3'-5' exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJQ7_LEIBR

TriTrypDb:

LbrM.31.3040 , LBRM2903_310040000

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HJQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJQ7

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	6
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	6
GO:0000469	cleavage involved in rRNA processing	7	6
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0016072	rRNA metabolic process	7	6
GO:0031123	RNA 3'-end processing	7	6
GO:0031125	rRNA 3'-end processing	9	6
GO:0034470	ncRNA processing	7	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034660	ncRNA metabolic process	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043628	regulatory ncRNA 3'-end processing	8	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	6
GO:0090501	RNA phosphodiester bond hydrolysis	6	6
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	6
GO:1901360	organic cyclic compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	6
GO:0003676	nucleic acid binding	3	10
GO:0003824	catalytic activity	1	8
GO:0004518	nuclease activity	4	8
GO:0004527	exonuclease activity	5	8
GO:0004532	RNA exonuclease activity	5	6
GO:0004540	RNA nuclease activity	4	6
GO:0005488	binding	1	10
GO:0008408	3'-5' exonuclease activity	6	7
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	6
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	6
GO:0097159	organic cyclic compound binding	2	10
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.465
CLV_C14_Caspase3-7	358	362	PF00656	0.756
CLV_C14_Caspase3-7	647	651	PF00656	0.417
CLV_C14_Caspase3-7	730	734	PF00656	0.357
CLV_NRD_NRD_1	214	216	PF00675	0.481
CLV_NRD_NRD_1	22	24	PF00675	0.418
CLV_NRD_NRD_1	243	245	PF00675	0.283
CLV_NRD_NRD_1	472	474	PF00675	0.465
CLV_NRD_NRD_1	506	508	PF00675	0.360
CLV_NRD_NRD_1	585	587	PF00675	0.443
CLV_NRD_NRD_1	643	645	PF00675	0.448
CLV_NRD_NRD_1	680	682	PF00675	0.709
CLV_NRD_NRD_1	704	706	PF00675	0.536
CLV_NRD_NRD_1	712	714	PF00675	0.478
CLV_NRD_NRD_1	725	727	PF00675	0.380
CLV_NRD_NRD_1	823	825	PF00675	0.643
CLV_NRD_NRD_1	90	92	PF00675	0.556
CLV_PCSK_FUR_1	677	681	PF00082	0.544
CLV_PCSK_KEX2_1	21	23	PF00082	0.421
CLV_PCSK_KEX2_1	243	245	PF00082	0.476
CLV_PCSK_KEX2_1	472	474	PF00082	0.465
CLV_PCSK_KEX2_1	506	508	PF00082	0.473
CLV_PCSK_KEX2_1	584	586	PF00082	0.461
CLV_PCSK_KEX2_1	643	645	PF00082	0.498
CLV_PCSK_KEX2_1	679	681	PF00082	0.701
