Endoplasmic reticulum vesicle transporter-domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HJR2_LEIBR

TriTrypDb:

LbrM.31.3090 , LBRM2903_310040700

Length:

541

Annotations

LeishMANIAdb annotations

A conserved ERGIC3 protein in all eukaryotes.. The N-terminal signal-anchor is very similar to a full signal peptide.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HJR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	412	416	PF00656	0.253
CLV_NRD_NRD_1	149	151	PF00675	0.309
CLV_NRD_NRD_1	365	367	PF00675	0.484
CLV_NRD_NRD_1	375	377	PF00675	0.428
CLV_NRD_NRD_1	51	53	PF00675	0.289
CLV_NRD_NRD_1	529	531	PF00675	0.308
CLV_NRD_NRD_1	532	534	PF00675	0.305
CLV_NRD_NRD_1	74	76	PF00675	0.362
CLV_PCSK_KEX2_1	140	142	PF00082	0.291
CLV_PCSK_KEX2_1	365	367	PF00082	0.524
CLV_PCSK_KEX2_1	51	53	PF00082	0.289
CLV_PCSK_KEX2_1	76	78	PF00082	0.353
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.216
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.353
CLV_PCSK_SKI1_1	137	141	PF00082	0.317
CLV_PCSK_SKI1_1	183	187	PF00082	0.416
CLV_PCSK_SKI1_1	263	267	PF00082	0.576
CLV_PCSK_SKI1_1	29	33	PF00082	0.335
CLV_PCSK_SKI1_1	326	330	PF00082	0.553
DEG_APCC_KENBOX_2	275	279	PF00400	0.372
DEG_Nend_UBRbox_4	1	3	PF02207	0.523
DEG_SCF_FBW7_1	102	108	PF00400	0.540
DOC_CKS1_1	102	107	PF01111	0.679
DOC_CKS1_1	36	41	PF01111	0.494
DOC_CYCLIN_RxL_1	26	33	PF00134	0.531
DOC_CYCLIN_RxL_1	373	383	PF00134	0.231
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.527
DOC_MAPK_gen_1	51	59	PF00069	0.495
DOC_MAPK_HePTP_8	49	61	PF00069	0.495
DOC_MAPK_MEF2A_6	205	212	PF00069	0.321
DOC_MAPK_MEF2A_6	52	61	PF00069	0.499
DOC_PP2B_LxvP_1	32	35	PF13499	0.527
DOC_PP2B_LxvP_1	96	99	PF13499	0.632
DOC_PP4_FxxP_1	61	64	PF00568	0.517
DOC_USP7_MATH_1	348	352	PF00917	0.347
DOC_USP7_MATH_1	404	408	PF00917	0.298
DOC_USP7_MATH_1	496	500	PF00917	0.207
DOC_USP7_UBL2_3	147	151	PF12436	0.441
DOC_USP7_UBL2_3	263	267	PF12436	0.371
DOC_WW_Pin1_4	101	106	PF00397	0.680
DOC_WW_Pin1_4	285	290	PF00397	0.167
DOC_WW_Pin1_4	35	40	PF00397	0.499
DOC_WW_Pin1_4	454	459	PF00397	0.227
DOC_WW_Pin1_4	465	470	PF00397	0.216
DOC_WW_Pin1_4	482	487	PF00397	0.177
LIG_14-3-3_CanoR_1	157	162	PF00244	0.416
LIG_14-3-3_CanoR_1	205	209	PF00244	0.233
LIG_14-3-3_CanoR_1	29	35	PF00244	0.531
LIG_14-3-3_CanoR_1	420	424	PF00244	0.224
LIG_14-3-3_CanoR_1	434	438	PF00244	0.216
LIG_14-3-3_CanoR_1	75	81	PF00244	0.557
LIG_BIR_III_4	270	274	PF00653	0.378
LIG_BRCT_BRCA1_1	350	354	PF00533	0.317
LIG_BRCT_BRCA1_1	522	526	PF00533	0.493
LIG_Clathr_ClatBox_1	219	223	PF01394	0.283
LIG_EH1_1	165	173	PF00400	0.239
LIG_eIF4E_1	432	438	PF01652	0.283
LIG_FHA_1	106	112	PF00498	0.594
LIG_FHA_1	116	122	PF00498	0.524
LIG_FHA_1	128	134	PF00498	0.483
LIG_FHA_1	205	211	PF00498	0.279
LIG_FHA_1	246	252	PF00498	0.375
LIG_FHA_1	264	270	PF00498	0.269
