Ferredoxin, 2fe-2s-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferredoxin, 2fe-2s-like protein

Species:

Leishmania braziliensis

UniProt:

A4HJN9_LEIBR

TriTrypDb:

LbrM.31.2850 , LBRM2903_310037700

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 23
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HJN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HJN9

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	26
GO:0008152	metabolic process	1	26
GO:0009987	cellular process	1	26
GO:0022900	electron transport chain	4	26
GO:0044237	cellular metabolic process	2	26
GO:0140647	P450-containing electron transport chain	5	26

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	26
GO:0051536	iron-sulfur cluster binding	3	26
GO:0051537	2 iron, 2 sulfur cluster binding	4	26
GO:0051540	metal cluster binding	2	26
GO:0003824	catalytic activity	1	5
GO:0009055	electron transfer activity	3	5
GO:0016491	oxidoreductase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.168
CLV_NRD_NRD_1	174	176	PF00675	0.494
CLV_NRD_NRD_1	5	7	PF00675	0.568
CLV_PCSK_KEX2_1	162	164	PF00082	0.346
CLV_PCSK_KEX2_1	174	176	PF00082	0.420
CLV_PCSK_KEX2_1	5	7	PF00082	0.564
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.331
CLV_PCSK_SKI1_1	48	52	PF00082	0.405
DEG_Nend_Nbox_1	1	3	PF02207	0.441
DOC_MAPK_gen_1	5	13	PF00069	0.439
DOC_MAPK_MEF2A_6	82	91	PF00069	0.276
DOC_PP4_FxxP_1	13	16	PF00568	0.426
DOC_USP7_MATH_1	135	139	PF00917	0.211
DOC_USP7_MATH_1	22	26	PF00917	0.469
DOC_USP7_MATH_1	32	36	PF00917	0.408
DOC_USP7_MATH_1	37	41	PF00917	0.521
DOC_WW_Pin1_4	35	40	PF00397	0.477
DOC_WW_Pin1_4	48	53	PF00397	0.512
LIG_14-3-3_CanoR_1	168	174	PF00244	0.389
LIG_14-3-3_CanoR_1	30	39	PF00244	0.479
LIG_14-3-3_CanoR_1	5	11	PF00244	0.573
LIG_14-3-3_CterR_2	174	179	PF00244	0.390
LIG_BRCT_BRCA1_1	42	46	PF00533	0.450
LIG_deltaCOP1_diTrp_1	166	173	PF00928	0.377
LIG_DLG_GKlike_1	15	23	PF00625	0.424
LIG_FHA_1	101	107	PF00498	0.393
LIG_FHA_1	138	144	PF00498	0.312
LIG_FHA_1	162	168	PF00498	0.617
LIG_FHA_1	84	90	PF00498	0.308
LIG_FHA_2	122	128	PF00498	0.267
LIG_FHA_2	146	152	PF00498	0.401
LIG_LIR_Apic_2	12	16	PF02991	0.397
LIG_Pex14_1	169	173	PF04695	0.495
LIG_SH2_CRK	8	12	PF00017	0.394
LIG_SH2_NCK_1	8	12	PF00017	0.394
LIG_SH3_3	36	42	PF00018	0.448
LIG_SH3_3	8	14	PF00018	0.441
LIG_SH3_3	86	92	PF00018	0.295
LIG_SUMO_SIM_par_1	83	90	PF11976	0.168
MOD_CDK_SPxK_1	48	54	PF00069	0.547
MOD_CK1_1	138	144	PF00069	0.333
MOD_CK1_1	35	41	PF00069	0.447
MOD_CK1_1	85	91	PF00069	0.168
MOD_CK1_1	9	15	PF00069	0.561
MOD_CK2_1	121	127	PF00069	0.326
MOD_DYRK1A_RPxSP_1	48	52	PF00069	0.410
MOD_GlcNHglycan	19	22	PF01048	0.465
MOD_GlcNHglycan	34	37	PF01048	0.446
MOD_GlcNHglycan	48	51	PF01048	0.435
MOD_GSK3_1	169	176	PF00069	0.425
MOD_GSK3_1	22	29	PF00069	0.491
MOD_GSK3_1	31	38	PF00069	0.439
MOD_GSK3_1	95	102	PF00069	0.371
MOD_N-GLC_1	95	100	PF02516	0.276
MOD_NEK2_1	173	178	PF00069	0.386
MOD_NEK2_1	46	51	PF00069	0.493
MOD_NEK2_1	77	82	PF00069	0.207
MOD_NEK2_2	169	174	PF00069	0.389
MOD_OFUCOSY	99	104	PF10250	0.395
MOD_PKA_2	173	179	PF00069	0.452
MOD_PKB_1	56	64	PF00069	0.346
MOD_Plk_1	138	144	PF00069	0.299
MOD_Plk_1	82	88	PF00069	0.225
MOD_Plk_4	116	122	PF00069	0.168
MOD_Plk_4	6	12	PF00069	0.409
MOD_ProDKin_1	35	41	PF00069	0.475
MOD_ProDKin_1	48	54	PF00069	0.530
TRG_ENDOCYTIC_2	8	11	PF00928	0.391
TRG_ER_diArg_1	173	175	PF00400	0.431
TRG_ER_diArg_1	55	58	PF00400	0.391
TRG_ER_diArg_1	59	62	PF00400	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	42%	100%
A0A0N1ILD8	Leptomonas seymouri	53%	100%
A0A0N1PE81	Leptomonas seymouri	40%	100%
A0A3Q8IIS3	Leishmania donovani	47%	100%
A0A3S7X4S6	Leishmania donovani	40%	100%
A0A3S7X4U4	Leishmania donovani	69%	98%
A0A3S7X4W8	Leishmania donovani	40%	100%
A4HJN2	Leishmania braziliensis	40%	100%
A4HJN3	Leishmania braziliensis	46%	100%
A4HJN4	Leishmania braziliensis	41%	100%
A4HJN8	Leishmania braziliensis	42%	100%
A4I755	Leishmania infantum	40%	100%
A4I756	Leishmania infantum	47%	100%
A4I757	Leishmania infantum	40%	100%
A4I758	Leishmania infantum	70%	98%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	98%
P00257	Bos taurus	33%	96%
P00258	Sus scrofa	33%	96%
P10109	Homo sapiens	33%	97%
P13216	Gallus gallus	32%	100%
P24483	Rattus norvegicus	33%	95%
P29330	Ovis aries	34%	100%
P46656	Mus musculus	31%	95%
Q12184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q4Q610	Leishmania major	69%	100%
Q4Q611	Leishmania major	42%	100%
Q4Q612	Leishmania major	46%	100%
Q4Q613	Leishmania major	39%	100%
Q4Q989	Leishmania major	38%	100%