Phosphatidylinositol-4-phosphate 5-kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol-4-phosphate 5-kinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJQ8_LEIBR

TriTrypDb:

LbrM.31.3050 , LBRM2903_310040100

Length:

1084

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0044237	cellular metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003774	cytoskeletal motor activity	1	7
GO:0003777	microtubule motor activity	2	7
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0005524	ATP binding	5	7
GO:0008017	microtubule binding	5	7
GO:0008092	cytoskeletal protein binding	3	7
GO:0015631	tubulin binding	4	7
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.552
CLV_C14_Caspase3-7	414	418	PF00656	0.779
CLV_C14_Caspase3-7	493	497	PF00656	0.528
CLV_C14_Caspase3-7	62	66	PF00656	0.430
CLV_C14_Caspase3-7	659	663	PF00656	0.383
CLV_C14_Caspase3-7	760	764	PF00656	0.539
CLV_C14_Caspase3-7	906	910	PF00656	0.249
CLV_NRD_NRD_1	270	272	PF00675	0.495
CLV_NRD_NRD_1	291	293	PF00675	0.547
CLV_NRD_NRD_1	357	359	PF00675	0.595
CLV_NRD_NRD_1	623	625	PF00675	0.746
CLV_NRD_NRD_1	703	705	PF00675	0.600
CLV_NRD_NRD_1	728	730	PF00675	0.407
CLV_NRD_NRD_1	915	917	PF00675	0.395
CLV_PCSK_KEX2_1	293	295	PF00082	0.514
CLV_PCSK_KEX2_1	623	625	PF00082	0.512
CLV_PCSK_KEX2_1	703	705	PF00082	0.577
CLV_PCSK_KEX2_1	728	730	PF00082	0.407
CLV_PCSK_KEX2_1	849	851	PF00082	0.362
CLV_PCSK_KEX2_1	914	916	PF00082	0.392
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.514
CLV_PCSK_PC1ET2_1	849	851	PF00082	0.362
CLV_PCSK_PC1ET2_1	914	916	PF00082	0.392
CLV_PCSK_SKI1_1	211	215	PF00082	0.376
CLV_PCSK_SKI1_1	217	221	PF00082	0.486
CLV_PCSK_SKI1_1	41	45	PF00082	0.610
CLV_PCSK_SKI1_1	427	431	PF00082	0.567
CLV_PCSK_SKI1_1	441	445	PF00082	0.632
CLV_PCSK_SKI1_1	619	623	PF00082	0.655
CLV_PCSK_SKI1_1	696	700	PF00082	0.506
CLV_PCSK_SKI1_1	703	707	PF00082	0.508
CLV_PCSK_SKI1_1	769	773	PF00082	0.455
CLV_PCSK_SKI1_1	830	834	PF00082	0.440
CLV_PCSK_SKI1_1	849	853	PF00082	0.223
CLV_Separin_Metazoa	577	581	PF03568	0.613
DEG_APCC_DBOX_1	251	259	PF00400	0.567
DEG_APCC_KENBOX_2	133	137	PF00400	0.249
DEG_Nend_UBRbox_3	1	3	PF02207	0.502
DOC_AGCK_PIF_1	852	857	PF00069	0.501
DOC_AGCK_PIF_2	780	785	PF00069	0.249
DOC_CYCLIN_RxL_1	38	48	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	800	806	PF00134	0.501
DOC_MAPK_FxFP_2	51	54	PF00069	0.524
DOC_MAPK_gen_1	215	222	PF00069	0.472
