3'-5' exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HJQ7_LEIBR

TriTrypDb:

LbrM.31.3040 , LBRM2903_310040000

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4HJQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJQ7

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	6
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	6
GO:0000469	cleavage involved in rRNA processing	7	6
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	6
GO:0003676	nucleic acid binding	3	10
GO:0003824	catalytic activity	1	8
GO:0004518	nuclease activity	4	8
GO:0004527	exonuclease activity	5	8
GO:0004532	RNA exonuclease activity	5	6
GO:0004540	RNA nuclease activity	4	6
GO:0005488	binding	1	10
GO:0008408	3'-5' exonuclease activity	6	7
GO:0016787	hydrolase activity	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.465
CLV_C14_Caspase3-7	358	362	PF00656	0.756
CLV_C14_Caspase3-7	647	651	PF00656	0.417
CLV_C14_Caspase3-7	730	734	PF00656	0.357
CLV_NRD_NRD_1	214	216	PF00675	0.481
CLV_NRD_NRD_1	22	24	PF00675	0.418
CLV_NRD_NRD_1	243	245	PF00675	0.283
CLV_NRD_NRD_1	472	474	PF00675	0.465
CLV_NRD_NRD_1	506	508	PF00675	0.360
CLV_NRD_NRD_1	585	587	PF00675	0.443

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJE4	Leptomonas seymouri	52%	99%
A0A1X0NK05	Trypanosomatidae	34%	100%
A0A3Q8ISV5	Leishmania donovani	78%	100%
A0A422NPF9	Trypanosoma rangeli	35%	100%
A4I774	Leishmania infantum	78%	100%
E9B268	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q5Z1	Leishmania major	76%	100%
V5D1X6	Trypanosoma cruzi	36%	100%

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