Kinetoplastid_kinetochore_protein_2_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 8, putative

Species:

Leishmania braziliensis

UniProt:

A4HJR3_LEIBR

TriTrypDb:

LbrM.31.3100 , LBRM2903_310040800

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HJR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJR3

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.603
CLV_NRD_NRD_1	188	190	PF00675	0.555
CLV_NRD_NRD_1	19	21	PF00675	0.589
CLV_NRD_NRD_1	271	273	PF00675	0.473
CLV_NRD_NRD_1	284	286	PF00675	0.376
CLV_NRD_NRD_1	309	311	PF00675	0.536
CLV_NRD_NRD_1	339	341	PF00675	0.621
CLV_NRD_NRD_1	428	430	PF00675	0.643
CLV_PCSK_FUR_1	282	286	PF00082	0.530
CLV_PCSK_KEX2_1	19	21	PF00082	0.577
CLV_PCSK_KEX2_1	190	192	PF00082	0.477
CLV_PCSK_KEX2_1	270	272	PF00082	0.488
CLV_PCSK_KEX2_1	282	284	PF00082	0.371
CLV_PCSK_KEX2_1	300	302	PF00082	0.488
CLV_PCSK_KEX2_1	339	341	PF00082	0.621
CLV_PCSK_KEX2_1	427	429	PF00082	0.544
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.477
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.428
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.544
CLV_PCSK_SKI1_1	344	348	PF00082	0.558
CLV_Separin_Metazoa	61	65	PF03568	0.496
DEG_APCC_DBOX_1	178	186	PF00400	0.495
DEG_SPOP_SBC_1	63	67	PF00917	0.495
DOC_MAPK_gen_1	179	187	PF00069	0.460
DOC_MAPK_gen_1	427	433	PF00069	0.570
DOC_MAPK_MEF2A_6	179	187	PF00069	0.321
DOC_MAPK_MEF2A_6	212	221	PF00069	0.504
DOC_PP1_RVXF_1	342	349	PF00149	0.535
DOC_PP2B_LxvP_1	39	42	PF13499	0.578
DOC_PP4_FxxP_1	141	144	PF00568	0.458
DOC_USP7_MATH_1	350	354	PF00917	0.560
DOC_USP7_MATH_1	49	53	PF00917	0.658
DOC_USP7_MATH_1	63	67	PF00917	0.718
DOC_USP7_MATH_1	89	93	PF00917	0.587
DOC_USP7_MATH_1	99	103	PF00917	0.468
DOC_USP7_UBL2_3	307	311	PF12436	0.522
DOC_WW_Pin1_4	10	15	PF00397	0.537
DOC_WW_Pin1_4	87	92	PF00397	0.721
LIG_14-3-3_CanoR_1	10	14	PF00244	0.538
LIG_14-3-3_CanoR_1	138	142	PF00244	0.594
LIG_14-3-3_CanoR_1	212	217	PF00244	0.536
LIG_14-3-3_CanoR_1	339	346	PF00244	0.567
LIG_14-3-3_CanoR_1	40	46	PF00244	0.632
LIG_14-3-3_CanoR_1	64	70	PF00244	0.705
LIG_14-3-3_CanoR_1	75	79	PF00244	0.616
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_BRCT_BRCA1_1	412	416	PF00533	0.684
LIG_CaM_IQ_9	182	198	PF13499	0.539
LIG_CaM_IQ_9	325	341	PF13499	0.431
LIG_FHA_1	11	17	PF00498	0.533
LIG_FHA_1	213	219	PF00498	0.482
LIG_FHA_1	254	260	PF00498	0.570
LIG_FHA_1	297	303	PF00498	0.421
LIG_FHA_1	65	71	PF00498	0.498
LIG_FHA_2	369	375	PF00498	0.730
LIG_IBAR_NPY_1	105	107	PF08397	0.662
LIG_LIR_Apic_2	140	144	PF02991	0.607
LIG_LIR_Apic_2	211	217	PF02991	0.468
LIG_LIR_Apic_2	27	32	PF02991	0.613
LIG_LIR_Apic_2	96	101	PF02991	0.689
LIG_LIR_Gen_1	200	207	PF02991	0.422
LIG_LIR_Gen_1	275	281	PF02991	0.421
LIG_LIR_Nem_3	27	31	PF02991	0.613
LIG_LIR_Nem_3	275	280	PF02991	0.408
LIG_LIR_Nem_3	292	297	PF02991	0.410
LIG_LYPXL_yS_3	151	154	PF13949	0.669
LIG_MYND_1	152	156	PF01753	0.575
LIG_SH2_CRK	29	33	PF00017	0.690
LIG_SH2_CRK	6	10	PF00017	0.623
LIG_SH2_CRK	98	102	PF00017	0.571
LIG_SH2_NCK_1	29	33	PF00017	0.690
LIG_SH2_NCK_1	98	102	PF00017	0.571
LIG_SH2_SRC	360	363	PF00017	0.451
LIG_SH2_STAP1	360	364	PF00017	0.455
LIG_SH2_STAT3	129	132	PF00017	0.648
LIG_SH2_STAT5	129	132	PF00017	0.576