DOC_MAPK_gen_1	292	301	PF00069	0.556
DOC_MAPK_gen_1	367	376	PF00069	0.526
DOC_MAPK_gen_1	638	647	PF00069	0.632
DOC_MAPK_MEF2A_6	536	544	PF00069	0.483
DOC_MAPK_MEF2A_6	995	1003	PF00069	0.249
DOC_PP1_RVXF_1	215	222	PF00149	0.474
DOC_PP1_RVXF_1	890	897	PF00149	0.501
DOC_PP1_SILK_1	288	293	PF00149	0.563
DOC_PP4_FxxP_1	399	402	PF00568	0.572
DOC_PP4_FxxP_1	51	54	PF00568	0.524
DOC_PP4_FxxP_1	888	891	PF00568	0.501
DOC_USP7_MATH_1	1064	1068	PF00917	0.687
DOC_USP7_MATH_1	267	271	PF00917	0.723
DOC_USP7_MATH_1	286	290	PF00917	0.568
DOC_USP7_MATH_1	402	406	PF00917	0.649
DOC_USP7_MATH_1	563	567	PF00917	0.773
DOC_USP7_MATH_1	592	596	PF00917	0.681
DOC_USP7_MATH_1	958	962	PF00917	0.448
DOC_USP7_MATH_1	970	974	PF00917	0.419
DOC_USP7_UBL2_3	338	342	PF12436	0.459
DOC_USP7_UBL2_3	378	382	PF12436	0.731
DOC_USP7_UBL2_3	38	42	PF12436	0.760
DOC_USP7_UBL2_3	451	455	PF12436	0.635
DOC_USP7_UBL2_3	696	700	PF12436	0.485
DOC_USP7_UBL2_3	838	842	PF12436	0.501
DOC_USP7_UBL2_3	88	92	PF12436	0.430
DOC_WW_Pin1_4	406	411	PF00397	0.622
DOC_WW_Pin1_4	508	513	PF00397	0.795
DOC_WW_Pin1_4	559	564	PF00397	0.729
LIG_14-3-3_CanoR_1	1017	1023	PF00244	0.430
LIG_14-3-3_CanoR_1	474	478	PF00244	0.675
LIG_14-3-3_CanoR_1	531	538	PF00244	0.450
LIG_14-3-3_CanoR_1	551	557	PF00244	0.579
LIG_14-3-3_CanoR_1	641	646	PF00244	0.641
LIG_14-3-3_CanoR_1	666	675	PF00244	0.644
LIG_14-3-3_CanoR_1	850	856	PF00244	0.397
LIG_14-3-3_CanoR_1	922	927	PF00244	0.411
LIG_14-3-3_CanoR_1	97	101	PF00244	0.249
LIG_14-3-3_CanoR_1	978	988	PF00244	0.249
LIG_Actin_WH2_2	809	824	PF00022	0.249
LIG_BRCT_BRCA1_1	884	888	PF00533	0.501
LIG_BRCT_BRCA1_1	965	969	PF00533	0.430
LIG_BRCT_BRCA1_1	999	1003	PF00533	0.501
LIG_CaM_IQ_9	691	706	PF13499	0.576
LIG_Clathr_ClatBox_1	220	224	PF01394	0.483
LIG_CtBP_PxDLS_1	512	516	PF00389	0.518
LIG_eIF4E_1	225	231	PF01652	0.549
LIG_FHA_1	1010	1016	PF00498	0.461
LIG_FHA_1	1029	1035	PF00498	0.430
LIG_FHA_1	276	282	PF00498	0.420
LIG_FHA_1	378	384	PF00498	0.509
LIG_FHA_1	766	772	PF00498	0.535
LIG_FHA_1	77	83	PF00498	0.507
LIG_FHA_1	835	841	PF00498	0.445
LIG_FHA_1	854	860	PF00498	0.214
LIG_FHA_1	932	938	PF00498	0.330
LIG_FHA_1	992	998	PF00498	0.424
LIG_FHA_2	1050	1056	PF00498	0.643
LIG_FHA_2	241	247	PF00498	0.669
LIG_FHA_2	347	353	PF00498	0.544
LIG_FHA_2	409	415	PF00498	0.653
LIG_FHA_2	451	457	PF00498	0.455
LIG_FHA_2	657	663	PF00498	0.562
LIG_FHA_2	758	764	PF00498	0.481