LIG_FHA_1	347	353	PF00498	0.216
LIG_FHA_1	479	485	PF00498	0.259
LIG_FHA_2	293	299	PF00498	0.207
LIG_FHA_2	468	474	PF00498	0.340
LIG_Integrin_isoDGR_2	418	420	PF01839	0.427
LIG_LIR_Gen_1	118	128	PF02991	0.496
LIG_LIR_Gen_1	211	220	PF02991	0.253
LIG_LIR_Gen_1	422	432	PF02991	0.221
LIG_LIR_Gen_1	523	532	PF02991	0.580
LIG_LIR_Nem_3	118	123	PF02991	0.493
LIG_LIR_Nem_3	143	148	PF02991	0.416
LIG_LIR_Nem_3	211	215	PF02991	0.207
LIG_LIR_Nem_3	226	231	PF02991	0.207
LIG_LIR_Nem_3	422	427	PF02991	0.221
LIG_LIR_Nem_3	430	435	PF02991	0.231
LIG_LIR_Nem_3	523	529	PF02991	0.494
LIG_LYPXL_yS_3	497	500	PF13949	0.259
LIG_MAD2	488	496	PF02301	0.253
LIG_Pex14_2	148	152	PF04695	0.416
LIG_Pex14_2	389	393	PF04695	0.216
LIG_SH2_CRK	360	364	PF00017	0.152
LIG_SH2_CRK	435	439	PF00017	0.340
LIG_SH2_NCK_1	435	439	PF00017	0.324
LIG_SH2_STAP1	340	344	PF00017	0.253
LIG_SH2_STAT5	184	187	PF00017	0.221
LIG_SH2_STAT5	42	45	PF00017	0.612
LIG_SH2_STAT5	423	426	PF00017	0.224
LIG_SH2_STAT5	450	453	PF00017	0.170
LIG_SH3_3	110	116	PF00018	0.546
LIG_SH3_3	34	40	PF00018	0.632
LIG_SH3_3	96	102	PF00018	0.695
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.260
LIG_SUMO_SIM_par_1	218	223	PF11976	0.317
LIG_TRAF2_1	187	190	PF00917	0.283
LIG_TRAF2_1	470	473	PF00917	0.152
LIG_TRFH_1	482	486	PF08558	0.216
LIG_WRC_WIRS_1	340	345	PF05994	0.253
LIG_WW_1	39	42	PF00397	0.481
MOD_CDC14_SPxK_1	485	488	PF00782	0.207
MOD_CDK_SPxK_1	482	488	PF00069	0.188
MOD_CK1_1	126	132	PF00069	0.569
MOD_CK1_1	20	26	PF00069	0.515
MOD_CK1_1	346	352	PF00069	0.300
MOD_CK1_1	407	413	PF00069	0.317
MOD_CK1_1	436	442	PF00069	0.317
MOD_CK1_1	459	465	PF00069	0.237
MOD_CK1_1	92	98	PF00069	0.659
MOD_CK2_1	184	190	PF00069	0.241
MOD_CK2_1	467	473	PF00069	0.340
MOD_CK2_1	76	82	PF00069	0.539
MOD_Cter_Amidation	363	366	PF01082	0.517
MOD_GlcNHglycan	161	164	PF01048	0.306
MOD_GlcNHglycan	252	255	PF01048	0.660
MOD_GlcNHglycan	32	35	PF01048	0.327
MOD_GlcNHglycan	372	375	PF01048	0.418
MOD_GlcNHglycan	406	409	PF01048	0.517
MOD_GlcNHglycan	458	461	PF01048	0.478
MOD_GSK3_1	101	108	PF00069	0.539
MOD_GSK3_1	123	130	PF00069	0.568
MOD_GSK3_1	17	24	PF00069	0.519
MOD_GSK3_1	204	211	PF00069	0.271
MOD_GSK3_1	339	346	PF00069	0.349
MOD_GSK3_1	400	407	PF00069	0.253
MOD_GSK3_1	444	451	PF00069	0.248
MOD_GSK3_1	459	466	PF00069	0.255
MOD_GSK3_1	478	485	PF00069	0.216
MOD_N-GLC_1	123	128	PF02516	0.298
MOD_N-GLC_1	208	213	PF02516	0.407
MOD_NEK2_1	123	128	PF00069	0.562
MOD_NEK2_1	204	209	PF00069	0.278
MOD_NEK2_1	30	35	PF00069	0.530
MOD_NEK2_1	339	344	PF00069	0.263
MOD_NEK2_1	370	375	PF00069	0.232
MOD_NEK2_1	378	383	PF00069	0.183
MOD_NEK2_1	400	405	PF00069	0.279
MOD_NEK2_1	520	525	PF00069	0.348
MOD_NEK2_1	89	94	PF00069	0.528
MOD_NEK2_2	525	530	PF00069	0.492
MOD_OFUCOSY	15	21	PF10250	0.323
MOD_PIKK_1	21	27	PF00454	0.517
MOD_PIKK_1	463	469	PF00454	0.349
