Regulator_of_chromosome_condensation_(RCC1)_repea t

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of chromosome condensation (RCC1) repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HJR0_LEIBR

TriTrypDb:

LbrM.31.3070 , LBRM2903_310040500

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.676
CLV_C14_Caspase3-7	244	248	PF00656	0.410
CLV_C14_Caspase3-7	75	79	PF00656	0.446
CLV_NRD_NRD_1	186	188	PF00675	0.351
CLV_NRD_NRD_1	3	5	PF00675	0.463
CLV_NRD_NRD_1	43	45	PF00675	0.531
CLV_NRD_NRD_1	521	523	PF00675	0.556
CLV_PCSK_FUR_1	519	523	PF00082	0.530
CLV_PCSK_KEX2_1	186	188	PF00082	0.351
CLV_PCSK_KEX2_1	205	207	PF00082	0.435
CLV_PCSK_KEX2_1	3	5	PF00082	0.463
CLV_PCSK_KEX2_1	43	45	PF00082	0.531
CLV_PCSK_KEX2_1	457	459	PF00082	0.523
CLV_PCSK_KEX2_1	521	523	PF00082	0.657
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.334
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.419
CLV_PCSK_SKI1_1	274	278	PF00082	0.382
CLV_PCSK_SKI1_1	284	288	PF00082	0.282
CLV_PCSK_SKI1_1	57	61	PF00082	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.523
DEG_ODPH_VHL_1	461	473	PF01847	0.519
DEG_SCF_FBW7_1	475	482	PF00400	0.341
DOC_CKS1_1	476	481	PF01111	0.419
DOC_MAPK_gen_1	281	290	PF00069	0.309
DOC_MAPK_MEF2A_6	163	171	PF00069	0.517
DOC_PP1_RVXF_1	185	192	PF00149	0.362
DOC_PP1_RVXF_1	272	279	PF00149	0.341
DOC_USP7_MATH_1	172	176	PF00917	0.392
DOC_USP7_MATH_1	407	411	PF00917	0.532
DOC_WW_Pin1_4	120	125	PF00397	0.695
DOC_WW_Pin1_4	163	168	PF00397	0.565
DOC_WW_Pin1_4	18	23	PF00397	0.517
DOC_WW_Pin1_4	30	35	PF00397	0.469
DOC_WW_Pin1_4	383	388	PF00397	0.406
DOC_WW_Pin1_4	475	480	PF00397	0.417
DOC_WW_Pin1_4	62	67	PF00397	0.670
LIG_14-3-3_CanoR_1	136	141	PF00244	0.674
LIG_14-3-3_CanoR_1	142	150	PF00244	0.602
LIG_14-3-3_CanoR_1	519	528	PF00244	0.639
LIG_14-3-3_CanoR_1	57	63	PF00244	0.708
LIG_BIR_III_2	36	40	PF00653	0.380
LIG_BRCT_BRCA1_1	385	389	PF00533	0.403
LIG_CSL_BTD_1	221	224	PF09270	0.287
LIG_deltaCOP1_diTrp_1	215	223	PF00928	0.397
LIG_EH1_1	414	422	PF00400	0.355
LIG_eIF4E_1	415	421	PF01652	0.276
LIG_EVH1_2	316	320	PF00568	0.497
LIG_FHA_1	104	110	PF00498	0.530
LIG_FHA_1	141	147	PF00498	0.427
LIG_FHA_1	271	277	PF00498	0.199
LIG_FHA_1	293	299	PF00498	0.300
LIG_FHA_1	424	430	PF00498	0.349
LIG_FHA_1	449	455	PF00498	0.537
LIG_FHA_1	5	11	PF00498	0.446
LIG_FHA_1	506	512	PF00498	0.572
LIG_FHA_1	523	529	PF00498	0.554
LIG_FHA_2	242	248	PF00498	0.474
LIG_KLC1_Yacidic_2	151	156	PF13176	0.508
LIG_LIR_Apic_2	500	505	PF02991	0.621
LIG_LIR_Gen_1	151	162	PF02991	0.516
LIG_LIR_Gen_1	175	181	PF02991	0.315
LIG_LIR_Gen_1	293	300	PF02991	0.277
LIG_LIR_Gen_1	386	397	PF02991	0.383
LIG_LIR_Gen_1	413	421	PF02991	0.425
LIG_LIR_Gen_1	71	81	PF02991	0.454
LIG_LIR_Nem_3	151	157	PF02991	0.456
LIG_LIR_Nem_3	175	180	PF02991	0.315
LIG_LIR_Nem_3	293	297	PF02991	0.277
LIG_LIR_Nem_3	379	383	PF02991	0.415
LIG_LIR_Nem_3	386	392	PF02991	0.385
LIG_LIR_Nem_3	413	418	PF02991	0.439
LIG_LIR_Nem_3	468	474	PF02991	0.478
LIG_LIR_Nem_3	71	77	PF02991	0.418
LIG_PCNA_PIPBox_1	394	403	PF02747	0.290
LIG_PCNA_yPIPBox_3	388	401	PF02747	0.281
LIG_Pex14_2	492	496	PF04695	0.436
LIG_PTB_Apo_2	97	104	PF02174	0.394
LIG_PTB_Phospho_1	97	103	PF10480	0.397
LIG_REV1ctd_RIR_1	275	285	PF16727	0.335
