LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HJS2_LEIBR
TriTrypDb:
LbrM.31.3200 , LBRM2903_310041900 *
Length:
380

Annotations

LeishMANIAdb annotations

Appears to be unique to Kinetoplastids, with very unclear topology, localization and function.. Despite the topology, no signal peptides are present, although a mitochondrial transit signal cannot be excluded

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4HJS2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJS2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 58 62 PF00656 0.419
CLV_PCSK_KEX2_1 365 367 PF00082 0.452
CLV_PCSK_KEX2_1 74 76 PF00082 0.546
CLV_PCSK_PC1ET2_1 365 367 PF00082 0.448
CLV_PCSK_PC1ET2_1 74 76 PF00082 0.546
CLV_PCSK_SKI1_1 329 333 PF00082 0.347
DEG_SPOP_SBC_1 149 153 PF00917 0.557
DOC_ANK_TNKS_1 354 361 PF00023 0.648
DOC_CYCLIN_yCln2_LP_2 86 92 PF00134 0.371
DOC_MAPK_gen_1 216 224 PF00069 0.539
DOC_PP2B_LxvP_1 5 8 PF13499 0.334
DOC_USP7_MATH_1 106 110 PF00917 0.339
DOC_USP7_MATH_1 186 190 PF00917 0.698
DOC_USP7_MATH_1 6 10 PF00917 0.332
DOC_USP7_MATH_2 89 95 PF00917 0.371
DOC_WW_Pin1_4 150 155 PF00397 0.638
DOC_WW_Pin1_4 204 209 PF00397 0.621
DOC_WW_Pin1_4 45 50 PF00397 0.373
LIG_Actin_WH2_2 17 34 PF00022 0.319
LIG_BIR_II_1 1 5 PF00653 0.345
LIG_BRCT_BRCA1_1 100 104 PF00533 0.401
LIG_BRCT_BRCA1_1 65 69 PF00533 0.418
LIG_Clathr_ClatBox_1 330 334 PF01394 0.559
LIG_deltaCOP1_diTrp_1 287 293 PF00928 0.492
LIG_eIF4E_1 325 331 PF01652 0.507
LIG_FHA_1 156 162 PF00498 0.677
LIG_FHA_1 219 225 PF00498 0.509
LIG_FHA_1 232 238 PF00498 0.376
LIG_FHA_1 342 348 PF00498 0.573
LIG_FHA_1 352 358 PF00498 0.595
LIG_FHA_2 150 156 PF00498 0.718
LIG_FHA_2 166 172 PF00498 0.490
LIG_FHA_2 282 288 PF00498 0.630
LIG_GBD_Chelix_1 322 330 PF00786 0.313
LIG_LIR_Gen_1 101 112 PF02991 0.452
LIG_LIR_Gen_1 189 200 PF02991 0.711
LIG_LIR_Gen_1 287 296 PF02991 0.526
LIG_LIR_Gen_1 372 380 PF02991 0.631
LIG_LIR_Nem_3 101 107 PF02991 0.411
LIG_LIR_Nem_3 178 183 PF02991 0.636
LIG_LIR_Nem_3 189 195 PF02991 0.706
LIG_LIR_Nem_3 267 272 PF02991 0.341
LIG_LIR_Nem_3 290 296 PF02991 0.367
LIG_LIR_Nem_3 372 377 PF02991 0.677
LIG_NRBOX 232 238 PF00104 0.348
LIG_Pex14_2 125 129 PF04695 0.314
LIG_REV1ctd_RIR_1 127 138 PF16727 0.480
LIG_SH2_CRK 192 196 PF00017 0.764
LIG_SH2_CRK 374 378 PF00017 0.579
LIG_SH2_NCK_1 192 196 PF00017 0.769
LIG_SH2_STAP1 131 135 PF00017 0.570
LIG_SH2_STAP1 16 20 PF00017 0.328
LIG_SH2_STAP1 374 378 PF00017 0.587
LIG_SH2_STAT5 257 260 PF00017 0.306
LIG_SH2_STAT5 270 273 PF00017 0.370
LIG_SH2_STAT5 325 328 PF00017 0.366
LIG_SH3_3 180 186 PF00018 0.709
LIG_SH3_3 225 231 PF00018 0.230
LIG_SH3_3 35 41 PF00018 0.411
LIG_SH3_3 353 359 PF00018 0.611
LIG_SUMO_SIM_anti_2 157 164 PF11976 0.605
