AP2 domain transcription factor AP2X-11

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJQ4_LEIBR

TriTrypDb:

LbrM.31.3000 , LBRM2903_310039300

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.574
CLV_NRD_NRD_1	459	461	PF00675	0.831
CLV_NRD_NRD_1	463	465	PF00675	0.759
CLV_NRD_NRD_1	497	499	PF00675	0.643
CLV_PCSK_FUR_1	495	499	PF00082	0.604
CLV_PCSK_KEX2_1	459	461	PF00082	0.831
CLV_PCSK_KEX2_1	463	465	PF00082	0.759
CLV_PCSK_KEX2_1	497	499	PF00082	0.643
CLV_PCSK_KEX2_1	79	81	PF00082	0.563
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.563
CLV_PCSK_PC7_1	459	465	PF00082	0.827
CLV_PCSK_SKI1_1	275	279	PF00082	0.687
CLV_PCSK_SKI1_1	423	427	PF00082	0.629
DOC_AGCK_PIF_1	149	154	PF00069	0.576
DOC_CKS1_1	439	444	PF01111	0.702
DOC_MAPK_MEF2A_6	355	364	PF00069	0.599
DOC_PP2B_LxvP_1	118	121	PF13499	0.595
DOC_PP4_FxxP_1	211	214	PF00568	0.536
DOC_PP4_FxxP_1	439	442	PF00568	0.546
DOC_USP7_MATH_1	171	175	PF00917	0.791
DOC_USP7_MATH_1	181	185	PF00917	0.545
DOC_USP7_MATH_1	247	251	PF00917	0.574
DOC_USP7_MATH_1	262	266	PF00917	0.510
DOC_USP7_MATH_1	301	305	PF00917	0.682
DOC_USP7_MATH_1	348	352	PF00917	0.787
DOC_USP7_MATH_1	413	417	PF00917	0.522
DOC_USP7_MATH_1	431	435	PF00917	0.802
DOC_USP7_MATH_1	488	492	PF00917	0.686
DOC_USP7_MATH_1	555	559	PF00917	0.549
DOC_USP7_MATH_1	560	564	PF00917	0.542
DOC_USP7_MATH_1	58	62	PF00917	0.736
DOC_USP7_MATH_1	63	67	PF00917	0.693
DOC_USP7_UBL2_3	338	342	PF12436	0.829
DOC_WW_Pin1_4	177	182	PF00397	0.706
DOC_WW_Pin1_4	297	302	PF00397	0.713
DOC_WW_Pin1_4	32	37	PF00397	0.531
DOC_WW_Pin1_4	354	359	PF00397	0.671
DOC_WW_Pin1_4	379	384	PF00397	0.571
DOC_WW_Pin1_4	438	443	PF00397	0.602
DOC_WW_Pin1_4	445	450	PF00397	0.615
DOC_WW_Pin1_4	452	457	PF00397	0.611
DOC_WW_Pin1_4	564	569	PF00397	0.578
DOC_WW_Pin1_4	64	69	PF00397	0.568
DOC_WW_Pin1_4	88	93	PF00397	0.812
LIG_14-3-3_CanoR_1	124	132	PF00244	0.637
LIG_14-3-3_CanoR_1	241	247	PF00244	0.686
LIG_14-3-3_CanoR_1	264	268	PF00244	0.573
LIG_14-3-3_CanoR_1	392	396	PF00244	0.499
LIG_14-3-3_CanoR_1	417	423	PF00244	0.748
LIG_14-3-3_CanoR_1	463	473	PF00244	0.773
LIG_14-3-3_CanoR_1	477	485	PF00244	0.631
LIG_14-3-3_CanoR_1	549	557	PF00244	0.673
LIG_14-3-3_CanoR_1	574	578	PF00244	0.601
LIG_Actin_WH2_2	537	554	PF00022	0.542
LIG_APCC_ABBAyCdc20_2	107	113	PF00400	0.546
LIG_BRCT_BRCA1_1	107	111	PF00533	0.544
LIG_BRCT_BRCA1_1	265	269	PF00533	0.818
LIG_BRCT_BRCA1_1	392	396	PF00533	0.713
LIG_BRCT_BRCA1_1	468	472	PF00533	0.554
LIG_BRCT_BRCA1_1	8	12	PF00533	0.491
LIG_EH_1	176	180	PF12763	0.582
LIG_FHA_1	23	29	PF00498	0.526
LIG_FHA_1	479	485	PF00498	0.573
LIG_FHA_1	65	71	PF00498	0.567
LIG_FHA_2	567	573	PF00498	0.691
LIG_LIR_Apic_2	208	214	PF02991	0.531
LIG_LIR_Gen_1	146	154	PF02991	0.582
LIG_LIR_Gen_1	359	368	PF02991	0.690
LIG_LIR_Gen_1	376	386	PF02991	0.464
LIG_LIR_Gen_1	479	488	PF02991	0.576
LIG_LIR_Gen_1	512	520	PF02991	0.529
LIG_LIR_Gen_1	7	16	PF02991	0.494
LIG_LIR_Nem_3	146	152	PF02991	0.582
LIG_LIR_Nem_3	359	364	PF02991	0.782
LIG_LIR_Nem_3	376	381	PF02991	0.513
LIG_LIR_Nem_3	440	446	PF02991	0.566
LIG_LIR_Nem_3	479	483	PF02991	0.572
LIG_LIR_Nem_3	512	518	PF02991	0.527
LIG_LIR_Nem_3	7	11	PF02991	0.490
LIG_MYND_1	117	121	PF01753	0.587
LIG_Pex14_2	8	12	PF04695	0.491
LIG_SH2_STAT5	443	446	PF00017	0.547
LIG_SH3_3	14	20	PF00018	0.496
LIG_SH3_3	175	181	PF00018	0.618
LIG_SH3_3	304	310	PF00018	0.589
LIG_SH3_3	482	488	PF00018	0.795
LIG_SH3_3	65	71	PF00018	0.820
LIG_SH3_3	79	85	PF00018	0.600
LIG_SxIP_EBH_1	254	268	PF03271	0.564
LIG_TRAF2_1	363	366	PF00917	0.587
MOD_CDC14_SPxK_1	91	94	PF00782	0.549
MOD_CDK_SPK_2	64	69	PF00069	0.568
MOD_CDK_SPxK_1	564	570	PF00069	0.580
MOD_CDK_SPxK_1	88	94	PF00069	0.559
MOD_CDK_SPxxK_3	452	459	PF00069	0.558
MOD_CDK_SPxxK_3	88	95	PF00069	0.557
MOD_CK1_1	145	151	PF00069	0.708
MOD_CK1_1	170	176	PF00069	0.797
MOD_CK1_1	192	198	PF00069	0.537
MOD_CK1_1	242	248	PF00069	0.659
MOD_CK1_1	250	256	PF00069	0.700
MOD_CK1_1	346	352	PF00069	0.726
MOD_CK1_1	354	360	PF00069	0.793
MOD_CK1_1	369	375	PF00069	0.578
MOD_CK1_1	387	393	PF00069	0.481
MOD_CK1_1	416	422	PF00069	0.767
MOD_CK1_1	479	485	PF00069	0.573
MOD_CK1_1	489	495	PF00069	0.550
MOD_CK1_1	531	537	PF00069	0.800
MOD_CK1_1	576	582	PF00069	0.796
MOD_CK1_1	61	67	PF00069	0.565
MOD_CK2_1	319	325	PF00069	0.596
MOD_CK2_1	360	366	PF00069	0.585
MOD_CK2_1	464	470	PF00069	0.556
MOD_CK2_1	501	507	PF00069	0.660
MOD_CK2_1	539	545	PF00069	0.567
MOD_CK2_1	566	572	PF00069	0.661
MOD_Cter_Amidation	77	80	PF01082	0.558
MOD_GlcNHglycan	112	116	PF01048	0.582
MOD_GlcNHglycan	135	138	PF01048	0.788
MOD_GlcNHglycan	169	172	PF01048	0.825
MOD_GlcNHglycan	253	256	PF01048	0.645
MOD_GlcNHglycan	330	334	PF01048	0.600
MOD_GlcNHglycan	368	371	PF01048	0.622
MOD_GlcNHglycan	389	392	PF01048	0.754
MOD_GlcNHglycan	429	432	PF01048	0.797
MOD_GlcNHglycan	433	436	PF01048	0.732
MOD_GlcNHglycan	488	491	PF01048	0.673
MOD_GlcNHglycan	584	587	PF01048	0.765
MOD_GlcNHglycan	63	66	PF01048	0.690
MOD_GSK3_1	101	108	PF00069	0.794
MOD_GSK3_1	119	126	PF00069	0.542
MOD_GSK3_1	143	150	PF00069	0.707
MOD_GSK3_1	155	162	PF00069	0.701
MOD_GSK3_1	166	173	PF00069	0.655
MOD_GSK3_1	177	184	PF00069	0.565
MOD_GSK3_1	18	25	PF00069	0.496
MOD_GSK3_1	188	195	PF00069	0.583
MOD_GSK3_1	203	210	PF00069	0.588
MOD_GSK3_1	242	249	PF00069	0.607
MOD_GSK3_1	251	258	PF00069	0.682
MOD_GSK3_1	281	288	PF00069	0.832
MOD_GSK3_1	297	304	PF00069	0.699
MOD_GSK3_1	356	363	PF00069	0.641
MOD_GSK3_1	387	394	PF00069	0.555
MOD_GSK3_1	412	419	PF00069	0.653
MOD_GSK3_1	427	434	PF00069	0.790
MOD_GSK3_1	520	527	PF00069	0.659
MOD_GSK3_1	560	567	PF00069	0.674
MOD_GSK3_1	573	580	PF00069	0.738
MOD_GSK3_1	59	66	PF00069	0.605
MOD_N-GLC_1	165	170	PF02516	0.771
MOD_N-GLC_1	239	244	PF02516	0.582
MOD_N-GLC_1	387	392	PF02516	0.519
MOD_N-GLC_1	431	436	PF02516	0.800
MOD_NEK2_1	105	110	PF00069	0.809
MOD_NEK2_1	111	116	PF00069	0.738
MOD_NEK2_1	165	170	PF00069	0.651
MOD_NEK2_1	189	194	PF00069	0.666
MOD_NEK2_1	239	244	PF00069	0.612
MOD_NEK2_1	251	256	PF00069	0.548
MOD_NEK2_1	343	348	PF00069	0.579
MOD_NEK2_1	384	389	PF00069	0.516
MOD_NEK2_1	577	582	PF00069	0.836
MOD_NEK2_2	263	268	PF00069	0.567
MOD_NEK2_2	391	396	PF00069	0.503
MOD_NEK2_2	41	46	PF00069	0.564
MOD_NEK2_2	560	565	PF00069	0.565
MOD_PIKK_1	416	422	PF00454	0.607
MOD_PIKK_1	489	495	PF00454	0.589
MOD_PK_1	34	40	PF00069	0.532
MOD_PKA_1	459	465	PF00069	0.827
MOD_PKA_2	123	129	PF00069	0.710
MOD_PKA_2	263	269	PF00069	0.691
MOD_PKA_2	391	397	PF00069	0.498
MOD_PKA_2	416	422	PF00069	0.767
MOD_PKA_2	427	433	PF00069	0.475
MOD_PKA_2	459	465	PF00069	0.827
MOD_PKA_2	476	482	PF00069	0.537
MOD_PKA_2	524	530	PF00069	0.686
MOD_PKA_2	531	537	PF00069	0.612
MOD_PKA_2	555	561	PF00069	0.601
MOD_PKA_2	573	579	PF00069	0.526
MOD_Plk_1	189	195	PF00069	0.544
MOD_Plk_1	239	245	PF00069	0.582
MOD_Plk_1	41	47	PF00069	0.562
MOD_Plk_2-3	190	196	PF00069	0.579
MOD_Plk_2-3	281	287	PF00069	0.605
MOD_Plk_2-3	319	325	PF00069	0.596
MOD_Plk_2-3	501	507	PF00069	0.597
MOD_Plk_4	256	262	PF00069	0.651
MOD_Plk_4	319	325	PF00069	0.596
MOD_Plk_4	391	397	PF00069	0.511
MOD_Plk_4	421	427	PF00069	0.772
MOD_Plk_4	479	485	PF00069	0.573
MOD_ProDKin_1	177	183	PF00069	0.708
MOD_ProDKin_1	297	303	PF00069	0.713
MOD_ProDKin_1	32	38	PF00069	0.533
MOD_ProDKin_1	354	360	PF00069	0.673
MOD_ProDKin_1	379	385	PF00069	0.573
MOD_ProDKin_1	438	444	PF00069	0.605
MOD_ProDKin_1	445	451	PF00069	0.614
MOD_ProDKin_1	452	458	PF00069	0.614
MOD_ProDKin_1	564	570	PF00069	0.580
MOD_ProDKin_1	64	70	PF00069	0.569
MOD_ProDKin_1	88	94	PF00069	0.811
MOD_SUMO_for_1	39	42	PF00179	0.547
MOD_SUMO_rev_2	273	280	PF00179	0.821
TRG_DiLeu_BaEn_1	319	324	PF01217	0.595
TRG_DiLeu_BaEn_2	467	473	PF01217	0.555
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.586
TRG_ENDOCYTIC_2	443	446	PF00928	0.547
TRG_ER_diArg_1	458	460	PF00400	0.834
TRG_ER_diArg_1	495	498	PF00400	0.621
TRG_ER_diArg_1	546	549	PF00400	0.533
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKC7	Leishmania donovani	53%	100%
A4I770	Leishmania infantum	53%	100%
E9B265	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
Q4Q5Z5	Leishmania major	52%	100%