Thermopsin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Thermopsin

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HJP0_LEIBR

TriTrypDb:

LbrM.31.2860 , LBRM2903_310037900

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 1
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HJP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJP0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.490
CLV_NRD_NRD_1	368	370	PF00675	0.600
CLV_NRD_NRD_1	6	8	PF00675	0.448
CLV_NRD_NRD_1	66	68	PF00675	0.487
CLV_PCSK_KEX2_1	368	370	PF00082	0.600
CLV_PCSK_KEX2_1	6	8	PF00082	0.448
CLV_PCSK_PC7_1	364	370	PF00082	0.507
CLV_PCSK_SKI1_1	364	368	PF00082	0.592
CLV_PCSK_SKI1_1	7	11	PF00082	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.476
DOC_CDC14_PxL_1	186	194	PF14671	0.392
DOC_CKS1_1	246	251	PF01111	0.384
DOC_MAPK_MEF2A_6	340	349	PF00069	0.538
DOC_PP2B_LxvP_1	353	356	PF13499	0.539
DOC_PP2B_LxvP_1	359	362	PF13499	0.501
DOC_PP4_FxxP_1	106	109	PF00568	0.394
DOC_PP4_FxxP_1	318	321	PF00568	0.539
DOC_USP7_MATH_1	132	136	PF00917	0.495
DOC_USP7_MATH_1	162	166	PF00917	0.448
DOC_USP7_MATH_1	310	314	PF00917	0.523
DOC_USP7_MATH_1	46	50	PF00917	0.430
DOC_WW_Pin1_4	105	110	PF00397	0.450
DOC_WW_Pin1_4	245	250	PF00397	0.434
DOC_WW_Pin1_4	316	321	PF00397	0.652
DOC_WW_Pin1_4	59	64	PF00397	0.449
LIG_14-3-3_CanoR_1	201	209	PF00244	0.358
LIG_14-3-3_CanoR_1	217	222	PF00244	0.286
LIG_BRCT_BRCA1_1	102	106	PF00533	0.437
LIG_BRCT_BRCA1_1	164	168	PF00533	0.439
LIG_deltaCOP1_diTrp_1	8	13	PF00928	0.420
LIG_FHA_1	135	141	PF00498	0.490
LIG_FHA_1	14	20	PF00498	0.437
LIG_FHA_1	201	207	PF00498	0.335
LIG_FHA_1	222	228	PF00498	0.457
LIG_FHA_1	232	238	PF00498	0.349
LIG_FHA_2	180	186	PF00498	0.363
LIG_FHA_2	56	62	PF00498	0.548
LIG_LIR_Apic_2	103	109	PF02991	0.405
LIG_LIR_Apic_2	315	321	PF02991	0.545
LIG_LIR_Gen_1	185	192	PF02991	0.357
LIG_LIR_Gen_1	8	19	PF02991	0.426
LIG_LIR_Nem_3	146	150	PF02991	0.380
LIG_LIR_Nem_3	185	189	PF02991	0.347
LIG_LIR_Nem_3	51	56	PF02991	0.389
LIG_LIR_Nem_3	8	14	PF02991	0.419
LIG_SH2_CRK	153	157	PF00017	0.408
LIG_SH2_CRK	186	190	PF00017	0.351
LIG_SH2_CRK	218	222	PF00017	0.448
LIG_SH2_CRK	56	60	PF00017	0.404
LIG_SH2_GRB2like	209	212	PF00017	0.397
LIG_SH2_NCK_1	153	157	PF00017	0.408
LIG_SH2_NCK_1	181	185	PF00017	0.373
LIG_SH2_SRC	209	212	PF00017	0.397
LIG_SH2_STAP1	238	242	PF00017	0.424
LIG_SH2_STAT5	100	103	PF00017	0.592
LIG_SH2_STAT5	118	121	PF00017	0.393
LIG_SH2_STAT5	181	184	PF00017	0.378
LIG_SH2_STAT5	186	189	PF00017	0.335
LIG_SH2_STAT5	35	38	PF00017	0.364
LIG_SH3_3	243	249	PF00018	0.389
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.504
LIG_SUMO_SIM_par_1	15	23	PF11976	0.445
LIG_SUMO_SIM_par_1	165	175	PF11976	0.438
LIG_TYR_ITIM	184	189	PF00017	0.347
MOD_CK1_1	134	140	PF00069	0.470
MOD_CK1_1	28	34	PF00069	0.425
MOD_CK2_1	160	166	PF00069	0.466
MOD_CK2_1	179	185	PF00069	0.375
MOD_CK2_1	2	8	PF00069	0.452
MOD_GlcNHglycan	162	165	PF01048	0.465
MOD_GlcNHglycan	173	177	PF01048	0.433
MOD_GlcNHglycan	2	5	PF01048	0.456
MOD_GlcNHglycan	290	293	PF01048	0.382
MOD_GSK3_1	127	134	PF00069	0.453
MOD_GSK3_1	156	163	PF00069	0.470
MOD_GSK3_1	164	171	PF00069	0.386
MOD_GSK3_1	217	224	PF00069	0.378
MOD_GSK3_1	241	248	PF00069	0.520
MOD_GSK3_1	293	300	PF00069	0.386
MOD_GSK3_1	306	313	PF00069	0.568
MOD_GSK3_1	36	43	PF00069	0.384
MOD_GSK3_1	55	62	PF00069	0.399
MOD_GSK3_1	95	102	PF00069	0.459
MOD_N-GLC_1	210	215	PF02516	0.363
MOD_N-GLC_1	95	100	PF02516	0.559
MOD_NEK2_1	127	132	PF00069	0.442
MOD_NEK2_1	13	18	PF00069	0.378
MOD_NEK2_1	157	162	PF00069	0.440
MOD_NEK2_1	19	24	PF00069	0.404
MOD_NEK2_1	2	7	PF00069	0.526
MOD_NEK2_1	236	241	PF00069	0.527
MOD_NEK2_1	288	293	PF00069	0.418
MOD_NEK2_1	311	316	PF00069	0.538
MOD_NEK2_1	71	76	PF00069	0.481
MOD_NEK2_2	238	243	PF00069	0.425
MOD_PIKK_1	40	46	PF00454	0.484
MOD_PKA_2	200	206	PF00069	0.357
MOD_PKA_2	28	34	PF00069	0.549
MOD_Plk_1	135	141	PF00069	0.475
MOD_Plk_1	46	52	PF00069	0.492
MOD_Plk_1	95	101	PF00069	0.464
MOD_Plk_4	135	141	PF00069	0.472
MOD_Plk_4	164	170	PF00069	0.430
MOD_Plk_4	210	216	PF00069	0.356
MOD_Plk_4	28	34	PF00069	0.425
MOD_Plk_4	294	300	PF00069	0.392
MOD_Plk_4	324	330	PF00069	0.549
MOD_Plk_4	95	101	PF00069	0.511
MOD_ProDKin_1	105	111	PF00069	0.457
MOD_ProDKin_1	245	251	PF00069	0.442
MOD_ProDKin_1	316	322	PF00069	0.652
MOD_ProDKin_1	59	65	PF00069	0.446
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.542
TRG_ENDOCYTIC_2	181	184	PF00928	0.378
TRG_ENDOCYTIC_2	186	189	PF00928	0.335
TRG_ENDOCYTIC_2	218	221	PF00928	0.448
TRG_ENDOCYTIC_2	56	59	PF00928	0.406
TRG_ER_diArg_1	343	346	PF00400	0.564
TRG_ER_diArg_1	367	369	PF00400	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1F4	Leptomonas seymouri	52%	71%