TerD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TerD domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HJP7_LEIBR

TriTrypDb:

LbrM.31.2930 , LBRM2903_310038400

Length:

906

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	485	489	PF00656	0.634
CLV_C14_Caspase3-7	747	751	PF00656	0.388
CLV_MEL_PAP_1	854	860	PF00089	0.511
CLV_NRD_NRD_1	105	107	PF00675	0.530
CLV_NRD_NRD_1	113	115	PF00675	0.620
CLV_NRD_NRD_1	179	181	PF00675	0.699
CLV_NRD_NRD_1	520	522	PF00675	0.615
CLV_NRD_NRD_1	657	659	PF00675	0.746
CLV_PCSK_FUR_1	111	115	PF00082	0.582
CLV_PCSK_KEX2_1	105	107	PF00082	0.526
CLV_PCSK_KEX2_1	111	113	PF00082	0.607
CLV_PCSK_KEX2_1	178	180	PF00082	0.732
CLV_PCSK_KEX2_1	435	437	PF00082	0.660
CLV_PCSK_KEX2_1	480	482	PF00082	0.453
CLV_PCSK_KEX2_1	520	522	PF00082	0.627
CLV_PCSK_KEX2_1	657	659	PF00082	0.742
CLV_PCSK_KEX2_1	889	891	PF00082	0.496
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.660
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.453
CLV_PCSK_PC1ET2_1	889	891	PF00082	0.505
CLV_PCSK_PC7_1	175	181	PF00082	0.716
CLV_PCSK_SKI1_1	636	640	PF00082	0.739
CLV_PCSK_SKI1_1	672	676	PF00082	0.468
CLV_PCSK_SKI1_1	677	681	PF00082	0.665
CLV_PCSK_SKI1_1	789	793	PF00082	0.483
DEG_APCC_DBOX_1	313	321	PF00400	0.618
DEG_APCC_DBOX_1	590	598	PF00400	0.448
DEG_APCC_DBOX_1	699	707	PF00400	0.567
DEG_COP1_1	437	447	PF00400	0.536
DEG_ODPH_VHL_1	336	348	PF01847	0.333
DOC_CDC14_PxL_1	441	449	PF14671	0.439
DOC_CKS1_1	611	616	PF01111	0.486
DOC_MAPK_gen_1	44	54	PF00069	0.521
DOC_MAPK_gen_1	752	760	PF00069	0.589
DOC_MAPK_gen_1	784	793	PF00069	0.424
DOC_MAPK_gen_1	855	863	PF00069	0.469
DOC_MAPK_gen_1	9	19	PF00069	0.434
DOC_MAPK_MEF2A_6	12	21	PF00069	0.439
DOC_MAPK_MEF2A_6	236	244	PF00069	0.363
DOC_MAPK_MEF2A_6	44	53	PF00069	0.520
DOC_MAPK_MEF2A_6	784	792	PF00069	0.420
DOC_MAPK_MEF2A_6	851	858	PF00069	0.416
DOC_MAPK_MEF2A_6	898	906	PF00069	0.416
DOC_PP1_RVXF_1	762	768	PF00149	0.576
DOC_PP2B_LxvP_1	310	313	PF13499	0.543
DOC_PP4_FxxP_1	11	14	PF00568	0.420
DOC_PP4_FxxP_1	442	445	PF00568	0.463
DOC_SPAK_OSR1_1	345	349	PF12202	0.315
DOC_USP7_MATH_1	313	317	PF00917	0.580
DOC_USP7_MATH_1	388	392	PF00917	0.429
DOC_USP7_MATH_1	638	642	PF00917	0.763
DOC_USP7_MATH_1	650	654	PF00917	0.724
DOC_WW_Pin1_4	610	615	PF00397	0.752
DOC_WW_Pin1_4	753	758	PF00397	0.480
LIG_14-3-3_CanoR_1	314	318	PF00244	0.624
LIG_14-3-3_CanoR_1	340	348	PF00244	0.445
LIG_14-3-3_CanoR_1	481	487	PF00244	0.484
LIG_14-3-3_CanoR_1	636	646	PF00244	0.564
LIG_14-3-3_CanoR_1	689	697	PF00244	0.592
LIG_14-3-3_CanoR_1	745	753	PF00244	0.490
LIG_14-3-3_CanoR_1	819	824	PF00244	0.418