CLV_PCSK_KEX2_1	704	706	PF00082	0.498
CLV_PCSK_KEX2_1	724	726	PF00082	0.339
CLV_PCSK_KEX2_1	90	92	PF00082	0.575
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.361
CLV_PCSK_SKI1_1	168	172	PF00082	0.436
CLV_PCSK_SKI1_1	320	324	PF00082	0.506
CLV_PCSK_SKI1_1	441	445	PF00082	0.372
CLV_PCSK_SKI1_1	506	510	PF00082	0.417
CLV_PCSK_SKI1_1	585	589	PF00082	0.592
CLV_PCSK_SKI1_1	6	10	PF00082	0.449
CLV_PCSK_SKI1_1	756	760	PF00082	0.426
CLV_PCSK_SKI1_1	786	790	PF00082	0.373
CLV_PCSK_SKI1_1	861	865	PF00082	0.513
CLV_PCSK_SKI1_1	90	94	PF00082	0.527
DEG_APCC_DBOX_1	5	13	PF00400	0.452
DEG_APCC_DBOX_1	605	613	PF00400	0.435
DEG_APCC_DBOX_1	621	629	PF00400	0.267
DEG_APCC_DBOX_1	755	763	PF00400	0.446
DEG_APCC_DBOX_1	89	97	PF00400	0.497
DEG_MDM2_SWIB_1	57	65	PF02201	0.438
DEG_SPOP_SBC_1	575	579	PF00917	0.312
DOC_CDC14_PxL_1	457	465	PF14671	0.317
DOC_CDC14_PxL_1	801	809	PF14671	0.517
DOC_CKS1_1	428	433	PF01111	0.470
DOC_CKS1_1	588	593	PF01111	0.575
DOC_CYCLIN_RxL_1	627	641	PF00134	0.373
DOC_CYCLIN_RxL_1	855	868	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	127	133	PF00134	0.492
DOC_MAPK_gen_1	168	176	PF00069	0.392
DOC_MAPK_gen_1	182	192	PF00069	0.348
DOC_MAPK_gen_1	243	251	PF00069	0.395
DOC_MAPK_gen_1	479	487	PF00069	0.447
DOC_MAPK_MEF2A_6	185	192	PF00069	0.532
DOC_MAPK_MEF2A_6	244	253	PF00069	0.329
DOC_MAPK_MEF2A_6	451	459	PF00069	0.253
DOC_MAPK_MEF2A_6	506	514	PF00069	0.360
DOC_PP1_RVXF_1	422	429	PF00149	0.412
DOC_PP2B_LxvP_1	524	527	PF13499	0.267
DOC_PP2B_LxvP_1	65	68	PF13499	0.578
DOC_PP4_FxxP_1	547	550	PF00568	0.409
DOC_SPAK_OSR1_1	497	501	PF12202	0.337
DOC_USP7_MATH_1	211	215	PF00917	0.536
DOC_USP7_MATH_1	275	279	PF00917	0.305
DOC_USP7_MATH_1	299	303	PF00917	0.730
DOC_USP7_MATH_1	362	366	PF00917	0.689
DOC_USP7_MATH_1	646	650	PF00917	0.537
DOC_USP7_MATH_1	841	845	PF00917	0.608
DOC_WW_Pin1_4	261	266	PF00397	0.431
DOC_WW_Pin1_4	427	432	PF00397	0.491
DOC_WW_Pin1_4	587	592	PF00397	0.692
DOC_WW_Pin1_4	661	666	PF00397	0.689
DOC_WW_Pin1_4	832	837	PF00397	0.677
DOC_WW_Pin1_4	903	908	PF00397	0.481
LIG_14-3-3_CanoR_1	142	152	PF00244	0.407
LIG_14-3-3_CanoR_1	215	224	PF00244	0.559
LIG_14-3-3_CanoR_1	511	521	PF00244	0.293
LIG_14-3-3_CanoR_1	576	581	PF00244	0.448
LIG_14-3-3_CanoR_1	585	591	PF00244	0.403
LIG_14-3-3_CanoR_1	704	708	PF00244	0.478
LIG_14-3-3_CanoR_1	713	719	PF00244	0.345
LIG_14-3-3_CanoR_1	887	893	PF00244	0.331
LIG_AP2alpha_2	129	131	PF02296	0.489
LIG_APCC_ABBA_1	174	179	PF00400	0.431
