 0.328
DEG_Nend_UBRbox_2 1 3 PF02207 0.749
DOC_ANK_TNKS_1 576 583 PF00023 0.294
DOC_CKS1_1 45 50 PF01111 0.741
DOC_CYCLIN_RxL_1 240 251 PF00134 0.424
DOC_CYCLIN_yCln2_LP_2 480 486 PF00134 0.414
DOC_CYCLIN_yCln2_LP_2 666 669 PF00134 0.668
DOC_MAPK_gen_1 170 177 PF00069 0.542
DOC_MAPK_gen_1 241 249 PF00069 0.426
DOC_MAPK_MEF2A_6 241 249 PF00069 0.538
DOC_MAPK_MEF2A_6 431 439 PF00069 0.414
DOC_PP1_RVXF_1 462 468 PF00149 0.414
DOC_PP1_RVXF_1 597 604 PF00149 0.328
DOC_PP2B_LxvP_1 347 350 PF13499 0.553
DOC_PP2B_LxvP_1 666 669 PF13499 0.675
DOC_PP4_FxxP_1 126 129 PF00568 0.676
DOC_USP7_MATH_1 265 269 PF00917 0.532
DOC_USP7_MATH_1 607 611 PF00917 0.294
DOC_USP7_MATH_1 65 69 PF00917 0.710
DOC_USP7_MATH_1 93 97 PF00917 0.685
DOC_USP7_UBL2_3 329 333 PF12436 0.428
DOC_WW_Pin1_4 23 28 PF00397 0.521
DOC_WW_Pin1_4 44 49 PF00397 0.706
DOC_WW_Pin1_4 479 484 PF00397 0.414
DOC_WW_Pin1_4 550 555 PF00397 0.294
DOC_WW_Pin1_4 661 666 PF00397 0.703
DOC_WW_Pin1_4 671 676 PF00397 0.711
DOC_WW_Pin1_4 86 91 PF00397 0.719
LIG_14-3-3_CanoR_1 241 246 PF00244 0.452
LIG_14-3-3_CanoR_1 303 310 PF00244 0.511
LIG_14-3-3_CanoR_1 454 459 PF00244 0.343
LIG_14-3-3_CanoR_1 475 481 PF00244 0.404
LIG_Actin_WH2_2 307 322 PF00022 0.550
LIG_APCC_ABBA_1 494 499 PF00400 0.414
LIG_BIR_III_2 24 28 PF00653 0.522
LIG_BIR_III_2 672 676 PF00653 0.680
LIG_BRCT_BRCA1_1 116 120 PF00533 0.585
LIG_deltaCOP1_diTrp_1 371 376 PF00928 0.294
LIG_deltaCOP1_diTrp_1 561 569 PF00928 0.294
LIG_eIF4E_1 358 364 PF01652 0.294
LIG_EVH1_2 544 548 PF00568 0.294
LIG_FHA_1 138 144 PF00498 0.589
LIG_FHA_1 242 248 PF00498 0.488
LIG_FHA_1 309 315 PF00498 0.517
LIG_FHA_1 399 405 PF00498 0.441
LIG_FHA_1 44 50 PF00498 0.700
LIG_FHA_1 551 557 PF00498 0.294
LIG_FHA_2 349 355 PF00498 0.491
LIG_FHA_2 455 461 PF00498 0.382
LIG_FHA_2 500 506 PF00498 0.414
LIG_Integrin_RGD_1 431 433 PF01839 0.414
LIG_LIR_Apic_2 539 545 PF02991 0.294
LIG_LIR_Gen_1 190 200 PF02991 0.492
LIG_LIR_Gen_1 244 252 PF02991 0.539
LIG_LIR_Gen_1 343 352 PF02991 0.402
LIG_LIR_Gen_1 356 364 PF02991 0.264
LIG_LIR_Gen_1 423 430 PF02991 0.294
LIG_LIR_Gen_1 433 442 PF02991 0.294
LIG_LIR_LC3C_4 53 56 PF02991 0.731
LIG_LIR_Nem_3 190 195 PF02991 0.467
LIG_LIR_Nem_3 244 249 PF02991 0.542
LIG_LIR_Nem_3 343 349 PF02991 0.417
LIG_LIR_Nem_3 370 376 PF02991 0.294
LIG_LIR_Nem_3 423 429 PF02991 0.294
LIG_LIR_Nem_3 433 439 PF02991 0.294
LIG_LIR_Nem_3 537 543 PF02991 0.297
LIG_NRBOX 359 365 PF00104 0.328
LIG_Pex14_2 369 373 PF04695 0.294
LIG_Rb_pABgroove_1 420 428 PF01858 0.294
