Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJS1_LEIBR

TriTrypDb:

LbrM.31.3190 , LBRM2903_310041800

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	450	454	PF00656	0.584
CLV_NRD_NRD_1	11	13	PF00675	0.716
CLV_NRD_NRD_1	132	134	PF00675	0.711
CLV_NRD_NRD_1	139	141	PF00675	0.716
CLV_NRD_NRD_1	242	244	PF00675	0.576
CLV_NRD_NRD_1	250	252	PF00675	0.598
CLV_NRD_NRD_1	331	333	PF00675	0.486
CLV_NRD_NRD_1	423	425	PF00675	0.831
CLV_NRD_NRD_1	473	475	PF00675	0.797
CLV_NRD_NRD_1	491	493	PF00675	0.682
CLV_NRD_NRD_1	520	522	PF00675	0.755
CLV_NRD_NRD_1	565	567	PF00675	0.738
CLV_NRD_NRD_1	620	622	PF00675	0.701
CLV_NRD_NRD_1	83	85	PF00675	0.843
CLV_NRD_NRD_1	91	93	PF00675	0.663
CLV_PCSK_KEX2_1	132	134	PF00082	0.711
CLV_PCSK_KEX2_1	139	141	PF00082	0.716
CLV_PCSK_KEX2_1	242	244	PF00082	0.576
CLV_PCSK_KEX2_1	250	252	PF00082	0.598
CLV_PCSK_KEX2_1	333	335	PF00082	0.487
CLV_PCSK_KEX2_1	473	475	PF00082	0.790
CLV_PCSK_KEX2_1	491	493	PF00082	0.696
CLV_PCSK_KEX2_1	565	567	PF00082	0.692
CLV_PCSK_KEX2_1	587	589	PF00082	0.794
CLV_PCSK_KEX2_1	620	622	PF00082	0.640
CLV_PCSK_KEX2_1	83	85	PF00082	0.841
CLV_PCSK_KEX2_1	91	93	PF00082	0.614
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.546
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.794
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.640
CLV_PCSK_SKI1_1	133	137	PF00082	0.792
CLV_PCSK_SKI1_1	227	231	PF00082	0.545
CLV_PCSK_SKI1_1	263	267	PF00082	0.565
CLV_PCSK_SKI1_1	351	355	PF00082	0.685
CLV_PCSK_SKI1_1	491	495	PF00082	0.682
CLV_PCSK_SKI1_1	530	534	PF00082	0.620
CLV_PCSK_SKI1_1	584	588	PF00082	0.783
CLV_PCSK_SKI1_1	602	606	PF00082	0.527
DEG_APCC_DBOX_1	226	234	PF00400	0.541
DEG_APCC_DBOX_1	346	354	PF00400	0.664
DEG_Kelch_Keap1_1	206	211	PF01344	0.577
DEG_Nend_Nbox_1	1	3	PF02207	0.602
DEG_SCF_FBW7_1	66	73	PF00400	0.557
DEG_SPOP_SBC_1	110	114	PF00917	0.580
DEG_SPOP_SBC_1	163	167	PF00917	0.729
DEG_SPOP_SBC_1	43	47	PF00917	0.599
DEG_SPOP_SBC_1	540	544	PF00917	0.578
DOC_CYCLIN_RxL_1	221	234	PF00134	0.552
DOC_CYCLIN_RxL_1	257	270	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.568
DOC_MAPK_RevD_3	235	251	PF00069	0.560
DOC_PP4_FxxP_1	74	77	PF00568	0.702
DOC_USP7_MATH_1	149	153	PF00917	0.739
DOC_USP7_MATH_1	163	167	PF00917	0.836
DOC_USP7_MATH_1	220	224	PF00917	0.587
DOC_USP7_MATH_1	43	47	PF00917	0.662
DOC_USP7_MATH_1	502	506	PF00917	0.647
DOC_USP7_MATH_1	524	528	PF00917	0.620
DOC_USP7_MATH_1	564	568	PF00917	0.704
DOC_USP7_MATH_1	593	597	PF00917	0.747
DOC_USP7_MATH_1	70	74	PF00917	0.773
DOC_USP7_MATH_2	88	94	PF00917	0.572
DOC_USP7_UBL2_3	484	488	PF12436	0.736
DOC_USP7_UBL2_3	494	498	PF12436	0.756
DOC_USP7_UBL2_3	499	503	PF12436	0.814
DOC_USP7_UBL2_3	601	605	PF12436	0.759
DOC_USP7_UBL2_3	618	622	PF12436	0.722
DOC_WW_Pin1_4	123	128	PF00397	0.786
DOC_WW_Pin1_4	140	145	PF00397	0.648
DOC_WW_Pin1_4	154	159	PF00397	0.620