MOD_PIKK_1	66	72	PF00454	0.536
MOD_PIKK_1	89	95	PF00454	0.521
MOD_PK_1	76	82	PF00069	0.539
MOD_PKA_1	76	82	PF00069	0.539
MOD_PKA_2	204	210	PF00069	0.233
MOD_PKA_2	346	352	PF00069	0.216
MOD_PKA_2	419	425	PF00069	0.216
MOD_PKA_2	433	439	PF00069	0.216
MOD_PKA_2	76	82	PF00069	0.700
MOD_PKB_1	157	165	PF00069	0.517
MOD_Plk_1	123	129	PF00069	0.499
MOD_Plk_1	208	214	PF00069	0.210
MOD_Plk_1	236	242	PF00069	0.411
MOD_Plk_1	313	319	PF00069	0.207
MOD_Plk_2-3	218	224	PF00069	0.283
MOD_Plk_2-3	313	319	PF00069	0.259
MOD_Plk_4	433	439	PF00069	0.231
MOD_Plk_4	496	502	PF00069	0.181
MOD_Plk_4	513	519	PF00069	0.268
MOD_ProDKin_1	101	107	PF00069	0.679
MOD_ProDKin_1	285	291	PF00069	0.167
MOD_ProDKin_1	35	41	PF00069	0.498
MOD_ProDKin_1	454	460	PF00069	0.227
MOD_ProDKin_1	465	471	PF00069	0.216
MOD_ProDKin_1	482	488	PF00069	0.177
MOD_SUMO_rev_2	143	152	PF00179	0.441
MOD_SUMO_rev_2	260	265	PF00179	0.377
MOD_SUMO_rev_2	407	416	PF00179	0.253
MOD_SUMO_rev_2	72	78	PF00179	0.557
TRG_DiLeu_BaEn_2	180	186	PF01217	0.283
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.531
TRG_ENDOCYTIC_2	340	343	PF00928	0.283
TRG_ENDOCYTIC_2	360	363	PF00928	0.120
TRG_ENDOCYTIC_2	42	45	PF00928	0.487
TRG_ENDOCYTIC_2	435	438	PF00928	0.319
TRG_ENDOCYTIC_2	497	500	PF00928	0.207
TRG_ER_diArg_1	27	30	PF00400	0.534
TRG_ER_diArg_1	365	367	PF00400	0.298
TRG_ER_diArg_1	50	52	PF00400	0.486
TRG_NLS_MonoExtC_3	529	534	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S9	Leptomonas seymouri	23%	100%
A0A0N0P4A5	Leptomonas seymouri	73%	100%
A0A0S4JE72	Bodo saltans	50%	100%
A0A0S4JXT2	Bodo saltans	23%	100%
A0A1X0NIB7	Trypanosomatidae	59%	100%
A0A1X0NVX1	Trypanosomatidae	24%	100%
A0A3Q8IGE1	Leishmania donovani	86%	100%
A0A3R7KGP9	Trypanosoma rangeli	59%	100%
A0A3R7MPC0	Trypanosoma rangeli	28%	100%
A0A3S5H6H6	Leishmania donovani	25%	100%
A4HUR4	Leishmania infantum	25%	100%
A4I779	Leishmania infantum	86%	100%
C9ZMG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZWM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D0A7P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9ANE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B273	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P39727	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q09895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q4Q5Y6	Leishmania major	87%	100%
Q4QH78	Leishmania major	23%	92%
Q4R5C3	Macaca fascicularis	21%	100%
Q4R8X1	Macaca fascicularis	34%	100%
Q54DW2	Dictyostelium discoideum	36%	100%
Q5EAE0	Bos taurus	34%	100%
Q5R8G3	Pongo abelii	34%	100%
Q66KH2	Xenopus laevis	32%	100%
Q6NVS2	Xenopus tropicalis	32%	100%
Q803I2	Danio rerio	33%	100%
Q96RQ1	Homo sapiens	21%	100%
Q9CQE7	Mus musculus	33%	100%
Q9CR89	Mus musculus	22%	100%
Q9Y282	Homo sapiens	34%	100%
V5AS26	Trypanosoma cruzi	59%	100%
V5BGJ7	Trypanosoma cruzi	28%	100%