LIG_SH2_CRK	380	384	PF00017	0.428
LIG_SH2_NCK_1	415	419	PF00017	0.429
LIG_SH2_NCK_1	502	506	PF00017	0.451
LIG_SH2_NCK_1	74	78	PF00017	0.454
LIG_SH2_PTP2	154	157	PF00017	0.411
LIG_SH2_SRC	181	184	PF00017	0.294
LIG_SH2_SRC	415	418	PF00017	0.428
LIG_SH2_STAT5	154	157	PF00017	0.411
LIG_SH2_STAT5	400	403	PF00017	0.404
LIG_SH3_2	269	274	PF14604	0.335
LIG_SH3_3	17	23	PF00018	0.522
LIG_SH3_3	266	272	PF00018	0.276
LIG_SH3_3	320	326	PF00018	0.501
LIG_SH3_3	379	385	PF00018	0.410
LIG_SH3_3	418	424	PF00018	0.347
LIG_SH3_3	473	479	PF00018	0.461
LIG_SH3_3	528	534	PF00018	0.753
LIG_SH3_3	64	70	PF00018	0.488
LIG_SUMO_SIM_anti_2	416	422	PF11976	0.343
LIG_SUMO_SIM_par_1	85	90	PF11976	0.391
LIG_WRC_WIRS_1	250	255	PF05994	0.272
MOD_CDC14_SPxK_1	65	68	PF00782	0.451
MOD_CDK_SPK_2	383	388	PF00069	0.406
MOD_CDK_SPxK_1	62	68	PF00069	0.458
MOD_CDK_SPxxK_3	163	170	PF00069	0.352
MOD_CK1_1	175	181	PF00069	0.321
MOD_CK1_1	517	523	PF00069	0.651
MOD_CK2_1	226	232	PF00069	0.419
MOD_CK2_1	373	379	PF00069	0.397
MOD_CK2_1	500	506	PF00069	0.436
MOD_Cter_Amidation	455	458	PF01082	0.434
MOD_GlcNHglycan	143	146	PF01048	0.537
MOD_GlcNHglycan	208	211	PF01048	0.455
MOD_GlcNHglycan	487	490	PF01048	0.378
MOD_GlcNHglycan	516	519	PF01048	0.652
MOD_GSK3_1	120	127	PF00069	0.755
MOD_GSK3_1	128	135	PF00069	0.679
MOD_GSK3_1	136	143	PF00069	0.558
MOD_GSK3_1	157	164	PF00069	0.382
MOD_GSK3_1	226	233	PF00069	0.394
MOD_GSK3_1	292	299	PF00069	0.276
MOD_GSK3_1	475	482	PF00069	0.443
MOD_GSK3_1	500	507	PF00069	0.442
MOD_GSK3_1	517	524	PF00069	0.529
MOD_GSK3_1	58	65	PF00069	0.664
MOD_N-GLC_1	175	180	PF02516	0.342
MOD_N-GLC_1	448	453	PF02516	0.534
MOD_N-GLC_1	465	470	PF02516	0.564
MOD_N-GLC_2	433	435	PF02516	0.363
MOD_NEK2_1	157	162	PF00069	0.330
MOD_NEK2_1	27	32	PF00069	0.481
MOD_NEK2_1	290	295	PF00069	0.393
MOD_NEK2_1	327	332	PF00069	0.489
MOD_NEK2_1	480	485	PF00069	0.550
MOD_PK_1	136	142	PF00069	0.672
MOD_PKA_1	521	527	PF00069	0.524
MOD_PKA_2	135	141	PF00069	0.677
MOD_PKA_2	520	526	PF00069	0.629
MOD_PKA_2	529	535	PF00069	0.567
MOD_PKB_1	519	527	PF00069	0.522
MOD_Plk_1	175	181	PF00069	0.322
MOD_Plk_2-3	500	506	PF00069	0.436
MOD_Plk_4	136	142	PF00069	0.693
MOD_Plk_4	226	232	PF00069	0.509
MOD_Plk_4	423	429	PF00069	0.333
MOD_ProDKin_1	120	126	PF00069	0.697
MOD_ProDKin_1	163	169	PF00069	0.550
MOD_ProDKin_1	18	24	PF00069	0.510
MOD_ProDKin_1	30	36	PF00069	0.472
MOD_ProDKin_1	383	389	PF00069	0.400
MOD_ProDKin_1	475	481	PF00069	0.411
MOD_ProDKin_1	62	68	PF00069	0.669
MOD_SUMO_for_1	367	370	PF00179	0.471
TRG_DiLeu_BaEn_1	379	384	PF01217	0.284
TRG_ENDOCYTIC_2	154	157	PF00928	0.411
TRG_ENDOCYTIC_2	380	383	PF00928	0.531
TRG_ENDOCYTIC_2	415	418	PF00928	0.531
TRG_ENDOCYTIC_2	42	45	PF00928	0.461
TRG_ENDOCYTIC_2	74	77	PF00928	0.513
TRG_ER_diArg_1	186	188	PF00400	0.378
TRG_ER_diArg_1	2	4	PF00400	0.486
TRG_ER_diArg_1	42	44	PF00400	0.611
TRG_ER_diArg_1	519	522	PF00400	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIU3	Leptomonas seymouri	69%	99%
A0A0S4JSP7	Bodo saltans	34%	86%
A0A3Q8ICS2	Leishmania donovani	84%	100%
A4I777	Leishmania infantum	84%	100%
C9ZWM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B271	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q5Y8	Leishmania major	86%	100%
V5BGM3	Trypanosoma cruzi	54%	100%