Smr domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KH domain/Domain of unknown function (DUF1771)/Smr domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJR9_LEIBR

TriTrypDb:

LbrM.31.3170 , LBRM2903_310041600

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJR9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.389
CLV_NRD_NRD_1	256	258	PF00675	0.603
CLV_NRD_NRD_1	81	83	PF00675	0.318
CLV_PCSK_KEX2_1	101	103	PF00082	0.352
CLV_PCSK_KEX2_1	247	249	PF00082	0.648
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.347
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.513
CLV_PCSK_SKI1_1	201	205	PF00082	0.351
DOC_MAPK_gen_1	128	136	PF00069	0.390
DOC_PP2B_PxIxI_1	1	7	PF00149	0.325
DOC_USP7_MATH_1	228	232	PF00917	0.477
DOC_USP7_MATH_1	256	260	PF00917	0.700
DOC_USP7_UBL2_3	113	117	PF12436	0.450
DOC_USP7_UBL2_3	119	123	PF12436	0.189
DOC_USP7_UBL2_3	243	247	PF12436	0.746
DOC_USP7_UBL2_3	258	262	PF12436	0.477
LIG_14-3-3_CanoR_1	7	13	PF00244	0.403
LIG_Actin_WH2_2	9	27	PF00022	0.346
LIG_APCC_ABBAyCdc20_2	92	98	PF00400	0.320
LIG_BRCT_BRCA1_1	92	96	PF00533	0.320
LIG_FHA_1	220	226	PF00498	0.363
LIG_FHA_2	177	183	PF00498	0.300
LIG_FHA_2	21	27	PF00498	0.454
LIG_FHA_2	244	250	PF00498	0.505
LIG_FHA_2	45	51	PF00498	0.529
LIG_LIR_Apic_2	72	76	PF02991	0.473
LIG_LIR_Gen_1	181	189	PF02991	0.342
LIG_LIR_Nem_3	181	186	PF02991	0.342
LIG_MAD2	63	71	PF02301	0.534
LIG_SH2_CRK	215	219	PF00017	0.194
LIG_SH2_NCK_1	215	219	PF00017	0.287
LIG_SH2_STAT5	207	210	PF00017	0.301
LIG_SH2_STAT5	213	216	PF00017	0.286
LIG_SH3_3	222	228	PF00018	0.504
LIG_TRAF2_1	66	69	PF00917	0.529
MOD_CK2_1	176	182	PF00069	0.311
MOD_CK2_1	233	239	PF00069	0.648
MOD_GlcNHglycan	192	195	PF01048	0.309
MOD_GSK3_1	256	263	PF00069	0.697
MOD_NEK2_2	20	25	PF00069	0.446
MOD_PKA_2	256	262	PF00069	0.460
MOD_PKA_2	44	50	PF00069	0.422
MOD_PKA_2	6	12	PF00069	0.335
MOD_Plk_4	219	225	PF00069	0.293
MOD_SUMO_for_1	33	36	PF00179	0.418
MOD_SUMO_rev_2	249	254	PF00179	0.637
MOD_SUMO_rev_2	49	55	PF00179	0.425
MOD_SUMO_rev_2	58	64	PF00179	0.418
TRG_DiLeu_BaEn_3	159	165	PF01217	0.320
TRG_ENDOCYTIC_2	215	218	PF00928	0.306
TRG_ER_diArg_1	79	82	PF00400	0.394
TRG_NLS_Bipartite_1	247	261	PF00514	0.628
TRG_NLS_MonoExtN_4	255	261	PF00514	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U4	Leptomonas seymouri	70%	100%
A0A0S4JKD1	Bodo saltans	29%	85%
A0A1X0NK68	Trypanosomatidae	50%	100%
A0A3Q8IKE2	Leishmania donovani	71%	96%
A0A422NF86	Trypanosoma rangeli	55%	100%
A4H981	Leishmania braziliensis	99%	100%
A4I785	Leishmania infantum	71%	96%
C9ZMG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B280	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	96%
Q4Q5X8	Leishmania major	69%	100%
Q9UTP4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5BGM8	Trypanosoma cruzi	55%	94%