LIG_APCC_ABBA_1	181	186	PF00400	0.452
LIG_APCC_ABBA_1	635	640	PF00400	0.309
LIG_BRCT_BRCA1_1	853	857	PF00533	0.357
LIG_DLG_GKlike_1	226	233	PF00625	0.438
LIG_EH1_1	856	864	PF00400	0.431
LIG_FHA_1	105	111	PF00498	0.330
LIG_FHA_1	156	162	PF00498	0.478
LIG_FHA_1	225	231	PF00498	0.520
LIG_FHA_1	326	332	PF00498	0.428
LIG_FHA_1	60	66	PF00498	0.467
LIG_FHA_1	96	102	PF00498	0.378
LIG_FHA_2	207	213	PF00498	0.463
LIG_FHA_2	356	362	PF00498	0.578
LIG_FHA_2	369	375	PF00498	0.667
LIG_FHA_2	435	441	PF00498	0.467
LIG_FHA_2	576	582	PF00498	0.313
LIG_FHA_2	794	800	PF00498	0.521
LIG_FHA_2	806	812	PF00498	0.602
LIG_FHA_2	904	910	PF00498	0.466
LIG_LIR_Apic_2	545	550	PF02991	0.360
LIG_LIR_Apic_2	844	850	PF02991	0.404
LIG_LIR_Gen_1	120	131	PF02991	0.468
LIG_LIR_Gen_1	155	164	PF02991	0.275
LIG_LIR_Gen_1	518	527	PF02991	0.350
LIG_LIR_Gen_1	560	570	PF02991	0.450
LIG_LIR_Gen_1	614	619	PF02991	0.384
LIG_LIR_Gen_1	854	864	PF02991	0.343
LIG_LIR_Nem_3	120	126	PF02991	0.525
LIG_LIR_Nem_3	135	141	PF02991	0.558
LIG_LIR_Nem_3	186	190	PF02991	0.371
LIG_LIR_Nem_3	27	33	PF02991	0.356
LIG_LIR_Nem_3	40	45	PF02991	0.405
LIG_LIR_Nem_3	48	54	PF02991	0.338
LIG_LIR_Nem_3	518	522	PF02991	0.345
LIG_LIR_Nem_3	560	565	PF02991	0.455
LIG_LIR_Nem_3	614	618	PF02991	0.384
LIG_LIR_Nem_3	717	722	PF02991	0.487
LIG_LIR_Nem_3	854	860	PF02991	0.347
LIG_LYPXL_S_1	718	722	PF13949	0.394
LIG_LYPXL_yS_3	187	190	PF13949	0.459
LIG_Pex14_1	847	851	PF04695	0.366
LIG_Pex14_1	888	892	PF04695	0.326
LIG_Pex14_2	57	61	PF04695	0.376
LIG_Pex14_2	884	888	PF04695	0.332
LIG_Rb_LxCxE_1	312	333	PF01857	0.542
LIG_REV1ctd_RIR_1	719	730	PF16727	0.501
LIG_SH2_CRK	392	396	PF00017	0.354
LIG_SH2_CRK	519	523	PF00017	0.325
LIG_SH2_CRK	536	540	PF00017	0.375
LIG_SH2_GRB2like	157	160	PF00017	0.248
LIG_SH2_GRB2like	392	395	PF00017	0.357
LIG_SH2_NCK_1	392	396	PF00017	0.378
LIG_SH2_SRC	392	395	PF00017	0.382
LIG_SH2_SRC	562	565	PF00017	0.444
LIG_SH2_SRC	580	583	PF00017	0.291
LIG_SH2_SRC	851	854	PF00017	0.475
LIG_SH2_STAP1	104	108	PF00017	0.326
LIG_SH2_STAP1	157	161	PF00017	0.405
LIG_SH2_STAP1	279	283	PF00017	0.428
LIG_SH2_STAP1	519	523	PF00017	0.347
LIG_SH2_STAP1	562	566	PF00017	0.478
LIG_SH2_STAT3	477	480	PF00017	0.366
LIG_SH2_STAT5	157	160	PF00017	0.405
LIG_SH2_STAT5	416	419	PF00017	0.377
LIG_SH2_STAT5	477	480	PF00017	0.366
LIG_SH2_STAT5	711	714	PF00017	0.425
LIG_SH2_STAT5	851	854	PF00017	0.475
LIG_SH3_3	127	133	PF00018	0.495
LIG_SH3_3	22	28	PF00018	0.414
LIG_SH3_3	394	400	PF00018	0.454
LIG_SH3_3	591	597	PF00018	0.452
LIG_SH3_3	659	665	PF00018	0.693
LIG_SH3_3	811	817	PF00018	0.490
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.449
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.376
LIG_SUMO_SIM_anti_2	520	525	PF11976	0.323
LIG_SUMO_SIM_anti_2	614	620	PF11976	0.457
LIG_SUMO_SIM_par_1	197	203	PF11976	0.435
LIG_TRAF2_1	437	440	PF00917	0.429
LIG_TRAF2_1	579	582	PF00917	0.481
LIG_TRAF2_2	814	819	PF00917	0.479
LIG_TYR_ITIM	534	539	PF00017	0.307
LIG_TYR_ITIM	637	642	PF00017	0.306
LIG_WRC_WIRS_1	331	336	PF05994	0.444
LIG_WRC_WIRS_1	628	633	PF05994	0.428
MOD_CK1_1	102	108	PF00069	0.305
MOD_CK1_1	146	152	PF00069	0.471
MOD_CK1_1	229	235	PF00069	0.543
MOD_CK1_1	302	308	PF00069	0.693
MOD_CK1_1	491	497	PF00069	0.409
MOD_CK1_1	515	521	PF00069	0.395
MOD_CK1_1	784	790	PF00069	0.450
MOD_CK1_1	828	834	PF00069	0.721
MOD_CK1_1	868	874	PF00069	0.514
MOD_CK2_1	434	440	PF00069	0.348
MOD_CK2_1	442	448	PF00069	0.395
MOD_CK2_1	575	581	PF00069	0.406
MOD_CK2_1	793	799	PF00069	0.519
MOD_CK2_1	805	811	PF00069	0.597
MOD_CK2_1	888	894	PF00069	0.472
MOD_Cter_Amidation	241	244	PF01082	0.293
MOD_GlcNHglycan	134	137	PF01048	0.609
MOD_GlcNHglycan	193	196	PF01048	0.466
MOD_GlcNHglycan	296	300	PF01048	0.606
MOD_GlcNHglycan	337	340	PF01048	0.657
MOD_GlcNHglycan	45	48	PF01048	0.523
MOD_GlcNHglycan	452	455	PF01048	0.457
MOD_GlcNHglycan	490	493	PF01048	0.473
MOD_GlcNHglycan	650	653	PF01048	0.665
MOD_GlcNHglycan	750	753	PF01048	0.565
MOD_GlcNHglycan	775	778	PF01048	0.695
MOD_GlcNHglycan	827	830	PF01048	0.571
MOD_GlcNHglycan	83	86	PF01048	0.707
MOD_GlcNHglycan	836	839	PF01048	0.553
MOD_GSK3_1	211	218	PF00069	0.650
MOD_GSK3_1	220	227	PF00069	0.489
MOD_GSK3_1	295	302	PF00069	0.564
MOD_GSK3_1	325	332	PF00069	0.381
MOD_GSK3_1	404	411	PF00069	0.418
MOD_GSK3_1	669	676	PF00069	0.723
MOD_GSK3_1	795	802	PF00069	0.449
MOD_GSK3_1	828	835	PF00069	0.735
MOD_GSK3_1	95	102	PF00069	0.314
MOD_LATS_1	213	219	PF00433	0.500
MOD_N-GLC_1	303	308	PF02516	0.507
MOD_N-GLC_1	782	787	PF02516	0.508
MOD_N-GLC_2	235	237	PF02516	0.414
MOD_N-GLC_2	484	486	PF02516	0.335
MOD_NEK2_1	334	339	PF00069	0.594
MOD_NEK2_1	450	455	PF00069	0.526
MOD_NEK2_1	529	534	PF00069	0.430
MOD_NEK2_1	59	64	PF00069	0.370
MOD_NEK2_1	757	762	PF00069	0.491
MOD_NEK2_2	330	335	PF00069	0.446
MOD_NEK2_2	638	643	PF00069	0.311
MOD_PIKK_1	143	149	PF00454	0.301
MOD_PIKK_1	683	689	PF00454	0.495
MOD_PIKK_1	828	834	PF00454	0.667
