Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HJP3_LEIBR

TriTrypDb:

LbrM.31.2890 , LBRM2903_310038000

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJP3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.306
CLV_C14_Caspase3-7	612	616	PF00656	0.529
CLV_NRD_NRD_1	260	262	PF00675	0.408
CLV_NRD_NRD_1	28	30	PF00675	0.430
CLV_NRD_NRD_1	444	446	PF00675	0.469
CLV_NRD_NRD_1	461	463	PF00675	0.458
CLV_NRD_NRD_1	487	489	PF00675	0.582
CLV_NRD_NRD_1	576	578	PF00675	0.538
CLV_NRD_NRD_1	580	582	PF00675	0.572
CLV_NRD_NRD_1	590	592	PF00675	0.613
CLV_NRD_NRD_1	676	678	PF00675	0.528
CLV_PCSK_KEX2_1	260	262	PF00082	0.408
CLV_PCSK_KEX2_1	28	30	PF00082	0.430
CLV_PCSK_KEX2_1	355	357	PF00082	0.494
CLV_PCSK_KEX2_1	444	446	PF00082	0.423
CLV_PCSK_KEX2_1	461	463	PF00082	0.458
CLV_PCSK_KEX2_1	487	489	PF00082	0.582
CLV_PCSK_KEX2_1	560	562	PF00082	0.659
CLV_PCSK_KEX2_1	576	578	PF00082	0.521
CLV_PCSK_KEX2_1	580	582	PF00082	0.573
CLV_PCSK_KEX2_1	589	591	PF00082	0.624
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.494
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.512
CLV_PCSK_PC7_1	576	582	PF00082	0.615
CLV_PCSK_SKI1_1	183	187	PF00082	0.468
CLV_PCSK_SKI1_1	248	252	PF00082	0.451
CLV_PCSK_SKI1_1	310	314	PF00082	0.391
CLV_PCSK_SKI1_1	355	359	PF00082	0.487
CLV_PCSK_SKI1_1	398	402	PF00082	0.392
CLV_PCSK_SKI1_1	444	448	PF00082	0.269
DEG_MDM2_SWIB_1	259	266	PF02201	0.309
DEG_Nend_Nbox_1	1	3	PF02207	0.408
DEG_SPOP_SBC_1	682	686	PF00917	0.507
DEG_SPOP_SBC_1	78	82	PF00917	0.510
DOC_CDC14_PxL_1	348	356	PF14671	0.355
DOC_CKS1_1	243	248	PF01111	0.337
DOC_CKS1_1	646	651	PF01111	0.726
DOC_CYCLIN_RxL_1	104	115	PF00134	0.301
DOC_CYCLIN_RxL_1	177	188	PF00134	0.455
DOC_CYCLIN_RxL_1	378	387	PF00134	0.479
DOC_CYCLIN_yClb1_LxF_4	246	251	PF00134	0.385
DOC_MAPK_gen_1	104	113	PF00069	0.407
DOC_MAPK_gen_1	355	365	PF00069	0.356
DOC_PP1_RVXF_1	18	25	PF00149	0.468
DOC_PP1_RVXF_1	246	252	PF00149	0.462
DOC_PP4_FxxP_1	421	424	PF00568	0.486
DOC_USP7_MATH_1	205	209	PF00917	0.549
DOC_USP7_MATH_1	602	606	PF00917	0.786
DOC_USP7_MATH_1	669	673	PF00917	0.676
DOC_USP7_MATH_1	722	726	PF00917	0.652
DOC_USP7_MATH_1	77	81	PF00917	0.700
DOC_USP7_UBL2_3	355	359	PF12436	0.392
DOC_WW_Pin1_4	227	232	PF00397	0.521
DOC_WW_Pin1_4	242	247	PF00397	0.471
DOC_WW_Pin1_4	435	440	PF00397	0.541
DOC_WW_Pin1_4	607	612	PF00397	0.710
DOC_WW_Pin1_4	626	631	PF00397	0.797
DOC_WW_Pin1_4	645	650	PF00397	0.773
DOC_WW_Pin1_4	725	730	PF00397	0.685
DOC_WW_Pin1_4	73	78	PF00397	0.713
LIG_14-3-3_CanoR_1	167	176	PF00244	0.507
LIG_14-3-3_CanoR_1	340	348	PF00244	0.672
LIG_14-3-3_CanoR_1	398	407	PF00244	0.312
LIG_14-3-3_CanoR_1	697	704	PF00244	0.621
