TPX2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJR6_LEIBR

TriTrypDb:

LbrM.31.3130 , LBRM2903_310041200

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.521
CLV_NRD_NRD_1	74	76	PF00675	0.763
CLV_PCSK_FUR_1	72	76	PF00082	0.624
CLV_PCSK_KEX2_1	141	143	PF00082	0.532
CLV_PCSK_KEX2_1	72	74	PF00082	0.760
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.532
CLV_PCSK_SKI1_1	42	46	PF00082	0.513
DEG_Nend_Nbox_1	1	3	PF02207	0.658
DEG_SPOP_SBC_1	108	112	PF00917	0.549
DOC_USP7_MATH_1	107	111	PF00917	0.625
DOC_USP7_UBL2_3	53	57	PF12436	0.507
DOC_WW_Pin1_4	115	120	PF00397	0.658
DOC_WW_Pin1_4	149	154	PF00397	0.654
DOC_WW_Pin1_4	211	216	PF00397	0.541
LIG_14-3-3_CanoR_1	21	31	PF00244	0.482
LIG_14-3-3_CanoR_1	230	235	PF00244	0.515
LIG_14-3-3_CanoR_1	72	78	PF00244	0.690
LIG_APCC_ABBA_1	120	125	PF00400	0.547
LIG_BRCT_BRCA1_1	24	28	PF00533	0.481
LIG_BRCT_BRCA1_1	60	64	PF00533	0.469
LIG_BRCT_BRCA1_2	24	30	PF00533	0.477
LIG_CtBP_PxDLS_1	215	219	PF00389	0.530
LIG_FHA_2	109	115	PF00498	0.641
LIG_FHA_2	157	163	PF00498	0.548
LIG_FHA_2	53	59	PF00498	0.503
LIG_FHA_2	97	103	PF00498	0.588
LIG_LIR_Gen_1	25	35	PF02991	0.474
LIG_LIR_Gen_1	61	71	PF02991	0.451
LIG_SH2_STAP1	129	133	PF00017	0.569
LIG_SH2_STAT5	70	73	PF00017	0.461
LIG_SH3_3	17	23	PF00018	0.596
LIG_SH3_3	26	32	PF00018	0.591
LIG_SH3_3	62	68	PF00018	0.589
LIG_SH3_4	179	186	PF00018	0.521
LIG_TRAF2_1	111	114	PF00917	0.547
LIG_TRAF2_1	124	127	PF00917	0.522
LIG_TRAF2_1	197	200	PF00917	0.590
MOD_CAAXbox	232	235	PF01239	0.652
MOD_CK1_1	149	155	PF00069	0.546
MOD_CK1_1	178	184	PF00069	0.592
MOD_CK1_1	214	220	PF00069	0.531
MOD_CK1_1	78	84	PF00069	0.505
MOD_CK2_1	107	113	PF00069	0.670
MOD_CK2_1	134	140	PF00069	0.530
MOD_CK2_1	144	150	PF00069	0.499
MOD_CK2_1	194	200	PF00069	0.587
MOD_CK2_1	214	220	PF00069	0.593
MOD_CK2_1	48	54	PF00069	0.608
MOD_GlcNHglycan	136	139	PF01048	0.629
MOD_GlcNHglycan	187	190	PF01048	0.725
MOD_GSK3_1	140	147	PF00069	0.572
MOD_GSK3_1	148	155	PF00069	0.560
MOD_GSK3_1	156	163	PF00069	0.580
MOD_GSK3_1	48	55	PF00069	0.642
MOD_LATS_1	144	150	PF00433	0.535
MOD_N-GLC_1	222	227	PF02516	0.519
MOD_N-GLC_1	48	53	PF02516	0.658
MOD_NEK2_1	148	153	PF00069	0.569
MOD_NEK2_1	173	178	PF00069	0.572
MOD_PIKK_1	206	212	PF00454	0.530
MOD_PIKK_1	22	28	PF00454	0.494
MOD_PIKK_1	48	54	PF00454	0.615
MOD_PKA_1	73	79	PF00069	0.636
MOD_PKA_2	223	229	PF00069	0.620
MOD_PKA_2	73	79	PF00069	0.752
MOD_PKB_1	36	44	PF00069	0.585
MOD_PKB_1	73	81	PF00069	0.639
MOD_Plk_1	131	137	PF00069	0.575
MOD_Plk_1	203	209	PF00069	0.534
MOD_Plk_2-3	160	166	PF00069	0.535
MOD_Plk_4	152	158	PF00069	0.529
MOD_ProDKin_1	115	121	PF00069	0.658
MOD_ProDKin_1	149	155	PF00069	0.652
MOD_ProDKin_1	211	217	PF00069	0.541
MOD_SUMO_for_1	201	204	PF00179	0.532
MOD_SUMO_rev_2	188	197	PF00179	0.563
MOD_SUMO_rev_2	199	203	PF00179	0.551
TRG_ER_diArg_1	71	74	PF00400	0.744
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	75	80	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X508	Leishmania donovani	38%	99%
A4I783	Leishmania infantum	38%	99%
E9B277	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	72%
Q4Q5Y2	Leishmania major	34%	100%