Acetoin dehydrogenase e3 component-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetoin dehydrogenase e3 component-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJQ3_LEIBR

TriTrypDb:

LbrM.31.2990 , LBRM2903_310039200

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0045239	tricarboxylic acid cycle enzyme complex	3	3
GO:0045240	dihydrolipoyl dehydrogenase complex	4	3
GO:0045252	oxoglutarate dehydrogenase complex	4	3
GO:0110165	cellular anatomical entity	1	3
GO:1902494	catalytic complex	2	3
GO:1990204	oxidoreductase complex	3	3
GO:1990234	transferase complex	3	3

Expansion

Sequence features

A4HJQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJQ3

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	31
GO:0019725	cellular homeostasis	2	31
GO:0042592	homeostatic process	3	31
GO:0045454	cell redox homeostasis	3	31
GO:0050789	regulation of biological process	2	31
GO:0050794	regulation of cellular process	3	31
GO:0065007	biological regulation	1	31
GO:0065008	regulation of biological quality	2	31

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	31
GO:0003824	catalytic activity	1	31
GO:0005488	binding	1	31
GO:0016491	oxidoreductase activity	2	31
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	4
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	4
GO:0019152	acetoin dehydrogenase activity	5	4
GO:0036094	small molecule binding	2	31
GO:0043167	ion binding	2	31
GO:0043168	anion binding	3	31
GO:0050660	flavin adenine dinucleotide binding	4	31
GO:0052587	diacetyl reductase ((R)-acetoin forming) activity	6	4
GO:0097159	organic cyclic compound binding	2	31
GO:1901265	nucleoside phosphate binding	3	31
GO:1901363	heterocyclic compound binding	2	31
GO:0004148	dihydrolipoyl dehydrogenase activity	5	12
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	12
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	12
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	5	4
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	4	4
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.414
CLV_NRD_NRD_1	191	193	PF00675	0.523
CLV_NRD_NRD_1	23	25	PF00675	0.423
CLV_NRD_NRD_1	296	298	PF00675	0.436
CLV_NRD_NRD_1	361	363	PF00675	0.290
CLV_NRD_NRD_1	601	603	PF00675	0.206
CLV_NRD_NRD_1	641	643	PF00675	0.382
CLV_NRD_NRD_1	66	68	PF00675	0.416
CLV_NRD_NRD_1	97	99	PF00675	0.438
CLV_PCSK_KEX2_1	131	133	PF00082	0.414
CLV_PCSK_KEX2_1	191	193	PF00082	0.535
CLV_PCSK_KEX2_1	23	25	PF00082	0.423
CLV_PCSK_KEX2_1	236	238	PF00082	0.244
CLV_PCSK_KEX2_1	296	298	PF00082	0.408
CLV_PCSK_KEX2_1	641	643	PF00082	0.366
CLV_PCSK_KEX2_1	66	68	PF00082	0.416
CLV_PCSK_KEX2_1	97	99	PF00082	0.438
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.236
CLV_PCSK_SKI1_1	346	350	PF00082	0.325
CLV_PCSK_SKI1_1	488	492	PF00082	0.428
CLV_PCSK_SKI1_1	641	645	PF00082	0.303
CLV_PCSK_SKI1_1	692	696	PF00082	0.331
CLV_PCSK_SKI1_1	71	75	PF00082	0.395
CLV_PCSK_SKI1_1	80	84	PF00082	0.372
DEG_APCC_DBOX_1	88	96	PF00400	0.409
DOC_MAPK_gen_1	12	22	PF00069	0.404
DOC_MAPK_gen_1	208	217	PF00069	0.426
DOC_MAPK_gen_1	270	279	PF00069	0.443
DOC_MAPK_gen_1	407	415	PF00069	0.343
DOC_MAPK_gen_1	66	74	PF00069	0.405
DOC_MAPK_gen_1	726	734	PF00069	0.401
DOC_MAPK_MEF2A_6	436	445	PF00069	0.347
DOC_MAPK_MEF2A_6	66	74	PF00069	0.405
DOC_PP1_RVXF_1	13	19	PF00149	0.404
DOC_PP2B_LxvP_1	695	698	PF13499	0.337
DOC_USP7_MATH_1	112	116	PF00917	0.432
DOC_USP7_MATH_1	154	158	PF00917	0.436
DOC_USP7_MATH_1	255	259	PF00917	0.292
DOC_USP7_MATH_1	356	360	PF00917	0.279
DOC_USP7_MATH_1	590	594	PF00917	0.359
DOC_USP7_MATH_1	681	685	PF00917	0.332
DOC_WW_Pin1_4	165	170	PF00397	0.582
DOC_WW_Pin1_4	172	177	PF00397	0.645
DOC_WW_Pin1_4	190	195	PF00397	0.641
DOC_WW_Pin1_4	733	738	PF00397	0.622
DOC_WW_Pin1_4	90	95	PF00397	0.412
LIG_14-3-3_CanoR_1	114	123	PF00244	0.442
LIG_14-3-3_CanoR_1	132	140	PF00244	0.410
LIG_14-3-3_CanoR_1	15	21	PF00244	0.409
LIG_14-3-3_CanoR_1	156	165	PF00244	0.433
LIG_14-3-3_CanoR_1	296	300	PF00244	0.328
LIG_14-3-3_CanoR_1	32	37	PF00244	0.380
LIG_14-3-3_CanoR_1	326	330	PF00244	0.417
LIG_14-3-3_CanoR_1	346	355	PF00244	0.300
LIG_14-3-3_CanoR_1	372	381	PF00244	0.309
LIG_14-3-3_CanoR_1	488	494	PF00244	0.392
LIG_14-3-3_CanoR_1	589	595	PF00244	0.386
LIG_14-3-3_CanoR_1	612	616	PF00244	0.387
LIG_14-3-3_CanoR_1	66	70	PF00244	0.424
LIG_14-3-3_CanoR_1	676	683	PF00244	0.327
LIG_14-3-3_CanoR_1	726	734	PF00244	0.571
LIG_APCC_ABBA_1	277	282	PF00400	0.237
LIG_BRCT_BRCA1_1	183	187	PF00533	0.398
LIG_BRCT_BRCA1_1	33	37	PF00533	0.396
LIG_BRCT_BRCA1_1	536	540	PF00533	0.151
LIG_BRCT_BRCA1_1	582	586	PF00533	0.417
LIG_BRCT_BRCA1_1	683	687	PF00533	0.286
LIG_DLG_GKlike_1	32	39	PF00625	0.395
LIG_FHA_1	191	197	PF00498	0.573
LIG_FHA_1	485	491	PF00498	0.263
LIG_FHA_1	534	540	PF00498	0.408
LIG_FHA_1	586	592	PF00498	0.370
LIG_FHA_1	727	733	PF00498	0.558
LIG_FHA_2	258	264	PF00498	0.294
LIG_FHA_2	458	464	PF00498	0.307
LIG_FHA_2	479	485	PF00498	0.355
LIG_FHA_2	653	659	PF00498	0.321
LIG_FHA_2	667	673	PF00498	0.321
LIG_GBD_Chelix_1	430	438	PF00786	0.302
LIG_IRF3_LxIS_1	11	17	PF10401	0.393
LIG_LIR_Apic_2	120	126	PF02991	0.431
LIG_LIR_Gen_1	104	112	PF02991	0.440
LIG_LIR_Gen_1	177	188	PF02991	0.622
LIG_LIR_Gen_1	263	271	PF02991	0.213
LIG_LIR_Gen_1	35	45	PF02991	0.391
LIG_LIR_Gen_1	507	513	PF02991	0.237
LIG_LIR_Gen_1	614	623	PF02991	0.326
LIG_LIR_Gen_1	627	636	PF02991	0.260
LIG_LIR_Nem_3	104	109	PF02991	0.447
LIG_LIR_Nem_3	177	183	PF02991	0.655
LIG_LIR_Nem_3	184	190	PF02991	0.585
LIG_LIR_Nem_3	263	267	PF02991	0.261
LIG_LIR_Nem_3	34	40	PF02991	0.393
LIG_LIR_Nem_3	342	348	PF02991	0.302
LIG_LIR_Nem_3	349	355	PF02991	0.300
LIG_LIR_Nem_3	400	404	PF02991	0.289
LIG_LIR_Nem_3	507	511	PF02991	0.237
LIG_LIR_Nem_3	627	633	PF02991	0.234
LIG_LIR_Nem_3	678	683	PF02991	0.251
LIG_LYPXL_yS_3	680	683	PF13949	0.300
LIG_MLH1_MIPbox_1	34	38	PF16413	0.395
LIG_NRBOX	35	41	PF00104	0.393
LIG_SH2_CRK	106	110	PF00017	0.450
LIG_SH2_CRK	123	127	PF00017	0.420
LIG_SH2_CRK	180	184	PF00017	0.655
LIG_SH2_CRK	264	268	PF00017	0.316
LIG_SH2_CRK	345	349	PF00017	0.256
LIG_SH2_SRC	565	568	PF00017	0.436
LIG_SH2_STAP1	264	268	PF00017	0.227
LIG_SH2_STAP1	613	617	PF00017	0.349
LIG_SH2_STAT3	452	455	PF00017	0.321
LIG_SH2_STAT5	172	175	PF00017	0.389
LIG_SH2_STAT5	195	198	PF00017	0.681
LIG_SH2_STAT5	352	355	PF00017	0.273
LIG_SH2_STAT5	480	483	PF00017	0.311
LIG_SH2_STAT5	565	568	PF00017	0.452
LIG_SH2_STAT5	608	611	PF00017	0.332
LIG_SH2_STAT5	64	67	PF00017	0.418
LIG_SH2_STAT5	81	84	PF00017	0.364
LIG_SH3_3	466	472	PF00018	0.325
LIG_SUMO_SIM_anti_2	159	168	PF11976	0.410
LIG_SUMO_SIM_anti_2	388	393	PF11976	0.295
LIG_SUMO_SIM_anti_2	411	417	PF11976	0.312
LIG_TRAF2_1	456	459	PF00917	0.358
LIG_TRAF2_1	686	689	PF00917	0.427
LIG_TRFH_1	172	176	PF08558	0.381
LIG_TRFH_1	195	199	PF08558	0.389
LIG_TRFH_1	83	87	PF08558	0.387
LIG_TRFH_1	90	94	PF08558	0.403
LIG_TYR_ITIM	178	183	PF00017	0.380
LIG_TYR_ITSM	676	683	PF00017	0.229
LIG_UBA3_1	310	315	PF00899	0.225
LIG_UBA3_1	404	412	PF00899	0.416
LIG_UBA3_1	72	76	PF00899	0.393
LIG_ULM_U2AF65_1	131	136	PF00076	0.411
LIG_WRC_WIRS_1	490	495	PF05994	0.427
MOD_CDK_SPxxK_3	90	97	PF00069	0.417
MOD_CK1_1	115	121	PF00069	0.454
MOD_CK1_1	144	150	PF00069	0.410
MOD_CK1_1	157	163	PF00069	0.409
MOD_CK1_1	167	173	PF00069	0.381
MOD_CK1_1	181	187	PF00069	0.606
MOD_CK1_1	298	304	PF00069	0.448
MOD_CK1_1	43	49	PF00069	0.396
MOD_CK1_1	56	62	PF00069	0.428
MOD_CK1_1	580	586	PF00069	0.249
MOD_CK2_1	257	263	PF00069	0.297
MOD_CK2_1	328	334	PF00069	0.267
MOD_CK2_1	457	463	PF00069	0.306
MOD_CK2_1	550	556	PF00069	0.292
MOD_CK2_1	652	658	PF00069	0.284
MOD_Cter_Amidation	129	132	PF01082	0.412
MOD_GlcNHglycan	119	122	PF01048	0.448
MOD_GlcNHglycan	316	319	PF01048	0.353
MOD_GlcNHglycan	475	478	PF01048	0.365
MOD_GlcNHglycan	56	59	PF01048	0.441
MOD_GlcNHglycan	61	64	PF01048	0.421
MOD_GlcNHglycan	704	707	PF01048	0.483
MOD_GlcNHglycan	8	11	PF01048	0.380
MOD_GSK3_1	14	21	PF00069	0.407
MOD_GSK3_1	141	148	PF00069	0.430
MOD_GSK3_1	152	159	PF00069	0.603
MOD_GSK3_1	163	170	PF00069	0.577
MOD_GSK3_1	174	181	PF00069	0.396
MOD_GSK3_1	40	47	PF00069	0.390
MOD_GSK3_1	484	491	PF00069	0.347
MOD_GSK3_1	513	520	PF00069	0.343
MOD_GSK3_1	575	582	PF00069	0.441
MOD_N-GLC_1	144	149	PF02516	0.416
MOD_N-GLC_1	201	206	PF02516	0.569
MOD_N-GLC_1	32	37	PF02516	0.396
MOD_N-GLC_1	514	519	PF02516	0.313
MOD_N-GLC_1	575	580	PF02516	0.405
MOD_N-GLC_1	596	601	PF02516	0.323
MOD_N-GLC_1	651	656	PF02516	0.383
MOD_N-GLC_1	666	671	PF02516	0.320
MOD_NEK2_1	14	19	PF00069	0.407
MOD_NEK2_1	178	183	PF00069	0.585
MOD_NEK2_1	314	319	PF00069	0.327
MOD_NEK2_1	40	45	PF00069	0.391
MOD_NEK2_1	408	413	PF00069	0.315
MOD_NEK2_1	483	488	PF00069	0.342
MOD_NEK2_1	489	494	PF00069	0.338
MOD_NEK2_1	577	582	PF00069	0.493
MOD_NEK2_1	651	656	PF00069	0.346
MOD_NEK2_1	732	737	PF00069	0.706
MOD_NEK2_1	74	79	PF00069	0.381
MOD_PIKK_1	115	121	PF00454	0.442
MOD_PIKK_1	520	526	PF00454	0.237
MOD_PIKK_1	596	602	PF00454	0.384
MOD_PIKK_1	681	687	PF00454	0.298
MOD_PKA_2	115	121	PF00069	0.436
MOD_PKA_2	133	139	PF00069	0.411
MOD_PKA_2	14	20	PF00069	0.407
MOD_PKA_2	295	301	PF00069	0.351
MOD_PKA_2	31	37	PF00069	0.379
MOD_PKA_2	325	331	PF00069	0.373
MOD_PKA_2	484	490	PF00069	0.339
MOD_PKA_2	520	526	PF00069	0.435
MOD_PKA_2	611	617	PF00069	0.398
MOD_PKA_2	65	71	PF00069	0.411
MOD_PKA_2	675	681	PF00069	0.370
MOD_PKA_2	732	738	PF00069	0.624
MOD_Plk_1	136	142	PF00069	0.407
MOD_Plk_1	241	247	PF00069	0.376
MOD_Plk_1	262	268	PF00069	0.468
MOD_Plk_1	32	38	PF00069	0.396
MOD_Plk_1	506	512	PF00069	0.404
MOD_Plk_1	513	519	PF00069	0.344
MOD_Plk_1	651	657	PF00069	0.339
MOD_Plk_1	666	672	PF00069	0.397
MOD_Plk_2-3	263	269	PF00069	0.461
MOD_Plk_4	174	180	PF00069	0.584
MOD_Plk_4	257	263	PF00069	0.286
MOD_Plk_4	32	38	PF00069	0.396
MOD_Plk_4	385	391	PF00069	0.300
MOD_Plk_4	40	46	PF00069	0.383
MOD_Plk_4	411	417	PF00069	0.321
MOD_Plk_4	478	484	PF00069	0.302
MOD_Plk_4	514	520	PF00069	0.151
MOD_Plk_4	652	658	PF00069	0.312
MOD_Plk_4	666	672	PF00069	0.300
MOD_ProDKin_1	165	171	PF00069	0.576
MOD_ProDKin_1	172	178	PF00069	0.644
MOD_ProDKin_1	190	196	PF00069	0.640
MOD_ProDKin_1	90	96	PF00069	0.414
MOD_SUMO_rev_2	289	295	PF00179	0.355
MOD_SUMO_rev_2	564	574	PF00179	0.340
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.383
TRG_ENDOCYTIC_2	106	109	PF00928	0.450
TRG_ENDOCYTIC_2	180	183	PF00928	0.378
TRG_ENDOCYTIC_2	264	267	PF00928	0.289
TRG_ENDOCYTIC_2	345	348	PF00928	0.290
TRG_ENDOCYTIC_2	352	355	PF00928	0.310
TRG_ENDOCYTIC_2	480	483	PF00928	0.302
TRG_ENDOCYTIC_2	615	618	PF00928	0.327
TRG_ENDOCYTIC_2	680	683	PF00928	0.294
TRG_ER_diArg_1	131	133	PF00400	0.415
TRG_ER_diArg_1	190	192	PF00400	0.515
TRG_ER_diArg_1	22	24	PF00400	0.415
TRG_ER_diArg_1	295	297	PF00400	0.319
TRG_ER_diArg_1	641	643	PF00400	0.417
TRG_ER_diArg_1	78	81	PF00400	0.372
TRG_Pf-PMV_PEXEL_1	286	291	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUA4	Leptomonas seymouri	79%	100%
A0A0N1IHT7	Leptomonas seymouri	37%	100%
A0A0N1IIN8	Leptomonas seymouri	37%	100%
A0A0S4J6A3	Bodo saltans	20%	100%
A0A0S4KLJ6	Bodo saltans	37%	100%
A0A1X0NJ18	Trypanosomatidae	51%	100%
A0A1X0NK15	Trypanosomatidae	45%	100%
A0A1X0NZX1	Trypanosomatidae	41%	100%
A0A3Q8IDT8	Leishmania donovani	39%	100%
A0A3Q8IF30	Leishmania donovani	85%	100%
A0A3R7NSH5	Trypanosoma rangeli	43%	100%
A0A3S7X4X4	Leishmania donovani	35%	100%
A0A422NPA5	Trypanosoma rangeli	52%	100%
A0A422NPB5	Trypanosoma rangeli	42%	100%
A4HIY7	Leishmania braziliensis	40%	98%
A4HJQ2	Leishmania braziliensis	35%	100%
A4I4P1	Leishmania infantum	39%	100%
A8MS68	Arabidopsis thaliana	25%	100%
C9ZLC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZMF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
C9ZWN2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D0A4H8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
E9AE44	Leishmania major	39%	99%
E9AHL8	Leishmania infantum	85%	100%
E9ALP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B263	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B264	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
F4JLP5	Arabidopsis thaliana	24%	100%
G0SB20	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	26%	100%
O00087	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O04955	Brassica rapa subsp. pekinensis	22%	100%
O15770	Plasmodium falciparum (isolate 3D7)	22%	100%
O17953	Caenorhabditis elegans	27%	100%
P09624	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P0A0E4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	22%	100%
P0A0E5	Staphylococcus aureus	22%	100%
P16171	Bacillus cereus	23%	100%
P17239	Acidithiobacillus ferrooxidans	26%	100%
P28593	Trypanosoma cruzi	21%	100%
P30635	Caenorhabditis elegans	22%	100%
P31023	Pisum sativum	28%	100%
P39051	Trypanosoma brucei brucei	21%	100%
P47791	Mus musculus	25%	100%
P48641	Arabidopsis thaliana	22%	100%
P61076	Plasmodium falciparum (isolate 3D7)	24%	100%
P80461	Nicotiana tabacum	22%	100%
P91938	Drosophila melanogaster	22%	100%
P9WHH6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WHH7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q02733	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q25861	Plasmodium falciparum (isolate FCH-5)	24%	100%
Q4Q5Z6	Leishmania major	84%	100%
Q4Q5Z7	Leishmania major	34%	100%
Q94655	Plasmodium falciparum (isolate K1 / Thailand)	22%	100%
Q9JMH6	Mus musculus	22%	100%
Q9M5K2	Arabidopsis thaliana	26%	100%
Q9M5K3	Arabidopsis thaliana	26%	100%
Q9N2I8	Bos taurus	21%	100%
Q9VNT5	Drosophila melanogaster	23%	100%
V5AJG2	Trypanosoma cruzi	21%	100%
V5B6P6	Trypanosoma cruzi	43%	100%
V5BB90	Trypanosoma cruzi	52%	100%
V5BDX2	Trypanosoma cruzi	42%	100%