MOD_PK_1	714	720	PF00069	0.273
MOD_PKA_1	215	221	PF00069	0.533
MOD_PKA_2	575	581	PF00069	0.440
MOD_PKA_2	621	627	PF00069	0.355
MOD_PKA_2	669	675	PF00069	0.573
MOD_PKA_2	703	709	PF00069	0.480
MOD_PKA_2	773	779	PF00069	0.663
MOD_PKA_2	888	894	PF00069	0.398
MOD_PKB_1	681	689	PF00069	0.599
MOD_Plk_1	275	281	PF00069	0.323
MOD_Plk_1	360	366	PF00069	0.664
MOD_Plk_1	868	874	PF00069	0.381
MOD_Plk_4	104	110	PF00069	0.314
MOD_Plk_4	148	154	PF00069	0.338
MOD_Plk_4	220	226	PF00069	0.643
MOD_Plk_4	491	497	PF00069	0.426
MOD_Plk_4	714	720	PF00069	0.393
MOD_Plk_4	799	805	PF00069	0.398
MOD_Plk_4	868	874	PF00069	0.381
MOD_Plk_4	888	894	PF00069	0.396
MOD_ProDKin_1	261	267	PF00069	0.425
MOD_ProDKin_1	427	433	PF00069	0.494
MOD_ProDKin_1	587	593	PF00069	0.694
MOD_ProDKin_1	661	667	PF00069	0.689
MOD_ProDKin_1	832	838	PF00069	0.675
MOD_ProDKin_1	903	909	PF00069	0.479
MOD_SUMO_rev_2	179	183	PF00179	0.492
MOD_SUMO_rev_2	214	223	PF00179	0.527
MOD_SUMO_rev_2	438	443	PF00179	0.507
TRG_DiLeu_BaLyEn_6	530	535	PF01217	0.313
TRG_DiLeu_BaLyEn_6	858	863	PF01217	0.385
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.565
TRG_ENDOCYTIC_2	157	160	PF00928	0.446
TRG_ENDOCYTIC_2	187	190	PF00928	0.344
TRG_ENDOCYTIC_2	38	41	PF00928	0.514
TRG_ENDOCYTIC_2	392	395	PF00928	0.357
TRG_ENDOCYTIC_2	466	469	PF00928	0.543
TRG_ENDOCYTIC_2	505	508	PF00928	0.385
TRG_ENDOCYTIC_2	519	522	PF00928	0.275
TRG_ENDOCYTIC_2	536	539	PF00928	0.378
TRG_ENDOCYTIC_2	562	565	PF00928	0.444
TRG_ENDOCYTIC_2	639	642	PF00928	0.540
TRG_ENDOCYTIC_2	719	722	PF00928	0.436
TRG_ER_diArg_1	20	23	PF00400	0.439
TRG_ER_diArg_1	243	245	PF00400	0.476
TRG_ER_diArg_1	471	473	PF00400	0.462
TRG_ER_diArg_1	505	507	PF00400	0.468
TRG_ER_diArg_1	605	608	PF00400	0.443
TRG_ER_diArg_1	642	644	PF00400	0.349
TRG_ER_diArg_1	677	680	PF00400	0.632
TRG_ER_diArg_1	724	726	PF00400	0.387
TRG_ER_diArg_1	90	92	PF00400	0.572
TRG_NES_CRM1_1	191	203	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	243	248	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	533	537	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	861	865	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJE4	Leptomonas seymouri	52%	99%
A0A1X0NK05	Trypanosomatidae	34%	100%
A0A3Q8ISV5	Leishmania donovani	78%	100%
A0A422NPF9	Trypanosoma rangeli	35%	100%
A4I774	Leishmania infantum	78%	100%
E9B268	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q5Z1	Leishmania major	76%	100%
V5D1X6	Trypanosoma cruzi	36%	100%