LIG_Actin_WH2_2	366	383	PF00022	0.473
LIG_APCC_ABBA_1	226	231	PF00400	0.475
LIG_APCC_ABBA_1	359	364	PF00400	0.488
LIG_APCC_ABBAyCdc20_2	225	231	PF00400	0.474
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BRCT_BRCA1_1	23	27	PF00533	0.522
LIG_BRCT_BRCA1_1	823	827	PF00533	0.568
LIG_Clathr_ClatBox_1	360	364	PF01394	0.490
LIG_deltaCOP1_diTrp_1	729	733	PF00928	0.536
LIG_eIF4E_1	754	760	PF01652	0.554
LIG_FHA_1	120	126	PF00498	0.751
LIG_FHA_1	248	254	PF00498	0.430
LIG_FHA_1	300	306	PF00498	0.549
LIG_FHA_1	409	415	PF00498	0.474
LIG_FHA_1	477	483	PF00498	0.692
LIG_FHA_1	678	684	PF00498	0.697
LIG_FHA_1	734	740	PF00498	0.647
LIG_FHA_1	793	799	PF00498	0.537
LIG_FHA_1	843	849	PF00498	0.653
LIG_FHA_2	212	218	PF00498	0.434
LIG_FHA_2	483	489	PF00498	0.484
LIG_HCF-1_HBM_1	371	374	PF13415	0.479
LIG_Integrin_isoDGR_2	518	520	PF01839	0.705
LIG_LIR_Apic_2	411	415	PF02991	0.442
LIG_LIR_Apic_2	440	445	PF02991	0.431
LIG_LIR_Gen_1	2	11	PF02991	0.422
LIG_LIR_Gen_1	204	213	PF02991	0.411
LIG_LIR_Gen_1	217	226	PF02991	0.404
LIG_LIR_Gen_1	24	33	PF02991	0.570
LIG_LIR_Gen_1	294	305	PF02991	0.390
LIG_LIR_Gen_1	357	363	PF02991	0.362
LIG_LIR_Gen_1	403	414	PF02991	0.406
LIG_LIR_Gen_1	446	456	PF02991	0.535
LIG_LIR_Gen_1	45	54	PF02991	0.516
LIG_LIR_Gen_1	509	517	PF02991	0.503
LIG_LIR_Gen_1	570	579	PF02991	0.336
LIG_LIR_Gen_1	613	623	PF02991	0.502
LIG_LIR_Nem_3	2	6	PF02991	0.464
LIG_LIR_Nem_3	204	210	PF02991	0.402
LIG_LIR_Nem_3	217	221	PF02991	0.410
LIG_LIR_Nem_3	24	28	PF02991	0.550
LIG_LIR_Nem_3	294	300	PF02991	0.402
LIG_LIR_Nem_3	357	362	PF02991	0.446
LIG_LIR_Nem_3	403	409	PF02991	0.412
LIG_LIR_Nem_3	446	451	PF02991	0.511
LIG_LIR_Nem_3	45	51	PF02991	0.520
LIG_LIR_Nem_3	509	515	PF02991	0.530
LIG_LIR_Nem_3	570	575	PF02991	0.409
LIG_LIR_Nem_3	613	618	PF02991	0.705
LIG_LIR_Nem_3	776	782	PF02991	0.506
LIG_LIR_Nem_3	824	830	PF02991	0.545
LIG_MYND_1	75	79	PF01753	0.626
LIG_Pex14_1	427	431	PF04695	0.543
LIG_Pex14_2	295	299	PF04695	0.424
LIG_Pex14_2	346	350	PF04695	0.299
LIG_Pex14_2	512	516	PF04695	0.599
LIG_Pex14_2	54	58	PF04695	0.435
LIG_PTB_Apo_2	137	144	PF02174	0.603
LIG_PTB_Apo_2	52	59	PF02174	0.419
LIG_PTB_Apo_2	748	755	PF02174	0.591
LIG_PTB_Apo_2	894	901	PF02174	0.637
LIG_PTB_Phospho_1	137	143	PF10480	0.602
LIG_PTB_Phospho_1	748	754	PF10480	0.592
LIG_PTB_Phospho_1	894	900	PF10480	0.633
LIG_SH2_CRK	615	619	PF00017	0.499
LIG_SH2_CRK	754	758	PF00017	0.504
LIG_SH2_CRK	785	789	PF00017	0.482
LIG_SH2_CRK	80	84	PF00017	0.458
LIG_SH2_GRB2like	131	134	PF00017	0.709
LIG_SH2_GRB2like	697	700	PF00017	0.678
LIG_SH2_GRB2like	895	898	PF00017	0.628
