RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HJR5_LEIBR

TriTrypDb:

LbrM.31.3120 , LBRM2903_310041000

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HJR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJR5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.472
CLV_NRD_NRD_1	128	130	PF00675	0.489
CLV_NRD_NRD_1	61	63	PF00675	0.258
CLV_PCSK_KEX2_1	128	130	PF00082	0.489
CLV_PCSK_KEX2_1	61	63	PF00082	0.258
CLV_Separin_Metazoa	125	129	PF03568	0.463
DEG_APCC_DBOX_1	225	233	PF00400	0.606
DEG_SCF_FBW7_2	55	60	PF00400	0.458
DOC_PP4_FxxP_1	89	92	PF00568	0.439
DOC_USP7_MATH_1	176	180	PF00917	0.636
DOC_USP7_MATH_1	201	205	PF00917	0.524
DOC_USP7_MATH_1	250	254	PF00917	0.560
DOC_USP7_MATH_1	279	283	PF00917	0.513
DOC_USP7_MATH_1	302	306	PF00917	0.537
DOC_WW_Pin1_4	107	112	PF00397	0.422
DOC_WW_Pin1_4	156	161	PF00397	0.610
DOC_WW_Pin1_4	231	236	PF00397	0.494
DOC_WW_Pin1_4	273	278	PF00397	0.495
DOC_WW_Pin1_4	53	58	PF00397	0.469
DOC_WW_Pin1_4	88	93	PF00397	0.446
LIG_14-3-3_CanoR_1	118	127	PF00244	0.505
LIG_14-3-3_CanoR_1	178	187	PF00244	0.595
LIG_14-3-3_CanoR_1	252	259	PF00244	0.587
LIG_14-3-3_CanoR_1	261	270	PF00244	0.600
LIG_14-3-3_CanoR_1	283	293	PF00244	0.572
LIG_14-3-3_CanoR_1	50	56	PF00244	0.464
LIG_14-3-3_CanoR_1	9	19	PF00244	0.389
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_FHA_1	201	207	PF00498	0.520
LIG_FHA_1	262	268	PF00498	0.502
LIG_FHA_1	63	69	PF00498	0.458
LIG_FHA_2	120	126	PF00498	0.423
LIG_FHA_2	27	33	PF00498	0.494
LIG_FHA_2	289	295	PF00498	0.519
LIG_FHA_2	54	60	PF00498	0.461
LIG_FHA_2	70	76	PF00498	0.501
LIG_LIR_Apic_2	154	160	PF02991	0.555
LIG_LIR_Apic_2	287	293	PF02991	0.559
LIG_LIR_Apic_2	88	92	PF02991	0.429
LIG_LIR_Gen_1	215	223	PF02991	0.585
LIG_LIR_Nem_3	215	220	PF02991	0.587
LIG_LIR_Nem_3	32	37	PF02991	0.485
LIG_LIR_Nem_3	38	43	PF02991	0.498
LIG_LIR_Nem_3	65	70	PF02991	0.489
LIG_LYPXL_S_1	33	37	PF13949	0.258
LIG_SH2_CRK	157	161	PF00017	0.553
LIG_SH2_CRK	217	221	PF00017	0.586
LIG_SH2_CRK	40	44	PF00017	0.470
LIG_SH2_GRB2like	217	220	PF00017	0.587
LIG_SH2_NCK_1	146	150	PF00017	0.689
LIG_SH2_NCK_1	157	161	PF00017	0.512
LIG_SH2_NCK_1	290	294	PF00017	0.545
LIG_SH2_PTP2	101	104	PF00017	0.384
LIG_SH2_STAP1	168	172	PF00017	0.597
LIG_SH2_STAP1	217	221	PF00017	0.586
LIG_SH2_STAT5	101	104	PF00017	0.426
LIG_SH2_STAT5	146	149	PF00017	0.521
LIG_SH2_STAT5	168	171	PF00017	0.577
LIG_SH2_STAT5	27	30	PF00017	0.458
LIG_SH2_STAT5	290	293	PF00017	0.548
LIG_SH3_2	192	197	PF14604	0.557
LIG_SH3_3	189	195	PF00018	0.591
LIG_SH3_3	229	235	PF00018	0.496
LIG_SH3_3	289	295	PF00018	0.477
LIG_TRAF2_1	57	60	PF00917	0.460
LIG_TRAF2_1	92	95	PF00917	0.570
LIG_TYR_ITIM	99	104	PF00017	0.400
LIG_WRC_WIRS_1	86	91	PF05994	0.411
MOD_CDK_SPxxK_3	111	118	PF00069	0.432
MOD_CK1_1	151	157	PF00069	0.588
MOD_CK1_1	179	185	PF00069	0.584
MOD_CK1_1	231	237	PF00069	0.499
MOD_CK1_1	253	259	PF00069	0.687
MOD_CK1_1	263	269	PF00069	0.578
MOD_CK2_1	119	125	PF00069	0.421
MOD_CK2_1	288	294	PF00069	0.597
MOD_CK2_1	53	59	PF00069	0.461
MOD_CK2_1	69	75	PF00069	0.491
MOD_CK2_1	88	94	PF00069	0.547
MOD_CMANNOS	116	119	PF00535	0.411
MOD_GlcNHglycan	132	135	PF01048	0.563
MOD_GlcNHglycan	150	153	PF01048	0.582
MOD_GlcNHglycan	154	157	PF01048	0.673
MOD_GlcNHglycan	170	173	PF01048	0.722
MOD_GlcNHglycan	182	185	PF01048	0.615
MOD_GlcNHglycan	255	258	PF01048	0.589
MOD_GlcNHglycan	309	312	PF01048	0.525
MOD_GSK3_1	107	114	PF00069	0.451
MOD_GSK3_1	130	137	PF00069	0.554
MOD_GSK3_1	144	151	PF00069	0.641
MOD_GSK3_1	152	159	PF00069	0.586
MOD_GSK3_1	166	173	PF00069	0.651
MOD_GSK3_1	176	183	PF00069	0.665
MOD_GSK3_1	224	231	PF00069	0.645
MOD_GSK3_1	253	260	PF00069	0.598
MOD_GSK3_1	284	291	PF00069	0.573
MOD_GSK3_1	302	309	PF00069	0.671
MOD_GSK3_1	49	56	PF00069	0.470
MOD_N-GLC_1	268	273	PF02516	0.680
MOD_NEK2_1	127	132	PF00069	0.505
MOD_NEK2_1	284	289	PF00069	0.617
MOD_NEK2_1	306	311	PF00069	0.531
MOD_NEK2_1	87	92	PF00069	0.424
MOD_NEK2_2	35	40	PF00069	0.464
MOD_PIKK_1	10	16	PF00454	0.401
MOD_PIKK_1	119	125	PF00454	0.421
MOD_PIKK_1	177	183	PF00454	0.606
MOD_PIKK_1	224	230	PF00454	0.487
MOD_PKA_2	127	133	PF00069	0.530
MOD_PKA_2	177	183	PF00069	0.592
MOD_PKA_2	260	266	PF00069	0.612
MOD_PKA_2	284	290	PF00069	0.574
MOD_PKA_2	49	55	PF00069	0.468
MOD_PKA_2	5	11	PF00069	0.461
MOD_Plk_1	250	256	PF00069	0.531
MOD_Plk_2-3	71	77	PF00069	0.473
MOD_Plk_4	263	269	PF00069	0.615
MOD_ProDKin_1	107	113	PF00069	0.420
MOD_ProDKin_1	156	162	PF00069	0.612
MOD_ProDKin_1	231	237	PF00069	0.496
MOD_ProDKin_1	273	279	PF00069	0.496
MOD_ProDKin_1	53	59	PF00069	0.469
MOD_ProDKin_1	88	94	PF00069	0.458
MOD_SUMO_rev_2	90	99	PF00179	0.477
TRG_ENDOCYTIC_2	101	104	PF00928	0.384
TRG_ENDOCYTIC_2	146	149	PF00928	0.631
TRG_ENDOCYTIC_2	217	220	PF00928	0.632
TRG_ENDOCYTIC_2	34	37	PF00928	0.482
TRG_ENDOCYTIC_2	40	43	PF00928	0.501
TRG_ER_diArg_1	127	129	PF00400	0.479
TRG_ER_diArg_1	61	63	PF00400	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M2	Leptomonas seymouri	66%	99%
A0A3S5H7Q7	Leishmania donovani	85%	100%
A4HLK6	Leishmania braziliensis	31%	100%
A4I782	Leishmania infantum	85%	100%
E9B276	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5Y3	Leishmania major	84%	100%