DOC_WW_Pin1_4	164	169	PF00397	0.797
DOC_WW_Pin1_4	191	196	PF00397	0.671
DOC_WW_Pin1_4	301	306	PF00397	0.487
DOC_WW_Pin1_4	32	37	PF00397	0.667
DOC_WW_Pin1_4	409	414	PF00397	0.793
DOC_WW_Pin1_4	588	593	PF00397	0.780
DOC_WW_Pin1_4	605	610	PF00397	0.548
DOC_WW_Pin1_4	66	71	PF00397	0.555
DOC_WW_Pin1_4	75	80	PF00397	0.529
LIG_14-3-3_CanoR_1	21	30	PF00244	0.817
LIG_14-3-3_CanoR_1	242	248	PF00244	0.569
LIG_14-3-3_CanoR_1	257	265	PF00244	0.567
LIG_14-3-3_CanoR_1	384	393	PF00244	0.532
LIG_14-3-3_CanoR_1	422	430	PF00244	0.848
LIG_14-3-3_CanoR_1	512	518	PF00244	0.604
LIG_14-3-3_CanoR_1	566	576	PF00244	0.690
LIG_14-3-3_CanoR_1	94	100	PF00244	0.771
LIG_BIR_III_4	201	205	PF00653	0.684
LIG_BRCT_BRCA1_1	590	594	PF00533	0.548
LIG_FHA_1	188	194	PF00498	0.639
LIG_FHA_1	257	263	PF00498	0.568
LIG_FHA_1	304	310	PF00498	0.614
LIG_FHA_1	554	560	PF00498	0.582
LIG_FHA_2	203	209	PF00498	0.837
LIG_FHA_2	285	291	PF00498	0.520
LIG_FHA_2	365	371	PF00498	0.565
LIG_FHA_2	454	460	PF00498	0.802
LIG_FHA_2	67	73	PF00498	0.556
LIG_LIR_Apic_2	72	77	PF02991	0.700
LIG_LIR_Gen_1	264	272	PF02991	0.558
LIG_LIR_Gen_1	359	368	PF02991	0.566
LIG_LIR_Nem_3	223	229	PF02991	0.555
LIG_LIR_Nem_3	270	276	PF02991	0.590
LIG_LIR_Nem_3	359	364	PF02991	0.577
LIG_NRBOX	349	355	PF00104	0.679
LIG_SH2_CRK	226	230	PF00017	0.550
LIG_SH2_NCK_1	336	340	PF00017	0.524
LIG_SH2_SRC	336	339	PF00017	0.529
LIG_SH2_STAP1	336	340	PF00017	0.524
LIG_SH2_STAT5	292	295	PF00017	0.518
LIG_SH2_STAT5	317	320	PF00017	0.472
LIG_SH2_STAT5	352	355	PF00017	0.589
LIG_SH3_2	127	132	PF14604	0.571
LIG_SH3_3	124	130	PF00018	0.682
LIG_SH3_3	24	30	PF00018	0.567
LIG_SH3_3	279	285	PF00018	0.602
LIG_SH3_3	302	308	PF00018	0.501
LIG_SH3_3	379	385	PF00018	0.681
LIG_SH3_3	587	593	PF00018	0.540
LIG_SH3_3	83	89	PF00018	0.789
LIG_TRAF2_1	437	440	PF00917	0.830
LIG_TRAF2_1	455	458	PF00917	0.615
LIG_WRC_WIRS_1	71	76	PF05994	0.564
MOD_CDC14_SPxK_1	129	132	PF00782	0.730
MOD_CDK_SPK_2	164	169	PF00069	0.836
MOD_CDK_SPxK_1	126	132	PF00069	0.765
MOD_CDK_SPxxK_3	126	133	PF00069	0.825
MOD_CDK_SPxxK_3	605	612	PF00069	0.716
MOD_CK1_1	100	106	PF00069	0.773
MOD_CK1_1	126	132	PF00069	0.610
MOD_CK1_1	206	212	PF00069	0.752
MOD_CK1_1	246	252	PF00069	0.584
MOD_CK1_1	37	43	PF00069	0.748
MOD_CK1_1	432	438	PF00069	0.728
MOD_CK1_1	544	550	PF00069	0.601
MOD_CK1_1	551	557	PF00069	0.572
MOD_CK1_1	567	573	PF00069	0.547
MOD_CK1_1	610	616	PF00069	0.688
MOD_CK2_1	110	116	PF00069	0.643
MOD_CK2_1	164	170	PF00069	0.737
MOD_CK2_1	202	208	PF00069	0.838
MOD_CK2_1	356	362	PF00069	0.550
MOD_CK2_1	364	370	PF00069	0.476
MOD_CK2_1	452	458	PF00069	0.758
MOD_CK2_1	66	72	PF00069	0.556
MOD_Cter_Amidation	330	333	PF01082	0.488
MOD_Cter_Amidation	422	425	PF01082	0.632
MOD_Cter_Amidation	519	522	PF01082	0.640
MOD_GlcNHglycan	102	105	PF01048	0.794
MOD_GlcNHglycan	144	147	PF01048	0.662
MOD_GlcNHglycan	149	152	PF01048	0.651