LIG_SH2_NCK_1	131	135	PF00017	0.643
LIG_SH2_PTP2	563	566	PF00017	0.492
LIG_SH2_SRC	369	372	PF00017	0.419
LIG_SH2_SRC	563	566	PF00017	0.456
LIG_SH2_STAP1	131	135	PF00017	0.672
LIG_SH2_STAP1	161	165	PF00017	0.612
LIG_SH2_STAP1	585	589	PF00017	0.586
LIG_SH2_STAP1	891	895	PF00017	0.619
LIG_SH2_STAT3	213	216	PF00017	0.558
LIG_SH2_STAT3	896	899	PF00017	0.634
LIG_SH2_STAT5	131	134	PF00017	0.682
LIG_SH2_STAT5	213	216	PF00017	0.461
LIG_SH2_STAT5	369	372	PF00017	0.419
LIG_SH2_STAT5	448	451	PF00017	0.438
LIG_SH2_STAT5	563	566	PF00017	0.462
LIG_SH2_STAT5	578	581	PF00017	0.336
LIG_SH2_STAT5	779	782	PF00017	0.509
LIG_SH3_2	718	723	PF14604	0.537
LIG_SH3_3	257	263	PF00018	0.425
LIG_SH3_3	453	459	PF00018	0.580
LIG_SH3_3	562	568	PF00018	0.552
LIG_SH3_3	715	721	PF00018	0.465
LIG_SUMO_SIM_anti_2	189	198	PF11976	0.419
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.588
LIG_SUMO_SIM_anti_2	403	411	PF11976	0.421
LIG_SUMO_SIM_anti_2	802	807	PF11976	0.454
LIG_SUMO_SIM_par_1	31	36	PF11976	0.420
LIG_SUMO_SIM_par_1	756	761	PF11976	0.582
LIG_TRAF2_1	262	265	PF00917	0.702
LIG_TRAF2_1	281	284	PF00917	0.650
LIG_TRAF2_1	66	69	PF00917	0.551
LIG_TRFH_1	555	559	PF08558	0.596
LIG_TYR_ITIM	78	83	PF00017	0.453
LIG_WRC_WIRS_1	292	297	PF05994	0.435
LIG_WRC_WIRS_1	428	433	PF05994	0.492
MOD_CAAXbox	903	906	PF01239	0.559
MOD_CK1_1	209	215	PF00069	0.498
MOD_CK1_1	276	282	PF00069	0.630
MOD_CK1_1	339	345	PF00069	0.434
MOD_CK1_1	511	517	PF00069	0.383
MOD_CK1_1	621	627	PF00069	0.611
MOD_CK1_1	84	90	PF00069	0.486
MOD_CK2_1	229	235	PF00069	0.522
MOD_CK2_1	539	545	PF00069	0.725
MOD_Cter_Amidation	518	521	PF01082	0.690
MOD_GlcNHglycan	278	281	PF01048	0.615
MOD_GlcNHglycan	36	40	PF01048	0.396
MOD_GlcNHglycan	390	393	PF01048	0.452
MOD_GlcNHglycan	399	402	PF01048	0.513
MOD_GlcNHglycan	620	623	PF01048	0.681
MOD_GlcNHglycan	652	655	PF01048	0.709
MOD_GlcNHglycan	746	749	PF01048	0.584
MOD_GlcNHglycan	83	86	PF01048	0.494
MOD_GSK3_1	125	132	PF00069	0.712
MOD_GSK3_1	13	20	PF00069	0.489
MOD_GSK3_1	190	197	PF00069	0.578
MOD_GSK3_1	243	250	PF00069	0.467
MOD_GSK3_1	291	298	PF00069	0.412
MOD_GSK3_1	504	511	PF00069	0.515
MOD_GSK3_1	613	620	PF00069	0.753
MOD_GSK3_1	621	628	PF00069	0.705
MOD_GSK3_1	81	88	PF00069	0.506
MOD_GSK3_1	834	841	PF00069	0.510
MOD_N-GLC_1	229	234	PF02516	0.502
MOD_N-GLC_1	247	252	PF02516	0.344
MOD_N-GLC_1	452	457	PF02516	0.507
MOD_N-GLC_1	62	67	PF02516	0.376
MOD_N-GLC_1	626	631	PF02516	0.689
MOD_N-GLC_1	698	703	PF02516	0.652
MOD_NEK2_1	208	213	PF00069	0.326
MOD_NEK2_1	295	300	PF00069	0.423
MOD_NEK2_1	35	40	PF00069	0.379
MOD_NEK2_1	395	400	PF00069	0.659