LIG_Actin_WH2_2	344	361	PF00022	0.364
LIG_AP2alpha_2	178	180	PF02296	0.393
LIG_BRCT_BRCA1_1	344	348	PF00533	0.493
LIG_FHA_1	17	23	PF00498	0.364
LIG_FHA_1	36	42	PF00498	0.513
LIG_FHA_1	374	380	PF00498	0.570
LIG_FHA_1	429	435	PF00498	0.561
LIG_FHA_1	436	442	PF00498	0.489
LIG_FHA_1	445	451	PF00498	0.423
LIG_FHA_1	458	464	PF00498	0.546
LIG_FHA_1	630	636	PF00498	0.700
LIG_FHA_1	640	646	PF00498	0.695
LIG_FHA_2	113	119	PF00498	0.482
LIG_FHA_2	168	174	PF00498	0.524
LIG_FHA_2	2	8	PF00498	0.457
LIG_FHA_2	321	327	PF00498	0.410
LIG_FHA_2	479	485	PF00498	0.556
LIG_FHA_2	57	63	PF00498	0.722
LIG_FHA_2	682	688	PF00498	0.666
LIG_FHA_2	719	725	PF00498	0.488
LIG_FHA_2	756	762	PF00498	0.561
LIG_LIR_Apic_2	419	424	PF02991	0.463
LIG_LIR_Apic_2	689	694	PF02991	0.714
LIG_LIR_Gen_1	184	193	PF02991	0.422
LIG_LIR_Gen_1	216	225	PF02991	0.441
LIG_LIR_Gen_1	300	308	PF02991	0.434
LIG_LIR_Gen_1	390	400	PF02991	0.393
LIG_LIR_Gen_1	452	463	PF02991	0.518
LIG_LIR_Gen_1	775	782	PF02991	0.470
LIG_LIR_Nem_3	184	189	PF02991	0.394
LIG_LIR_Nem_3	191	196	PF02991	0.440
LIG_LIR_Nem_3	216	221	PF02991	0.478
LIG_LIR_Nem_3	256	262	PF02991	0.373
LIG_LIR_Nem_3	300	305	PF02991	0.444
LIG_LIR_Nem_3	345	351	PF02991	0.606
LIG_LIR_Nem_3	390	396	PF02991	0.366
LIG_LIR_Nem_3	419	425	PF02991	0.525
LIG_LIR_Nem_3	452	458	PF02991	0.477
LIG_LIR_Nem_3	685	691	PF02991	0.680
LIG_LIR_Nem_3	775	780	PF02991	0.462
LIG_MAD2	109	117	PF02301	0.333
LIG_MYND_1	152	156	PF01753	0.516
LIG_PDZ_Class_2	777	782	PF00595	0.480
LIG_Pex14_2	13	17	PF04695	0.570
LIG_Pex14_2	259	263	PF04695	0.308
LIG_Rb_pABgroove_1	180	188	PF01858	0.461
LIG_REV1ctd_RIR_1	178	187	PF16727	0.456
LIG_SH2_CRK	218	222	PF00017	0.495
LIG_SH2_CRK	272	276	PF00017	0.485
LIG_SH2_CRK	280	284	PF00017	0.407
LIG_SH2_CRK	437	441	PF00017	0.428
LIG_SH2_NCK_1	218	222	PF00017	0.495
LIG_SH2_NCK_1	709	713	PF00017	0.567
LIG_SH2_PTP2	691	694	PF00017	0.489
LIG_SH2_STAP1	272	276	PF00017	0.535
LIG_SH2_STAP1	536	540	PF00017	0.535
LIG_SH2_STAP1	688	692	PF00017	0.576
LIG_SH2_STAT3	264	267	PF00017	0.390
LIG_SH2_STAT3	698	701	PF00017	0.521
LIG_SH2_STAT5	175	178	PF00017	0.454
LIG_SH2_STAT5	264	267	PF00017	0.390
LIG_SH2_STAT5	3	6	PF00017	0.450
LIG_SH2_STAT5	30	33	PF00017	0.380
LIG_SH2_STAT5	314	317	PF00017	0.335
LIG_SH2_STAT5	322	325	PF00017	0.396
LIG_SH2_STAT5	362	365	PF00017	0.343
LIG_SH2_STAT5	437	440	PF00017	0.379
LIG_SH2_STAT5	477	480	PF00017	0.417
LIG_SH2_STAT5	654	657	PF00017	0.526
LIG_SH2_STAT5	691	694	PF00017	0.671
LIG_SH2_STAT5	698	701	PF00017	0.632
LIG_SH3_3	146	152	PF00018	0.462
LIG_SH3_3	228	234	PF00018	0.502
LIG_SH3_3	240	246	PF00018	0.398
LIG_SH3_3	282	288	PF00018	0.394
LIG_SH3_3	409	415	PF00018	0.485
LIG_SH3_3	421	427	PF00018	0.373
LIG_SH3_3	565	571	PF00018	0.605
LIG_SH3_3	66	72	PF00018	0.779
LIG_SH3_3	89	95	PF00018	0.619
LIG_TRAF2_1	323	326	PF00917	0.372
LIG_TRAF2_1	481	484	PF00917	0.443
LIG_TRAF2_1	769	772	PF00917	0.521
LIG_TYR_ITIM	270	275	PF00017	0.478
LIG_TYR_ITSM	214	221	PF00017	0.442
LIG_Vh1_VBS_1	730	748	PF01044	0.504
LIG_WRC_WIRS_1	313	318	PF05994	0.394
MOD_CDK_SPK_2	227	232	PF00069	0.505
MOD_CDK_SPxK_1	242	248	PF00069	0.546
MOD_CK1_1	16	22	PF00069	0.583
MOD_CK1_1	328	334	PF00069	0.592
MOD_CK1_1	342	348	PF00069	0.472
MOD_CK1_1	375	381	PF00069	0.405
MOD_CK1_1	457	463	PF00069	0.456
MOD_CK1_1	473	479	PF00069	0.547
MOD_CK1_1	499	505	PF00069	0.585
MOD_CK1_1	616	622	PF00069	0.625
MOD_CK1_1	625	631	PF00069	0.781
MOD_CK1_1	671	677	PF00069	0.723
MOD_CK1_1	686	692	PF00069	0.667
MOD_CK1_1	725	731	PF00069	0.494
MOD_CK1_1	80	86	PF00069	0.783
MOD_CK2_1	1	7	PF00069	0.425
MOD_CK2_1	112	118	PF00069	0.445
MOD_CK2_1	158	164	PF00069	0.561
MOD_CK2_1	320	326	PF00069	0.384
MOD_CK2_1	478	484	PF00069	0.578
MOD_CK2_1	548	554	PF00069	0.563
MOD_CK2_1	673	679	PF00069	0.754
MOD_CK2_1	681	687	PF00069	0.744
MOD_CK2_1	697	703	PF00069	0.615
MOD_CK2_1	755	761	PF00069	0.623
MOD_GlcNHglycan	207	210	PF01048	0.559
MOD_GlcNHglycan	328	331	PF01048	0.519
MOD_GlcNHglycan	344	347	PF01048	0.444
MOD_GlcNHglycan	550	553	PF01048	0.525
MOD_GlcNHglycan	618	621	PF01048	0.742
MOD_GlcNHglycan	624	627	PF01048	0.747
MOD_GlcNHglycan	64	67	PF01048	0.805
MOD_GlcNHglycan	679	682	PF01048	0.786
MOD_GlcNHglycan	705	708	PF01048	0.747
MOD_GSK3_1	163	170	PF00069	0.436
MOD_GSK3_1	297	304	PF00069	0.544
MOD_GSK3_1	31	38	PF00069	0.427
MOD_GSK3_1	340	347	PF00069	0.676
MOD_GSK3_1	45	52	PF00069	0.561
MOD_GSK3_1	450	457	PF00069	0.415
MOD_GSK3_1	53	60	PF00069	0.683
MOD_GSK3_1	609	616	PF00069	0.592
MOD_GSK3_1	622	629	PF00069	0.715
MOD_GSK3_1	667	674	PF00069	0.710
MOD_GSK3_1	677	684	PF00069	0.725
MOD_GSK3_1	718	725	PF00069	0.719
MOD_GSK3_1	73	80	PF00069	0.741
MOD_GSK3_1	737	744	PF00069	0.718
MOD_GSK3_1	747	754	PF00069	0.619
MOD_GSK3_1	9	16	PF00069	0.416
MOD_N-GLC_1	333	338	PF02516	0.626
MOD_N-GLC_1	497	502	PF02516	0.590
MOD_N-GLC_1	602	607	PF02516	0.614
MOD_NEK2_1	1	6	PF00069	0.483
MOD_NEK2_1	13	18	PF00069	0.559
MOD_NEK2_1	163	168	PF00069	0.409
MOD_NEK2_1	185	190	PF00069	0.476
MOD_NEK2_1	333	338	PF00069	0.515
MOD_NEK2_1	373	378	PF00069	0.497
MOD_NEK2_1	43	48	PF00069	0.563
MOD_NEK2_1	770	775	PF00069	0.665
MOD_NEK2_2	23	28	PF00069	0.540
MOD_OFUCOSY	448	454	PF10250	0.452
MOD_PIKK_1	158	164	PF00454	0.585
MOD_PIKK_1	198	204	PF00454	0.450
MOD_PIKK_1	697	703	PF00454	0.541
MOD_PK_1	711	717	PF00069	0.470
MOD_PKA_1	444	450	PF00069	0.477
MOD_PKA_1	487	493	PF00069	0.413
MOD_PKA_1	580	586	PF00069	0.554
MOD_PKA_1	677	683	PF00069	0.519
MOD_PKA_2	339	345	PF00069	0.674
MOD_PKA_2	373	379	PF00069	0.495
MOD_PKA_2	444	450	PF00069	0.339
MOD_PKA_2	487	493	PF00069	0.636
MOD_PKA_2	580	586	PF00069	0.660
MOD_PKB_1	165	173	PF00069	0.321
MOD_Plk_1	497	503	PF00069	0.477
MOD_Plk_1	602	608	PF00069	0.705
MOD_Plk_1	686	692	PF00069	0.570
MOD_Plk_1	755	761	PF00069	0.598
MOD_Plk_2-3	755	761	PF00069	0.623
MOD_Plk_4	224	230	PF00069	0.570
MOD_Plk_4	265	271	PF00069	0.446
MOD_Plk_4	297	303	PF00069	0.421
MOD_Plk_4	312	318	PF00069	0.319
MOD_Plk_4	328	334	PF00069	0.605
MOD_Plk_4	366	372	PF00069	0.445
MOD_Plk_4	45	51	PF00069	0.720
MOD_Plk_4	473	479	PF00069	0.413
MOD_Plk_4	609	615	PF00069	0.535
MOD_Plk_4	687	693	PF00069	0.534
MOD_Plk_4	711	717	PF00069	0.583
MOD_Plk_4	9	15	PF00069	0.503
MOD_ProDKin_1	227	233	PF00069	0.519
MOD_ProDKin_1	242	248	PF00069	0.468
MOD_ProDKin_1	435	441	PF00069	0.531
MOD_ProDKin_1	607	613	PF00069	0.711
MOD_ProDKin_1	626	632	PF00069	0.797
MOD_ProDKin_1	645	651	PF00069	0.725
MOD_ProDKin_1	725	731	PF00069	0.686
MOD_ProDKin_1	73	79	PF00069	0.712
MOD_SUMO_for_1	234	237	PF00179	0.546
TRG_AP2beta_CARGO_1	191	200	PF09066	0.532
TRG_AP2beta_CARGO_1	452	462	PF09066	0.511
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.503
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.398
TRG_ENDOCYTIC_2	218	221	PF00928	0.447
TRG_ENDOCYTIC_2	272	275	PF00928	0.487
TRG_ENDOCYTIC_2	280	283	PF00928	0.424
TRG_ENDOCYTIC_2	314	317	PF00928	0.344
TRG_ENDOCYTIC_2	362	365	PF00928	0.343
TRG_ENDOCYTIC_2	437	440	PF00928	0.451
TRG_ER_diArg_1	251	254	PF00400	0.406
TRG_ER_diArg_1	259	261	PF00400	0.362
TRG_ER_diArg_1	27	29	PF00400	0.515
TRG_ER_diArg_1	443	445	PF00400	0.438
TRG_ER_diArg_1	461	463	PF00400	0.388
TRG_ER_diArg_1	464	467	PF00400	0.394
TRG_ER_diArg_1	487	489	PF00400	0.572
TRG_ER_diArg_1	576	578	PF00400	0.510
TRG_ER_diArg_1	588	591	PF00400	0.673
TRG_ER_diArg_1	594	597	PF00400	0.694
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	555	559	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW18	Leptomonas seymouri	42%	87%
A0A0N1PBA0	Leptomonas seymouri	53%	95%
A0A1X0NIQ9	Trypanosomatidae	37%	100%
A0A3Q8ICR1	Leishmania donovani	41%	89%
A0A3Q8ISU5	Leishmania donovani	73%	99%
A0A3R7KGN9	Trypanosoma rangeli	35%	100%
A4HJP4	Leishmania braziliensis	45%	88%
A4I760	Leishmania infantum	73%	99%
A4I761	Leishmania infantum	41%	89%
E9B254	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
E9B255	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	76%
Q4Q605	Leishmania major	44%	77%
Q4Q606	Leishmania major	74%	100%
V5BC23	Trypanosoma cruzi	33%	100%