LIG_SH2_STAT5	198	201	PF00017	0.547
LIG_SH2_STAT5	214	217	PF00017	0.504
LIG_SH2_STAT5	258	261	PF00017	0.551
LIG_SH2_STAT5	29	32	PF00017	0.581
LIG_SH2_STAT5	294	297	PF00017	0.510
LIG_SH2_STAT5	383	386	PF00017	0.677
LIG_SH3_3	100	106	PF00018	0.554
LIG_SH3_3	117	123	PF00018	0.648
LIG_SH3_3	146	152	PF00018	0.634
LIG_SUMO_SIM_par_1	368	376	PF11976	0.627
LIG_TRAF2_1	172	175	PF00917	0.496
LIG_WW_1	14	17	PF00397	0.531
MOD_CDK_SPxxK_3	87	94	PF00069	0.491
MOD_CK1_1	108	114	PF00069	0.476
MOD_CK1_1	137	143	PF00069	0.474
MOD_CK1_1	27	33	PF00069	0.636
MOD_CK1_1	363	369	PF00069	0.687
MOD_CK1_1	381	387	PF00069	0.691
MOD_CK1_1	93	99	PF00069	0.523
MOD_CK2_1	362	368	PF00069	0.627
MOD_Cter_Amidation	337	340	PF01082	0.612
MOD_DYRK1A_RPxSP_1	10	14	PF00069	0.538
MOD_GlcNHglycan	1	4	PF01048	0.729
MOD_GlcNHglycan	336	339	PF01048	0.638
MOD_GlcNHglycan	340	343	PF01048	0.624
MOD_GlcNHglycan	361	365	PF01048	0.627
MOD_GlcNHglycan	384	387	PF01048	0.735
MOD_GlcNHglycan	396	399	PF01048	0.739
MOD_GlcNHglycan	51	54	PF01048	0.563
MOD_GlcNHglycan	6	9	PF01048	0.661
MOD_GlcNHglycan	95	98	PF01048	0.639
MOD_GSK3_1	105	112	PF00069	0.453
MOD_GSK3_1	334	341	PF00069	0.607
MOD_GSK3_1	373	380	PF00069	0.703
MOD_GSK3_1	382	389	PF00069	0.657
MOD_GSK3_1	4	11	PF00069	0.699
MOD_GSK3_1	410	417	PF00069	0.589
MOD_GSK3_1	49	56	PF00069	0.643
MOD_GSK3_1	65	72	PF00069	0.598
MOD_GSK3_1	80	87	PF00069	0.621
MOD_GSK3_1	89	96	PF00069	0.641
MOD_N-GLC_1	418	423	PF02516	0.628
MOD_NEK2_1	197	202	PF00069	0.488
MOD_NEK2_1	9	14	PF00069	0.554
MOD_PIKK_1	105	111	PF00454	0.599
MOD_PIKK_1	248	254	PF00454	0.548
MOD_PIKK_1	311	317	PF00454	0.504
MOD_PKA_2	137	143	PF00069	0.555
MOD_PKA_2	338	344	PF00069	0.646
MOD_PKA_2	63	69	PF00069	0.707
MOD_PKA_2	74	80	PF00069	0.650
MOD_PKA_2	9	15	PF00069	0.539
MOD_PKA_2	93	99	PF00069	0.691
MOD_Plk_1	350	356	PF00069	0.635
MOD_Plk_1	73	79	PF00069	0.659
MOD_Plk_2-3	262	268	PF00069	0.460
MOD_Plk_2-3	368	374	PF00069	0.692
MOD_Plk_4	125	131	PF00069	0.680
MOD_Plk_4	24	30	PF00069	0.689
MOD_Plk_4	350	356	PF00069	0.539
MOD_Plk_4	421	427	PF00069	0.641
MOD_Plk_4	65	71	PF00069	0.626
MOD_Plk_4	99	105	PF00069	0.584
MOD_ProDKin_1	10	16	PF00069	0.535
MOD_ProDKin_1	87	93	PF00069	0.719
MOD_SUMO_rev_2	292	302	PF00179	0.428
MOD_SUMO_rev_2	417	424	PF00179	0.564
TRG_DiLeu_BaEn_4	173	179	PF01217	0.397
TRG_DiLeu_BaEn_4	194	200	PF01217	0.491
TRG_ENDOCYTIC_2	151	154	PF00928	0.669
TRG_ENDOCYTIC_2	28	31	PF00928	0.724
TRG_ENDOCYTIC_2	294	297	PF00928	0.505
TRG_ENDOCYTIC_2	6	9	PF00928	0.743
TRG_ER_diArg_1	18	20	PF00400	0.602
TRG_ER_diArg_1	270	272	PF00400	0.471
TRG_ER_diArg_1	282	285	PF00400	0.384
TRG_ER_FFAT_2	381	389	PF00635	0.585
TRG_NLS_MonoCore_2	426	431	PF00514	0.632
TRG_NLS_MonoExtC_3	426	432	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	310	315	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH8	Leptomonas seymouri	61%	100%
A0A0S4JLB3	Bodo saltans	26%	80%
A0A1X0NJ59	Trypanosomatidae	37%	100%
A0A3S7X4V3	Leishmania donovani	85%	100%
A0A422NPB6	Trypanosoma rangeli	38%	100%
A4I780	Leishmania infantum	85%	100%
C9ZMG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B274	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4Q5Y5	Leishmania major	85%	100%
V5D822	Trypanosoma cruzi	40%	100%