Ribosomal protein l7/l12-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein l7/l12-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJS3_LEIBR

TriTrypDb:

LbrM.31.3210 , LBRM2903_310042000

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A4HJS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJS3

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	142	146	PF00082	0.569
CLV_PCSK_SKI1_1	159	163	PF00082	0.242
CLV_PCSK_SKI1_1	8	12	PF00082	0.620
CLV_Separin_Metazoa	77	81	PF03568	0.668
DEG_Nend_UBRbox_1	1	4	PF02207	0.706
DEG_SIAH_1	112	120	PF03145	0.603
DOC_MAPK_gen_1	137	145	PF00069	0.594
DOC_MAPK_gen_1	162	172	PF00069	0.328
DOC_MAPK_gen_1	197	205	PF00069	0.449
DOC_MAPK_gen_1	35	45	PF00069	0.654
DOC_MAPK_MEF2A_6	38	45	PF00069	0.435
DOC_PP2B_LxvP_1	170	173	PF13499	0.223
DOC_USP7_MATH_1	121	125	PF00917	0.578
DOC_USP7_MATH_1	128	132	PF00917	0.637
DOC_USP7_MATH_1	58	62	PF00917	0.579
DOC_USP7_UBL2_3	138	142	PF12436	0.589
DOC_WW_Pin1_4	107	112	PF00397	0.698
DOC_WW_Pin1_4	179	184	PF00397	0.223
LIG_Actin_WH2_2	183	201	PF00022	0.413
LIG_FHA_2	72	78	PF00498	0.532
LIG_LIR_Gen_1	57	67	PF02991	0.484
LIG_PCNA_yPIPBox_3	2	10	PF02747	0.432
LIG_SH2_STAP1	93	97	PF00017	0.567
LIG_SH2_STAT5	59	62	PF00017	0.477
LIG_SxIP_EBH_1	29	38	PF03271	0.462
MOD_CK1_1	131	137	PF00069	0.678
MOD_CK1_1	23	29	PF00069	0.528
MOD_CK2_1	168	174	PF00069	0.410
MOD_CK2_1	71	77	PF00069	0.564
MOD_GlcNHglycan	13	16	PF01048	0.501
MOD_GlcNHglycan	81	84	PF01048	0.582
MOD_GSK3_1	19	26	PF00069	0.570
MOD_GSK3_1	79	86	PF00069	0.533
MOD_NEK2_1	145	150	PF00069	0.385
MOD_NEK2_1	20	25	PF00069	0.655
MOD_NEK2_1	79	84	PF00069	0.500
MOD_PIKK_1	83	89	PF00454	0.642
MOD_PKA_2	11	17	PF00069	0.600
MOD_PKA_2	79	85	PF00069	0.570
MOD_Plk_1	145	151	PF00069	0.349
MOD_ProDKin_1	107	113	PF00069	0.694
MOD_ProDKin_1	179	185	PF00069	0.223
MOD_SUMO_rev_2	171	178	PF00179	0.397
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.444
TRG_ENDOCYTIC_2	59	62	PF00928	0.477
TRG_ER_diArg_1	1	4	PF00400	0.700
TRG_NES_CRM1_1	163	174	PF08389	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G0	Leptomonas seymouri	63%	100%
A0A0S4JKH3	Bodo saltans	39%	88%
A0A1X0NIA7	Trypanosomatidae	48%	100%
A0A3Q8IFU2	Leishmania donovani	76%	100%
A0A422NF54	Trypanosoma rangeli	43%	100%
A4I789	Leishmania infantum	76%	100%
C9ZMG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B284	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q5X4	Leishmania major	70%	99%
V5BGN2	Trypanosoma cruzi	43%	72%