LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

EGF-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
EGF-like domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HJP1_LEIBR
TriTrypDb:
LbrM.31.2870 , LBRM2903_310037900
Length:
467

Annotations

LeishMANIAdb annotations

The last domain of this multidomain protein is related to animal Stabilins, known lipoprotein receptors. related to the T. cruzi protein “Enriched in surface-labeled proteome protein 10”. Family has expanded on multiple Kinetoplastid branches, also in free-living species. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 1, no: 1
NetGPI no yes: 0, no: 2
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4HJP1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJP1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 398 400 PF00675 0.564
CLV_NRD_NRD_1 422 424 PF00675 0.568
CLV_NRD_NRD_1 458 460 PF00675 0.576
CLV_PCSK_KEX2_1 398 400 PF00082 0.564
CLV_PCSK_KEX2_1 422 424 PF00082 0.555
CLV_PCSK_KEX2_1 457 459 PF00082 0.578
CLV_PCSK_PC1ET2_1 457 459 PF00082 0.603
CLV_PCSK_PC7_1 454 460 PF00082 0.588
CLV_PCSK_SKI1_1 454 458 PF00082 0.583
DEG_SCF_FBW7_2 28 35 PF00400 0.446
DOC_CKS1_1 29 34 PF01111 0.581
DOC_CKS1_1 346 351 PF01111 0.550
DOC_MAPK_gen_1 362 372 PF00069 0.471
DOC_MAPK_gen_1 422 432 PF00069 0.756
DOC_MAPK_MEF2A_6 185 192 PF00069 0.504
DOC_MAPK_MEF2A_6 365 372 PF00069 0.469
DOC_MAPK_MEF2A_6 423 432 PF00069 0.736
DOC_MAPK_MEF2A_6 440 447 PF00069 0.702
DOC_MAPK_RevD_3 384 399 PF00069 0.541
DOC_MAPK_RevD_3 445 459 PF00069 0.796
DOC_PP4_FxxP_1 29 32 PF00568 0.574
DOC_USP7_MATH_1 194 198 PF00917 0.534
DOC_USP7_MATH_1 2 6 PF00917 0.622
DOC_USP7_MATH_1 259 263 PF00917 0.462
DOC_USP7_MATH_1 267 271 PF00917 0.387
DOC_USP7_MATH_1 41 45 PF00917 0.388
DOC_USP7_MATH_1 72 76 PF00917 0.420
DOC_USP7_MATH_1 9 13 PF00917 0.514
DOC_USP7_MATH_1 91 95 PF00917 0.413
DOC_WW_Pin1_4 28 33 PF00397 0.570
DOC_WW_Pin1_4 335 340 PF00397 0.481
DOC_WW_Pin1_4 345 350 PF00397 0.486
DOC_WW_Pin1_4 412 417 PF00397 0.719
LIG_14-3-3_CanoR_1 306 311 PF00244 0.529
LIG_14-3-3_CanoR_1 4 9 PF00244 0.595
LIG_14-3-3_CanoR_1 434 439 PF00244 0.694
LIG_14-3-3_CanoR_1 448 453 PF00244 0.580
LIG_Actin_WH2_2 435 450 PF00022 0.689
LIG_APCC_ABBA_1 131 136 PF00400 0.359
LIG_BIR_II_1 1 5 PF00653 0.805
LIG_BIR_III_4 275 279 PF00653 0.527
LIG_BRCT_BRCA1_1 11 15 PF00533 0.506
LIG_BRCT_BRCA1_1 327 331 PF00533 0.506
LIG_BRCT_BRCA1_1 4 8 PF00533 0.596
LIG_DLG_GKlike_1 448 455 PF00625 0.663
LIG_eIF4E_1 123 129 PF01652 0.543
LIG_FHA_1 29 35 PF00498 0.451
LIG_FHA_1 407 413 PF00498 0.714
LIG_FHA_1 5 11 PF00498 0.542
LIG_FHA_1 65 71 PF00498 0.481
LIG_LIR_Apic_2 343 349 PF02991 0.546
LIG_LIR_Apic_2 35 41 PF02991 0.423
LIG_LIR_Gen_1 120 131 PF02991 0.525
LIG_LIR_Gen_1 373 382 PF02991 0.449
LIG_LIR_Gen_1 67 73 PF02991 0.361
LIG_LIR_Nem_3 12 17 PF02991 0.705
LIG_LIR_Nem_3 373 377 PF02991 0.449