LIG_FHA_2	815	821	PF00498	0.346
LIG_FHA_2	945	951	PF00498	0.430
LIG_GBD_Chelix_1	582	590	PF00786	0.709
LIG_GBD_Chelix_1	980	988	PF00786	0.462
LIG_Integrin_isoDGR_2	920	922	PF01839	0.430
LIG_LIR_Apic_2	396	402	PF02991	0.568
LIG_LIR_Apic_2	48	54	PF02991	0.369
LIG_LIR_Apic_2	885	891	PF02991	0.515
LIG_LIR_Gen_1	1000	1011	PF02991	0.501
LIG_LIR_Gen_1	460	471	PF02991	0.627
LIG_LIR_Gen_1	794	805	PF02991	0.426
LIG_LIR_Gen_1	923	932	PF02991	0.430
LIG_LIR_Nem_3	1000	1006	PF02991	0.501
LIG_LIR_Nem_3	1055	1061	PF02991	0.621
LIG_LIR_Nem_3	151	156	PF02991	0.430
LIG_LIR_Nem_3	248	254	PF02991	0.369
LIG_LIR_Nem_3	460	466	PF02991	0.632
LIG_LIR_Nem_3	69	74	PF02991	0.430
LIG_LIR_Nem_3	777	783	PF02991	0.322
LIG_LIR_Nem_3	794	800	PF02991	0.381
LIG_LIR_Nem_3	923	929	PF02991	0.378
LIG_NRBOX	1001	1007	PF00104	0.430
LIG_NRBOX	651	657	PF00104	0.571
LIG_PCNA_yPIPBox_3	464	474	PF02747	0.440
LIG_PCNA_yPIPBox_3	649	660	PF02747	0.565
LIG_Pex14_1	247	251	PF04695	0.465
LIG_Pex14_2	851	855	PF04695	0.330
LIG_Rb_pABgroove_1	997	1005	PF01858	0.249
LIG_REV1ctd_RIR_1	833	842	PF16727	0.249
LIG_SH2_CRK	463	467	PF00017	0.695
LIG_SH2_GRB2like	170	173	PF00017	0.313
LIG_SH2_SRC	170	173	PF00017	0.249
LIG_SH2_SRC	229	232	PF00017	0.556
LIG_SH2_SRC	74	77	PF00017	0.249
LIG_SH2_STAP1	783	787	PF00017	0.498
LIG_SH2_STAP1	993	997	PF00017	0.430
LIG_SH2_STAT3	106	109	PF00017	0.430
LIG_SH2_STAT3	199	202	PF00017	0.501
LIG_SH2_STAT3	720	723	PF00017	0.546
LIG_SH2_STAT5	106	109	PF00017	0.351
LIG_SH2_STAT5	129	132	PF00017	0.395
LIG_SH2_STAT5	199	202	PF00017	0.376
LIG_SH2_STAT5	225	228	PF00017	0.529
LIG_SH2_STAT5	229	232	PF00017	0.565
LIG_SH2_STAT5	254	257	PF00017	0.536
LIG_SH2_STAT5	839	842	PF00017	0.501
LIG_SH2_STAT5	98	101	PF00017	0.413
LIG_SH2_STAT5	993	996	PF00017	0.404
LIG_SH3_1	1042	1048	PF00018	0.453
LIG_SH3_2	264	269	PF14604	0.521
LIG_SH3_3	1042	1048	PF00018	0.609
LIG_SH3_3	261	267	PF00018	0.492
LIG_SH3_3	554	560	PF00018	0.560
LIG_SH3_3	8	14	PF00018	0.772
LIG_SH3_3	986	992	PF00018	0.390
LIG_SUMO_SIM_anti_2	998	1004	PF11976	0.249
LIG_SUMO_SIM_par_1	511	516	PF11976	0.588
LIG_SUMO_SIM_par_1	739	745	PF11976	0.334
LIG_SUMO_SIM_par_1	860	865	PF11976	0.421
LIG_TRAF2_1	323	326	PF00917	0.625
LIG_TRAF2_1	565	568	PF00917	0.640
LIG_TRAF2_1	843	846	PF00917	0.311
LIG_WRC_WIRS_1	852	857	PF05994	0.501
MOD_CK1_1	22	28	PF00069	0.614
MOD_CK1_1	315	321	PF00069	0.763
MOD_CK1_1	511	517	PF00069	0.611
MOD_CK1_1	55	61	PF00069	0.481
MOD_CK1_1	585	591	PF00069	0.546
MOD_CK1_1	595	601	PF00069	0.577
MOD_CK1_1	683	689	PF00069	0.616
MOD_CK1_1	823	829	PF00069	0.385
MOD_CK1_1	903	909	PF00069	0.380
MOD_CK1_1	910	916	PF00069	0.251
MOD_CK1_1	956	962	PF00069	0.263
MOD_CK2_1	1017	1023	PF00069	0.430
MOD_CK2_1	1049	1055	PF00069	0.650
MOD_CK2_1	129	135	PF00069	0.249
MOD_CK2_1	240	246	PF00069	0.681
MOD_CK2_1	267	273	PF00069	0.728
MOD_CK2_1	346	352	PF00069	0.541
MOD_CK2_1	389	395	PF00069	0.666
MOD_CK2_1	406	412	PF00069	0.592
MOD_CK2_1	450	456	PF00069	0.453
MOD_CK2_1	595	601	PF00069	0.562
MOD_CK2_1	814	820	PF00069	0.346
MOD_GlcNHglycan	181	184	PF01048	0.468
MOD_GlcNHglycan	307	310	PF01048	0.715
MOD_GlcNHglycan	320	323	PF01048	0.673
MOD_GlcNHglycan	391	394	PF01048	0.758
MOD_GlcNHglycan	404	407	PF01048	0.692
MOD_GlcNHglycan	54	57	PF01048	0.491
MOD_GlcNHglycan	594	597	PF01048	0.652
MOD_GlcNHglycan	669	672	PF01048	0.489
MOD_GlcNHglycan	682	685	PF01048	0.535
MOD_GlcNHglycan	748	751	PF01048	0.553
MOD_GlcNHglycan	756	760	PF01048	0.644
MOD_GlcNHglycan	808	811	PF01048	0.430
MOD_GlcNHglycan	822	825	PF01048	0.430
MOD_GlcNHglycan	863	867	PF01048	0.425
MOD_GlcNHglycan	873	876	PF01048	0.437
MOD_GlcNHglycan	900	903	PF01048	0.444
MOD_GlcNHglycan	953	956	PF01048	0.478
MOD_GlcNHglycan	965	968	PF01048	0.357
MOD_GSK3_1	389	396	PF00069	0.723
MOD_GSK3_1	402	409	PF00069	0.551
MOD_GSK3_1	511	518	PF00069	0.650
MOD_GSK3_1	55	62	PF00069	0.513
MOD_GSK3_1	559	566	PF00069	0.706
MOD_GSK3_1	578	585	PF00069	0.572
MOD_GSK3_1	742	749	PF00069	0.499
MOD_GSK3_1	834	841	PF00069	0.433
MOD_GSK3_1	903	910	PF00069	0.363
MOD_GSK3_1	993	1000	PF00069	0.501
MOD_N-GLC_1	1049	1054	PF02516	0.723
MOD_N-GLC_1	393	398	PF02516	0.557
MOD_N-GLC_1	44	49	PF02516	0.558
MOD_N-GLC_1	970	975	PF02516	0.430
MOD_NEK2_1	145	150	PF00069	0.502
MOD_NEK2_1	346	351	PF00069	0.557
MOD_NEK2_1	490	495	PF00069	0.685
MOD_NEK2_1	549	554	PF00069	0.765
MOD_NEK2_1	582	587	PF00069	0.600
MOD_NEK2_1	656	661	PF00069	0.516
MOD_NEK2_1	719	724	PF00069	0.664
MOD_NEK2_1	806	811	PF00069	0.387
MOD_NEK2_1	851	856	PF00069	0.390
MOD_NEK2_2	164	169	PF00069	0.311
MOD_NEK2_2	450	455	PF00069	0.452
MOD_NEK2_2	59	64	PF00069	0.376
MOD_NEK2_2	776	781	PF00069	0.249
MOD_NEK2_2	944	949	PF00069	0.430
MOD_PIKK_1	400	406	PF00454	0.571
MOD_PIKK_1	484	490	PF00454	0.654
MOD_PIKK_1	530	536	PF00454	0.630
MOD_PIKK_1	550	556	PF00454	0.462
MOD_PIKK_1	563	569	PF00454	0.684
MOD_PIKK_1	719	725	PF00454	0.447
MOD_PIKK_1	956	962	PF00454	0.492
MOD_PIKK_1	971	977	PF00454	0.316
MOD_PKA_1	706	712	PF00069	0.577
MOD_PKA_2	1018	1024	PF00069	0.501
MOD_PKA_2	234	240	PF00069	0.694
MOD_PKA_2	275	281	PF00069	0.422
MOD_PKA_2	302	308	PF00069	0.479
MOD_PKA_2	473	479	PF00069	0.697
MOD_PKA_2	530	536	PF00069	0.453
MOD_PKA_2	550	556	PF00069	0.555
MOD_PKA_2	944	950	PF00069	0.383
MOD_PKA_2	96	102	PF00069	0.249
MOD_Plk_1	1025	1031	PF00069	0.430
MOD_Plk_1	286	292	PF00069	0.585
MOD_Plk_1	346	352	PF00069	0.580
MOD_Plk_1	393	399	PF00069	0.561
MOD_Plk_1	776	782	PF00069	0.460
MOD_Plk_1	997	1003	PF00069	0.501
MOD_Plk_2-3	1074	1080	PF00069	0.446
MOD_Plk_2-3	412	418	PF00069	0.646
MOD_Plk_4	1034	1040	PF00069	0.573
MOD_Plk_4	164	170	PF00069	0.249
MOD_Plk_4	286	292	PF00069	0.567
MOD_Plk_4	332	338	PF00069	0.449
MOD_Plk_4	903	909	PF00069	0.296
MOD_Plk_4	922	928	PF00069	0.408
MOD_Plk_4	944	950	PF00069	0.427
MOD_Plk_4	997	1003	PF00069	0.426
MOD_ProDKin_1	406	412	PF00069	0.621
MOD_ProDKin_1	508	514	PF00069	0.793
MOD_ProDKin_1	559	565	PF00069	0.724
MOD_SUMO_for_1	337	340	PF00179	0.397
MOD_SUMO_for_1	454	457	PF00179	0.639
MOD_SUMO_for_1	586	589	PF00179	0.709
MOD_SUMO_rev_2	205	213	PF00179	0.434
MOD_SUMO_rev_2	334	343	PF00179	0.462
MOD_SUMO_rev_2	496	504	PF00179	0.565
MOD_SUMO_rev_2	595	605	PF00179	0.470
MOD_SUMO_rev_2	633	639	PF00179	0.622
MOD_SUMO_rev_2	693	701	PF00179	0.605
MOD_SUMO_rev_2	81	89	PF00179	0.430
MOD_SUMO_rev_2	841	851	PF00179	0.249
TRG_DiLeu_BaEn_1	426	431	PF01217	0.459
TRG_DiLeu_BaEn_1	651	656	PF01217	0.566
TRG_DiLeu_BaLyEn_6	1042	1047	PF01217	0.506
TRG_DiLeu_LyEn_5	651	656	PF01217	0.566
TRG_ENDOCYTIC_2	141	144	PF00928	0.405
TRG_ENDOCYTIC_2	463	466	PF00928	0.625
TRG_ER_diArg_1	291	294	PF00400	0.572
TRG_ER_diArg_1	542	545	PF00400	0.637
TRG_ER_diArg_1	703	705	PF00400	0.642
TRG_NES_CRM1_1	334	347	PF08389	0.655
TRG_NLS_MonoCore_2	37	42	PF00514	0.663
TRG_NLS_MonoExtC_3	37	42	PF00514	0.689
TRG_NLS_MonoExtN_4	35	42	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	521	526	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	654	658	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAY9	Leptomonas seymouri	53%	100%
A0A1X0NJ05	Trypanosomatidae	30%	100%
A0A3S7X4W4	Leishmania donovani	71%	100%
A4I775	Leishmania infantum	71%	100%
E9B269	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q5Z0	Leishmania major	71%	100%