LIG_SUMO_SIM_anti_2 234 240 PF11976 0.440
LIG_SUMO_SIM_par_1 157 164 PF11976 0.605
LIG_SUMO_SIM_par_1 221 227 PF11976 0.346
LIG_UBA3_1 330 335 PF00899 0.564
MOD_CK1_1 102 108 PF00069 0.346
MOD_CK1_1 19 25 PF00069 0.371
MOD_CK1_1 253 259 PF00069 0.338
MOD_CK1_1 51 57 PF00069 0.432
MOD_CK1_1 63 69 PF00069 0.430
MOD_CK2_1 281 287 PF00069 0.580
MOD_Cter_Amidation 214 217 PF01082 0.314
MOD_GlcNHglycan 200 203 PF01048 0.492
MOD_GlcNHglycan 302 305 PF01048 0.423
MOD_GlcNHglycan 367 370 PF01048 0.464
MOD_GlcNHglycan 374 377 PF01048 0.506
MOD_GlcNHglycan 50 53 PF01048 0.606
MOD_GSK3_1 16 23 PF00069 0.364
MOD_GSK3_1 161 168 PF00069 0.594
MOD_GSK3_1 271 278 PF00069 0.518
MOD_GSK3_1 314 321 PF00069 0.460
MOD_GSK3_1 361 368 PF00069 0.714
MOD_GSK3_1 372 379 PF00069 0.559
MOD_GSK3_1 51 58 PF00069 0.444
MOD_GSK3_1 6 13 PF00069 0.330
MOD_GSK3_1 98 105 PF00069 0.389
MOD_NEK2_1 10 15 PF00069 0.349
MOD_NEK2_1 108 113 PF00069 0.381
MOD_NEK2_1 165 170 PF00069 0.584
MOD_NEK2_1 20 25 PF00069 0.309
MOD_NEK2_1 244 249 PF00069 0.408
MOD_NEK2_1 264 269 PF00069 0.368
MOD_NEK2_1 281 286 PF00069 0.545
MOD_NEK2_1 300 305 PF00069 0.420
MOD_NEK2_1 31 36 PF00069 0.310
MOD_NEK2_1 98 103 PF00069 0.474
MOD_PIKK_1 244 250 PF00454 0.290
MOD_PIKK_1 275 281 PF00454 0.658
MOD_PIKK_1 341 347 PF00454 0.576
MOD_PIKK_1 96 102 PF00454 0.380
MOD_PKA_1 365 371 PF00069 0.649
MOD_PKA_2 178 184 PF00069 0.665
MOD_PKA_2 31 37 PF00069 0.330
MOD_PKA_2 341 347 PF00069 0.617
MOD_PKA_2 365 371 PF00069 0.700
MOD_Plk_1 16 22 PF00069 0.325
MOD_Plk_1 275 281 PF00069 0.634
MOD_Plk_1 351 357 PF00069 0.646
MOD_Plk_1 55 61 PF00069 0.363
MOD_Plk_4 117 123 PF00069 0.263
MOD_Plk_4 20 26 PF00069 0.342
MOD_Plk_4 218 224 PF00069 0.503
MOD_Plk_4 231 237 PF00069 0.327
MOD_Plk_4 239 245 PF00069 0.534
MOD_Plk_4 253 259 PF00069 0.235
MOD_Plk_4 6 12 PF00069 0.371
MOD_ProDKin_1 150 156 PF00069 0.633
MOD_ProDKin_1 204 210 PF00069 0.619
MOD_ProDKin_1 45 51 PF00069 0.373
MOD_SUMO_for_1 331 334 PF00179 0.542
MOD_SUMO_rev_2 362 367 PF00179 0.681
TRG_ENDOCYTIC_2 192 195 PF00928 0.700
TRG_ENDOCYTIC_2 374 377 PF00928 0.599
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.433

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4U5 Leptomonas seymouri 69% 100%
A0A0S4JIB3 Bodo saltans 33% 100%
A0A1X0NIE1 Trypanosomatidae 45% 100%
A0A3R7NC34 Trypanosoma rangeli 41% 100%
A0A3S7X4W5 Leishmania donovani 80% 100%
A4I788 Leishmania infantum 80% 100%
C9ZMG7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZWL8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9B283 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 99%
Q4Q5X5 Leishmania major 71% 100%
V5BC20 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS