Calreticulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Calreticulin

Gene product:

calreticulin, putative

Species:

Leishmania braziliensis

UniProt:

A4HJP8_LEIBR

TriTrypDb:

LbrM.31.2940 , LBRM2903_310038500

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	12
GO:0031974	membrane-enclosed lumen	2	12
GO:0043233	organelle lumen	3	12
GO:0070013	intracellular organelle lumen	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

A4HJP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJP8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0005515	protein binding	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051082	unfolded protein binding	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	281	283	PF00675	0.482
CLV_NRD_NRD_1	370	372	PF00675	0.465
CLV_NRD_NRD_1	373	375	PF00675	0.460
CLV_PCSK_KEX2_1	281	283	PF00082	0.482
CLV_PCSK_SKI1_1	4	8	PF00082	0.611
DEG_APCC_DBOX_1	3	11	PF00400	0.611
DEG_APCC_KENBOX_2	386	390	PF00400	0.412
DOC_CKS1_1	81	86	PF01111	0.171
DOC_CYCLIN_yClb1_LxF_4	140	145	PF00134	0.183
DOC_PP1_RVXF_1	140	146	PF00149	0.347
DOC_PP4_MxPP_1	204	207	PF00568	0.302
DOC_WW_Pin1_4	123	128	PF00397	0.245
DOC_WW_Pin1_4	176	181	PF00397	0.210
DOC_WW_Pin1_4	290	295	PF00397	0.181
DOC_WW_Pin1_4	308	313	PF00397	0.122
DOC_WW_Pin1_4	80	85	PF00397	0.215
LIG_Actin_WH2_2	91	107	PF00022	0.161
LIG_CSL_BTD_1	277	280	PF09270	0.226
LIG_CSL_BTD_1	291	294	PF09270	0.150
LIG_FHA_1	161	167	PF00498	0.245
LIG_FHA_1	173	179	PF00498	0.215
LIG_FHA_1	181	187	PF00498	0.208
LIG_FHA_1	390	396	PF00498	0.437
LIG_FHA_2	207	213	PF00498	0.294
LIG_FHA_2	231	237	PF00498	0.254
LIG_FHA_2	242	248	PF00498	0.260
LIG_FHA_2	381	387	PF00498	0.553
LIG_LIR_Apic_2	261	267	PF02991	0.266
LIG_LIR_Gen_1	126	136	PF02991	0.169
LIG_LIR_Gen_1	200	210	PF02991	0.265
LIG_LIR_Gen_1	29	38	PF02991	0.369
LIG_LIR_Gen_1	329	336	PF02991	0.290
LIG_LIR_Nem_3	126	132	PF02991	0.177
LIG_LIR_Nem_3	158	162	PF02991	0.161
LIG_LIR_Nem_3	183	187	PF02991	0.230
LIG_LIR_Nem_3	200	205	PF02991	0.290
LIG_LIR_Nem_3	29	34	PF02991	0.287
LIG_LIR_Nem_3	329	334	PF02991	0.224
LIG_LIR_Nem_3	44	49	PF02991	0.263
LIG_LIR_Nem_3	71	77	PF02991	0.235
LIG_PDZ_Class_3	417	422	PF00595	0.639
LIG_Pex14_2	27	31	PF04695	0.302
LIG_PTB_Apo_2	268	275	PF02174	0.277
LIG_PTB_Apo_2	282	289	PF02174	0.168
LIG_PTB_Apo_2	296	303	PF02174	0.224
LIG_PTB_Phospho_1	268	274	PF10480	0.277
LIG_PTB_Phospho_1	282	288	PF10480	0.168
LIG_PTB_Phospho_1	296	302	PF10480	0.224
LIG_SH2_CRK	309	313	PF00017	0.322
LIG_SH2_PTP2	317	320	PF00017	0.322
LIG_SH2_SRC	187	190	PF00017	0.322
LIG_SH2_SRC	75	78	PF00017	0.224
LIG_SH2_STAP1	174	178	PF00017	0.224
LIG_SH2_STAT3	174	177	PF00017	0.305
LIG_SH2_STAT5	110	113	PF00017	0.234
LIG_SH2_STAT5	174	177	PF00017	0.224
LIG_SH2_STAT5	187	190	PF00017	0.224
LIG_SH2_STAT5	192	195	PF00017	0.224
LIG_SH2_STAT5	317	320	PF00017	0.301
LIG_SH3_3	264	270	PF00018	0.235
LIG_SH3_3	288	294	PF00018	0.182
LIG_SH3_5	298	302	PF00018	0.161
LIG_SUMO_SIM_par_1	90	95	PF11976	0.305
LIG_TRAF2_1	383	386	PF00917	0.481
LIG_TYR_ITIM	315	320	PF00017	0.322
LIG_WRC_WIRS_1	93	98	PF05994	0.235
MOD_CK2_1	230	236	PF00069	0.336
MOD_CK2_1	378	384	PF00069	0.423
MOD_CK2_1	387	393	PF00069	0.562
MOD_CK2_1	414	420	PF00069	0.499
MOD_GlcNHglycan	326	329	PF01048	0.369
MOD_GlcNHglycan	50	54	PF01048	0.355
MOD_GSK3_1	168	175	PF00069	0.204
MOD_GSK3_1	176	183	PF00069	0.187
MOD_N-GLC_1	180	185	PF02516	0.502
MOD_NEK2_1	155	160	PF00069	0.221
MOD_NEK2_1	92	97	PF00069	0.169
MOD_PK_1	387	393	PF00069	0.422
MOD_PKA_1	216	222	PF00069	0.161
MOD_PKA_2	160	166	PF00069	0.252
MOD_Plk_1	180	186	PF00069	0.264
MOD_Plk_1	222	228	PF00069	0.184
MOD_Plk_1	246	252	PF00069	0.161
MOD_Plk_1	347	353	PF00069	0.358
MOD_Plk_1	378	384	PF00069	0.369
MOD_Plk_1	387	393	PF00069	0.394
MOD_Plk_2-3	241	247	PF00069	0.298
MOD_Plk_2-3	30	36	PF00069	0.360
MOD_Plk_2-3	326	332	PF00069	0.322
MOD_Plk_2-3	378	384	PF00069	0.369
MOD_Plk_4	194	200	PF00069	0.298
MOD_Plk_4	222	228	PF00069	0.245
MOD_Plk_4	326	332	PF00069	0.224
MOD_ProDKin_1	123	129	PF00069	0.245
MOD_ProDKin_1	176	182	PF00069	0.210
MOD_ProDKin_1	290	296	PF00069	0.181
MOD_ProDKin_1	308	314	PF00069	0.122
MOD_ProDKin_1	80	86	PF00069	0.215
MOD_SUMO_for_1	98	101	PF00179	0.235
MOD_SUMO_rev_2	212	219	PF00179	0.233
MOD_SUMO_rev_2	228	235	PF00179	0.309
MOD_SUMO_rev_2	70	74	PF00179	0.362
MOD_SUMO_rev_2	86	92	PF00179	0.270
TRG_DiLeu_BaEn_4	29	35	PF01217	0.275
TRG_DiLeu_BaEn_4	377	383	PF01217	0.367
TRG_ENDOCYTIC_2	110	113	PF00928	0.234
TRG_ENDOCYTIC_2	128	131	PF00928	0.219
TRG_ENDOCYTIC_2	288	291	PF00928	0.203
TRG_ENDOCYTIC_2	317	320	PF00928	0.322
TRG_ENDOCYTIC_2	351	354	PF00928	0.417
TRG_ENDOCYTIC_2	46	49	PF00928	0.267
TRG_ER_diArg_1	280	282	PF00400	0.314
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D1C6P2	Ustilago maydis (strain 521 / FGSC 9021)	33%	81%
A0A0N1IJA0	Leptomonas seymouri	64%	100%
A0A0S4KMN1	Bodo saltans	53%	100%
A0A1X0NIG9	Trypanosomatidae	53%	100%
A0A3R7KPX3	Trypanosoma rangeli	53%	100%
A0A3S7X4V0	Leishmania donovani	72%	100%
A4I765	Leishmania infantum	68%	100%
A8XA40	Caenorhabditis briggsae	33%	68%
C9ZMF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D4AVD4	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	35%	75%
E2RA18	Canis lupus familiaris	36%	68%
E9B259	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
J9VLH0	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	32%	77%
O04151	Arabidopsis thaliana	44%	99%
O04153	Arabidopsis thaliana	41%	100%
O14967	Homo sapiens	35%	69%
O81919	Beta vulgaris	44%	100%
O82709	Pisum sativum	31%	77%
P11012	Onchocerca volvulus	45%	100%
P14211	Mus musculus	44%	100%
P15253	Oryctolagus cuniculus	44%	100%
P18418	Rattus norvegicus	44%	100%
P24643	Canis lupus familiaris	36%	71%
P27797	Homo sapiens	43%	100%
P27798	Caenorhabditis elegans	45%	100%
P27824	Homo sapiens	35%	71%
P27825	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	84%
P28491	Sus scrofa	42%	100%
P29402	Arabidopsis thaliana	34%	80%
P29413	Drosophila melanogaster	41%	100%
P34652	Caenorhabditis elegans	30%	68%
P35564	Mus musculus	36%	71%
P35565	Rattus norvegicus	36%	71%
P36581	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	75%
P52193	Bos taurus	43%	100%
P52194	Mus musculus	35%	69%
P93508	Ricinus communis	47%	100%
Q06814	Schistosoma mansoni	45%	100%
Q23858	Dictyostelium discoideum	43%	100%
Q2HWU3	Macaca fuscata fuscata	43%	100%
Q2TBR8	Bos taurus	33%	100%
Q38798	Arabidopsis thaliana	34%	79%
Q38858	Arabidopsis thaliana	45%	100%
Q39817	Glycine max	31%	77%
Q39994	Helianthus tuberosus	32%	78%
Q3SYT6	Bos taurus	36%	70%
Q40401	Nicotiana plumbaginifolia	48%	100%
Q4Q601	Leishmania major	72%	100%
Q4R6K8	Macaca fascicularis	43%	100%
Q4VIT5	Chlorocebus aethiops	43%	100%
Q5R440	Pongo abelii	36%	71%
Q61KR9	Caenorhabditis briggsae	44%	100%
Q6Q487	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	75%
Q7Z1E6	Bombyx mori	46%	100%
Q8K3H7	Cricetulus griseus	44%	100%
Q96L12	Homo sapiens	34%	100%
Q9D9Q6	Mus musculus	33%	100%
Q9SLY8	Oryza sativa subsp. japonica	44%	100%
Q9SP22	Zea mays	42%	100%
Q9STD3	Chlamydomonas reinhardtii	45%	100%
Q9XF98	Prunus armeniaca	44%	100%
Q9ZNY3	Euglena gracilis	44%	100%
Q9ZPP1	Berberis stolonifera	45%	100%
V5AMP1	Trypanosoma cruzi	51%	100%