MOD_NEK2_1	504	509	PF00069	0.525
MOD_NEK2_1	618	623	PF00069	0.744
MOD_NEK2_1	626	631	PF00069	0.701
MOD_NEK2_1	733	738	PF00069	0.635
MOD_NEK2_1	792	797	PF00069	0.506
MOD_NEK2_1	856	861	PF00069	0.460
MOD_NEK2_2	224	229	PF00069	0.297
MOD_PIKK_1	506	512	PF00454	0.571
MOD_PK_1	379	385	PF00069	0.528
MOD_PKA_2	174	180	PF00069	0.637
MOD_PKA_2	242	248	PF00069	0.550
MOD_PKA_2	313	319	PF00069	0.596
MOD_PKA_2	339	345	PF00069	0.321
MOD_PKA_2	388	394	PF00069	0.453
MOD_PKA_2	590	596	PF00069	0.640
MOD_PKA_2	744	750	PF00069	0.665
MOD_PKA_2	818	824	PF00069	0.421
MOD_PKA_2	856	862	PF00069	0.480
MOD_Plk_1	216	222	PF00069	0.450
MOD_Plk_1	325	331	PF00069	0.503
MOD_Plk_1	35	41	PF00069	0.364
MOD_Plk_1	452	458	PF00069	0.567
MOD_Plk_1	62	68	PF00069	0.633
MOD_Plk_1	85	91	PF00069	0.595
MOD_Plk_4	13	19	PF00069	0.529
MOD_Plk_4	190	196	PF00069	0.441
MOD_Plk_4	224	230	PF00069	0.301
MOD_Plk_4	295	301	PF00069	0.415
MOD_Plk_4	313	319	PF00069	0.430
MOD_Plk_4	417	423	PF00069	0.399
MOD_Plk_4	437	443	PF00069	0.233
MOD_Plk_4	511	517	PF00069	0.584
MOD_Plk_4	613	619	PF00069	0.578
MOD_Plk_4	838	844	PF00069	0.430
MOD_ProDKin_1	610	616	PF00069	0.752
MOD_ProDKin_1	753	759	PF00069	0.475
MOD_SUMO_for_1	332	335	PF00179	0.651
MOD_SUMO_rev_2	472	479	PF00179	0.622
MOD_SUMO_rev_2	747	753	PF00179	0.600
TRG_AP2beta_CARGO_1	403	413	PF09066	0.424
TRG_DiLeu_BaEn_1	190	195	PF01217	0.458
TRG_DiLeu_BaEn_1	405	410	PF01217	0.420
TRG_ENDOCYTIC_2	297	300	PF00928	0.400
TRG_ENDOCYTIC_2	3	6	PF00928	0.464
TRG_ENDOCYTIC_2	448	451	PF00928	0.403
TRG_ENDOCYTIC_2	563	566	PF00928	0.445
TRG_ENDOCYTIC_2	615	618	PF00928	0.704
TRG_ENDOCYTIC_2	687	690	PF00928	0.631
TRG_ENDOCYTIC_2	779	782	PF00928	0.464
TRG_ENDOCYTIC_2	785	788	PF00928	0.429
TRG_ENDOCYTIC_2	80	83	PF00928	0.446
TRG_ER_diArg_1	111	114	PF00400	0.692
TRG_ER_diArg_1	178	180	PF00400	0.757
TRG_ER_diArg_1	520	522	PF00400	0.620
TRG_ER_diArg_1	656	658	PF00400	0.743
TRG_ER_diArg_1	683	686	PF00400	0.533
TRG_ER_diArg_1	787	790	PF00400	0.398
TRG_ER_diArg_1	854	857	PF00400	0.419
TRG_NES_CRM1_1	186	198	PF08389	0.344
TRG_NES_CRM1_1	301	315	PF08389	0.310
TRG_NES_CRM1_1	556	570	PF08389	0.599
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P463	Leptomonas seymouri	64%	97%
A0A0S4KIE0	Bodo saltans	27%	100%
A0A1X0NIL2	Trypanosomatidae	40%	100%
A0A3S7X4T6	Leishmania donovani	78%	98%
A0A422NPC4	Trypanosoma rangeli	46%	100%
A4I764	Leishmania infantum	78%	98%
C9ZME9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B258	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	98%
Q4Q602	Leishmania major	77%	100%
V5B2Y1	Trypanosoma cruzi	40%	100%