MOD_GlcNHglycan	205	208	PF01048	0.726
MOD_GlcNHglycan	211	214	PF01048	0.677
MOD_GlcNHglycan	24	27	PF01048	0.691
MOD_GlcNHglycan	30	33	PF01048	0.748
MOD_GlcNHglycan	39	42	PF01048	0.746
MOD_GlcNHglycan	434	437	PF01048	0.816
MOD_GlcNHglycan	513	516	PF01048	0.731
MOD_GlcNHglycan	526	529	PF01048	0.840
MOD_GlcNHglycan	543	546	PF01048	0.660
MOD_GlcNHglycan	550	553	PF01048	0.629
MOD_GlcNHglycan	566	569	PF01048	0.608
MOD_GlcNHglycan	595	598	PF01048	0.815
MOD_GlcNHglycan	612	615	PF01048	0.611
MOD_GSK3_1	187	194	PF00069	0.737
MOD_GSK3_1	202	209	PF00069	0.716
MOD_GSK3_1	215	222	PF00069	0.581
MOD_GSK3_1	242	249	PF00069	0.557
MOD_GSK3_1	271	278	PF00069	0.709
MOD_GSK3_1	28	35	PF00069	0.729
MOD_GSK3_1	352	359	PF00069	0.555
MOD_GSK3_1	540	547	PF00069	0.609
MOD_GSK3_1	588	595	PF00069	0.757
MOD_GSK3_1	66	73	PF00069	0.557
MOD_GSK3_1	95	102	PF00069	0.821
MOD_LATS_1	501	507	PF00433	0.590
MOD_NEK2_1	364	369	PF00069	0.531
MOD_NEK2_2	44	49	PF00069	0.699
MOD_PIKK_1	256	262	PF00454	0.567
MOD_PIKK_1	429	435	PF00454	0.592
MOD_PK_1	243	249	PF00069	0.569
MOD_PKA_1	242	248	PF00069	0.539
MOD_PKA_2	2	8	PF00069	0.616
MOD_PKA_2	202	208	PF00069	0.586
MOD_PKA_2	242	248	PF00069	0.539
MOD_PKA_2	256	262	PF00069	0.598
MOD_PKA_2	383	389	PF00069	0.536
MOD_PKA_2	423	429	PF00069	0.847
MOD_PKA_2	511	517	PF00069	0.584
MOD_PKA_2	564	570	PF00069	0.791
MOD_PKA_2	90	96	PF00069	0.578
MOD_Plk_1	369	375	PF00069	0.571
MOD_Plk_2-3	453	459	PF00069	0.599
MOD_Plk_2-3	59	65	PF00069	0.594
MOD_Plk_4	2	8	PF00069	0.601
MOD_Plk_4	44	50	PF00069	0.816
MOD_ProDKin_1	123	129	PF00069	0.784
MOD_ProDKin_1	140	146	PF00069	0.648
MOD_ProDKin_1	154	160	PF00069	0.619
MOD_ProDKin_1	164	170	PF00069	0.796
MOD_ProDKin_1	191	197	PF00069	0.673
MOD_ProDKin_1	301	307	PF00069	0.492
MOD_ProDKin_1	32	38	PF00069	0.668
MOD_ProDKin_1	409	415	PF00069	0.795
MOD_ProDKin_1	588	594	PF00069	0.786
MOD_ProDKin_1	605	611	PF00069	0.549
MOD_ProDKin_1	66	72	PF00069	0.556
MOD_ProDKin_1	75	81	PF00069	0.529
MOD_SUMO_rev_2	348	353	PF00179	0.670
MOD_SUMO_rev_2	374	382	PF00179	0.483
MOD_SUMO_rev_2	551	559	PF00179	0.723
TRG_DiLeu_BaEn_1	349	354	PF01217	0.675
TRG_ENDOCYTIC_2	226	229	PF00928	0.552
TRG_ENDOCYTIC_2	325	328	PF00928	0.513
TRG_ER_diArg_1	120	123	PF00400	0.784
TRG_ER_diArg_1	132	134	PF00400	0.691
TRG_ER_diArg_1	332	335	PF00400	0.495
TRG_ER_diArg_1	491	493	PF00400	0.662
TRG_ER_diArg_1	82	84	PF00400	0.842
TRG_ER_diArg_1	91	94	PF00400	0.601
TRG_ER_diLys_1	618	623	PF00400	0.817
TRG_NLS_MonoExtC_3	331	337	PF00514	0.541
TRG_NLS_MonoExtC_3	583	588	PF00514	0.781
TRG_NLS_MonoExtN_4	329	336	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.783
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P585	Leptomonas seymouri	50%	100%
A0A3Q8IIU7	Leishmania donovani	69%	100%
A4I787	Leishmania infantum	69%	100%
E9B282	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q5X6	Leishmania major	70%	100%