LIG_SH2_CRK 134 138 PF00017 0.565
LIG_SH2_CRK 570 574 PF00017 0.294
LIG_SH2_GRB2like 442 445 PF00017 0.440
LIG_SH2_SRC 542 545 PF00017 0.294
LIG_SH2_STAT5 358 361 PF00017 0.294
LIG_SH2_STAT5 383 386 PF00017 0.294
LIG_SH2_STAT5 403 406 PF00017 0.110
LIG_SH2_STAT5 451 454 PF00017 0.414
LIG_SH2_STAT5 476 479 PF00017 0.294
LIG_SH2_STAT5 542 545 PF00017 0.280
LIG_SH2_STAT5 639 642 PF00017 0.397
LIG_SH3_3 601 607 PF00018 0.294
LIG_SH3_3 662 668 PF00018 0.646
LIG_SH3_3 67 73 PF00018 0.691
LIG_SH3_3 84 90 PF00018 0.640
LIG_SUMO_SIM_anti_2 410 415 PF11976 0.328
LIG_SUMO_SIM_par_1 53 59 PF11976 0.719
LIG_TRAF2_1 19 22 PF00917 0.772
LIG_TRAF2_1 26 29 PF00917 0.767
LIG_TRAF2_1 274 277 PF00917 0.568
LIG_TRFH_1 487 491 PF08558 0.294
LIG_TYR_ITIM 568 573 PF00017 0.294
LIG_UBA3_1 360 366 PF00899 0.294
LIG_UBA3_1 503 507 PF00899 0.414
LIG_WRC_WIRS_1 455 460 PF05994 0.343
MOD_CDK_SPK_2 550 555 PF00069 0.294
MOD_CK1_1 115 121 PF00069 0.644
MOD_CK1_1 23 29 PF00069 0.755
MOD_CK1_1 31 37 PF00069 0.742
MOD_CK1_1 44 50 PF00069 0.698
MOD_CK1_1 479 485 PF00069 0.412
MOD_CK1_1 534 540 PF00069 0.328
MOD_CK1_1 597 603 PF00069 0.294
MOD_CK1_1 644 650 PF00069 0.597
MOD_CK2_1 149 155 PF00069 0.567
MOD_CK2_1 23 29 PF00069 0.673
MOD_CK2_1 348 354 PF00069 0.504
MOD_CK2_1 435 441 PF00069 0.294
MOD_CK2_1 454 460 PF00069 0.294
MOD_CK2_1 93 99 PF00069 0.504
MOD_Cter_Amidation 168 171 PF01082 0.570
MOD_Cter_Amidation 574 577 PF01082 0.294
MOD_GlcNHglycan 117 120 PF01048 0.651
MOD_GlcNHglycan 201 204 PF01048 0.509
MOD_GlcNHglycan 281 285 PF01048 0.633
MOD_GlcNHglycan 563 566 PF01048 0.404
MOD_GlcNHglycan 596 599 PF01048 0.294
MOD_GlcNHglycan 652 655 PF01048 0.669
MOD_GlcNHglycan 67 70 PF01048 0.634
MOD_GlcNHglycan 95 98 PF01048 0.725
MOD_GSK3_1 109 116 PF00069 0.612
MOD_GSK3_1 145 152 PF00069 0.560
MOD_GSK3_1 227 234 PF00069 0.601
MOD_GSK3_1 241 248 PF00069 0.515
MOD_GSK3_1 31 38 PF00069 0.750
MOD_GSK3_1 394 401 PF00069 0.188
MOD_GSK3_1 522 529 PF00069 0.294
MOD_GSK3_1 530 537 PF00069 0.262
MOD_GSK3_1 550 557 PF00069 0.294
MOD_GSK3_1 640 647 PF00069 0.511
MOD_GSK3_1 91 98 PF00069 0.734
MOD_N-GLC_1 31 36 PF02516 0.741
MOD_N-GLC_2 661 663 PF02516 0.472
MOD_NEK2_1 113 118 PF00069 0.694
MOD_NEK2_1 222 227 PF00069 0.472
MOD_NEK2_1 245 250 PF00069 0.524
MOD_NEK2_1 310 315 PF00069 0.452
MOD_NEK2_1 435 440 PF00069 0.301
MOD_NEK2_1 511 516 PF00069 0.379
MOD_NEK2_1 640 645 PF00069 0.509
MOD_NEK2_2 266 271 PF00069 0.312
MOD_PIKK_1 250 256 PF00454 0.525
MOD_PIKK_1 394 400 PF00454 0.232
MOD_PIKK_1 531 537 PF00454 0.294
MOD_PIKK_1 581 587 PF00454 0.294
MOD_PIKK_1 632 638 PF00454 0.309
MOD_PKA_1 645 651 PF00069 0.478
MOD_PKA_2 149 155 PF00069 0.567
MOD_PKA_2 302 308 PF00069 0.515
MOD_PKA_2 554 560 PF00069 0.294
MOD_PKA_2 641 647 PF00069 0.517
MOD_PKB_1 18 26 PF00069 0.777
MOD_PKB_1 278 286 PF00069 0.615
MOD_Plk_1 31 37 PF00069 0.651
MOD_Plk_1 41 47 PF00069 0.676
MOD_Plk_2-3 499 505 PF00069 0.414
MOD_Plk_2-3 526 532 PF00069 0.294
MOD_Plk_4 191 197 PF00069 0.563
MOD_Plk_4 231 237 PF00069 0.568
MOD_Plk_4 447 453 PF00069 0.357
MOD_Plk_4 499 505 PF00069 0.340
MOD_Plk_4 536 542 PF00069 0.294
MOD_ProDKin_1 23 29 PF00069 0.523
MOD_ProDKin_1 44 50 PF00069 0.706
MOD_ProDKin_1 479 485 PF00069 0.414
MOD_ProDKin_1 550 556 PF00069 0.294
MOD_ProDKin_1 661 667 PF00069 0.705
MOD_ProDKin_1 671 677 PF00069 0.715
MOD_ProDKin_1 86 92 PF00069 0.720
MOD_SUMO_for_1 143 146 PF00179 0.533
MOD_SUMO_rev_2 313 319 PF00179 0.460
MOD_SUMO_rev_2 323 331 PF00179 0.392
MOD_SUMO_rev_2 482 492 PF00179 0.397
MOD_SUMO_rev_2 499 509 PF00179 0.194
MOD_SUMO_rev_2 610 616 PF00179 0.294
TRG_DiLeu_BaEn_2 326 332 PF01217 0.412
TRG_DiLeu_BaEn_4 257 263 PF01217 0.560
TRG_DiLeu_BaLyEn_6 461 466 PF01217 0.309
TRG_ENDOCYTIC_2 134 137 PF00928 0.563
TRG_ENDOCYTIC_2 358 361 PF00928 0.283
TRG_ENDOCYTIC_2 426 429 PF00928 0.328
TRG_ENDOCYTIC_2 455 458 PF00928 0.379
TRG_ENDOCYTIC_2 540 543 PF00928 0.292
TRG_ENDOCYTIC_2 570 573 PF00928 0.289
TRG_ER_diArg_1 124 126 PF00400 0.675
TRG_ER_diArg_1 212 214 PF00400 0.525
TRG_ER_diArg_1 335 337 PF00400 0.408
TRG_ER_diArg_1 576 578 PF00400 0.267
TRG_ER_diArg_1 586 588 PF00400 0.318
TRG_ER_diArg_1 73 76 PF00400 0.769
TRG_Pf-PMV_PEXEL_1 213 217 PF00026 0.529
TRG_Pf-PMV_PEXEL_1 586 590 PF00026 0.328

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBJ1 Leptomonas seymouri 76% 99%
A0A1X0NJ50 Trypanosomatidae 58% 100%
A0A3S5IR34 Trypanosoma rangeli 58% 100%
A0A3S7X4W6 Leishmania donovani 92% 100%
A4H485 Leishmania braziliensis 24% 93%
A4I790 Leishmania infantum 92% 100%
C9ZMG9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
C9ZWL6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
E9B285 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
O55047 Mus musculus 38% 94%
Q08CW1 Xenopus tropicalis 38% 97%
Q1ECX4 Danio rerio 35% 97%
Q39238 Arabidopsis thaliana 40% 98%
Q4Q5X3 Leishmania major 92% 100%
Q86UE8 Homo sapiens 36% 88%
Q8C0V0 Mus musculus 37% 88%
Q90ZY6 Danio rerio 35% 90%
Q9UKI8 Homo sapiens 37% 88%
V5B7L8 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS