Calreticulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Calreticulin

Gene product:

calreticulin, putative

Species:

Leishmania braziliensis

UniProt:

A4HJP8_LEIBR

TriTrypDb:

LbrM.31.2940 , LBRM2903_310038500

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	12
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031974	membrane-enclosed lumen	2	12
GO:0043233	organelle lumen	3	12
GO:0070013	intracellular organelle lumen	4	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4HJP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJP8

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	12
GO:0010033	response to organic substance	3	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0005515	protein binding	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051082	unfolded protein binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	281	283	PF00675	0.482
CLV_NRD_NRD_1	370	372	PF00675	0.465
CLV_NRD_NRD_1	373	375	PF00675	0.460
CLV_PCSK_KEX2_1	281	283	PF00082	0.482
CLV_PCSK_SKI1_1	4	8	PF00082	0.611
DEG_APCC_DBOX_1	3	11	PF00400	0.611
DEG_APCC_KENBOX_2	386	390	PF00400	0.412
DOC_CKS1_1	81	86	PF01111	0.171
DOC_CYCLIN_yClb1_LxF_4	140	145	PF00134	0.183
DOC_PP1_RVXF_1	140	146	PF00149	0.347

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0D1C6P2	Ustilago maydis (strain 521 / FGSC 9021)	33%	81%
A0A0N1IJA0	Leptomonas seymouri	64%	100%
A0A0S4KMN1	Bodo saltans	53%	100%
A0A1X0NIG9	Trypanosomatidae	53%	100%
A0A3R7KPX3	Trypanosoma rangeli	53%	100%
A0A3S7X4V0	Leishmania donovani	72%	100%
A4I765	Leishmania infantum	68%	100%
A8XA40	Caenorhabditis briggsae	33%	68%
C9ZMF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D4AVD4	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	35%	75%

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