Fluoride ion transporter CrcB

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CrcB-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJQ0_LEIBR

TriTrypDb:

LbrM.31.2960 , LBRM2903_310038900

Length:

283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	8
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HJQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJQ0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006820	monoatomic anion transport	5	1
GO:0009987	cellular process	1	1
GO:0015698	inorganic anion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098661	inorganic anion transmembrane transport	5	1
GO:1903424	fluoride transmembrane transport	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0008509	monoatomic anion transmembrane transporter activity	4	8
GO:0015075	monoatomic ion transmembrane transporter activity	3	8
GO:0015103	inorganic anion transmembrane transporter activity	4	8
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	8
GO:0022857	transmembrane transporter activity	2	8
GO:1903425	fluoride transmembrane transporter activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.354
CLV_NRD_NRD_1	277	279	PF00675	0.473
CLV_PCSK_KEX2_1	277	279	PF00082	0.531
CLV_PCSK_PC7_1	273	279	PF00082	0.379
CLV_PCSK_SKI1_1	195	199	PF00082	0.441
CLV_PCSK_SKI1_1	250	254	PF00082	0.342
CLV_PCSK_SKI1_1	75	79	PF00082	0.590
DEG_Nend_UBRbox_2	1	3	PF02207	0.574
DEG_ODPH_VHL_1	242	255	PF01847	0.432
DOC_CYCLIN_RxL_1	247	254	PF00134	0.423
DOC_PP1_RVXF_1	172	179	PF00149	0.606
DOC_PP2B_LxvP_1	38	41	PF13499	0.558
DOC_WW_Pin1_4	158	163	PF00397	0.227
DOC_WW_Pin1_4	183	188	PF00397	0.638
DOC_WW_Pin1_4	42	47	PF00397	0.634
LIG_14-3-3_CanoR_1	199	207	PF00244	0.478
LIG_14-3-3_CanoR_1	250	256	PF00244	0.480
LIG_BRCT_BRCA1_1	84	88	PF00533	0.240
LIG_BRCT_BRCA1_2	84	90	PF00533	0.240
LIG_deltaCOP1_diTrp_1	185	191	PF00928	0.583
LIG_FHA_1	158	164	PF00498	0.379
LIG_FHA_1	227	233	PF00498	0.436
LIG_FHA_2	145	151	PF00498	0.354
LIG_GBD_Chelix_1	211	219	PF00786	0.227
LIG_HP1_1	53	57	PF01393	0.407
LIG_LIR_Gen_1	131	140	PF02991	0.432
LIG_LIR_Gen_1	150	157	PF02991	0.293
LIG_LIR_Nem_3	131	135	PF02991	0.486
LIG_LIR_Nem_3	150	155	PF02991	0.272
LIG_LIR_Nem_3	48	54	PF02991	0.660
LIG_LIR_Nem_3	85	91	PF02991	0.270
LIG_MLH1_MIPbox_1	84	88	PF16413	0.240
LIG_Pex14_2	128	132	PF04695	0.424
LIG_Pex14_2	152	156	PF04695	0.290
LIG_Pex14_2	251	255	PF04695	0.312
LIG_SH2_CRK	91	95	PF00017	0.390
LIG_SH2_PTP2	54	57	PF00017	0.227
LIG_SH2_PTP2	93	96	PF00017	0.432
LIG_SH2_STAP1	47	51	PF00017	0.584
LIG_SH2_STAT3	31	34	PF00017	0.766
LIG_SH2_STAT5	47	50	PF00017	0.658
LIG_SH2_STAT5	54	57	PF00017	0.352
LIG_SH2_STAT5	93	96	PF00017	0.353
LIG_SH3_3	106	112	PF00018	0.432
LIG_SH3_3	238	244	PF00018	0.286
LIG_SH3_3	29	35	PF00018	0.740
LIG_WRC_WIRS_1	132	137	PF05994	0.351
LIG_WRC_WIRS_1	252	257	PF05994	0.227
LIG_WRC_WIRS_1	99	104	PF05994	0.432
MOD_CK1_1	131	137	PF00069	0.373
MOD_CK1_1	193	199	PF00069	0.600
MOD_CK1_1	21	27	PF00069	0.603
MOD_CK1_1	33	39	PF00069	0.715
MOD_CK2_1	21	27	PF00069	0.603
MOD_CK2_1	220	226	PF00069	0.292
MOD_CMANNOS	188	191	PF00535	0.449
MOD_GSK3_1	130	137	PF00069	0.384
MOD_GSK3_1	183	190	PF00069	0.649
MOD_GSK3_1	226	233	PF00069	0.321
MOD_GSK3_1	30	37	PF00069	0.645
MOD_GSK3_1	41	48	PF00069	0.587
MOD_N-GLC_1	19	24	PF02516	0.583
MOD_NEK2_1	128	133	PF00069	0.351
MOD_NEK2_1	157	162	PF00069	0.281
MOD_NEK2_1	251	256	PF00069	0.419
MOD_NEK2_1	60	65	PF00069	0.376
MOD_NEK2_1	82	87	PF00069	0.288
MOD_PIKK_1	226	232	PF00454	0.325
MOD_PIKK_1	30	36	PF00454	0.767
MOD_PKA_2	18	24	PF00069	0.596
MOD_PKA_2	198	204	PF00069	0.645
MOD_PKA_2	276	282	PF00069	0.705
MOD_Plk_4	134	140	PF00069	0.382
MOD_Plk_4	6	12	PF00069	0.736
MOD_Plk_4	98	104	PF00069	0.409
MOD_ProDKin_1	158	164	PF00069	0.227
MOD_ProDKin_1	183	189	PF00069	0.643
MOD_ProDKin_1	42	48	PF00069	0.624
TRG_ENDOCYTIC_2	54	57	PF00928	0.483
TRG_ENDOCYTIC_2	91	94	PF00928	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P462	Leptomonas seymouri	61%	100%
A0A1X0NID7	Trypanosomatidae	35%	84%
A0A3Q8IGC8	Leishmania donovani	72%	72%
A0A422NPK8	Trypanosoma rangeli	32%	76%
A4I767	Leishmania infantum	73%	72%
Q4Q5Z9	Leishmania major	73%	100%