LIG_LIR_Nem_3 67 71 PF02991 0.326
LIG_MLH1_MIPbox_1 11 15 PF16413 0.568
LIG_NRBOX 389 395 PF00104 0.375
LIG_PCNA_PIPBox_1 449 458 PF02747 0.789
LIG_PCNA_yPIPBox_3 448 456 PF02747 0.788
LIG_SH2_CRK 346 350 PF00017 0.545
LIG_SH2_CRK 38 42 PF00017 0.414
LIG_SH2_NCK_1 134 138 PF00017 0.504
LIG_SH2_NCK_1 346 350 PF00017 0.545
LIG_SH2_SRC 134 137 PF00017 0.497
LIG_SH2_STAP1 342 346 PF00017 0.547
LIG_SH2_STAP1 66 70 PF00017 0.479
LIG_SH2_STAT5 14 17 PF00017 0.645
LIG_SH2_STAT5 342 345 PF00017 0.541
LIG_SH2_STAT5 38 41 PF00017 0.414
LIG_SH2_STAT5 66 69 PF00017 0.369
LIG_SH3_3 149 155 PF00018 0.515
LIG_SH3_3 174 180 PF00018 0.439
LIG_SH3_3 381 387 PF00018 0.375
LIG_Sin3_3 374 381 PF02671 0.375
LIG_SUMO_SIM_anti_2 373 379 PF11976 0.449
LIG_SUMO_SIM_par_1 138 144 PF11976 0.484
LIG_SUMO_SIM_par_1 69 76 PF11976 0.369
LIG_WRC_WIRS_1 407 412 PF05994 0.638
MOD_CDK_SPxxK_3 412 419 PF00069 0.647
MOD_CK1_1 210 216 PF00069 0.635
MOD_CK1_1 241 247 PF00069 0.461
MOD_CK1_1 262 268 PF00069 0.750
MOD_CK1_1 345 351 PF00069 0.693
MOD_CK2_1 91 97 PF00069 0.645
MOD_GlcNHglycan 11 14 PF01048 0.578
MOD_GlcNHglycan 136 140 PF01048 0.458
MOD_GlcNHglycan 185 188 PF01048 0.635
MOD_GlcNHglycan 208 213 PF01048 0.635
MOD_GlcNHglycan 243 246 PF01048 0.629
MOD_GlcNHglycan 261 264 PF01048 0.435
MOD_GlcNHglycan 335 338 PF01048 0.674
MOD_GlcNHglycan 399 402 PF01048 0.579
MOD_GSK3_1 117 124 PF00069 0.507
MOD_GSK3_1 239 246 PF00069 0.459
MOD_GSK3_1 258 265 PF00069 0.397
MOD_GSK3_1 340 347 PF00069 0.679
MOD_GSK3_1 406 413 PF00069 0.637
MOD_GSK3_1 430 437 PF00069 0.617
MOD_N-GLC_1 64 69 PF02516 0.631
MOD_N-GLC_2 59 61 PF02516 0.414
MOD_NEK2_1 183 188 PF00069 0.642
MOD_NEK2_1 389 394 PF00069 0.470
MOD_NEK2_1 410 415 PF00069 0.645
MOD_NEK2_1 57 62 PF00069 0.503
MOD_OFUCOSY 207 214 PF10250 0.641
MOD_OFUCOSY 325 330 PF10250 0.639
MOD_OFUCOSY 39 45 PF10250 0.484
MOD_OFUCOSY 54 61 PF10250 0.504
MOD_PIKK_1 350 356 PF00454 0.708
MOD_PKA_2 112 118 PF00069 0.562
MOD_PKA_2 397 403 PF00069 0.549
MOD_Plk_1 141 147 PF00069 0.512
MOD_Plk_1 172 178 PF00069 0.685
MOD_Plk_1 326 332 PF00069 0.637
MOD_Plk_1 64 70 PF00069 0.501
MOD_Plk_4 173 179 PF00069 0.498
MOD_Plk_4 389 395 PF00069 0.375
MOD_ProDKin_1 28 34 PF00069 0.724
MOD_ProDKin_1 335 341 PF00069 0.589
MOD_ProDKin_1 345 351 PF00069 0.606
MOD_ProDKin_1 412 418 PF00069 0.646
TRG_ENDOCYTIC_2 123 126 PF00928 0.559
TRG_ENDOCYTIC_2 134 137 PF00928 0.416
TRG_ENDOCYTIC_2 14 17 PF00928 0.698
TRG_ER_diArg_1 359 362 PF00400 0.755
TRG_ER_diArg_1 397 399 PF00400 0.705
TRG_ER_diArg_1 421 423 PF00400 0.702
TRG_NES_CRM1_1 136 146 PF08389 0.436
TRG_NES_CRM1_1 441 453 PF08389 0.595
TRG_Pf-PMV_PEXEL_1 419 424 PF00026 0.815
TRG_Pf-PMV_PEXEL_1 436 441 PF00026 0.489
TRG_Pf-PMV_PEXEL_1 88 92 PF00026 0.656

Homologs

Protein Taxonomy Sequence identity Coverage
A4I712 Leishmania infantum 72% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS