Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJR8_LEIBR

TriTrypDb:

LbrM.31.3160 , LBRM2903_310041500

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.493
CLV_C14_Caspase3-7	8	12	PF00656	0.522
CLV_C14_Caspase3-7	88	92	PF00656	0.562
CLV_NRD_NRD_1	106	108	PF00675	0.565
CLV_NRD_NRD_1	134	136	PF00675	0.547
CLV_NRD_NRD_1	183	185	PF00675	0.586
CLV_NRD_NRD_1	32	34	PF00675	0.543
CLV_PCSK_FUR_1	104	108	PF00082	0.568
CLV_PCSK_KEX2_1	106	108	PF00082	0.565
CLV_PCSK_KEX2_1	128	130	PF00082	0.534
CLV_PCSK_KEX2_1	159	161	PF00082	0.512
CLV_PCSK_KEX2_1	182	184	PF00082	0.578
CLV_PCSK_KEX2_1	32	34	PF00082	0.602
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.515
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.512
CLV_PCSK_SKI1_1	129	133	PF00082	0.511
CLV_PCSK_SKI1_1	159	163	PF00082	0.504
CLV_Separin_Metazoa	179	183	PF03568	0.635
DOC_MAPK_gen_1	116	123	PF00069	0.570
DOC_MAPK_gen_1	182	190	PF00069	0.560
DOC_PP1_RVXF_1	62	68	PF00149	0.537
DOC_USP7_MATH_1	108	112	PF00917	0.568
DOC_USP7_MATH_1	122	126	PF00917	0.519
DOC_USP7_MATH_1	150	154	PF00917	0.525
DOC_USP7_MATH_1	194	198	PF00917	0.545
DOC_USP7_UBL2_3	128	132	PF12436	0.513
DOC_WW_Pin1_4	154	159	PF00397	0.549
DOC_WW_Pin1_4	236	241	PF00397	0.529
DOC_WW_Pin1_4	27	32	PF00397	0.569
DOC_WW_Pin1_4	44	49	PF00397	0.513
DOC_WW_Pin1_4	83	88	PF00397	0.537
LIG_14-3-3_CanoR_1	107	113	PF00244	0.664
LIG_14-3-3_CanoR_1	149	158	PF00244	0.619
LIG_14-3-3_CanoR_1	182	192	PF00244	0.512
LIG_14-3-3_CanoR_1	27	31	PF00244	0.657
LIG_14-3-3_CanoR_1	64	68	PF00244	0.583
LIG_APCC_ABBA_1	200	205	PF00400	0.690
LIG_BRCT_BRCA1_1	238	242	PF00533	0.475
LIG_CAP-Gly_1	244	248	PF01302	0.479
LIG_CSL_BTD_1	21	24	PF09270	0.499
LIG_FHA_1	160	166	PF00498	0.497
LIG_LIR_Gen_1	66	75	PF02991	0.612
LIG_LIR_Nem_3	119	123	PF02991	0.565
LIG_LIR_Nem_3	66	70	PF02991	0.532
LIG_Pex14_2	18	22	PF04695	0.686
LIG_SH2_GRB2like	145	148	PF00017	0.513
LIG_SH2_PTP2	120	123	PF00017	0.545
LIG_SH2_STAT5	120	123	PF00017	0.545
LIG_SH2_STAT5	231	234	PF00017	0.475
LIG_SH3_3	28	34	PF00018	0.535
LIG_TRAF2_1	213	216	PF00917	0.702
LIG_TRAF2_1	58	61	PF00917	0.530
MOD_CDC14_SPxK_1	30	33	PF00782	0.592
MOD_CDK_SPK_2	154	159	PF00069	0.517
MOD_CDK_SPK_2	27	32	PF00069	0.534
MOD_CDK_SPxK_1	154	160	PF00069	0.516
MOD_CDK_SPxK_1	27	33	PF00069	0.592
MOD_CDK_SPxxK_3	44	51	PF00069	0.534
MOD_CK1_1	230	236	PF00069	0.481
MOD_CK1_1	39	45	PF00069	0.799
MOD_CK1_1	47	53	PF00069	0.586
MOD_CK1_1	86	92	PF00069	0.792
MOD_CK1_1	96	102	PF00069	0.570
MOD_CK2_1	121	127	PF00069	0.662
MOD_CK2_1	2	8	PF00069	0.534
MOD_CK2_1	231	237	PF00069	0.492
MOD_CK2_1	63	69	PF00069	0.584
MOD_DYRK1A_RPxSP_1	27	31	PF00069	0.530
MOD_GlcNHglycan	185	188	PF01048	0.471
MOD_GlcNHglycan	222	225	PF01048	0.548
MOD_GlcNHglycan	44	47	PF01048	0.769
MOD_GlcNHglycan	72	75	PF01048	0.677
MOD_GSK3_1	150	157	PF00069	0.628
MOD_GSK3_1	227	234	PF00069	0.565
MOD_GSK3_1	37	44	PF00069	0.811
MOD_GSK3_1	47	54	PF00069	0.515
MOD_GSK3_1	89	96	PF00069	0.694
MOD_NEK2_1	220	225	PF00069	0.572
MOD_NEK2_1	227	232	PF00069	0.559
MOD_NEK2_1	70	75	PF00069	0.676
MOD_NEK2_1	77	82	PF00069	0.566
MOD_PIKK_1	150	156	PF00454	0.542
MOD_PKA_1	159	165	PF00069	0.500
MOD_PKA_1	182	188	PF00069	0.543
MOD_PKA_2	134	140	PF00069	0.520
MOD_PKA_2	159	165	PF00069	0.500
MOD_PKA_2	182	188	PF00069	0.543
MOD_PKA_2	26	32	PF00069	0.633
MOD_PKA_2	63	69	PF00069	0.580
MOD_Plk_2-3	63	69	PF00069	0.539
MOD_Plk_2-3	93	99	PF00069	0.632
MOD_Plk_4	108	114	PF00069	0.572
MOD_Plk_4	141	147	PF00069	0.492
MOD_Plk_4	222	228	PF00069	0.563
MOD_ProDKin_1	154	160	PF00069	0.548
MOD_ProDKin_1	236	242	PF00069	0.530
MOD_ProDKin_1	27	33	PF00069	0.571
MOD_ProDKin_1	44	50	PF00069	0.510
MOD_ProDKin_1	83	89	PF00069	0.539
MOD_SUMO_rev_2	124	130	PF00179	0.586
TRG_DiLeu_BaEn_1	176	181	PF01217	0.566
TRG_DiLeu_BaEn_1	216	221	PF01217	0.480
TRG_DiLeu_BaEn_3	237	243	PF01217	0.665
TRG_DiLeu_BaEn_4	60	66	PF01217	0.540
TRG_ENDOCYTIC_2	120	123	PF00928	0.545
TRG_ER_diArg_1	104	107	PF00400	0.570
TRG_ER_diArg_1	181	184	PF00400	0.585
TRG_ER_diArg_1	31	33	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJH6	Leptomonas seymouri	40%	98%
A0A3Q8IF41	Leishmania donovani	55%	92%
E9AHL9	Leishmania infantum	54%	92%
E9B279	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	93%
Q4Q5X9	Leishmania major	56%	100%